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Project Area A - Chromatin changes mediated by enzymatic modification

Group A projects investigate transcription factor and enzyme-driven chromatin changes, which are are largely modulated and shaped by DNA binding transcription factors targeting enzymatic functions, such as histone modifying and nucleosome remodelling enzymes, to chromatin. The PIs assigned to that group are listed in the text.
Photo: Alexander Brehm
Thematic assignment of projects from Area A.

Epigenome regulation by ATP-dependent nucleosome remodelers

Delineating the interplay of epigenetic modifiers and transcription factors in the control of muscle stem cell homeostasis and higher order chromatin organization

Functional analysis of the histone arginine methyltransferase PRMT6

Repurposing CRISPR/Cas9 for targeted demethylation of the gamma-globin promoters

Functional characterization of novel histone phosphorylations

Autism-relevant transcriptional networks in human neural stem cells

Role of p73-directed chromatin alterations for neuroendocrine differentiation in small cell lung cancer

Chromatin regulation mediated by the RBP-J/SHARP corepressor complex

Zeb2 in cell determination regulated by the Activin-Nodal/BMP system: genome-wide binding sites, endogenous partners and long-range locus control

Role of mammalian histone variants H3.3 and H2A.Z in differentiation and disease

Functional epigenomics of type-2 immune responses in allergic asthma

Molecular mechanisms and (patho)physiological consequences of PRC2.1-mediated gene regulation