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Publications
Publication list at Google Scholar
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2024
253. Yanzhi Yang, Linlan Tao, Yunyun Li, Ying Wu, Qianqian Ran, Dan Li, Shu-Ming Li, Xia Yu, Chun-Mao Yuan, and Kang Zhou* (2024) Fungal prenyltransferase AnaPT and its F265 mutants catalyze the dimethylallylation at the nonaromatic carbon of phloretin. Journal of Agricultural and Food Chemistry, 72, 8018–8026, DOI: 10.1021/acs.jafc.4c00928
Abstract
252. Meiting Wu*, Daniel J. Janzen*, Zhenhua Guan, Ying Ye, Yonghui Zhang, and Shu-Ming Li (2024) The promiscuous flavin-dependent monooxygenase PboD from Aspergillus ustus enables an extension of the structural diversity of hydroxylated pyrroloindoline diketopiperazines. Journal of Natural Products, DOI: 10.1021/acs.jnatprod.4c00127 (*equal contribution)
Abstract
251. Jin-Ling Chang*, Yu-Tian Gan*, Yin-Hui Zhou, Xiao-Gang Peng, Zuo-Ye Xie, Xiang-Gao Meng, Shu-Ming Li and Han-Li Ruan (2024) Asperustins A−J, Austocystins with immunosuppressive and cytotoxic activities from Aspergillus ustus NRRL 5856. Journal of Natural Products, DOI: 10.1021/acs.jnatprod.3c01243(* equal contribution)
Abstract
250. Jasmin Freytag*, Andreas Martin*, Joshua C. Müller, Tjark Kelm, Thilo Stehle, Shu-Ming Li and Georg Zocher (2024) Intramolecular coupling and nucleobase transfer – how cytochrome P450 enzymes GymBx establish their chemoselectivity. ChemCatChem, DOI: 10.1002/cctc.202400105. (* equal contribution)
Abstract
249. Aili Fan*, Boyuan Zhong*, Dong Liu*, Yubo Lu*, Mengyue Wu, Hongwei Jin, Xiao-Meng Shi, Jinwei Ren, Bo Zhang, Xiao-dong Su, Ming Ma, Shu-Ming Li, and Wenhan Lin (2024) Biosynthesis of epipyrone A reveals a highly specific membrane-bound fungal C-glycosyltransferase for pyrone galactosylation. Organic Letters, 26, 1160–1165, DOI: 10.1021/acs.orglett.3c04259 (* equal contribution)
Abstract
2023
248. Sina A. Stierle, Lauritz Harken and Shu-Ming Li (2023) P450 in C–C coupling of cyclodipeptides with nucleobases. In Hans Renata (ed.) Methods in Enzymology, vol 693, pp 231–262, DOI: 10.1016/bs.mie.2023.09.012 (book capital)
Abstract
247. Wen Li, Xiulan Xie, Jing Liu, Huili Yu and Shu-Ming Li (2023) Prenylation of dimeric cyclo-L-Trp-L-Trp by the promiscuous cyclo-L-Trp-L-Ala prenyltransferase EchPT1. Applied Microbiology and Biotechnology, 107, 6887–6895, DOI: 10.1007/s00253-023-12773-0
Abstract
246. Daniel J. Janzen*, Jing Zhou*, and Shu-Ming Li (2023) Biosynthesis of p-terphenyls in Aspergillus ustus implies enzymatic reductive dehydration and spontaneous dibenzofuran formation. Organic Letters, 25, 6311–6316, DOI: 10.1021/acs.orglett.3c02234 (* equal contribution)
Abstract
245. Jing Zhou, Huiling Wei, and Shu-Ming Li (2023) Colletotriauxins A–D, New plant growth inhibitors from the phytopathogenic Colletotrichum gloeosporioides. Journal of Agricultural and Food Chemistry, 71, 1104–1109, DOI: 10.1021/acs.jafc.3c03143
Abstract
244. Daniel J. Janzen*, Haowen Wang*, and Shu-Ming Li (2023) A flavin-dependent oxygenase catalyzes hydroxylation and simultaneous pyrrolidine ring formation in the protubonine biosynthesis in Aspergillus ustus. Journal of Natural Products, 86, 1779–1785, DOI: 10.1021/acs.jnatprod.3c00274 (* equal contribution)
Abstract
243. Andreas Martin, Nele Dierlamm, Georg Zocher and Shu-Ming Li (2023) A basidomycetous hydroxynaphthalene-prenylating enzyme exhibits promiscuity towards prenyl donors. Applied Microbiology and Biotechnology, 107, 4845–4852, DOI: 10.1007/s00253-023-12621-1
Abstract
242. Yu Dai, Xiu-Lan Xie, Hao-Fu Dai, and Shu-Ming Li (2023) Formation of fungal 2,18-dioxo-2,18-seco indole diterpenes by nonenzymatic flavin-catalyzed oxidative ring expansion and oxygen incorporation from solvent water, Organic Letters, 25, 4092–4097, DOI: 10.1021/acs.orglett.3c01320
Abstract
241. Jie Fan*, Huomiao Ran*, Peng-Lin Wei, Yuanyuan Li, Huan Liu, Shu-Ming Li, and Wen-Bing Yin (2023) An ortho-quinone methide mediates disulfide migration in the biosynthesis of epidithiodiketopiperazines, Angewandte Chemie International Edition, 62, e202304252, DOI: 10.1002/anie.202304252, DOI: 10.1002/ange.202304252 (* equal contribution)
Abstract
240. Sina A. Stierle*, Lauritz Harken*, and Shu-Ming Li (2023) Production of diketopiperazine derivatives by pathway engineering with different cyclodipeptide synthases from various Streptomyces strains, ACS Synthetic Biology, 12, 1804–181, DOI: 10.1021/acssynbio.3c00115. (* equal contribution)
Abstract
239. Zheng-Xi Zhang*, Zhang-Hai Li*, and Shu-Ming Li (2023) Formation of the fungal indole alkaloid speradine F implies multiple nonenzymatic oxidation steps. Journal of Natural Products, 86, 1053–1060, DOI: 10.1021/acs.jnatprod.3c00155. (* equal contribution)
Abstract
238. Qianqian Ran, Linlan Tao, Xiang Zhou, Shu-Ming Li, Chun-Mao Yuan, Song Yang, and Kang Zhou (2023) Geranylation of chalcones by a fungal aromatic prenyltransferases. Journal of Agricultural and Food Chemistry, 71, 4675–4682, DOI: 10.1021/acs.jafc.2c08743
Abstract
237. Jie Fan*, Huomiao Ran*, Peng-Lin Wei, Yuanyuan Li, Huan Liu, Shu-Ming Li, Youcai Hu, and Wen-Bing Yin (2023) Pretrichodermamide A biosynthesis reveals the hidden diversity of epidithiodiketopiperazines. Angewandte Chemie International Edition, 62, e202217212, DOI:10.1002/anie.202217212, DOI: 10.1002/ange.202217212. (* equal contribution)
Abstract
236. Jing Liu*, Yiling Yang*, Xiulan Xie and Shu-Ming Li (2023) A new Streptomyces cytochrome P450 enzyme catalyzes regiospecific C2-guaninylation for the synthesis of diverse guanitrypmycin analogs. Journal of Natural Products, 86, 94–102, DOI: 10.1021/acs.jnatprod.2c00787. (* equal contribution)
Abstract
235. Wen Li, Lindsay Coby, Jing Zhou and Shu-Ming Li (2023) Diprenylated cyclodipeptide production by changing the prenylation sequence of the nature´s synthetic machinery. Applied Microbiology and Biotechnology, 107, 261–271, DOI: 10.1007/s00253-022-12303-4.
