Publikationen

Originalarbeiten

Synthesis of the compatible solute 5-hydroxyectoine from ectoine: Crystal structure of the non-heme iron(II)-dependent dioxygenase EctD.
K. Reuter,M.Pittelkow, J. Bursy, A. Heine, T. Craan, E. Bremer
PloS One, 2010, 5, e10647
A crystallization screen based on alternative polymeric percipitants.
C. Grimm, A. Chari, K. Reuter, U. Fischer
Acta Crystallogr. Sect. D 2010, 66, 685-697
An integrative approach combining noncovalent mass spectrometry, enzyme kinetics and X-ray crystallography to decipher Tgt protein-protein and protein-RNA interaction.
T. Ritschel, C. Atmanene, K. Reuter, A. Van Dorsselaer, S. Sanglier-Cianferani, G. Klebe
J. Mol. Biol. 2009, 393, 833-847
Glutamate versus glutamine exchange swaps substrate selectivity in tRNA-guanine transglycosylase: insight into the regulation of substrate selectivity by kinetic and crystallographic studies.
N. Tidten, B. Stengl, A. Heine, G.A. Garcia, G. Klebe, K. Reuter
J. Mol. Biol. 2007, 374, 764-776
Crystal structure of Bacillus subtilis S-adenosylmethionine:tRNA ribosyltransferase-isomerase.
C. Grimm, R. Ficner, T. Sgraja, P. Haebel, G. Klebe, K. Reuter
Biochem. Biophys. Res. Comm. 2006, 351, 695-701
Synthesis, biological evaluation, and crystallographic studies of extended guanine-based (lin-Benzoguanine) inhibitors for tRNA-guanine transglycosylase (TGT).
E. A. Meyer, N. Donati, M. Guillot, W.B. Schweizer, F. Diederich, B. Stengl, R. Brenk, K. Reuter, G. Klebe
Helv. Chim. Acta 2006, 89, 573-597
Structural insights into the neuroprotective acting carbonyl reductase Sniffer ofDrosophila melanogaster.
T. Sgraja, J. Ulschmid, K. Becker, S. Schneuwly, G. Klebe, K. Reuter, A. Heine
J. Mol. Biol. 2004, 342, 1613-1624
Crystallographic study of inhibitors of tRNA-guanine transglycosylase suggests a new structure-based pharmacophore for virtual screening.
R. Brenk, E. Meyer, K. Reuter, M.T. Stubbs, G.A. Garcia, F. Diederich, G. Klebe
J. Mol. Biol. 2004, 338, 55-75
Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design.
R. Brenk, M.T. Stubbs, A. Heine, K. Reuter, G. Klebe
ChemBioChem. 2003, 4, 1066-1077
An essential role for aspartate 264 in catalysis by tRNA-guanine transglycosylase from Escherichia coli.
J.D. Kittendorf, T. Sgraja, K. Reuter, G. Klebe, G.A. Garcia
J. Biol. Chem. 2003, 278, 42369-42376
From hit to lead: De novo design based on virtual screening hits of inhibitors of tRNA-guanine transglycosylase, a putative target of shigellosis therapy.
R. Brenk, H.-D. Gerber, J.D. Kittendorf, G.A. Garcia, K. Reuter, G. Klebe
Helv. Chim. Acta 2003, 86, 1435-1452
Crystal structure of 2-methylisocitrate lyase (PrpB) from Escherichia coli and modeling of its ligand bound active centre.
C. Grimm, A. Evers, W. Buckel, C. Maerker, G. Klebe, M. Brock, K. Reuter
J. Mol. Biol. 2003, 328, 609-621
Virtual screening for submicromolar leads of Tgt based on a new unexpected binding mode detected by crystal structure analysis.
R. Brenk, L. Naerum, U. Grädler, H.-D. Gerber, G.A. Garcia, K. Reuter, M.T. Stubbs, G. Klebe
J. Med. Chem. 2003, 46, 1133-1143
A novel recessive hyperekplexia allele GLRA1 (S231R): genotyping by MALDI-TOF mass spectrometry and functional characterization as a determinant of cellular glycine receptor trafficking.
A. Humeny, T. Bonk, K. Becker, M. Jafari-Boroujerdi, U. Stephani, K. Reuter, C.-M. Becker
Eur. J. Hum. Genet. 2002, 10, 188-196
Crystal structure of 1-deoxy-d-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis.
K. Reuter, S. Sanderbrand, H. Jomaa, J. Wiesner, I. Steinbrecher, E. Beck, M. Hintz, G. Klebe, M.T. Stubbs
J. Biol. Chem. 2002, 277, 5378-5384
A new target for Shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanin transglycosylase.
U. Grädler, H.D. Gerber, D.A.M. Goodenough-Lashua, G.A. Garcia, R. Ficner, K. Reuter, M.T. Stubbs, G. Klebe
