Hauptinhalt

Publications

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2020

194.    Kangping Xu, Can Yang, Yuanyuan Xu, Dan Li, Shumin Bao, Zhenxing Zou, Fenghua Kang, Guishan Tan, Shu-Ming Li and  Xia Yu (2020) Selective geranylation of biflavonoids by Aspergillus terreus aromatic prenyltransferase (AtaPT). Organic and Biomolecular Chemistry, DOI: 10.1039/C9OB02296A. Abstract

2019

193.    Huili Yu, Xiulan Xie, and Shu-Ming Li (2019) Coupling of cyclo-L-Trp-L-Trp with hypoxanthine increases structure diversity of guanitrypmycins. Organic Letters, 21, 9104-9108, DOI:10.1021/acs.orglett.9b03491.
Abstract

192.    Huili Yu and Shu-Ming Li (2019) Two cytochrome P450 enzymes from Streptomyces sp. NRRL S-1868 catalyze distinct dimerization of tryptophan-containing cyclodipeptides. Organic Letters, 21, 7094-7098, DOI: 10.1021/acs.orglett.9b02666.
Abstract

191.    Jing Liu, Xiulan Xie, and Shu-Ming Li (2019) Guanitrypmycin biosynthetic pathways imply cytochrome P450-mediated regio- and stereospecific guaninyl transfer reactions. Angewandte Chemie International Edition, 58, 11534-11540, DOI: 10.1002/anie.201906891.
Abstract

190.    Florian Kindinger, Jonas Nies, Anke Becker, Tianjiao Zhu, and Shu-Ming Li (2019) Genomic locus of a Penicillium crustosum pigment as integration site for secondary metabolite gene expression. ACS Chemical Biology, 14, 1227-1234, DOI: 10.1021/acschembio.9b00164.
Abstract

189.    Peter Mai*, Lindsay Coby* and Shu-Ming Li (2019) Different behaviors of cyclic dipeptide prenyltransferases toward the tripeptide derivative ardeemin fumiquinazoline and its enantiomer. Applied Microbiology and Biotechnology. 103, 3773–3781, DOI: 10.1007/s00253-019-09723-0. (* equal contribution).
Abstract

188.    Jie Fan*, Ge Liao*, Florian Kindinger, Lena Ludwig-Radtke, Wen-Bing Yin and Shu-Ming Li (2019) Peniphenone and penilactone formation in Penicillium crustosum via 1,4-Michael additions of ortho-quinone methide from hydroxyclavatol to γ-butyrolactones from crustosic acid. Journal of the American Chemical Society. 141, 4225–4229, DOI: 10.1021/jacs.9b00110. (* equal contribution)
Abstract

187.    Elisabeth Hühner, Kristin Öqvist and Shu-Ming Li (2019) Design of α-keto carboxylic acid dimers by domain recombination of nonribosomal peptide synthetase (NRPS)-like enzymes. Organic Letters, 21, 498-502, Doi: 10.1021/acs.orglett.8b03793.
Abstract

186.    Shuang Zhou, Peng Zhang, Haichuan Zhou, Xingzhong Liu, Shu-Ming Li, Liangdong Guo, Kuan Li and Wen-Bing Yin (2019) A new regulator RsdA mediating fungal secondary metabolism has a detrimental impact on asexual development in Pestalotiopsis fici. Environmental Microbiology, 21, 416 – 426, DOI: 10.1111/1462-2920.14473.
Abstract

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2018

185.    Ge Liao*, Peter Mai*, Jie Fan, Georg Zocher, Thilo Stehle and Shu-Ming Li (2018) Complete decoration of the indolyl residue of tryptophan-containing cyclic dipeptides with geranyl moieties via protein engineering. Organic Letters, 20, 7201– 7205, Doi: 10.1021/acs.orglett.8b03124. (* equal contribution)
Abstract

184.    Huomiao Ran, Viola Wohlgemuth, Xiulan Xie and Shu-Ming Li (2018) A non-heme FeII/2-oxoglutarate-dependent oxygenase catalyzes a double bond migration within a dimethylallyl moiety accompanied by hydroxylation. ACS Chemical Biology, 13, 2949 – 2955, DOI: 10.1021/acschembio.8b00588.
Abstract

183.    Peter Mai, Georg Zocher, Thilo Stehle and Shu-Ming Li (2018) Structure-based protein engineering enables prenyl donor switching of a fungal aromatic prenyltransferase. Organic and Biomolecular Chemistry, 16, 7461 – 7469, DOI: 10.1039/C8OB02037J. 10.1039/C8OB02037J.
Abstract

182.    Bei-Bei He, Xu-Liang Bu, Ting Zhou, Shu-Ming Li, Minjuan Xu and Jun Xu. (2018) Combinatory biosynthesis of prenylated 4-hydroxybenzoate derivatives by overexpression of the substrate-promiscuous prenyltransferase XimB in engineered E. coli. ACS Synthetic Biology, 7, 2094 - 2104, DOI: 10.1021/acssynbio.8b00070.
Abstract

181.    Liujuan Zheng*, Peter Mai*, Aili Fan and Shu-Ming Li (2018) Switching a regular tryptophan C4-prenyltransferase to a reverse tryptophan-containing cyclic dipeptide C3-prenyltransferase by sequential site-directed mutagenesis. Organic and Biomolecular Chemistry, 16, 6688 – 6694, DOI: 10.1039/C8OB01735B. (* equal contribution)
Abstract

180.    Huili Yu, Xiulan Xie and Shu-Ming Li (2018) Coupling of guanine with cyclo-L-Trp-L-Trp Mediated by a cytochrome P450 homologue from Streptomyces purpureus. Organic Letters, 20: 4921-4925, Doi: 10.1021/acs.orglett.8b02051.
Abstract

179.    Jing Liu*, Huili Yu* and Shu-Ming Li (2018) Expanding tryptophan-containing cyclodipeptide synthase spectrum by identification of nine members from Streptomyces strains. Applied Microbiology and Biotechnology 102: 4435–4444, DOI: 10.1007/s00253-018-8908-6; 102: 5787-5789, DOI: 10.1007/s00253-018-9074-6. (* equal contribution)
Abstract

178.    Viola Wohlgemuth*, Florian Kindinger* and Shu-Ming Li (2018) Convenient synthetic approach for tri- and tetraprenylated cyclodipeptides by consecutive enzymatic prenylations. Applied Microbiology and Biotechnology 102: 2671-2681, DOI: 10.1007/s00253-018-8761-7. (* equal contribution)
Abstract

177.    Elisabeth Hühner, Katja Backhaus, Rixa Kraut and Shu-Ming Li (2018) Production of α-keto carboxylic acid dimers in yeast by overexpression of NRPS-like genes from Aspergillus terreus. Applied Microbiology and Biotechnology 102: 1663-1672, DOI: 10.1007/s00253-017-8719-1.
Abstract

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2017

176.    Kirsten Brockmeyer and Shu-Ming Li (2017) Mutations of residues in pocket P1 of a cyclodipeptide synthase strongly increase product formation. Journal of natural products. 80: 2917-2922, DOI: 10.1021/acs.jnatprod.7b00430.
Abstract

175.    Viola Wohlgemuth, Florian Kindinger, Xiulan Xie, Bin-Gui Wang, and Shu-Ming Li (2017) Two Prenyltransferases govern a consecutive prenylation cascade in the biosynthesis of echinulin and neoechinulin. Organic Letters. 19: 5928-5931, DOI: 10.1021/acs.orglett.7b02926.
Abstract

174.    Nina Gerhards and Shu-Ming Li (2017) A bifunctional old yellow enzyme from Penicillium roqueforti is involved in the ergot alkaloid biosynthesis. Organic and Biomolecular Chemistry 15: 8069-8071, DOI: 10.1039/C7OB02095C.
Abstract

173.    Qingbo Zhang, Huixian Li, Lu Yu, Yu Sun, Yiguang Zhu, Hanning Zhu, Liping Zhang, Shu-Ming Li, Yuemao Shen, Changlin Tian, Ang Li, Hung-wen Liu and Changsheng Zhang (2017) Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification.Chemical Science. 8:5067-5077, DOI: 10.1039/C7SC01182B.
Abstract