Abstract
234. Jing Liu and Shu-Ming Li (2023) Genomics-guided efficient identification of 2,5-diketopiperazine derivatives from actinobacteria. ChemBioChem, 24, e202200502, DOI: 10.1002/cbic.202200502.
Abstract
2022
233. Jie Liu, Xiang Guo, Xingchen Guo, Boyuan Zhong, Tao Wang, Dong Liu, Hongwei Jin, Jinwei Ren, Zihe Liu, Jiangtao Gao, Shu-Ming Li, Aili Fan and Wenhan Lin (2022) Concise biosynthesis of tropone-containing spiromaterpenes by a sesquiterpene cyclase and a multi-functional P450 from a deep-sea derived Spiromastix sp. fungus. Journal of Natural Products, 85, 2723−2730, DOI: 10.1021/acs.jnatprod.2c00614.
Abstract
232. Hongjiao Zhang,* Zixin Li,* Shuang Zhou, Shu-Ming Li, Huomiao Ran, Zili Song, Tao Yu and Wen-Bing Yin (2022) A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin. Nature Communications, 13, 6361, DOI: 10.1038/s41467-022-34150-7. (* equal contribution)
Abstract
231. Marlies Peter, Yiling Yang and Shu-Ming Li (2022) A terpene cyclase from Aspergillus ustus is involved in the biosynthesis of geosmin precursor germacradienol. RSC Advances, 12, 28171-28177, DOI: 10.1039/D2RA05033A.
Abstract
230. Yuanyuan Xu, Dan Li, Wenxuan Wang, Kangping Xu, Guishan Tan, Jing Li, Shu-Ming Li and Xia Yu (2022) Dearomative gem-diprenylation of hydroxynaphthalenes by an engineered fungal prenyltransferase. RSC Advances, 12, 27550-27554, DOI: 10.1039/D2RA04837J.
Abstract
229. Pan Xiang,* Bastian Kemmerich,* Li Yang and Shu-Ming Li (2022) Biosynthesis of annullatin D in Penicillium roqueforti implies oxidative lactonization between two hydroxyl groups catalyzed by a BBE-like enzyme. Organic Letters, 24, 6072–6077, DOI: 10.1021/acs.orglett.2c02438. (* equal contribution)
Abstract
228. Sina A. Stierle and Shu-Ming Li (2022) Biosynthesis of xylariolide D in Penicillium crustosum implies a chain branching reaction catalyzed by a highly reducing polyketide synthase. Journal of Fungi, 8, 493, DOI:10.3390/jof8050493.
Abstract
227. Jing Liu,* Lauritz Harken,* Yiling Yang, Xiulan Xie, and Shu-Ming Li (2022) Widely distributed bifunctional bacterial cytochrome P450 enzymes catalyze both intramolecular C-C bond formation in cyclo-L-Tyr-L-Tyr and its coupling with nucleobases. Angewandte Chemie International Edition, 61, e202200377, DOI: 10.1002/anie.202200377, DOI: 10.1002/ange.202200377 (* equal contribution).
Abstract
226. Abraham M. Abraham, Sabrina Wiemann, Ghazala Ambreen, Jenny Zhou, Konrad Engelhardt, Jana Brüßler, Udo Bakowsky, Shu-Ming Li, Robert Mandic, Gabriella Pocsfalvi, Cornelia M. Keck (2022) Cucumber derived exosome-like vesicles and PlantCrystals for improved dermal drug delivery. Pharmaceutics 14, 476, DOI: 10.3390/pharmaceutics14030476.
Abstract
225. Yunyun Li, Xiang Zhou, Shu-Ming Li, Yuping Zhang, Chun-Mao Yuan, Shuzhong He, Zaichang Yang, Song Yang and Kang Zhou (2022) Increasing structural diversity of prenylated chalcones by two fungal prenyltransferases. Journal of Agricultural and Food Chemistry, 70, 1610–1617, DOI: 10.1021/acs.jafc.1c07786.
