Main Content

Publications - 2nd Funding Period (2014-2018)

  • Kovač, K., Sauer, A., Mačinković, I., Awe, S., Finkernagel, F., Hoffmeister, H., Fuchs, A., Müller, R., Rathke, C., Längst, G., and Brehm, A. (2018). Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner. Nat Commun 9, 2112. 10.1038/s41467-018-04503-2.

    Kreher, J., Kovač, K., Bouazoune, K., Mačinković, I., Ernst, A.L., Engelen, E., Pahl, R., Finkernagel, F., Murawska, M., Ullah, I., and Brehm, A. (2017). EcR recruits dMi-2 and increases efficiency of dMi-2-mediated remodelling to constrain transcription of hormone-regulated genes. Nat Commun 8, 14806. 10.1038/ncomms14806.

    Theofel, I., Bartkuhn, M., Boettger, T., Gärtner, S.M.K., Kreher, J., Brehm, A., and Rathke, C. (2017). tBRD-1 and tBRD-2 regulate expression of genes necessary for spermatid differentiation. Biol Open 6, 439-448. 10.1242/bio.022467.

    Jox, T., Buxa, M.K., Bohla, D., Ullah, I., Mačinković, I., Brehm, A., Bartkuhn, M., and Renkawitz, R. (2017). CP190- and dCTCF-mediated enhancer blocking is augmented by SUMOylation. Epigenetics Chromatin 10, 32. 10.1186/s13072-017-0140-6.

    Kim, J., Lu, C., Srinivasan, S., Awe, S., Brehm, A., and Fuller, M.T. (2017). Blocking promiscuous activation at cryptic promoters directs cell type-specific gene expression. Science 356, 717-721. 10.1126/science.aal3096.

    Fritsch, K., Mernberger, M., Nist, A., Stiewe, T., Brehm, A., and Jacob, R. (2016). Galectin-3 interacts with components of the nuclear ribonucleoprotein complex. BMC Cancer 16, 502. 10.1186/s12885-016-2546-0. 

  • Ianni, A., Yuan, X., Bober, E., and Braun, T. (2018). Sirtuins in the Cardiovascular System: Potential Targets in Pediatric Cardiology. Pediatr Cardiol 39, 983-992. 10.1007/s00246-018-1848-1.

    Meier-Soelch, J., Jurida, L., Weber, A., Newel, D., Kim, J., Braun, T., Schmitz, M.L., and Kracht, M. (2018). RNAi-Based Identification of Gene-Specific Nuclear Cofactor Networks Regulating Interleukin-1 Target Genes. Front Immunol 9, 775. 10.3389/fimmu.2018.00775.

    Wüst, S., Dröse, S., Heidler, J., Wittig, I., Klockner, I., Franko, A., Bonke, E., Günther, S., Gärtner, U., Boettger, T., and Braun, T. (2018). Metabolic Maturation during Muscle Stem Cell Differentiation Is Achieved by miR-1/133a-Mediated Inhibition of the Dlk1-Dio3 Mega Gene Cluster. Cell Metab 27, 1026-1039.e1026. 10.1016/j.cmet.2018.02.022.

    Moradi, S., Braun, T., and Baharvand, H. (2018). miR-302b-3p Promotes Self-Renewal Properties in Leukemia Inhibitory Factor-Withdrawn Embryonic Stem Cells. Cell J 20, 61-72. 10.22074/cellj.2018.4846.

    Sreenivasan, K., Braun, T., and Kim, J. (2017). Systematic Identification of Genes Regulating Muscle Stem Cell Self-Renewal and Differentiation. Methods Mol Biol 1556, 343-353. 10.1007/978-1-4939-6771-1_19.

    Fang, J., Ianni, A., Smolka, C., Vakhrusheva, O., Nolte, H., Krüger, M., Wietelmann, A., Simonet, N.G., Adrian-Segarra, J.M., Vaquero, A., et al. (2017). Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1. Proc Natl Acad Sci U S A 114, E8352-E8361. 10.1073/pnas.1706945114.

    Moradi, S., Sharifi-Zarchi, A., Ahmadi, A., Mollamohammadi, S., Stubenvoll, A., Günther, S., Salekdeh, G.H., Asgari, S., Braun, T., and Baharvand, H. (2017). Small RNA Sequencing Reveals Dlk1-Dio3 Locus-Embedded MicroRNAs as Major Drivers of Ground-State Pluripotency. Stem Cell Reports 9, 2081-2096. 10.1016/j.stemcr.2017.10.009.

