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A09 - Raymond Poot:

Autism-relevant transcriptional networks in human neural stem cells

Chromatin modifiers and transcription factors are frequently mutated in ASDs. However, the protein and gene networks they function in are not understood. We will biochemically purify ASD-associated factors from human neural stem cells and identify their protein interaction networks by mass spectrometry. Our new method will allow 5-10 fold more interactors to be identified than current standards and will provide quantitative information on their stoichiometry. Subsequently, we will determine common target genes of several selected ASD-related factors to define relevant pathways and diagnostic marker genes. These pathways may ultimately be targeted by future early-intervention therapeutic strategies.

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