Abstract
224. Pan Xiang and Shu-Ming Li (2022) Formation of 3-orsellinoxypropanoic acid in Penicillium crustosum is catalyzed by a bifunctional nonreducing polyketide synthase. Organic Letters, 24, 462–466, DOI: 10.1021/acs.orglett.1c04189
Abstract
223. Lauritz Harken, Jing Liu, Oliver Kreuz, Robert Berger and Shu-Ming Li (2022) Biosynthesis of guatrypmethine C implies two different oxidases for exo-double bond installation at the diketopiperazine ring. ACS Catalysis, 12, 648–654, DOI:10.1021/acscatal.1c04609
Abstract
222. Zheng-Xi Zhang,* Zhang-Hai Li,* Wen-Bing Yin and Shu-Ming Li (2022) Biosynthesis of viridicatol in Penicillium palitans implies a cytochrome P450-mediated meta hydroxylation at a monoalkylated benzene ring. Organic Letters, 24, 262–267, DOI:10.1021/acs.orglett.1c03932 (* equal contribution).
Abstract
2021
221. Jing Liu,* Yiling Yang,* Lauritz Harken and Shu-Ming Li (2021) Elucidation of the streptoazine biosynthetic pathway in Streptomyces aurantiacus reveals the presence of a promiscuous prenyltransferases. Journal of Natural Products, 84, 3100–3109, DOI: 10.1021/acs.jnatprod.1c00844 (* equal contribution).
Abstract
220. Dong-Sheng Zhao, Zhi-Wei Hu, Ling-Li Dong, Xiao-Jie Wan, Shengqin Wang, Nan Li, Yao Wang, Shu-Ming Li, Hui-Xi Zou, Xiufeng Yan (2021) A type III polyketide synthase (SfuPKS1) isolated from the edible seaweed Sargassum fusiforme exhibits broad substrate and catalysis specificity. Journal of Agricultural and Food Chemistry, 69, 14643-14649, DOI: 10.1021/acs.jafc.1c05868
Abstract
219. Jenny Zhou and Shu-Ming Li (2021) Conversion of viridicatic acid to crustosic acid by cytochrome P450 enzyme-catalysed hydroxylation and spontaneous cyclisation. Applied Microbiology and Biotechnology, 105, 9181-9189, DOI: 10.1007/s00253-021-11674-4
Abstract
218. Hai-Ning Lyu, Jinyu Zhang, Shuang Zhou, Hong-Wei Liu, Wen-Ying Zhuang, Shu-Ming Li, Wen-Bing Yin (2021) Heterologous expression of a single fungal HR-PKS leads to the formation of diverse 2-alkenyl-tetrahydropyrans in model fungi. Organic & Biomolecular Chemistry, 19, 8377-8383, DOI: 10.1039/D1OB01501J
Abstract
217. Wen Li, Jie Fan, Ge Liao, Wen-Bing Yin and Shu-Ming Li (2021) Precursor supply increases the accumulation of 4-hydroxy-6-(4-hydroxyphenyl)-α-pyrone after NRPS-PKS gene expression. Journal of Natural Products, 84, 2380-2384, DOI: acs.jnatprod.1c00120.
Abstract
216. Kang Zhou, Song Yang and Shu-Ming Li (2021) Naturally occurring prenylated chalcones from plants: Structural diversity, distribution, activities and biosynthesis. Natural Product Reports, 38, 2236-2260, DOI: 10.1039/ D0NP00083C.
Abstract
215. Zhiguo Liu,* Wei Li,* Peng Zhang, Jie Fan, Fangbo Zhang, Caixia Wang, Shuming Li, Yi Sun, Shilin Chen, Wenbing Yin (2021) Tricarbocyclic core formation of tyrosine-decahydrofluorenes implies a three-enzyme cascade with XenF-mediated sigmatropic rearrangement as a prerequisite. Acta Pharmaceutica Sinica B, 11, 3655-3664, Doi: 10.1016/j.apsb.2021.03.034 (* equal contribution).
Abstract
214. Shumin Bao, Ling Luo, Ying Wan, Kangping Xu, Guishan Tan, Jie Fan, Shu-Ming Li and Xia Yu (2021) Regiospecific 7-O-prenylation of anthocyanins by a fungal prenyltransferase. Bioorganic Chemistry, 110, 104787, DOI: 10.1016/j.bioorg.2021.104787 .
Abstract
213. Liujuan Zheng,* Haowen Wang,* Lena Ludwig-Radtke and Shu-Ming Li (2021) Oxepin formation in fungi implies specific and stereoselective ring expansion. Organic Letters, 23, 2024-2028, DOI: 10.1021/acs.orglett.1c00166 (* equal contribution).
Abstract
212. Lauritz Harken and Shu-Ming Li (2021) Modifications of diketopiperazines assembled by cyclodipeptide synthases with cytochrome P450 enzymes. Applied Microbiology and Biotechnology, 105, 2277–2285, DOI 10.1007/s00253-021-11178-1.
Abstract
211. Huan Liu,* Jie Fan,* Peng Zhang, Youcai Hu, Xingzhong Liu, Shu-Ming Li and Wen-Bing Yin (2021) New insights into the disulfide bond formation enzymes in epidithiodiketopiperazine alkaloids. Chemical Science, 12, 4132-4138, DOI: 10.1039/d0sc06647h (* equal contribution).
Abstract
210. Liujuan Zheng and Shu-Ming Li (2021) Benzoyl ester formation in Aspergillus ustus by hijacking the polyketide acyl intermediates with alcohols. Archives of Microbiology, 203, 1795-1800, DOI: 10.1007/s00203-021-02182-0.
Abstract
209. Jonas Nies and Shu-Ming Li (2021) Prenylation and dehydrogenation of a C2-reversely prenylated diketopiperazine as a branching point in the biosynthesis of echinulin family alkaloids in Aspergillus ruber. ACS Chemical Biology, 16, 185-192, DOI: 10.1021/acschembio.0c00874.
Abstract
208. Yuanyuan Xu, Dan Li, Guishan Tan, Yan Zhang, Zhansheng Li, Kangping Xu, Shu-Ming Li and Xia Yu (2021). A single amino acid switch alters the prenyl donor specificity of a fungal aromatic prenyltransferase toward bioflavonoids. Organic Letters, 23, 497-502, DOI: 10.1021/acs.orglett.0c04015.