J. Mol. Biol. 2001, 306, 455-467
The crystal structure of 3α-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni shows a novel oligomerization pattern within the short chain dehydrogenase/reductase family.
C. Grimm, E. Maser, E. Möbus, G. Klebe, K. Reuter, F. Ficner
J. Biol. Chem. 2000, 275, 41333-41339
Screening orthologs as an important variable in crystallization: preliminary X-ray diffraction studies of the tRNA-modifying enzyme S-adenosyl-methionine:tRNA ribosyl transferase/isomerase.
C. Grimm, G. Klebe, R. Ficner, K. Reuter
Acta Crystallogr. Sect. D 2000, 56, 484-488
Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin.
U. Reidt, K. Reuter, T. Achsel, D. Ingelfinger, R. Lührmann, R. Ficner
J. Biol. Chem. 2000, 275, 7439-7442
Crystal structure of the surfactin synthetase activating enzyme Sfp: a prototype of the 4´-phosphopantetheinyl transferase superfamily.
K. Reuter, M.R. Mofid, M.A. Marahiel, R. Ficner
EMBO J. 1999, 18, 6823-6831
Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15 kD protein.
K. Reuter, S. Nottrott, P. Fabrizio, R. Lührmann, R. Ficner
J. Mol. Biol. 1999, 249, 515-525
Mutagenesis and crystallographic studies of Zymomonas mobils tRNA-guanine transglycosylase to elucidate the role of serine¹⁰³ for enzymatic activity.
U. Grädler, R. Ficner, G.A. Garcia, M.T. Stubbs, G. Klebe, K. Reuter
FEBS Lett. 1999, 454, 142-146
Crystallization and preliminary crystallographic studies of Sfp: a phosphopantetheinyl transferase of modular peptide synthetases.
M.R. Mofid, M.A. Marahiel, R. Ficner, K. Reuter
Acta Crystallogr. Sect. D 1999, 55, 1098-1100
Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein U5-15kD.
K. Reuter, R. Ficner
Acta Crystallogr. Sect. D 1999, 55, 888-890
Cloning and functional characterization of the genes encoding 3-dehydroquinate synthase (aroB) and tRNA-guanine transglycosylase (tgt) from Helicobacter pylori.
S. Bereswill, F. Faßbinder, C. Völzing, R. Haas, K. Reuter, R. Ficner, M. Kist
Med. Microbiol. Immunol. 1997, 186, 125-134
Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase reveal aspartate¹⁰² as the active site nucleophile.
C. Romier, K. Reuter, D. Suck, R. Ficner
Biochemistry 1996, 35, 15734-15739
Crystal structure of tRNA-guanine transglycosylase: RNA modification by base exchange.
C. Romier, K. Reuter, D. Suck, R. Ficner
EMBO J. 1996, 15, 2850-2857
Purification, crystallization, and preliminary X-ray diffraction studies of tRNA-guanine transglycosylase from Zymomonas mobilis.
C. Romier, R. Ficner, K. Reuter, D. Suck
Proteins: Struct. Funct. Genet. 1996, 24, 516-519
Sequence analysis and overexpression of the Zymomonas mobilis tgt gene encoding tRNA-guanine transglycosylase: purification and biochemical characterization of the enzyme.
K. Reuter, R. Ficner
J. Bacteriol. 1995, 177, 5284-5288
Serine⁹⁰ is required for enzymic activity by tRNA-guanine transglycosylase from Escherichia coli.
K. Reuter, S. Chong, F. Ullrich, H. Kersten, G.A. Garcia
Biochemistry 1994, 33, 7041-7046
Structure and organization of Escherichia coli genes involved in biosynthesis of the deazaguanine derivative queuine, a nutrient factor for eucaryotes.
K. Reuter, R. Slany, F. Ullrich, H. Kersten
J. Bacteriol. 1991, 173, 2256-2264

Übersichtsartikel

Mechanism and substrate specificity of tRNA-guanine transglycosylases (TGTs): tRNA-modifying enzymes from the three different kingdoms of life share a common catalytic mechanism.
B. Stengl, K. Reuter, G. Klebe
ChemBioChem. 2005, 6, 1926-1939
Neue Konzepte zur Arzneistoffsuche und Synthese.
W. Diederich, P. Haebel, A. Heine, K. Reuter, C. Sotriffer, G. Klebe
LaborPraxis 2004, 28, 24-26
3α-Hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni: biological significance, three-dimensional structure and gene regulation.
E. Maser, G. Xiong, C. Grimm, R. Ficner, K. Reuter
Chem.-Biol. Interact. 2000, 130, 707-722