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B07 - Gergana Dobreva:

Lamins and Rnf20 at the interface of cancer metabolism and epigenetics

Mounting evidence indicates that tumour metabolism is intricately interconnected with epigenetic reprogramming and nuclear reorganization in cancer cells. We found that lamin B1 and the H2B E3-ubiquitin ligase RNF20 play a fundamental role in lung cancer development and progression and in regulating tumour cell metabolism. The objective of the proposed research program is to elucidate on the one hand the mechanisms by which lamins and Rnf20 regulate cancer cell metabolism and on the other hand how changes of cell metabolism affect chromatin association with the nuclear lamina, genome architecture and the epigenetic landscape.

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