Abstract
207. Elena Ostertag, Liujuan Zheng, Karina Broger, Thilo Stehle, Shu-Ming Li, and Georg Zocher (2021). Reprogramming substrate and catalytic promiscuity of tryptophan prenyltransferases, Journal of Molecular Biology, 433, 166726, DOI: 10.1016/j.jmb.2020.11.025.
Abstract
206. Huomiao Ran and Shu-Ming Li (2021). Fungal benzene carbaldehydes: occurrence, structural diversity, activities and biosynthesis. Natural Product Reports, 38, 240-263, DOI: 10.1039/d0np0026d.
Abstract
2020
205. Liujuan Zheng,* Yiling Yang,* Haowen Wang, Aili Fan, and Shu-Ming Li (2020). Ustethylin biosynthesis implies phenethyl derivative formation in Aspergillus ustus. Organic Letters, 22, 7837–7841, DOI: 10.1021/acs.orglett.0c02719 (* equal contribution).
Abstract
204. Liujuan Zheng,* Haowen Wang,* Aili Fan, and Shu-Ming Li (2020). Oxepinamide F biosynthesis involves enzymatic D-aminoacyl epimerization, 3H-oxepin formation, and hydroxylation induced double bond migration. Nature Communications, 11, 4914, DOI: 10.1038/s41467-020-18713-0 (* equal contribution).
Abstract
203. Jing Liu, Xiulan Xie and Shu-Ming Li (2020). Increasing cytochrome P450 enzyme diversity by identification of two distinct cyclodipeptide dimerases. Chemical Communications, 56, 11042–11045, DOI: 10.1039/D0CC04772D.
Abstract
202. Xu-Liang Bu, Bei-Bei He, Jing-Yi Weng, Chu-Chu Jiang, Yi-Lei Zhao, Shu-Ming Li, Jun Xu, and Min-Juan Xu (2020). Constructing microbial hosts for the production of benzoheterocyclic derivatives. ACS Synthetic Biology, 9, 2282-2290, DOI: 10.1021/acssynbio.9b00405.
Abstract
201. Pan Xiang, Lena Ludwig-Radtke, Wen-Bing Yin and Shu-Ming Li (2020). Isocoumarin formation by heterologous gene expression and modification by host enzymes. Organic and Biomolecular Chemistry, 18, 4946-4948, DOI: 10.1039/D0OB00989J.
Abstract
200. Keyan Yang, Shu-Ming Li, Xiao-Qing Liu and Aili Fan (2020). Reinvestigation of the substrate specificity of a reverse prenyltransferase NotF from Aspergillus sp. MF297-2. Archives of Microbiology, 202, 1419–1424, DOI: 10.1007/s00203-020-01854-7.
Abstract
199. Jinglin Wang,* Huomiao Ran,* Xiulan Xie, Kaiping Wang, and Shu-Ming Li. (2020). Spontaneous oxidative rearrangement of 1,3-dihydroxyl 4-dimethylallylnaphthalene leading to the formation of tricyclic derivatives. Organic and Biomolecular Chemistry, 18, 2646-2649, DOI: 10.1039/D0OB00354A (* equal contribution).
Abstract
198. Jonas Nies,* Huomiao Ran,* Viola Wohlgemuth, Wen-Bing Yin and Shu-Ming Li (2020) Biosynthesis of the prenylated salicylaldehyde flavoglaucin requires temporary reduction to salicyl alcohol for decoration before reoxidation to final product. Organic Letters, 22, 2256-2260, DOI: 10.1021/acs.orglett.0c00440 (* equal contribution).
Abstract
197. Lena Mikulski,* Johanna Schäfer,* Kirsten Brockmeyer, Rixa Kraut and Shu-Ming Li (2020) Comparative studies on similarities and differences of cyclodipeptide oxidases for installation of C–C double bonds at the diketopiperazine ring. Applied Microbiology and Biotechnology. 104, 2523-2536, DOI: 10.1007/s00253-020-10392-7 (* equal contribution).
Abstract
196. Ge Liao,* Jie Fan,* Lena Ludwig-Radtke, Katja Backhaus, and Shu-Ming Li (2020) Increasing structural diversity of natural products by Michael addition with ortho-quinone methide as the acceptor. The Journal of Organic Chemistry, 85, 1298-1307, DOI:10.1021/acs.joc.9b02971 (* equal contribution).
Abstract
195. Jie Fan,* Ge Liao,* Lena Ludwig-Radtke, Wen-Bing Yin, and Shu-Ming Li (2020) Formation of terrestric acid in Penicillium crustosum requires redox-assisted decarboxylation and stereoisomerization. Organic Letters, 22, 88-92, DOI: 10.1021/acs.orglett.9b04002 (* equal contribution).
Abstract
194. Kangping Xu, Can Yang, Yuanyuan Xu, Dan Li, Shumin Bao, Zhenxing Zou, Fenghua Kang, Guishan Tan, Shu-Ming Li and Xia Yu (2020) Selective geranylation of biflavonoids by Aspergillus terreus aromatic prenyltransferase (AtaPT). Organic and Biomolecular Chemistry, 18, 28-31, DOI: 10.1039/C9OB02296A.
Abstract
2019
193. Huili Yu, Xiulan Xie, and Shu-Ming Li (2019) Coupling of cyclo-L-Trp-L-Trp with hypoxanthine increases structure diversity of guanitrypmycins. Organic Letters, 21, 9104-9108, DOI:10.1021/acs.orglett.9b03491.
Abstract
192. Huili Yu and Shu-Ming Li (2019) Two cytochrome P450 enzymes from Streptomyces sp. NRRL S-1868 catalyze distinct dimerization of tryptophan-containing cyclodipeptides. Organic Letters, 21, 7094-7098, DOI: 10.1021/acs.orglett.9b02666.
Abstract
191. Jing Liu, Xiulan Xie, and Shu-Ming Li (2019) Guanitrypmycin biosynthetic pathways imply cytochrome P450-mediated regio- and stereospecific guaninyl transfer reactions. Angewandte Chemie International Edition, 58, 11534-11540, DOI: 10.1002/anie.201906891.