172.    Katja Backhaus, Lena Ludwig-Radtke, Xiulan Xie, Shu-Ming Li (2017) Manipulation of the precursor supply in yeast significantly enhances the accumulation of prenylated β-carbolines. ACS Synthetic Biology 6: 1056-1064, DOI: 10.1021/acssynbio.6b00387.
Abstract

171.    Jin Feng, Peng Zhang, Yinglu Cui, Kai Li, Xue Qiao, Ying-Tao Zhang, Shu-Ming Li, Russell J. Cox, Bian Wu, Min Ye and Wen-Bing Yin (2017) Regio- and stereospecific O-glycosylation of phenolic compounds catalysed by a fungal glycosyltransferase from Mucor hiemalis. Advanced Synthesis & Catalysis. 359: 995-1006, DOI: 10.1002/adsc.201601317.
Abstract

170.    Jakub Gunera*, Florian Kindinger*, Shu-Ming Li and Peter Kolb (2017) PrenDB: A substrate prediction database to enable biocatalytic use of prenyltransferases. Journal of Biological Chemistry 292: 4003-4021, DOI: 10.1074/jbc.M116.759118. (* equal contribution)
Abstract

169.    Anja Greule, Marija Marolt, Denise Deubel, Iris Peintner, Songya Zhang, Claudia Jessen-Trefzer, Christian De Ford, Sabrina Burschel, Shuming Li, Thorsten Friedrich, Irmgard Merfort, Steffen Lüdeke, Philippe Bisel, Michael Müller, Thomas Paululat, Andreas Bechthold (2017) Wide distribution of foxicin biosynthetic gene clusters in Streptomyces strains – an unusual secondary metabolite with various properties. Frontiers in Microbiology, section Evolutionary and Genomic Microbiology 8: 221, DOI: 10.3389/fmicb.2017.00221.
Abstract

168.    Wei Zhao, Aili Fan, Sylwia Tarcz, Kang Zhou, Wen-Bing Yin, Xiao-Qing Liu and Shu-Ming Li (2017). Mutation on Gly115 and Tyr205 of the cyclic dipeptide C2-prenyltransferase FtmPT1 increases its catalytic activity toward hydroxynaphthalenes. Applied Microbiology and Biotechnology 101: 1989–1998, DOI: 10.1021/ja106817c.
Abstract

167.    Kang Zhou, Carsten Wunsch, Jungui Dai and Shu-Ming Li (2017) Gem-diprenylation of acylphloroglucinols by a fungal prenyltransferase of the dimethylallyltryptophan synthase superfamily. Organic Letters 19: 388-391, DOI: 10.1021/acs.orglett.6b03594.
Abstract

166.    Ridao Chen, Bingquan Gao, Xiao Liu, Feiying Ruan, Yong Zhang, Jizhong Lou, Keping Feng, Carsten Wunsch, Shu-Ming Li, Jungui Dai, Fei Sun (2017). Molecular insights into the promiscuity of the aromatic prenyltransferase AtaPT. Nature Chemical Biology 13: 226-234, DOI: 10.1038/nchembio.2263.
Abstract

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2016

165.    Kang Zhou, Wei Zhao, Xiao-Qing Liu and Shu-Ming Li (2016) Saturation mutagenesis on Tyr205 of the cyclic dipeptide C2-prenyltransferase FtmPT1 results in mutants with strongly increased C3-prenylating activity. Applied Microbiology and Biotechnology. 100: 9943–9953, DOI: 10.1007/s00253-016-7663-9.
Abstract

164.    Julia Winkelblech, Xiulan Xie, Shu-Ming Li (2016) Characterisation of 6-DMATSMo from Micromonospora olivasterospora leading to identification of divergence in enantioselectivity, regioselectivity and multiple prenylation of tryptophan prenyltransferases. Organic and Biomolecular Chemistry. 14: 9883 – 9895, DOI: 10.1039/C6OB01803C.
Abstract

163.    Aili Fan and Shu-Ming Li (2016) Saturation mutagenesis on Arg244 of the tryptophan C4-prenyltransferase FgaPT2 leads to enhanced catalytic ability and different preferences for tryptophan containing-cyclic dipeptides. Applied Microbiology and Biotechnology. 100: 5389 - 5399, DOI: 10.1007/s00253-016-7365-3.
Abstract

162.    Peter Mai, Georg Zocher, Lena Ludwig, Thilo Stehle, and Shu-Ming Li (2016) Actions of tryptophan prenyltransferases toward fumiquinazolines and their potential application for the generation of prenylated derivatives by combining chemical and chemoenzymatic syntheses. Advanced Synthesis & Catalysis. 358: 1639-1653, DOI: 10.1002/adsc.201600064.
Abstract

161.    Mike Liebhold and Shu-Ming Li (2016). Regiospecific benzylation of tryptophan and derivatives catalyzed by a fungal dimethylallyl transferase. In: Practical Methods for Biocatalysis and Biotransformations 3 (Eds. John Whittall, Peter Sutton and Wolfgang Kroutil), John Wiley &Sons, Ltd.,West Sussex, Volume 3, pp 102-105 (Book Article).

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2015

160.    Kang Zhou, Xia Yu, Xiulan Xie and Shu-Ming Li (2015) Complementary flavonoid prenylations by fungal indole prenyltransferases. Journal of natural products. 78: 2229 – 2235, DOI: 10.1021/acs.jnatprod.5b00422.
Abstract

159.    Julia Winkelblech, Aili Fan and Shu-Ming Li (2015) Prenyltransferases as key enzymes in primary and secondary metabolism. Applied Microbiology and Biotechnology. 99: 7379 - 7397, DOI: 10.1007/s00253-015-6811-y.
Abstract

158.    Aili Fan, Julia Winkelblech and Shu-Ming Li (2015) Impacts and perspectives of prenyltransferases of the DMATS superfamily for use in biotechnology. Applied Microbiology and Biotechnology. 99: 7399 - 7415, DOI: 10.1007/s00253-015-6813-9.
Abstract

157.    Huili Yu, Mike Liebhold, Xiulan Xie and Shu-Ming Li (2015) Tyrosine O-prenyltransferases TyrPT and SirD displaying similar behavior toward unnatural alkyl or benzyl diphosphate as their natural prenyl donor dimethylallyl diphosphate. Applied Microbiology and Biotechnology. 99: 7115–7124, DOI: 10.1007/s00253-015-6452-1
Abstract

156.    Aili Fan, Xiulan Xie and Shu-Ming Li (2015) Tryptophan prenyltransferases showing higher catalytic activities for Friedel-Crafts alkylation of o- and m-tyrosine than tyrosine prenyltransferases. Organic and Biomolecular Chemistry. 13: 7551- 7557, DOI: 10.1039/C5OB01040C.
Abstract

155.    Nina Gerhards, Marco Matuschek, Christiane Wallwey and Shu-Ming Li (2015) Genome mining of ascomycetous fungi reveals their genetic potential for ergot alkaloid production. Archives of Microbiology. 197:701-713, DOI:10.1007/s00203-015-1105-4.
Abstract

154.    Carsten Wunsch, Kathrin Mundt and Shu-Ming Li (2015) Targeted production of secondary metabolites by coexpression of non-ribosomal peptide synthetase and prenyltransferase genes in Aspergillus. Applied Microbiology and Biotechnology. 99: 4213 - 4233, DOI: 10.1007/s00253-015-6490-8.
Abstract

153.    Kang Zhou, Lena Ludwig and Shu-Ming Li (2015) Friedel-Crafts alkylation of acylphloroglucinols catalyzed by a fungal indole prenyltransferase. Journal of Natural Products. 78: 929 - 933, DOI: 10.1021/np5009784.
Abstract

152.    Ulrike Steiner, Sabine Hellwig, Mahalia Ahimsa-Müller, Nicola Grundmann, Shu-Ming Li, Christel Drewke, Eckhard Leistner (2015) The key role of peltate glandular trichomes in symbiota comprising clavicipitaceous fungi of the genus Periglandula and their host plants. Toxins 7: 1355-1373, DOI: 10.3390/toxins7041355.
Abstract