    Joshi, S., Davidson, G., Le Gras, S., Watanabe, S., Braun, T., Mengus, G., and Davidson, I. (2017). TEAD transcription factors are required for normal primary myoblast differentiation in vitro and muscle regeneration in vivo. PLoS Genet 13, e1006600. 10.1371/journal.pgen.1006600.

    Bergmann, O., and Braun, T. (2016). Caught Red-Handed: Cycling Cardiomyocytes. Circ Res 118, 3-5. 10.1161/CIRCRESAHA.115.307936.

    Shin, J., Watanabe, S., Hoelper, S., Krüger, M., Kostin, S., Pöling, J., Kubin, T., and Braun, T. (2016). BRAF activates PAX3 to control muscle precursor cell migration during forelimb muscle development. Elife 5. 10.7554/eLife.18351.

    Boonsanay, V., Zhang, T., Georgieva, A., Kostin, S., Qi, H., Yuan, X., Zhou, Y., and Braun, T. (2016). Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation. Cell Stem Cell 18, 229-242. 10.1016/j.stem.2015.11.002.

    Rodriguez-Gil, A., Ritter, O., Hornung, J., Stekman, H., Krüger, M., Braun, T., Kremmer, E., Kracht, M., and Schmitz, M.L. (2016). HIPK family kinases bind and regulate the function of the CCR4-NOT complex. Mol Biol Cell 27, 1969-1980. 10.1091/mbc.E15-09-0629.

    Caputo, L., Witzel, H.R., Kolovos, P., Cheedipudi, S., Looso, M., Mylona, A., van IJcken, W.F., Laugwitz, K.L., Evans, S.M., Braun, T., et al. (2015). The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors. Cell Stem Cell 17, 287-299. 10.1016/j.stem.2015.08.007.

    Biesemann, N., and Braun, T. (2015). Response to letter regarding article, "Myostatin regulates energy homeostasis in the heart and prevents heart failure". Circ Res 116, e97-98. 10.1161/CIRCRESAHA.115.306486.

    Al-Furoukh, N., Ianni, A., Nolte, H., Hölper, S., Krüger, M., Wanrooij, S., and Braun, T. (2015). ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells. Biochim Biophys Acta 1853, 2580-2591. 10.1016/j.bbamcr.2015.06.016.

    Piatkowski, T., and Braun, T. (2015). Long-term organ cultures of newt hearts. Methods Mol Biol 1290, 241-251. 10.1007/978-1-4939-2495-0_19.

    Stubenvoll, A., Rice, M., Wietelmann, A., Wheeler, M., and Braun, T. (2015). Attenuation of Wnt/β-catenin activity reverses enhanced generation of cardiomyocytes and cardiac defects caused by the loss of emerin. Hum Mol Genet 24, 802-813. 10.1093/hmg/ddu498.

    Looso, M., and Braun, T. (2015). Data mining in newt-omics, the repository for omics data from the newt. Methods Mol Biol 1290, 337-351. 10.1007/978-1-4939-2495-0_26.

    Zhang, T., Günther, S., Looso, M., Künne, C., Krüger, M., Kim, J., Zhou, Y., and Braun, T. (2015). Prmt5 is a regulator of muscle stem cell expansion in adult mice. Nat Commun 6, 7140. 10.1038/ncomms8140.

    Biesemann, N., Mendler, L., Wietelmann, A., Hermann, S., Schäfers, M., Krüger, M., Boettger, T., Borchardt, T., and Braun, T. (2014). Myostatin regulates energy homeostasis in the heart and prevents heart failure. Circ Res 115, 296-310. 10.1161/CIRCRESAHA.115.304185.

    Kim, J., and Braun, T. (2014). Skeletal muscle stem cells for muscle regeneration. Methods Mol Biol 1213, 245-253. 10.1007/978-1-4939-1453-1_20.

  • Feld, C., Sahu, P., Frech, M., Finkernagel, F., Nist, A., Stiewe, T., Bauer, U.M., and Neubauer, A. (2018). Combined cistrome and transcriptome analysis of SKI in AML cells identifies SKI as a co-repressor for RUNX1. Nucleic Acids Res 46, 3412-3428. 10.1093/nar/gky119.

    Frech, M., Teichler, S., Feld, C., Bouchard, C., Berberich, H., Sorg, K., Mernberger, M., Bullinger, L., Bauer, U.M., and Neubauer, A. (2018). MYB induces the expression of the oncogenic corepressor SKI in acute myeloid leukemia. Oncotarget 9, 22423-22435. 10.18632/oncotarget.25051.