Abstract
190. Florian Kindinger, Jonas Nies, Anke Becker, Tianjiao Zhu, and Shu-Ming Li (2019) Genomic locus of a Penicillium crustosum pigment as integration site for secondary metabolite gene expression. ACS Chemical Biology, 14, 1227-1234, DOI: 10.1021/acschembio.9b00164.
Abstract
189. Peter Mai,* Lindsay Coby* and Shu-Ming Li (2019) Different behaviors of cyclic dipeptide prenyltransferases toward the tripeptide derivative ardeemin fumiquinazoline and its enantiomer. Applied Microbiology and Biotechnology, 103, 3773–3781, DOI: 10.1007/s00253-019-09723-0. (* equal contribution).
Abstract
188. Jie Fan*, Ge Liao*, Florian Kindinger, Lena Ludwig-Radtke, Wen-Bing Yin and Shu-Ming Li (2019) Peniphenone and penilactone formation in Penicillium crustosum via 1,4-Michael additions of ortho-quinone methide from hydroxyclavatol to γ-butyrolactones from crustosic acid. Journal of the American Chemical Society, 141, 4225–4229, DOI: 10.1021/jacs.9b00110 (PHOENIX Pharmaceutics Science Award 2020). (* equal contribution)
Abstract
187. Elisabeth Hühner, Kristin Öqvist and Shu-Ming Li (2019) Design of α-keto carboxylic acid dimers by domain recombination of nonribosomal peptide synthetase (NRPS)-like enzymes. Organic Letters, 21, 498-502, Doi: 10.1021/acs.orglett.8b03793.
Abstract
186. Shuang Zhou, Peng Zhang, Haichuan Zhou, Xingzhong Liu, Shu-Ming Li, Liangdong Guo, Kuan Li and Wen-Bing Yin (2019) A new regulator RsdA mediating fungal secondary metabolism has a detrimental impact on asexual development in Pestalotiopsis fici. Environmental Microbiology, 21, 416–426, DOI: 10.1111/1462-2920.14473.
Abstract
2018
185. Ge Liao,* Peter Mai,* Jie Fan, Georg Zocher, Thilo Stehle and Shu-Ming Li (2018) Complete decoration of the indolyl residue of tryptophan-containing cyclic dipeptides with geranyl moieties via protein engineering. Organic Letters, 20, 7201–7205, Doi: 10.1021/acs.orglett.8b03124. (* equal contribution)
Abstract
184. Huomiao Ran, Viola Wohlgemuth, Xiulan Xie and Shu-Ming Li (2018) A non-heme FeII/2-oxoglutarate-dependent oxygenase catalyzes a double bond migration within a dimethylallyl moiety accompanied by hydroxylation. ACS Chemical Biology, 13, 2949 – 2955, DOI: 10.1021/acschembio.8b00588.
Abstract
183. Peter Mai, Georg Zocher, Thilo Stehle and Shu-Ming Li (2018) Structure-based protein engineering enables prenyl donor switching of a fungal aromatic prenyltransferase. Organic and Biomolecular Chemistry, 16, 7461–7469, DOI: 10.1039/C8OB02037J. 10.1039/C8OB02037J.
Abstract
182. Bei-Bei He, Xu-Liang Bu, Ting Zhou, Shu-Ming Li, Minjuan Xu and Jun Xu. (2018) Combinatory biosynthesis of prenylated 4-hydroxybenzoate derivatives by overexpression of the substrate-promiscuous prenyltransferase XimB in engineered E. coli. ACS Synthetic Biology, 7, 2094-2104, DOI: 10.1021/acssynbio.8b00070.
Abstract
181. Liujuan Zheng,* Peter Mai,* Aili Fan and Shu-Ming Li (2018) Switching a regular tryptophan C4-prenyltransferase to a reverse tryptophan-containing cyclic dipeptide C3-prenyltransferase by sequential site-directed mutagenesis. Organic and Biomolecular Chemistry, 16, 6688–6694, DOI: 10.1039/C8OB01735B. (* equal contribution)
Abstract
180. Huili Yu, Xiulan Xie and Shu-Ming Li (2018) Coupling of guanine with cyclo-L-Trp-L-Trp Mediated by a cytochrome P450 homologue from Streptomyces purpureus. Organic Letters, 20: 4921-4925, Doi: 10.1021/acs.orglett.8b02051.
Abstract
179. Jing Liu,* Huili Yu* and Shu-Ming Li (2018) Expanding tryptophan-containing cyclodipeptide synthase spectrum by identification of nine members from Streptomyces strains. Applied Microbiology and Biotechnology, 102: 4435–4444, DOI: 10.1007/s00253-018-8908-6; 102: 5787-5789, DOI: 10.1007/s00253-018-9074-6. (* equal contribution)
Abstract
178. Viola Wohlgemuth,* Florian Kindinger* and Shu-Ming Li (2018) Convenient synthetic approach for tri- and tetraprenylated cyclodipeptides by consecutive enzymatic prenylations. Applied Microbiology and Biotechnology, 102: 2671-2681, DOI: 10.1007/s00253-018-8761-7. (* equal contribution)
Abstract
177. Elisabeth Hühner, Katja Backhaus, Rixa Kraut and Shu-Ming Li (2018) Production of α-keto carboxylic acid dimers in yeast by overexpression of NRPS-like genes from Aspergillus terreus. Applied Microbiology and Biotechnology, 102: 1663-1672, DOI: 10.1007/s00253-017-8719-1.
Abstract
2017
176. Kirsten Brockmeyer and Shu-Ming Li (2017) Mutations of residues in pocket P1 of a cyclodipeptide synthase strongly increase product formation. Journal of natural products, 80: 2917-2922, DOI: 10.1021/acs.jnatprod.7b00430.
Abstract
175. Viola Wohlgemuth, Florian Kindinger, Xiulan Xie, Bin-Gui Wang, and Shu-Ming Li (2017) Two Prenyltransferases govern a consecutive prenylation cascade in the biosynthesis of echinulin and neoechinulin. Organic Letters, 19: 5928-5931, DOI: 10.1021/acs.orglett.7b02926.