151.    Julia Winkelblech*, Mike Liebhold*, Jakub Gunera, Xiulan Xie, Peter Kolb and Shu-Ming Li (2015) Tryptophan C5-, C6- and C7-prenylating enzymes displaying a preference for C-6 of the indole ring in the presence of unnatural dimethylallyl diphosphate analogues. Advanced Synthesis & Catalysis. 357: 975-986, DOI: 10.1002/adsc.201400958. (* equal contribution)
Abstract

150.    Carsten Wunsch, Hui-Xi Zou, Uwe Linne and Shu-Ming Li (2015) C7-prenylation of tryptophanyl and O-prenylation of tyrosyl residues in dipeptides by an Aspergillus terreus prenyltransferase. Applied Microbiology and Biotechnology. 99: 1719-1730, DOI: 10.1007/s00253-014-5999-6.
Abstract

149.    Huixian Li, Yu Sun, Qingbo Zhang, Yiguang Zhu, Shu-Ming Li, Ang Li and Changsheng Zhang (2015) Elucidating the cyclization cascades in xiamycin biosynthesis by substrate synthesis and enzyme characterizations. Organic Letters 17: 306–309, DOI: 10.1021/ol503399b.
Abstract

148.    Aili Fan, Georg Zocher, Edyta Stec, Thilo Stehle and Shu-Ming Li (2015) Site-directed mutagenesis switching a dimethylallyl tryptophan synthase to a specific tyrosine C3-prenylating enzyme. Journal of Biological Chemistry 290: 1364–1373, DOI: 10.1074/jbc.M114.623413
Abstract

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2014

147.    Nina Gerhards, Lisa Neubauer, Paul Tudzynski and Shu-Ming Li (2014) Biosynthetic pathways of ergot alkaloids. Toxins 6: 3281 – 3295 (review article), DOI: 10.3390/toxins6123281.
Abstract

146.    Aili Fan, Huizhi Chen, Rui Wu, Hui Xu and Shu-Ming Li (2014) A new member of the DMATS superfamily from Aspergillus niger catalyzes prenylations of both tyrosine and tryptophan derivatives. Applied Microbiology and Biotechnology 98: 10119–10129, DOI: 10.1007/s00253-014-5872-7.
Abstract

145.    Aili Fan and Shu-Ming Li (2014) Prenylation of tyrosine and derivatives by a tryptophan C7-prenyltransferase. Tetrahydron Letters 55: 5199 – 5202, DOI: 10.1016/j.tetlet.2014.07.080.
Abstract

144.    Daniel Pockrandt, Christopher Sack, Tatjana Kosiol and Shu-Ming Li (2014) A Promiscuous Prenyltransferase from Aspergillus oryzae catalyses C-prenylations of hydroxynaphthalenes in the presence of different prenyl donors. Applied Microbiology and Biotechnology 98: 4987 - 4994, DOI: 10.1007/s00253-014-5509-x.
Abstract

143.    Julia Winkelblech and Shu-Ming Li (2014) Biochemical investigations of two 6-DMATS enzymes from Streptomyces revealing novel features of L-tryptophan prenyltransferases. ChemBioChem 15: 1030 - 1039, DOI: 10.1002/cbic.201400046.
Abstract

142.    Sylwia Tarcz, Xiulan Xie and Shu-Ming Li (2014). Substrate and catalytic promiscuity of secondary metabolite enzymes: O-prenylation of hydroxyxanthones with different prenyl donors by a bisindolyl benzoquinone C- and N-prenyltransferase. ACS Advances 4: 17986 – 17992, DOI: 10.1039/C4RA00337C.
Abstract

141.    Sylwia Tarcz, Lena Ludwig and Shu-Ming Li (2014). AstPT catalyses both reverse N1- and regular C2-prenylation of a methylated bisindolyl benzoquinone. ChemBioChem 15: 108-116, DOI: 10.1002/cbic.201300610.
Abstract

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2013

140.    Xia Yu, Georg Zocher, Xiulan Xie, Mike Liebhold, Stefan Schütz, Thilo Stehle, and Shu-Ming Li (2013). Catalytic mechanism of stereospecific formation of cis-configured prenylated pyrroloindoline diketopiperazines by indole prenyltransferases. Chemistry and Biology 20: 1492-1501, DOI: 10.1016/j.chembiol.2013.10.007.
Abstract

139.    Mike Liebhold and Shu-Ming Li (2013) Regiospecific benzylation of tryptophan and derivatives catalyzed by a fungal dimethylallyl transferase. Organic Letters 15: 5834-5837, DOI: 10.1021/ol4029012.
Abstract

138.    Daniel Pockrandt and Shu-Ming Li (2013). Geranylation of cyclic dipeptides by the dimethylallyl transferase AnaPT resulting in a shift of prenylation position on the indole ring. ChemBioChem 14: 2023-2028, DOI: 10.1002/cbic.201300372.
Abstract

137.    Kathrin Mundt and Shu-Ming Li (2013). CdpC2PT, a reverse prenyltransferase from Neosartorya fischeri with distinct substrate preference from known C2-prenyltransferases. Microbiology 159: 2169-2179, DOI: 10.1099/mic.0.069542-0 .
Abstract

136.    Aili Fan and Shu-Ming Li (2013). One substrate – seven products with different prenylation positions in one-step reactions: Prenyltransferases make it possible. Advanced Synthesis and Catalysis 355: 2659-2666, DOI: 10.1002/adsc.201300386.
Abstract

135.    Peter Mai and Shu-Ming Li (2013) Alkaloids derived from tryptophan: a focus on ergot alkaloids. In Handbook of Natural products Vol. I (Eds K.G. Ramawat and J.M. Merillon) pp 683-714, DOI: 10.1007/978-3-642-22144-6_24
Abstract

134.    Mike Liebhold, Xiulan Xie and Shu-Ming Li (2013). Breaking cyclic dipeptide prenyltransferase regioselectivity by unnatural alkyl donors. Organic Letters 15: 3062-3065, DOI: 10.1021/ol401247s.
Abstract

133.    Suqin Yin, Xia Yu, Qing Wang, Xiao-Qing Liu and Shu-Ming Li (2013). Identification of a brevianamide F reverse prenyltransferase BrePT from Aspergillus versicolor with a broad substrate specificity towards tryptophan-containing cyclic dipeptides. Applied Microbiology and Biotechnology 97: 1649-1660, DOI: 10.1007/s00253-012-4130-0
Abstract

132.    Marco Matuschek and Shu-Ming Li (2013). Tryptophanyl aminopeptidase 7-DMATS-type peptidase In: Handbook of Proteolytic Enzymes, 3rd Edition (Eds Neil D. Rawlings and Guy Salvesen), Elsevier Ltd, Chapter 394, pp1691-1697 (book article).

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2012

131.    Daniel Pockrandt, Lena Ludwig, Aili Fan, Gabriele M. König and Shu-Ming Li (2012). New insights into the biosynthesis of prenylated xanthones: XptB from Aspergillus nidulans catalyses an O-prenylation of xanthones. ChemBioChem13: 2764-2771, DOI: 10.1002/cbic.201200545.
Abstract

130.    Kathrin Mundt, Beate Wollinsky, Han-Li Ruan, Tianjiao Zhu and Shu-Ming Li (2012). Identification of the verruculogen prenyltransferase FtmPT3 by a combination of chemical, bioinformatic and biochemical approaches. ChemBioChem 13: 2583-2592, DOI: 10.1002/cbic.201200523.

