Main Content
A15 - Sandra Hake:
Role of mammalian histone variants H3.3 and H2A.Z in differentiation and disease
The main aim is to discover and functionally dissect the molecular mechanisms during differentiation and disease development of:
A) DAXX-dependent H3.3-mediated silencing of heterochromatic genes and the chaperone dependence of H3.3K27M in tumor development, and
B) the PWWP2A-interactome with a functional focus on the novel “core NuRD” and the proposed PHF14-RAI1-TCF20-HMG20A (PRTH) complexes in transcriptional regulation of PWWP2A-bound H2A.Z target genes.
Email: Sandra.Hake@gen.bio.uni-giessen.de
Phone: +49 641-99-35460