Abstract
174. Nina Gerhards and Shu-Ming Li (2017) A bifunctional old yellow enzyme from Penicillium roqueforti is involved in the ergot alkaloid biosynthesis. Organic and Biomolecular Chemistry, 15: 8069-8071, DOI: 10.1039/C7OB02095C.
Abstract
173. Qingbo Zhang, Huixian Li, Lu Yu, Yu Sun, Yiguang Zhu, Hanning Zhu, Liping Zhang, Shu-Ming Li, Yuemao Shen, Changlin Tian, Ang Li, Hung-wen Liu and Changsheng Zhang (2017) Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification.Chemical Science, 8:5067-5077, DOI: 10.1039/C7SC01182B.
Abstract
172. Katja Backhaus, Lena Ludwig-Radtke, Xiulan Xie, Shu-Ming Li (2017) Manipulation of the precursor supply in yeast significantly enhances the accumulation of prenylated β-carbolines. ACS Synthetic Biology, 6: 1056-1064, DOI: 10.1021/acssynbio.6b00387.
Abstract
171. Jin Feng, Peng Zhang, Yinglu Cui, Kai Li, Xue Qiao, Ying-Tao Zhang, Shu-Ming Li, Russell J. Cox, Bian Wu, Min Ye and Wen-Bing Yin (2017) Regio- and stereospecific O-glycosylation of phenolic compounds catalysed by a fungal glycosyltransferase from Mucor hiemalis. Advanced Synthesis and Catalysis, 359: 995-1006, DOI: 10.1002/adsc.201601317.
Abstract
170. Jakub Gunera,* Florian Kindinger,* Shu-Ming Li and Peter Kolb (2017) PrenDB: A substrate prediction database to enable biocatalytic use of prenyltransferases. Journal of Biological Chemistry, 292: 4003-4021, DOI: 10.1074/jbc.M116.759118. (* equal contribution)
Abstract
169. Anja Greule, Marija Marolt, Denise Deubel, Iris Peintner, Songya Zhang, Claudia Jessen-Trefzer, Christian De Ford, Sabrina Burschel, Shuming Li, Thorsten Friedrich, Irmgard Merfort, Steffen Lüdeke, Philippe Bisel, Michael Müller, Thomas Paululat, Andreas Bechthold (2017) Wide distribution of foxicin biosynthetic gene clusters in Streptomyces strains – an unusual secondary metabolite with various properties. Frontiers in Microbiology, section Evolutionary and Genomic Microbiology, 8: 221, DOI: 10.3389/fmicb.2017.00221.
Abstract
168. Wei Zhao, Aili Fan, Sylwia Tarcz, Kang Zhou, Wen-Bing Yin, Xiao-Qing Liu and Shu-Ming Li (2017). Mutation on Gly115 and Tyr205 of the cyclic dipeptide C2-prenyltransferase FtmPT1 increases its catalytic activity toward hydroxynaphthalenes. Applied Microbiology and Biotechnology, 101: 1989–1998, DOI: 10.1021/ja106817c.
Abstract
167. Kang Zhou, Carsten Wunsch, Jungui Dai and Shu-Ming Li (2017) Gem-diprenylation of acylphloroglucinols by a fungal prenyltransferase of the dimethylallyltryptophan synthase superfamily. Organic Letters, 19: 388-391, DOI: 10.1021/acs.orglett.6b03594.
Abstract
166. Ridao Chen, Bingquan Gao, Xiao Liu, Feiying Ruan, Yong Zhang, Jizhong Lou, Keping Feng, Carsten Wunsch, Shu-Ming Li, Jungui Dai, Fei Sun (2017). Molecular insights into the promiscuity of the aromatic prenyltransferase AtaPT. Nature Chemical Biology, 13: 226-234, DOI: 10.1038/nchembio.2263.
Abstract
2016
165. Kang Zhou, Wei Zhao, Xiao-Qing Liu and Shu-Ming Li (2016) Saturation mutagenesis on Tyr205 of the cyclic dipeptide C2-prenyltransferase FtmPT1 results in mutants with strongly increased C3-prenylating activity. Applied Microbiology and Biotechnology, 100: 9943–9953, DOI: 10.1007/s00253-016-7663-9.
Abstract
164. Julia Winkelblech, Xiulan Xie, Shu-Ming Li (2016) Characterisation of 6-DMATSMo from Micromonospora olivasterospora leading to identification of divergence in enantioselectivity, regioselectivity and multiple prenylation of tryptophan prenyltransferases. Organic and Biomolecular Chemistry, 14: 9883 – 9895, DOI: 10.1039/C6OB01803C.
Abstract
163. Aili Fan and Shu-Ming Li (2016) Saturation mutagenesis on Arg244 of the tryptophan C4-prenyltransferase FgaPT2 leads to enhanced catalytic ability and different preferences for tryptophan containing-cyclic dipeptides. Applied Microbiology and Biotechnology, 100: 5389 - 5399, DOI: 10.1007/s00253-016-7365-3.
Abstract
162. Peter Mai, Georg Zocher, Lena Ludwig, Thilo Stehle, and Shu-Ming Li (2016) Actions of tryptophan prenyltransferases toward fumiquinazolines and their potential application for the generation of prenylated derivatives by combining chemical and chemoenzymatic syntheses. Advanced Synthesis and Catalysis, 358: 1639-1653, DOI: 10.1002/adsc.201600064.
Abstract
161. Mike Liebhold and Shu-Ming Li (2016). Regiospecific benzylation of tryptophan and derivatives catalyzed by a fungal dimethylallyl transferase. In: Practical Methods for Biocatalysis and Biotransformations 3 (Eds. John Whittall, Peter Sutton and Wolfgang Kroutil), John Wiley &Sons, Ltd.,West Sussex, Volume 3, pp 102-105 (Book Article).
2015
160. Kang Zhou, Xia Yu, Xiulan Xie and Shu-Ming Li (2015) Complementary flavonoid prenylations by fungal indole prenyltransferases. Journal of natural products, 78: 2229 – 2235, DOI: 10.1021/acs.jnatprod.5b00422.