    Berberich, H., Terwesten, F., Rakow, S., Sahu, P., Bouchard, C., Meixner, M., Philipsen, S., Kolb, P., and Bauer, U.M. (2017). Identification and. FEBS Open Bio 7, 1909-1923. 10.1002/2211-5463.12323.

    Stein, C., Nötzold, R.R., Riedl, S., Bouchard, C., and Bauer, U.M. (2016). The Arginine Methyltransferase PRMT6 Cooperates with Polycomb Proteins in Regulating HOXA Gene Expression. PLoS One 11, e0148892. 10.1371/journal.pone.0148892. 

  • Berberich, H., Terwesten, F., Rakow, S., Sahu, P., Bouchard, C., Meixner, M., Philipsen, S., Kolb, P., and Bauer, U.M. (2017). Identification and. FEBS Open Bio 7, 1909-1923. 10.1002/2211-5463.12323.

  • Stielow, B., Finkernagel, F., Stiewe, T., Nist, A., and Suske, G. (2018). MGA, L3MBTL2 and E2F6 determine genomic binding of the non-canonical Polycomb repressive complex PRC1.6. PLoS Genet 14, e1007193. 10.1371/journal.pgen.1007193.

  • Meier-Soelch, J., Jurida, L., Weber, A., Newel, D., Kim, J., Braun, T., Schmitz, M.L., and Kracht, M. (2018). RNAi-Based Identification of Gene-Specific Nuclear Cofactor Networks Regulating Interleukin-1 Target Genes. Front Immunol 9, 775. 10.3389/fimmu.2018.00775.

    Riedlinger, T., Haas, J., Busch, J., van de Sluis, B., Kracht, M., and Schmitz, M.L. (2018). The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice. Biomedicines 6. 10.3390/biomedicines6010036.

    Rodríguez-Gil, A., Riedlinger, T., Ritter, O., Saul, V.V., and Schmitz, M.L. (2018). Formaldehyde-assisted Isolation of Regulatory Elements to Measure Chromatin Accessibility in Mammalian Cells. J Vis Exp. 10.3791/57272.

    Schmitz, M.L., Shaban, M.S., Albert, B.V., Gökçen, A., and Kracht, M. (2018). The Crosstalk of Endoplasmic Reticulum (ER) Stress Pathways with NF-κB: Complex Mechanisms Relevant for Cancer, Inflammation and Infection. Biomedicines 6. 10.3390/biomedicines6020058.

    Rodríguez-Gil, A., Ritter, O., Saul, V.V., Wilhelm, J., Yang, C.Y., Grosschedl, R., Imai, Y., Kuba, K., Kracht, M., and Schmitz, M.L. (2017). The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription. Sci Rep 7, 3547. 10.1038/s41598-017-03708-7.

    Hagenbucher, J., Stekman, H., Rodriguez-Gil, A., Kracht, M., and Schmitz, M.L. (2017). Testing the Effects of SIAH Ubiquitin E3 Ligases on Lysine Acetyl Transferases. Methods Mol Biol 1510, 297-312. 10.1007/978-1-4939-6527-4_22.

    Poppe, M., Wittig, S., Jurida, L., Bartkuhn, M., Wilhelm, J., Müller, H., Beuerlein, K., Karl, N., Bhuju, S., Ziebuhr, J., et al. (2017). The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells. PLoS Pathog 13, e1006286. 10.1371/journal.ppat.1006286.

    Riedlinger, T., Dommerholt, M.B., Wijshake, T., Kruit, J.K., Huijkman, N., Dekker, D., Koster, M., Kloosterhuis, N., Koonen, D.P.Y., de Bruin, A., et al. (2017). NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation. Biochim Biophys Acta Mol Cell Res 1864, 1785-1798. 10.1016/j.bbamcr.2017.07.005.

    Tenekeci, U., Poppe, M., Beuerlein, K., Buro, C., Müller, H., Weiser, H., Kettner-Buhrow, D., Porada, K., Newel, D., Xu, M., et al. (2016). K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping. Mol Cell 62, 943-957. 10.1016/j.molcel.2016.05.017.

    Dam, S., Kracht, M., Pleschka, S., and Schmitz, M.L. (2016). The Influenza A Virus Genotype Determines the Antiviral Function of NF-κB. J Virol 90, 7980-7990. 10.1128/JVI.00946-16.