Abstract

129.    Beate Wollinsky, Lena Ludwig, Xiulan Xie and Shu-Ming Li (2012). Breaking the regioselectivity of indole prenyltransferases: identification of regular C3-prenylated hexahydropyrrolo[2,3-b]indoles as side products of the regular C2-prenyltransferase FtmPT1. Organic and Biomolecular Chemistry 10:9262-9270, DOI: 10.1039/C2OB26149A.
Abstract

128.    Xia Yu, Aigang Yang, Wenhan Lin and Shu-Ming Li (2012). Friedel-Crafts alkylation on indolocarbazoles catalyzed by two dimethylallyltryptophan synthases from Aspergillus. Tetrahedron Letters 53: 6861-6864, DOI: 10.1016/j.tetlet.2012.10.039.
Abstract

127.    Mike Liebhold, Xiulan Xie and Shu-Ming Li (2012) Expansion of enzymatic Friedel-Crafts alkylation on indoles: Acceptance of unnatural β-unsaturated allyl diphospates by DMAT Synthases. Organic Letters 14: 4882-4885, DOI: 10.1021/ol302207r
Abstract

126.    Jan Michael Schuller, Georg Zocher, Mike Liebhold, Xiulan Xie, Mark Stahl, Shu-Ming Li and Thilo Stehle (2012) Structure and catalytic mechanism of a cyclic dipeptide prenyltransferase with broad substrate promiscuity. Journal of Molecular Biology, 422:87–99, DOI: 10.1016/j.jmb.2012.05.033.
Abstract

125.    Edyta Stec and Shu-Ming Li (2012) Mutagenesis and biochemical studies on AuaA confirmed the importance of the two conserved aspartate-rich motifs and suggested difference in the amino acids for substrate binding in membrane-bound prenyltransferases. Archives of Microbiology 194:589–595, DOI: 10.1007/s00203-012-0795-0.
Abstract

124.    Jia-Xiang Sun, Xiao-Ya Zhao, Xiao-Fang Fu, Heng-Yi Yu, Xue Li, Shu-Ming Li, Han-Li Ruan (2012) Three new naphthalenyl glycosides from the root bark of Juglans cathayensis. Chemical and Pharmaceutical Bulletin 60: 785-789, DOI: 10.1248/cpb.60.785.
Abstract

123.    Beate Wollinsky, Lena Ludwig, Alexandra Hamacher, Xia Yu, Matthias Kassack and Shu-Ming Li (2012) Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides. Bioorganic and Medicinal Chemistry Letters 22: 3866–3869, DOI: 10.1016/j.bmcl.2012.04.119.
Abstract

122.    Christiane Wallwey, Christoph Heddergott, Xiulan Xie, Axel A. Brakhage and Shu-Ming Li (2012) Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae. Microbiology 158: 1634 - 1644, DOI: 10.1099/mic.0.056796-0.
Abstract

121.    Marco Matuschek, Christiane Wallwey, Beate Wollinsky, Xiulan Xie and Shu-Ming Li (2012) In vitro conversion of chanoclavine-I aldehyde to the stereoisomers festuclavine and pyroclavine was controlled by the second reduction step. RSC Advances 2: 3662-3669, DOI: 10.1039/C2RA20104F.
Abstract

120.    Xia Yu, Yan Liu, Xiulan Xie, Xiao-Dong Zheng and Shu-Ming Li (2012) Biochemical characterization of indole prenyltransferases: Filling the last gap of prenylation positions by a 5-dimethylallyltryptophan synthase from Aspergillus clavatus. Journal of Biological Chemistry 287: 1371-1380, DOI: 10.1074/jbc.M111.317982.
Abstract

119.    Viola Wohlgemuth und Shu-Ming Li (2012) Monoklonale Antikörper, die magischen Kugeln Paul Ehrlichs. Apotheken Magazin 30(3): 7-14 (review article).
Abstract

118.    Wen-Bing Yin and Shu-Ming Li (2012) Stereospecific synthesis of aszonalenins by using two recombinant prenyltransferases. Practical Methods for Biocatalysis and Biotransformations (Eds. John Whittall and Peter Sutton) Volume 2, pp 254-258 (review article).

117.    Xia Yu and Shu-Ming Li (2012) Prenyltransferases of the dimethylallyltryptophan synthase superfamily. Methods in Enzymology, Vol 516 (Natural Product Biosynthesis by Microorganisms and Plants, Part B), Ed.: D. A. Hopwood, pp 259-278 (review article).

116.    Christiane Wallwey and Shu-Ming Li (2012). Production, detection and purification of clavine-type ergot alkaloids. Methods in Molecular Biology Vol.944 (Fungal Secondary Metabolism: Methods and Protocols) Eds.: Nancy Keller and Geoffrey Turner, pp 121-131 (review article).

115.    Beate Wollinsky and Shu-Ming Li (2012). Detection and purification of non-ribosomal peptide synthetase products in Neosartorya fischeri. Methods in Molecular Biology Vol. 944 (Fungal Secondary Metabolism: Methods and Protocols), Eds.: N. Keller and G. Turner, pp 111-119 (review article).

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2011

114.    Xia Yu, Xiulan Xie and Shu-Ming Li (2011) Substrate promiscuity of secondary metabolite enzymes: Prenylation of hydroxynaphthalenes by fungal indole prenyltransferases. Applied Microbiology and Biotechnology. 92: 237-248, DOI: 10.1007/s00253-011-3351-y.
Abstract

113.    Xia Yu and Shu-Ming Li (2011) Prenylation of flavonoids by using a dimethylallyltryptophan synthase 7-DMATS from Aspergillus fumigatus. ChemBioChem 12: 2280-2283, DOI: 10.1002/cbic.201100413.
Abstract

112.    Xiulan
Xie, Christiane Wallwey, Marco Matuschek, Klaus Steinbach, Shu-Ming Li (2011) Formyl migration product of chanoclavine-I aldehyde in the presence of the old yellow enzyme FgaOx3 from Aspergillus fumigatus: a NMR structure elucidation. Magnetic Resonance in Chemistry 49: 678-681, DOI: 10.1002/mrc.2796.
Abstract

111.    Chuan-Ling Si, Shu-Ming Li, Zhong Liu, Jin-Kyu Kim and Young-Soo Bae (2011) Antioxidant phenolic glycosides from the bark of Populus ussuriensis Kom. Natural Product Research 25: 1396-1401, DOI: 10.1080/14786410802267700.
Abstract

110.    Edyta Stec, Dominik Pistorius, Rolf Müller and Shu-Ming Li (2011) AuaA, a membrane-bound farnesyltransferase from Stigmatella aurantiaca, catalyzes the prenylation of 2-methyl-4-hydroxyquinoline in the biosynthesis of aurachins. ChemBioChem 11: 1724-1730, DOI: 10.1002/cbic.201100188. 
Inside cover
Abstract

109.    Eva Kranen, Nicola Steffan, Ruth Maas, Shu-Ming Li and Joachim Jose (2011) Development of a whole cell biocatalyst for the efficient prenylation of indole derivatives by Autodisplay of the aromatic prenyltransferase FgaPT2. ChemCatChem 3, 1200-1207, DOI: 10.1002/cctc.201000429.
Abstract

108.    Marco Matuschek, Christiane Wallwey, Xiulan Xie and Shu-Ming Li (2011) New insights into ergot alkaloid biosynthesis in Claviceps purpurea: An agroclavine synthase EasG catalyses, via a non-enzymatic adduct with reduced glutathione, the conversion of chanoclavine-I aldehyde to agroclavine. Organic and Biomolecular Chemistry. 9: 4328-4335, DOI: 10.1039/C0OB01215G.
Abstract

107.    Fan-Yu Meng, Jia-Xiang Sun,  Xue Li, Heng-Yi Yu, Shu-Ming Li and Han-Li Ruan (2011) Schiglautone A, a new tricyclic triterpenoid with a unique 6/7/9-fused skeleton from the stems of Schisandra glaucescens. Organic Letters 13:1502–1505, DOI: 10.1021/ol200188n.
Abstract

106.    Christiane Wallwey and Shu-Ming Li (2011) Ergot alkaloids: structure diversity, biosynthetic gene clusters and functional proof of biosynthetic genes. Natural product reports 28: 496-510, DOI: 10.1039/C0NP00060D.
Abstract

105.    Hui-Xi Zou, Xiulan Xie, Xiao-Dong Zheng and Shu-Ming Li (2011) The tyrosine O-prenyltransferase SirD catalyzes O-, N- and C prenylations. Applied Microbiology and Biotechnology 89:1443-1451, DOI: 10.1007/s00253-010-2956-x.
Abstract

104.    Shu-Ming Li (2011) Genome mining and biosynthesis of fumitremorgin-type alkaloids in ascomycetes. Journal of Antibiotics 64:45-49 (review article), DOI: 10.1038/ja.2010.128.
Abstract