Abstract
159. Julia Winkelblech, Aili Fan and Shu-Ming Li (2015) Prenyltransferases as key enzymes in primary and secondary metabolism. Applied Microbiology and Biotechnology, 99: 7379 - 7397, DOI: 10.1007/s00253-015-6811-y.
Abstract
158. Aili Fan, Julia Winkelblech and Shu-Ming Li (2015) Impacts and perspectives of prenyltransferases of the DMATS superfamily for use in biotechnology. Applied Microbiology and Biotechnology, 99: 7399 - 7415, DOI: 10.1007/s00253-015-6813-9.
Abstract
157. Huili Yu, Mike Liebhold, Xiulan Xie and Shu-Ming Li (2015) Tyrosine O-prenyltransferases TyrPT and SirD displaying similar behavior toward unnatural alkyl or benzyl diphosphate as their natural prenyl donor dimethylallyl diphosphate. Applied Microbiology and Biotechnology, 99: 7115–7124, DOI: 10.1007/s00253-015-6452-1
Abstract
156. Aili Fan, Xiulan Xie and Shu-Ming Li (2015) Tryptophan prenyltransferases showing higher catalytic activities for Friedel-Crafts alkylation of o- and m-tyrosine than tyrosine prenyltransferases. Organic and Biomolecular Chemistry, 13: 7551- 7557, DOI: 10.1039/C5OB01040C.
Abstract
155. Nina Gerhards, Marco Matuschek, Christiane Wallwey and Shu-Ming Li (2015) Genome mining of ascomycetous fungi reveals their genetic potential for ergot alkaloid production. Archives of Microbiology, 197:701-713, DOI:10.1007/s00203-015-1105-4.
Abstract
154. Carsten Wunsch, Kathrin Mundt and Shu-Ming Li (2015) Targeted production of secondary metabolites by coexpression of non-ribosomal peptide synthetase and prenyltransferase genes in Aspergillus. Applied Microbiology and Biotechnology, 99: 4213 - 4233, DOI: 10.1007/s00253-015-6490-8.
Abstract
153. Kang Zhou, Lena Ludwig and Shu-Ming Li (2015) Friedel-Crafts alkylation of acylphloroglucinols catalyzed by a fungal indole prenyltransferase. Journal of Natural Products, 78: 929 - 933, DOI: 10.1021/np5009784.
Abstract
152. Ulrike Steiner, Sabine Hellwig, Mahalia Ahimsa-Müller, Nicola Grundmann, Shu-Ming Li, Christel Drewke, Eckhard Leistner (2015) The key role of peltate glandular trichomes in symbiota comprising clavicipitaceous fungi of the genus Periglandula and their host plants. Toxins, 7: 1355-1373, DOI: 10.3390/toxins7041355.
Abstract
151. Julia Winkelblech*, Mike Liebhold*, Jakub Gunera, Xiulan Xie, Peter Kolb and Shu-Ming Li (2015) Tryptophan C5-, C6- and C7-prenylating enzymes displaying a preference for C-6 of the indole ring in the presence of unnatural dimethylallyl diphosphate analogues. Advanced Synthesis and Catalysis, 357: 975-986, DOI: 10.1002/adsc.201400958. (* equal contribution)
Abstract
150. Carsten Wunsch, Hui-Xi Zou, Uwe Linne and Shu-Ming Li (2015) C7-prenylation of tryptophanyl and O-prenylation of tyrosyl residues in dipeptides by an Aspergillus terreus prenyltransferase. Applied Microbiology and Biotechnology, 99: 1719-1730, DOI: 10.1007/s00253-014-5999-6.
Abstract
149. Huixian Li, Yu Sun, Qingbo Zhang, Yiguang Zhu, Shu-Ming Li, Ang Li and Changsheng Zhang (2015) Elucidating the cyclization cascades in xiamycin biosynthesis by substrate synthesis and enzyme characterizations. Organic Letters, 17: 306–309, DOI: 10.1021/ol503399b.
Abstract
148. Aili Fan, Georg Zocher, Edyta Stec, Thilo Stehle and Shu-Ming Li (2015) Site-directed mutagenesis switching a dimethylallyl tryptophan synthase to a specific tyrosine C3-prenylating enzyme. Journal of Biological Chemistry, 290: 1364–1373, DOI: 10.1074/jbc.M114.623413
Abstract
2014
147. Nina Gerhards, Lisa Neubauer, Paul Tudzynski and Shu-Ming Li (2014) Biosynthetic pathways of ergot alkaloids. Toxins, 6: 3281 – 3295 (review article), DOI: 10.3390/toxins6123281.
Abstract
146. Aili Fan, Huizhi Chen, Rui Wu, Hui Xu and Shu-Ming Li (2014) A new member of the DMATS superfamily from Aspergillus niger catalyzes prenylations of both tyrosine and tryptophan derivatives. Applied Microbiology and Biotechnology, 98: 10119–10129, DOI: 10.1007/s00253-014-5872-7.
Abstract
145. Aili Fan and Shu-Ming Li (2014) Prenylation of tyrosine and derivatives by a tryptophan C7-prenyltransferase. Tetrahedron Letters, 55: 5199 – 5202, DOI: 10.1016/j.tetlet.2014.07.080.
Abstract
144. Daniel Pockrandt, Christopher Sack, Tatjana Kosiol and Shu-Ming Li (2014) A Promiscuous Prenyltransferase from Aspergillus oryzae catalyses C-prenylations of hydroxynaphthalenes in the presence of different prenyl donors. Applied Microbiology and Biotechnology, 98: 4987 - 4994, DOI: 10.1007/s00253-014-5509-x.
Abstract
143. Julia Winkelblech and Shu-Ming Li (2014) Biochemical investigations of two 6-DMATS enzymes from Streptomyces revealing novel features of L-tryptophan prenyltransferases. ChemBioChem, 15: 1030 - 1039, DOI: 10.1002/cbic.201400046.