    Rodriguez-Gil, A., Ritter, O., Hornung, J., Stekman, H., Krüger, M., Braun, T., Kremmer, E., Kracht, M., and Schmitz, M.L. (2016). HIPK family kinases bind and regulate the function of the CCR4-NOT complex. Mol Biol Cell 27, 1969-1980. 10.1091/mbc.E15-09-0629.

    Schmitz, M.L., and Kracht, M. (2016). Cyclin-Dependent Kinases as Coregulators of Inflammatory Gene Expression. Trends Pharmacol Sci 37, 101-113. 10.1016/j.tips.2015.10.004.

    Katzav, S., and Schmitz, M.L. (2015). Mutations of c-Cbl in myeloid malignancies. Oncotarget 6, 10689-10696. 10.18632/oncotarget.3986.

    Jurida, L., Soelch, J., Bartkuhn, M., Handschick, K., Müller, H., Newel, D., Weber, A., Dittrich-Breiholz, O., Schneider, H., Bhuju, S., et al. (2015). The Activation of IL-1-Induced Enhancers Depends on TAK1 Kinase Activity and NF-κB p65. Cell Rep 10, 726-739. 10.1016/j.celrep.2015.01.001.

  • Ding, D., Bergmaier, P., Sachs, P., Klangwart, M., Rückert, T., Bartels, N., Demmers, J., Dekker, M., Poot, R.A., and Mermoud, J.E. (2018). The CUE1 domain of the SNF2-like chromatin remodeler SMARCAD1 mediates its association with KRAB-associated protein 1 (KAP1) and KAP1 target genes. J Biol Chem 293, 2711-2724. 10.1074/jbc.RA117.000959.

  • Stielow, B., Finkernagel, F., Stiewe, T., Nist, A., and Suske, G. (2018). MGA, L3MBTL2 and E2F6 determine genomic binding of the non-canonical Polycomb repressive complex PRC1.6. PLoS Genet 14, e1007193. 10.1371/journal.pgen.1007193.

    Feld, C., Sahu, P., Frech, M., Finkernagel, F., Nist, A., Stiewe, T., Bauer, U.M., and Neubauer, A. (2018). Combined cistrome and transcriptome analysis of SKI in AML cells identifies SKI as a co-repressor for RUNX1. Nucleic Acids Res 46, 3412-3428. 10.1093/nar/gky119.

    Bretz, A.C., Gittler, M.P., Charles, J.P., Gremke, N., Eckhardt, I., Mernberger, M., Mandic, R., Thomale, J., Nist, A., Wanzel, M., and Stiewe, T. (2016). ΔNp63 activates the Fanconi anemia DNA repair pathway and limits the efficacy of cisplatin treatment in squamous cell carcinoma. Nucleic Acids Res 44, 3204-3218. 10.1093/nar/gkw036.

    Fritsch, K., Mernberger, M., Nist, A., Stiewe, T., Brehm, A., and Jacob, R. (2016). Galectin-3 interacts with components of the nuclear ribonucleoprotein complex. BMC Cancer 16, 502. 10.1186/s12885-016-2546-0.

    Vogiatzi, F., Brandt, D.T., Schneikert, J., Fuchs, J., Grikscheit, K., Wanzel, M., Pavlakis, E., Charles, J.P., Timofeev, O., Nist, A., et al. (2016). Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5. Proc Natl Acad Sci U S A 113, E8433-E8442. 10.1073/pnas.1612711114.

    Wanzel, M., Vischedyk, J.B., Gittler, M.P., Gremke, N., Seiz, J.R., Hefter, M., Noack, M., Savai, R., Mernberger, M., Charles, J.P., et al. (2016). CRISPR-Cas9-based target validation for p53-reactivating model compounds. Nat Chem Biol 12, 22-28. 10.1038/nchembio.1965.

  • Thiel, V.N., Giaimo, B.D., Schwarz, P., Soller, K., Vas, V., Bartkuhn, M., Blätte, T.J., Döhner, K., Bullinger, L., Borggrefe, T., et al. (2017). Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation. Leukemia 31, 2491-2502. 10.1038/leu.2017.105.

    Giaimo, B.D., Ferrante, F., and Borggrefe, T. (2017a). Chromatin Immunoprecipitation (ChIP) in Mouse T-cell Lines. J Vis Exp. 10.3791/55907.

