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B16 - Bas van Steensel:

Cancer chromosome rearrangements, nuclear lamina interactions and gene regulation

The spatial organization of the genome is critical for the correct regulation of gene expression. Lamin-associated domains (LADs) comprise 35% of the human genome, connect it to the nuclear lamina (NL) and play important roles in gene repression. We have identified hundreds of genome rearrangements in cancer that delete or duplicate large parts of LADs or cause aberrant fusions of LADs to inter-LAD regions. Here we propose to investigate how such rearrangements affect the interactions of the genome with the NL and might thereby cause changes in the expression of nearby genes. Towards this goal we will use unique genomics approaches combined with bioinformatics.

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