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2010

103.    Marco Jost, Georg Zocher, Sylwia Tarcz, Marco Matuschek, Xiulan Xie, Shu-Ming Li and Thilo Stehle (2010) Structure-function analysis of an enzymatic prenyl transfer reaction identifies a reaction chamber with modifiable specificity. Journal of the American Chemical Society. 132: 17849-17858, DOI: 10.1021/ja106817c.
Abstract

102.    Christiane Wallwey, Marco Matuschek, Xiu-Lan Xie and Shu-Ming Li (2010) Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3. Organic and Biomolecular Chemistry 8: 3500-3508, DOI: 10.1039/C003823G.
Abstract

101.    Hui-Xi Zou, Xiu-Lan Xie, Uwe Linne, Xiao-Dong Zheng and Shu-Ming Li (2010) Simultaneous C7- and N1-prenylation of cyclo-L-Trp-L-Trp catalyzed by a prenyltransferase from Aspergillus oryzae. Organic and Biomolecular Chemistry 8: 3037-3044, DOI: 10.1039/C002850A.
Abstract

100.    Wen-Bing Yin, Xia Yu, Xiu-Lan Xie, and Shu-Ming Li (2010) Preparation of pyrrolo[2,3-b]indoles carrying a ß-configured reverse C3 dimethylallyl moiety by using a recombinant prenyltransferase CdpC3PT. Organic and Biomolecular Chemistry 8, 2430-2438, DOI: 10.1039/C000587H.
Abstract

99.    Anika Kremer and Shu-Ming Li (2010). A tyrosine O-prenyltransferase catalyses the first pathway-specific step in the biosynthesis of sirodesmin. PL. Microbiology 156: 278-286, DOI: 10.1099/mic.0.033886-0
Abstract

98.    Christiane Wallwey, Marco Matuschek and Shu-Ming Li (2010) Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenaseFgaDH. Archives of Microbiology 192: 127-134, DOI: 10.1007/s00203-009-0536-1.
Abstract

97.    Wen-Bing Yin, Xiu-Lan Xie, Marco Matuschek and Shu-Ming Li  (2010). Reconstruction of pyrrolo[2,3-b]indoles carrying an a-configured reverse C3-dimethylallyl moiety by using recombinant enzymes. Organic and Biomolecular Chemistry 8: 1133-1141, DOI: 10.1039/B922440H.
Abstract

96.    Shu-Ming Li (2010) Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis. Natural Product Reports 27: 57-78 (Review article), DOI: 10.1039/B909987P.
Abstract

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2009

95.    Han-Li Ruan, Edyta Stec and Shu-Ming Li (2009). Production of diprenylated indole derivatives by tandem incubation of two recombinant dimethylallyltryptophan synthases. Archives of Microbiology 191:791-795, DOI: 10.1007/s00203-009-0504-9.
Abstract

94.    Chuan-Ling Si, Jin-Kyu Kim, Young-Soo Bae and Shu-Ming Li (2009). Phenolic compounds in the leaves of Populus ussuriensis and their anti-oxidantactivities. Planta Medica 75: 1165-1167, DOI: 10.1055/s-0029-1185476.
Abstract

93.    Nicola Steffan, Alexander Grundmann, Shamil Afiyatullov, Hanli Ruan and Shu-Ming Li (2009). FtmOx1, a non heme Fe(II) and alpha-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus. Organic and Biomolecular Chemistry 7: 4082 – 4087, DOI: 10.1039/B908392H.
Abstract

92.    Xiaoqing Liu, Lu Wang, Nicola Steffan, Wen-Bing Yin and Shu-Ming Li (2009). Ergot alkaloid biosynthesis in Aspergillus fumigatus: FgaAT catalyses theacetylation of fumigaclavine B. ChemBioChem 10: 2325-2328, DOI: 10.1002/cbic.200900395.
Abstract

91.    Ute Metzger, Christoph Schall, Georg Zocher, Inge Unsöld, Edyta Stec, Shu-Ming Li, Lutz Heide, Thilo Stehle (2009). The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria. Proceedings of the National Acaddemy of Sciences USA 106: 14309-14314, DOI: 10.1073/pnas.0904897106.
Abstract

90.    Lu Wang, Wen-Bing Yin, Shu-Ming Li and Xiao-Qing Liu (2009) Chemoenzymatic synthesis of prenylated indole alkaloids. Chinese Journal of Biochemistryand Molecular Biology 25: 580-584.
Abstract

89.    Wen-Bing Yin, Jun Cheng and Shu-Ming Li (2009). Stereospecific synthesis of aszonalenins. Organic and Biomolecular Chemistry 7: 2202-2207, DOI: 10.1039/B902413A.
Abstract

88.    Nicola Steffan and Shu-Ming Li (2009). Increasing structure diversity of prenylated diketopiperazine derivatives by using a 4-dimethylallyltryptophan synthase. Archives of Microbiology 191: 461-466, DOI: 10.1007/s00203-009-0467-x.
Abstract

87.    Shubha Maiya, Alexander Grundmann, Shu-Ming Li and Geoffrey Turner (2009). Improved tryprostatin B production by heterologous gene expression in Aspergillus nidulans. Fungal Genetics and Biology 46: 436-440, DOI: 10.1016/j.fgb.2009.01.003.
Abstract

86.    Huixi Zou, Xiaodong Zheng and Shu-Ming Li (2009). Substrate promiscuity of the cyclic dipeptide prenyltransferases from Aspergillus fumigatus. Journal of Natural Products. 72: 44-52, DOI: 10.1021/np800501m.
Abstract

85.    Wen-Bing Yin, Alexander Grundmann, Jun Cheng and Shu-Ming Li (2009). Acetylaszonalenin biosynthesis in Neosartorya fischeri. Identification of the biosynthetic gene cluster by genomic mining and functional proof of the genes by biochemical investigation. Journal of Biological Chemistry. 284, 100-109, DOI: 10.1074/jbc.M807606200.
Abstract

84.    Shu-Ming Li (2009). Evolution of aromatic prenyltransferases in the biosynthesis of indole derivatives. Phytocemstry 70: 1746-1757 (Review article), DOI: 10.1016/j.phytochem.2009.03.019.
Abstract

83.    Nicola Steffan and Shu-Ming Li (2009) Gewinnung biologisch aktiver Substanzen aus Mikroorganismen durch Genomforschung. Apotheken Magazin27(9): 8-13 (Review article).
Abstract

82.    Shu-Ming Li (2009). Applications of dimethylallyltryptophan synthases and other indole prenyltransferases for structural modification of natural products. Applied Microbiology and Biotechnology 84: 631-639 (Review article), DOI:10.1007/s00253-009-2128-z.
Abstract

81.    Nicola Steffan, Alexander Grundmann, Wenbing Yin, Anika Kremer and Shu-Ming Li (2009). Indole prenyltransferases from Aspergillus, a new enzyme group with high potential for the production of prenylated indole derivatives. Current Medicinal Chemistry 16: 218-231 (Review article), DOI : 10.2174/092986709787002772.
Abstract

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2008

80.    Ole Rigbers and Shu-Ming Li (2008) Ergot alkaloid biosynthesis in Aspergillus fumigatus: overproduction and biochemical characterisation of a 4-dimethylallyltryptophan N-methyltransferase. Journal of Biological Chemistry. 283: 26859-26868, DOI: 10.1074/jbc.M804979200.
Abstract

79.    Alexander Grundmann, Tatyana Kuznetsova, Shamil Sh. Afiyatullov and Shu-Ming Li (2008) FtmPT2, an N-prenyltransferase from Aspergillus fumigatus, catalyses the last step in the biosynthesis of fumitremorgin B. ChemBioChem 9: 2059-2063, DOI: 10.1002/cbic.200800240.
Abstract

78.    Edyta Stec, Nicola Steffan, Anika Kremer, Huixi Zou, Xiaodong Zheng and Shu-Ming Li (2008) Two lysine residues are responsible for the enzymatic activities of indole prenyltransferases from fungi. ChemBioChem 9: 2055-2058, DOI: 10.1002/cbic.200800237.
Abstract

77.    Anika Kremer and Shu-Ming Li (2008). Tryptophan aminopeptidase activity of the indole prenyltransferases from Aspergillus fumigatus. Chemistry and Biology 15: 729-738, DOI: 10.1016/j.chembiol.2008.05.019.
Abstract