    Giaimo, B.D., Oswald, F., and Borggrefe, T. (2017b). Dynamic chromatin regulation at Notch target genes. Transcription 8, 61-66. 10.1080/21541264.2016.1265702.

    Borggrefe, T., Lauth, M., Zwijsen, A., Huylebroeck, D., Oswald, F., and Giaimo, B.D. (2016). The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways. Biochim Biophys Acta 1863, 303-313. 10.1016/j.bbamcr.2015.11.020.

    Borggrefe, T., and Oswald, F. (2016). Setting the Stage for Notch: The Drosophila Su(H)-Hairless Repressor Complex. PLoS Biol 14, e1002524. 10.1371/journal.pbio.1002524.

    Oswald, F., Rodriguez, P., Giaimo, B.D., Antonello, Z.A., Mira, L., Mittler, G., Thiel, V.N., Collins, K.J., Tabaja, N., Cizelsky, W., et al. (2016). A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes. Nucleic Acids Res 44, 4703-4720. 10.1093/nar/gkw105.

    Hein, K., Mittler, G., Cizelsky, W., Kühl, M., Ferrante, F., Liefke, R., Berger, I.M., Just, S., Sträng, J.E., Kestler, H.A., et al. (2015). Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response. Sci Signal 8, ra30. 10.1126/scisignal.2005892.

  • Chereji, R.V., Kan, T.W., Grudniewska, M.K., Romashchenko, A.V., Berezikov, E., Zhimulev, I.F., Guryev, V., Morozov, A.V., and Moshkin, Y.M. (2016). Genome-wide profiling of nucleosome sensitivity and chromatin accessibility in Drosophila melanogaster. Nucleic Acids Res 44, 1036-1051. 10.1093/nar/gkv978.

  • Borggrefe, T., Lauth, M., Zwijsen, A., Huylebroeck, D., Oswald, F., and Giaimo, B.D. (2016). The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways. Biochim Biophys Acta 1863, 303-313. 10.1016/j.bbamcr.2015.11.020.

  • Knoch, T.A., Wachsmuth, M., Kepper, N., Lesnussa, M., Abuseiris, A., Ali Imam, A.M., Kolovos, P., Zuin, J., Kockx, C.E.M., Brouwer, R.W.W., et al. (2016). The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes. Epigenetics Chromatin 9, 58. 10.1186/s13072-016-0089-x.

    Caputo, L., Witzel, H.R., Kolovos, P., Cheedipudi, S., Looso, M., Mylona, A., van IJcken, W.F., Laugwitz, K.L., Evans, S.M., Braun, T., et al. (2015). The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors. Cell Stem Cell 17, 287-299. 10.1016/j.stem.2015.08.007.

  • Meier-Soelch, J., Jurida, L., Weber, A., Newel, D., Kim, J., Braun, T., Schmitz, M.L., and Kracht, M. (2018). RNAi-Based Identification of Gene-Specific Nuclear Cofactor Networks Regulating Interleukin-1 Target Genes. Front Immunol 9, 775. 10.3389/fimmu.2018.00775.

    Riedlinger, T., Haas, J., Busch, J., van de Sluis, B., Kracht, M., and Schmitz, M.L. (2018). The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice. Biomedicines 6. 10.3390/biomedicines6010036.

    Schmitz, M.L., Shaban, M.S., Albert, B.V., Gökçen, A., and Kracht, M. (2018). The Crosstalk of Endoplasmic Reticulum (ER) Stress Pathways with NF-κB: Complex Mechanisms Relevant for Cancer, Inflammation and Infection. Biomedicines 6. 10.3390/biomedicines6020058.

    Hagenbucher, J., Stekman, H., Rodriguez-Gil, A., Kracht, M., and Schmitz, M.L. (2017). Testing the Effects of SIAH Ubiquitin E3 Ligases on Lysine Acetyl Transferases. Methods Mol Biol 1510, 297-312. 10.1007/978-1-4939-6527-4_22.

    Rodríguez-Gil, A., Ritter, O., Saul, V.V., Wilhelm, J., Yang, C.Y., Grosschedl, R., Imai, Y., Kuba, K., Kracht, M., and Schmitz, M.L. (2017). The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription. Sci Rep 7, 3547. 10.1038/s41598-017-03708-7.

    Poppe, M., Wittig, S., Jurida, L., Bartkuhn, M., Wilhelm, J., Müller, H., Beuerlein, K., Karl, N., Bhuju, S., Ziebuhr, J., et al. (2017). The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells. PLoS Pathog 13, e1006286. 10.1371/journal.ppat.1006286.

    Dam, S., Kracht, M., Pleschka, S., and Schmitz, M.L. (2016). The Influenza A Virus Genotype Determines the Antiviral Function of NF-κB. J Virol 90, 7980-7990. 10.1128/JVI.00946-16.

    Schmitz, M.L., and Kracht, M. (2016). Cyclin-Dependent Kinases as Coregulators of Inflammatory Gene Expression. Trends Pharmacol Sci 37, 101-113. 10.1016/j.tips.2015.10.004.

    Rodriguez-Gil, A., Ritter, O., Hornung, J., Stekman, H., Krüger, M., Braun, T., Kremmer, E., Kracht, M., and Schmitz, M.L. (2016). HIPK family kinases bind and regulate the function of the CCR4-NOT complex. Mol Biol Cell 27, 1969-1980. 10.1091/mbc.E15-09-0629.

    Jurida, L., Soelch, J., Bartkuhn, M., Handschick, K., Müller, H., Newel, D., Weber, A., Dittrich-Breiholz, O., Schneider, H., Bhuju, S., et al. (2015). The Activation of IL-1-Induced Enhancers Depends on TAK1 Kinase Activity and NF-κB p65. Cell Rep 10, 726-739. 10.1016/j.celrep.2015.01.001.

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  • Knoch, T.A., Wachsmuth, M., Kepper, N., Lesnussa, M., Abuseiris, A., Ali Imam, A.M., Kolovos, P., Zuin, J., Kockx, C.E.M., Brouwer, R.W.W., et al. (2016). The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes. Epigenetics Chromatin 9, 58. 10.1186/s13072-016-0089-x. 

  • Yuan, X., Qi, H., Li, X., Wu, F., Fang, J., Bober, E., Dobreva, G., Zhou, Y., and Braun, T. (2017). Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice. J Clin Invest 127, 2235-2248. 10.1172/JCI88725.

    Caputo, L., Witzel, H.R., Kolovos, P., Cheedipudi, S., Looso, M., Mylona, A., van IJcken, W.F., Laugwitz, K.L., Evans, S.M., Braun, T., et al. (2015). The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors. Cell Stem Cell 17, 287-299. 10.1016/j.stem.2015.08.007.

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  • Buxa, M.K., Slotman, J.A., van Royen, M.E., Paul, M.W., Houtsmuller, A.B., and Renkawitz, R. (2016). Insulator speckles associated with long-distance chromatin contacts. Biol Open 5, 1266-1274. 10.1242/bio.019455.

  • Sachs, P., Ding, D., Bergmaier, P., Lamp, B., Schlagheck, C., Finkernagel, F., Nist, A., Stiewe, T., and Mermoud, J.E. (2019). SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells. Nat Commun 10, 1335. 10.1038/s41467-019-09078-0.

    Ding, D., Bergmaier, P., Sachs, P., Klangwart, M., Rückert, T., Bartels, N., Demmers, J., Dekker, M., Poot, R.A., and Mermoud, J.E. (2018). The CUE1 domain of the SNF2-like chromatin remodeler SMARCAD1 mediates its association with KRAB-associated protein 1 (KAP1) and KAP1 target genes. J Biol Chem 293, 2711-2724. 10.1074/jbc.RA117.000959.

  • Hundertmark, T., Kreutz, S., Merle, N., Nist, A., Lamp, B., Stiewe, T., Brehm, A., Renkawitz-Pohl, R., and Rathke, C. (2019). Drosophila melanogaster tPlus3a and tPlus3b ensure full male fertility by regulating transcription of Y-chromosomal, seminal fluid, and heat shock genes. PLoS One 14, e0213177. 10.1371/journal.pone.0213177.

    Mačinković, I., Theofel, I., Hundertmark, T., Kovač, K., Awe, S., Lenz, J., Forné, I., Lamp, B., Nist, A., Imhof, A., et al. (2019). Distinct CoREST complexes act in a cell-type-specific manner. Nucleic Acids Res 47, 11649-11666. 10.1093/nar/gkz1050.

    Hundertmark, T., Gärtner, S.M.K., Rathke, C., and Renkawitz-Pohl, R. (2018). Nejire/dCBP-mediated histone H3 acetylation during spermatogenesis is essential for male fertility in Drosophila melanogaster. PLoS One 13, e0203622. 10.1371/journal.pone.0203622.

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