76.    Anika Kremer and Shu-Ming Li (2008). Potential of a 7-dimethylallyltryptophan synthase as a tool for production of prenylated indole derivatives. Applied Microbiology and Biotechnology 79: 951-961, DOI: 10.1007/s00253-008-1505-3.
Abstract

75.    Anne Markert, Nicola Steffan, Kerstin Ploss, Sabine Hellwig, Ulrike Steiner, Christel Drewke, Shu-Ming Li, Wilhelm Boland, and Eckhard Leistner (2008). Biosynthesis and accumulation of ergoline alkaloids in a mutualistic association between Ipomoea asarifolia (Convolvulaceae) and a Clavicipitalean fungus. Plant Physiology 147: 296-305, DOI: 10.1104/pp.108.116699.
Abstract

74.    Han-Li Ruan, Wen-Bing Yin, Ji-Zhou Wu and Shu-Ming Li (2008). Reinvestigation on a cyclic dipeptide N-prenyltransferase reveals rearrangement of N1-prenylated indole derivatives. ChemBioChem 9: 1044-1047, DOI: 10.1002/cbic.200700723.
Abstract

73.    L. Heide, B. Gust, C. Anderle and S.-M. Li (2008). Combinatorial biosynthesis, metabolic engineering and mutasynthesis for the generation of new aminocoumarin antibiotics. Current Topics in Medicinal Chemistry 8: 667-679 (Review article), DOI: 10.2174/156802608784221505.
Abstract

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2007

72.    Christine Anderle, Shu-Ming Li, Bernd Kammerer, Bertolt Gust and Lutz Heide (2007). New aminocoumarin antibiotics derived from 4-hydroxycinnamic acid are formed after heterologous expression of a modified clorobiocin biosynthetic gene cluster. Journal of Antibiotics 60: 504 - 10, DOI: 10.1038/ja.2007.64.
Abstract

71.    Christine Anderle, Susanne Hennig, Bernd Kammerer, Shu-Ming Li, Ludger Wessjohann, Bertolt Gust and Lutz Heide (2007). Improved mutasynthetic approaches for the production of modified aminocoumarin antibiotics. Chemistry and Biology 14: 955-967, DOI: 10.1016/j.chembiol.2007.07.014.
Abstract

70.    Shubha Maiya, Alexander Grundmann, Xiang Li, Shu-Ming Li and Geoffrey Turner (2007). Identification of a hybrid PKS/NRPS required for pseurotin A biosynthesis in the human pathogen, Aspergillus fumigatus. ChemBioChem 8: 1736-1743, DOI: 10.1002/cbic.200700202.
Abstract

69.    Anika Kremer, Lucia Westrich and Shu-Ming Li (2007). A 7-dimethylallyltryptophan synthase from Aspergillus fumigatus. Overproduction, purification and biochemical characterization. Microbiology 153: 3409-3416, DOI:10.1099/mic.0.2007/009019-0.
Abstract

68.    Nicola Steffan, Inge A. Unsöld and Shu-Ming Li (2007). Chemoenzymatic synthesis of indole derivatives using a dimethylallyltryptophan synthases from Aspergillus fumigatus. ChemBioChem 8: 1298-1307, DOI: 10.1002/cbic.200700107.
Abstract

67.    Wen-Bing Yin, Han-Li Ruan, Lucia Westrich, Alexander Grundmann and Shu-Ming Li (2007). CdpNPT, an N-prenyltransferase from Aspergillus fumigatus: Overproduction, purification and biochemical characterization. ChemBioChem 8: 1154-1161, DOI: 10.1002/cbic.200700079.
Abstract

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2006

66.    Anja Freitag , Carmen Méndez, José A. Salas, Bernd Kammerer, Shu-Ming Li and Lutz Heide (2006). Metabolic engineering of the heterologous production of clorobiocin derivatives and elloramycin in Streptomyces coelicolor M512. Metabolic Engineering 8:653-661, DOI: 10.1016/j.ymben.2006.07.003.
Abstract

65.    Anja Freitag, Shu-Ming Li and Lutz Heide (2006). Biosynthesis of the unusual 5,5-gem-dimethyl-deoxysugar noviose: investigation of the C-methyltransferase gene cloU. Microbiology 152:2433-2442, DOI: 10.1099/mic.0.28931-0.
Abstract

64.    Shubha Maiya, Alexander Grundmann, Shu-Ming Li and Geoffrey Turner (2006). The fumitremorgin gene cluster of Aspergillus fumigatus: Identification of a gene encoding brevianamide F synthetase. ChemBioChem 7: 1062-1069, DOI: 10.1002/cbic.200600003.
Abstract

63.    Ruth H. Flatman, Alessandra Eustaquio, Shu-Ming Li, Lutz Heide and Anthony Maxwell (2006). Structure-activity relationships of aminocoumarin-type gyrase and topoisomerase IV inhibitors obtained by combinatorial biosynthesis. Antimicrobial Agents and Chemotherapy 50:1136-1142, DOI: 10.1128/AAC.50.4.1136-1142.2006.
Abstract

62.    Inge A. Unsöld and Shu-Ming Li (2006). Reverse prenyltransferase in the biosynthesis of fumigaclavine C in Aspergillus fumigatus. gene expression, purification and characterization of fumigaclavine C synthase FgaPT1. ChemBioChem 7:158-164, DOI: 10.1002/cbic.200500318.
Abstract

61.    Shu-Ming Li and Inge A. Unsöld (2006). Post genome research in the biosynthesis of ergot alkaloids. Planta Medica 72:1117-1120 (Review article), DOI:10.1055/s-2006-947195.
Abstract

60.    Shu-Ming Li and Lutz Heide (2006). The biosynthetic gene clusters of aminocoumarin antibiotics. Planta Medica 72:1093-1099 (Review article), DOI:10.1055/s-2006-946699.
Abstract

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2005

59.    Anja Freitag, Emmanuel Wemakor, Shu-Ming Li and Lutz Heide (2005) Acyl transfer in clorobiocin biosynthesis: Involvement of several proteins in the transfer of the pyrrole-2-carboxyl moiety to the deoxysugar. ChemBioChem 6: 2316-2325, DOI: 10.1002/cbic.200500252
Abstract

58.    Alexander Grundmann and Shu-Ming Li (2005). Overproduction, purification and characterization of FtmPT1, a brevianamide F prenyltransferase from Aspergillus fumigatus. Microbiology 151: 2199-2207, DOI:10.1099/mic.0.27962-0.
Abstract

57.    Anja Freitag, Heike Rapp, Lutz Heide and Shu-Ming Li (2005). Metabolic engineering of aminocoumarins: Inactivation of the methyltransferase gene cloP and generation of new clorobiocin derivatives in a heterologous host. ChemBioChem 6: 1411-1418, DOI: 10.1002/cbic.200500019.
Abstract

56.    Inge A. Unsöld und Shu-Ming Li (2005). Overproduction, purification and characterization of FgaPT2, a dimethylallyltryptophan synthase from Aspergillus fumigatus. Microbiology 151: 1499-1505, DOI:10.1099/mic.0.27759-0
Abstract

55.    Thomas Luft, Shu-Ming Li, Holger Scheible, Bernd Kammerer, Lutz Heide (2005). Overexpression, purification and characterization of SimL, an amide synthetase involved in simocyclinone biosynthesis. Archives of Microbiology 183:277-285, DOI: 10.1007/s00203-005-0770-0.
Abstract

54.    Alessandra S. Eustáquio, Shu-Ming Li and Lutz Heide (2005). NovG, a DNA-binding protein acting as a positive regulator of novobiocin biosynthesis. Microbiology 151:1949-1961, DOI:
10.1099/mic.0.27669-0.
Abstract

53.    Alessandra S. Eustáquio, Bertolt Gust, Ute Galm, Shu-Ming Li, Keith F. Chater and Lutz Heide (2005). Heterologous expression of biosynthetic gene clusters and generation of structurally modified antibiotics. Applied and Environmental Microbiology 71: 2452-2459.

52.    Shu-Ming Li and Lutz Heide (2005). New aminocoumarin antibiotics from genetically engineered Streptomyces strains. Current Medicinal Chemistry 12 (3): 763-771 (review article).
Abstract

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2004

51.    Hui Xu, Lutz Heide and Shu-Ming Li (2004). New aminocoumarin antibiotics formed by a combined mutational and chemoenzymatic approach, utilizing the carbamoyltransferase NovN. Chemistry and Biology 11: 655-662, DOI: 10.1016/j.chembiol.2004.02.028.
Abstract

50.    Elisabeth Schmutz, Susanne Hennig, Shu-Ming Li and Lutz Heide (2004). Identification of a topoisomerase IV in actinobacteria: Purification and characterization of ParYR and GyrBR from the coumermycin A1 producer Streptomyces rishiriensis DSM 40489. Microbiology 150: 641-647, DOI: 10.1099/mic.0.26867-0.
Abstract

49.    Alessandra S. Eustáquio, Bertolt Gust, Shu-Ming Li, Stefan Pelzer, Wolfgang Wohlleben, Keith F. Chater, and Lutz Heide (2004). Production of 8´-halogenated and 8´-unsubstituted novobiocin derivatives in genetically engineered Streptomyces coelicolor strains. Chemistry and Biology 11: 1561-1572, DOI: 10.1016/j.chembiol.2004.09.009.
Abstract

48.    Bernd Kammerer, Rainer Kahlich, Stefan Laufer, Shu-Ming Li, Lutz Heide and Christoph H. Gleiter (2004). Mass spectrometric pathway monitoring of secondary metabolites: Systematic analysis of culture extracts of Streptomyces species. Analytical Biochemistry 335: 17-29, DOI: 10.1016/j.ab.2004.08.018.
Abstract

47.    Ute Galm, Stefanie Heller, Stuart Shapiro, Malcolm Page, Shu-Ming Li and Lutz Heide (2004). Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis. Antimicrobial Agents and Chemotherapy 48: 1307-1312, DOI: 10.1128/AAC.48.4.1307-1312.2004.
Abstract

46.    Anja Freitag, Ute Galm, Shu-Ming Li and Lutz Heide (2004). New aminocoumarin antibiotics from a cloQ-defective mutant of the clorobiocin producer Streptomyces roseochromogenes DS12.976. Journal of Antibiotics 57: 205-209, DOI: 10.7164/antibiotics.57.205.
Abstract

45.    Karin Räth, Katja Taxis, Gitta Walz, Christoph H. Gleiter, Shu-Ming Li and Lutz Heide (2004). Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (Annual Wormwood). American Journal of Tropical Medicine & Hygiene 70: 128-132, DOI: 10.4269/ajtmh.2004.70.128.
Abstract

44.    Shu-Ming Li (2004). Abenteuer Genomsequenz und Naturstoffforschung. Pharmazeutische Zeitung 149 (43): 3760-3766 (review article).
Abstract

43.    Shu-Ming Li and Lutz Heide (2004). Functional analysis of biosynthetic genes of aminocoumarins and production of hybrid antibiotics. Current Medicinal Chemistry Anti-infective Agents 3 (4): 279-295 (review article), DOI: 10.2174/1568012043353801.
Abstract

42.    Shu-Ming Li (2004). Molekulares Farming: Produktion rekombinanter Proteine in Pflanzen. Deutsche Apotheker Zeitung 144 (26): 2969-2973 (review article).
Abstract

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2003

41.    Elisabeth Schmutz, Marion Steffensky, Jürgen Schmidt, Andera Porzel, Shu-Ming Li and Lutz Heide (2003). An unusual amide synthetase (CouL) from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis DSM 40489. European Journal of Biochemistry 270: 4413-4419, DOI: 10.1046/j.1432-1033.2003.03830.x.
Abstract

40.    Lucia Westrich, Lutz Heide and Shu-Ming Li (2003). CloN6, a novel methyltransferase catalysing the methylation of the pyrrole-2-carboxyl moiety of clorobiocin. ChemBioChem 4: 268-773, DOI:10.1002/cbic.200300609.
Abstract

39.    Hui Xu, Rainer Kahlich, Bernd Kammerer, Lutz Heide and Shu-Ming Li (2003). CloN2, a novel acyltransferase involved in the attachment of the pyrrole-2-carboxyl moiety to the deoxysugar of clorobiocin. Microbiology 149: 2183-2191, DOI 10.1099/mic.0.26314-0.
Abstract

38.    Florence Pojer, Rainer Kahlich, Bernd Kammerer, Shu-Ming Li and Lutz Heide (2003). CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis. Journal of Biological Chemistry 278: 30661-30668, DOI: 10.1074/jbc.M303190200.
Abstract

37.    Alessandra S. Eustáquio, Thomas Luft, Zhao-Xin Wang, Bertolt Gust, Keith F. Chater, Shu-Ming Li and Lutz Heide (2003). Novobiocin biosynthesis: Inactivation of the putative regulatory gene novE and heterologous expression of genes involved in aminocoumarin ring formation. Archives of Microbiology 180: 25-32, DOI: 10.1007/s00203-003-0555-2.
Abstract

36.    Alessandra S. Eustáquio, Bertolt Gust, Thomas Luft, Shu-Ming Li, Keith F. Chater, and Lutz Heide (2003). Clorobiocin biosynthesis in Streptomyces. Identification of the halogenase and generation of structural analogs. Chemistry and Biology 10: 279-288, DOI: 10.1016/S1074-5521(03)00051-6.
Abstract

35.    Florence Pojer, Emmanuel Wemakor, Bernd Kammerer, Huawei Chen, Christopher T. Walsh, Shu-Ming Li and Lutz Heide (2003). CloQ, a novel prenyltransferase involved in clorobiocin biosynthesis. Proc. Natl. Acad. Sci. USA 100: 2316-2321, DOI: 10.1073/pnas.0337708100.
Abstract

34.    Elisabeth Schmutz, Agnes Mühlenweg, Shu-Ming Li and Lutz Heide (2003). Resistance genes of aminocoumarin producers: Two type II topoisomerase genes confer resistance against coumermycin A1 and clorobiocin. Antimicrobial Agents and Chemotherapy 47: 869-877, DOI: 10.1128/AAC.47.3.869-877.2003.
Abstract

33.    Annegret Köhle, Susanne Sommer, Shu-Ming Li, Lieselotte Schilde-Rentschler, Helga Ninnemann and Lutz Heide (2003). Secondary metabolites in transgenic tobacco and potato: High accumulation of 4-hydroxybenzoic acid glucosides results from high expression of the bacterial gene ubiC. Molecular Breeding 11: 15-24, DOI: 10.1023/A:1022211521390.
Abstract

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2002

32.    Florence Pojer, Shu-Ming Li and Lutz Heide (2002). Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: New insights into the biosynthesis of aminocoumarin antibiotics. Microbiology 148: 3901-3911, DOI:10.1099/00221287-148-12-3901.
Abstract

31.    H. Xu, Z.-X.Wang, J. Schmidt, L. Heide and S.-M. Li (2002). Genetic analysis of the biosynthesis of the pyrrole and carbamoyl moieties of coumermycin A1 and novobiocin. Molecular Genetics and Genomics 268: 387-396, DOI: 10.1007/s00438-002-0759-1.
Abstract

30.    Shu-Ming Li, Lucia Westrich, Jürgen Schmidt, Christine Kuhnt and Lutz Heide (2002). Methyltransferase genes in Streptomyces rishiriensis: New coumermycin derivatives from gene-inactivation experiments. Microbiology 148: 3317-3326 (original work), DOI: 10.1099/00221287-148-10-3317.
Abstract

29.    Annegret Köhle, Susanne Sommer, Kazufumi Yazaki, Albert Ferrer, Albert Boronat, Shu-Ming Li and Lutz Heide (2002). High level expression of chorismate pyruvate-lyase (UbiC) and HMG-CoA reductase in hairy root cultures of Lithospermum erythrorhizon. Plant and Cell Physiology 43: 894-902, DOI: 10.1093/pcp/pcf106.
Abstract

28.    Ute Galm, Judith Schimana, Hans-Peter Fiedler, Jürgen Schmidt, Shu-Ming Li, and Lutz Heide (2002). Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tü 6040. Archives of Microbiology 178: 102-114, DOI: 10.1007/s00203-002-0429-z.
Abstract

27.    Lutz Heide and Shu-Ming Li (2002). Aminocoumarin antibiotics. Microbial Secondary Metabolites: Biosynthesis, Genetics and Regulation (Eds: J.F. Martin and F. Fierro). pp 63-83 (book article).

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2001

26.    Shu-Ming Li, Emmanuel Wemakor and Lutz Heide (2001). PCR amplification of 1-deoxy-D-xylulose 5-phosphate synthase (dxs) genes from different Streptomyces species: Evidence for the existence of two dxs gene families. Molecular Biology Today 2: 61-66.
Abstract

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2000

25.    Robert Boehm, Susanne Sommer, Klaus Severin, Shu-Ming Li and Lutz Heide (2000). Active expression of the ubiA gene from E. coli in tobacco: Influence of plant ER-specific signal peptides on the expression of a membrane-bound prenyltransferase in plant cells. Transgenic Research 9: 477-486, DOI: 10.1023/A:1026507803067.
Abstract

24.    Zhao-Xin Wang, Shu-Ming Li and Lutz Heide (2000). Identification of the coumermycin A1 biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489. Antimicrobial Agents and Chemotherapy 44: 3040-3048, DOI: 10.1128/AAC.44.11.3040-3048.2000.
Abstract

23.    Robert Boehm, Susanne Sommer, Shu-Ming Li, Lutz Heide (2000). Genetic engineering on shikonin biosynthesis: Expression of the bacterial ubiA gene in Lithospermum erythrorhizon. Plant and Cell Physiology 41: 911-919, DOI: 10.1093/pcp/pcd013.
Abstract

22.    Marion Steffensky, Shu-Ming Li and Lutz Heide (2000). Cloning, overexpression, and purification of novobiocic acid synthetase from Streptomyces spheroides NCIMB 11891. Journal of Biological Chemistry 275: 21754-21760, DOI: 10.1074/jbc.M003066200.
Abstract

21.    Marion Steffensky, Agnes Mühlenweg, Zhao-Xin Wang, Shu-Ming Li and Lutz Heide (2000). Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891. Antimicrobial Agents and Chemotherapy 44: 1214-1222, DOI: 10.1128/AAC.44.5.1214-1222.2000.
Abstract

20.    Hirobumi Yamamoto, Kenichiro Inoue, Shu-Ming Li and Lutz Heide (2000). Geranylhydroquinone 3”-hydroxylase, a cytochrome P-450 monooxygenase from Lithospermum erythrorhizon cell suspension cultures. Planta 210: 312-317, DOI: 10.1007/PL00008139.
Abstract

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1998

19.    Shu-Ming Li, Andreas Bechthold and Lutz Heide (1998). Putative retrotransposon polyprotein. Plant Molecular Biology 38: 505.

18.    Agnes Mühlenweg, Martin Melzer, Shu-Ming Li and Lutz Heide (1998). 4-Hydroxybenzoate 3-geranyltransferase from Lithospermum erythrorhizon. Purification of a plant membrane-bound prenyltransferase. Planta 205: 407-413, DOI: 10.1007/s004250050337.
Abstract

17.    Shu-Ming Li, Susanne Hennig and Lutz Heide (1998) Shikonin: A geranyl diphosphate-derived plant hemiterpenoid formed via the mevalonate pathway. Tetrahedron Letters 39: 2121-2124.

16.    Shu-Ming Li, Susanne Hennig and Lutz Heide (1998) Biosynthesis of the dimethylallyl moiety of novobiocin via a non-mevalonate pathway. Tetrahedron Letters 39: 2717-2720, DOI: 10.1016/S0040-4039(98)00386-4
Abstract

15.    Marion Steffensky, Shu-Ming Li, Bernhard Vogler and Lutz Heide (1998). Novobiocin biosynthesis in Streptomyces spheroides. Identification of a dimethylallyl diphosphate: 4-hydroxyphenylpyruvate dimethylallyl transferase. FEMS Microbiology Letters 161: 69-74, DOI: 10.1111/j.1574-6968.1998.tb12930.x
Abstract

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1997

14.    Zhao-Xin Wang, Shu-Ming Li, Ralf Löscher and Lutz Heide (1997). 4-Coumaroyl coenzyme A 3-hydroxylase activity from cell cultures of Lithospermum erythrorhizon and its relationship to polyphenol oxidase. Archives of Biochemistry and Biophysics. 347: 249-255, DOI: 10.1006/abbi.1997.0337
Abstract

13.    Shu-Ming Li, Zhao-Xin Wang and Lutz Heide (1997). Purification of UDP-glucose: 4-hydroxybenzoate glucosyltransferase from cell cultures of Lithospermum erythrorhizon. Phytochemistry 46: 27-32, DOI: 10.1016/S0031-9422(97)00212-4
Abstract

12.    Shu-Ming Li, Zhao-Xin Wang, Emmanuel Wemakor and Lutz Heide (1997). Metabolization of the artificial secondary metabolite 4-hydroxybenzoate in ubiC-transformed tobacco. Plant and Cell Physiology 38: 844-850, DOI: 10.1093/oxfordjournals.pcp.a029243
Abstract

11.    Robert Boehm, Shu-Ming Li, Martin Melzer and Lutz Heide (1997). 4-Hydroxybenzoate prenyltransferases in cell-free extracts of Lithospermum erythrorhizon cell cultures. Phytochemistry 44: 419-424, DOI: 10.1016/S0031-9422(96)00458-X
Abstract

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1996

10.    Marion Siebert, Susanne Sommer, Shu-Ming Li, Zhao-Xin Wang, Klaus Severin and Lutz Heide (1996). Genetic engineering of plant secondary metabolism: Accumulation of 4-hydroxybenzoate glucosides as a result of the expression of the bacterial ubiC gene in tobacco. Plant Physiology 112: 811-819.
Abstract

9.    Shu-Ming Li, Zhao-Xin Wang and Lutz Heide (1996). Purification and characterization of an alcohol dehydrogenase from Lithosperrmum erythrohrizon cell cultures. Plant Cell Reports 15: 786-790.

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1991

8.    S.-M. Li and K-W. Glombitza (1991). Phlorotannins from the brown alga Landsburgia quercifolia (Hook. fil. et Harv.) Harv. Botanica Marina 34: 455-457, DOI: 10.1515/botm.1991.34.5.455.
Abstract

7.    Karl-Werner Glombitza and Shu-Ming Li (1991). Fucophlorethols from the brown alga Carpophyllum maschalocarpum. Phytochemistry 30: 3423-3427, DOI: 10.1016/0031-9422(91)83221-6.
Abstract

6.    Shu-Ming Li and Karl-Werner Glombitza (1991). Carmalols and phlorethofuhalols from the brown alga Carpophyllum maschalocarpum. Phytochemistry 30: 3417-3421, DOI: 10.1016/0031-9422(91)83220-F.
Abstract

5.    Karl-Werner Glombitza and Shu-Ming Li (1991). Hydroxyphlorethols from the brown alga Carpophyllum maschalocarpum. Phytochemistry 30: 2741-2745, DOI: 10.1016/0031-9422(91)85135-M.
Abstract

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1987

4.    Chang-Ling Li, Jian Ma, Yin-Ye Wang, Gui-Qiu Han and Shu-Ming Li (1987). Preliminary investigation of activity of the ethanolic extract from Piper hancei against platelet-activating factor. Physiological Sciences 7: 316-317.

3.    Shu-Ming Li and Gui-Qiu Han (1987). Studies on the chemical constituents of Piper hancei Maxim (III). Acta Botanica Sinica 29: 293-296. CA: vol 108:3404u 1988.

2.    Shu-Ming Li, Gui-Qiu Han, B.H. Arison and M.N. Chang (1987). Studies on chemical constituents of Piper hancei Maxim (II). Acta Pharmaceutica Sinica 22: 196-202. CA: vol 107:20765j 1987.

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1986

1.    Gui-Qiu Han, Shu-Ming Li, Chang-Ling Li, J.P. Springer, S.B. Hwang and M.N. Chang (1986). Neolignans from Piper hancei Maxim. Acta Pharmaceutica Sinica 21: 361-365. CA: vol 105:111982c, 1986.

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