Abstract
142. Sylwia Tarcz, Xiulan Xie and Shu-Ming Li (2014). Substrate and catalytic promiscuity of secondary metabolite enzymes: O-prenylation of hydroxyxanthones with different prenyl donors by a bisindolyl benzoquinone C- and N-prenyltransferase. RSC Advances, 4: 17986 – 17992, DOI: 10.1039/C4RA00337C.
Abstract
141. Sylwia Tarcz, Lena Ludwig and Shu-Ming Li (2014). AstPT catalyses both reverse N1- and regular C2-prenylation of a methylated bisindolyl benzoquinone. ChemBioChem, 15: 108-116, DOI: 10.1002/cbic.201300610.
Abstract
2013
140. Xia Yu, Georg Zocher, Xiulan Xie, Mike Liebhold, Stefan Schütz, Thilo Stehle, and Shu-Ming Li (2013). Catalytic mechanism of stereospecific formation of cis-configured prenylated pyrroloindoline diketopiperazines by indole prenyltransferases. Chemistry and Biology, 20: 1492-1501, DOI: 10.1016/j.chembiol.2013.10.007.
Abstract
139. Mike Liebhold and Shu-Ming Li (2013) Regiospecific benzylation of tryptophan and derivatives catalyzed by a fungal dimethylallyl transferase. Organic Letters, 15: 5834-5837, DOI: 10.1021/ol4029012.
Abstract
138. Daniel Pockrandt and Shu-Ming Li (2013). Geranylation of cyclic dipeptides by the dimethylallyl transferase AnaPT resulting in a shift of prenylation position on the indole ring. ChemBioChem, 14: 2023-2028, DOI: 10.1002/cbic.201300372.
Abstract
137. Kathrin Mundt and Shu-Ming Li (2013). CdpC2PT, a reverse prenyltransferase from Neosartorya fischeri with distinct substrate preference from known C2-prenyltransferases. Microbiology, 159: 2169-2179, DOI: 10.1099/mic.0.069542-0 .
Abstract
136. Aili Fan and Shu-Ming Li (2013). One substrate – seven products with different prenylation positions in one-step reactions: Prenyltransferases make it possible. Advanced Synthesis and Catalysis, 355: 2659-2666, DOI: 10.1002/adsc.201300386.
Abstract
135. Peter Mai and Shu-Ming Li (2013) Alkaloids derived from tryptophan: a focus on ergot alkaloids. In Handbook of Natural products, Vol. I (Eds K.G. Ramawat and J.M. Merillon) pp 683-714, DOI: 10.1007/978-3-642-22144-6_24
Abstract
134. Mike Liebhold, Xiulan Xie and Shu-Ming Li (2013). Breaking cyclic dipeptide prenyltransferase regioselectivity by unnatural alkyl donors. Organic Letters, 15: 3062-3065, DOI: 10.1021/ol401247s.
Abstract
133. Suqin Yin, Xia Yu, Qing Wang, Xiao-Qing Liu and Shu-Ming Li (2013). Identification of a brevianamide F reverse prenyltransferase BrePT from Aspergillus versicolor with a broad substrate specificity towards tryptophan-containing cyclic dipeptides. Applied Microbiology and Biotechnology, 97: 1649-1660, DOI: 10.1007/s00253-012-4130-0
Abstract
132. Marco Matuschek and Shu-Ming Li (2013). Tryptophanyl aminopeptidase 7-DMATS-type peptidase In: Handbook of Proteolytic Enzymes, 3rd Edition (Eds Neil D. Rawlings and Guy Salvesen), Elsevier Ltd, Chapter 394, pp1691-1697 (book article).
2012
131. Daniel Pockrandt, Lena Ludwig, Aili Fan, Gabriele M. König and Shu-Ming Li (2012). New insights into the biosynthesis of prenylated xanthones: XptB from Aspergillus nidulans catalyses an O-prenylation of xanthones. ChemBioChem, 13: 2764-2771, DOI: 10.1002/cbic.201200545.
Abstract
130. Kathrin Mundt, Beate Wollinsky, Han-Li Ruan, Tianjiao Zhu and Shu-Ming Li (2012). Identification of the verruculogen prenyltransferase FtmPT3 by a combination of chemical, bioinformatic and biochemical approaches. ChemBioChem, 13: 2583-2592, DOI: 10.1002/cbic.201200523.
Abstract
129. Beate Wollinsky, Lena Ludwig, Xiulan Xie and Shu-Ming Li (2012). Breaking the regioselectivity of indole prenyltransferases: identification of regular C3-prenylated hexahydropyrrolo[2,3-b]indoles as side products of the regular C2-prenyltransferase FtmPT1. Organic and Biomolecular Chemistry, 10:9262-9270, DOI: 10.1039/C2OB26149A.
Abstract
128. Xia Yu, Aigang Yang, Wenhan Lin and Shu-Ming Li (2012). Friedel-Crafts alkylation on indolocarbazoles catalyzed by two dimethylallyltryptophan synthases from Aspergillus. Tetrahedron Letters, 53: 6861-6864, DOI: 10.1016/j.tetlet.2012.10.039.
Abstract
127. Mike Liebhold, Xiulan Xie and Shu-Ming Li (2012) Expansion of enzymatic Friedel-Crafts alkylation on indoles: Acceptance of unnatural β-unsaturated allyl diphospates by DMAT Synthases. Organic Letters, 14: 4882-4885, DOI: 10.1021/ol302207r
Abstract
126. Jan Michael Schuller, Georg Zocher, Mike Liebhold, Xiulan Xie, Mark Stahl, Shu-Ming Li and Thilo Stehle (2012) Structure and catalytic mechanism of a cyclic dipeptide prenyltransferase with broad substrate promiscuity. Journal of Molecular Biology, 422:87–99, DOI: 10.1016/j.jmb.2012.05.033.
Abstract
125. Edyta Stec and Shu-Ming Li (2012) Mutagenesis and biochemical studies on AuaA confirmed the importance of the two conserved aspartate-rich motifs and suggested difference in the amino acids for substrate binding in membrane-bound prenyltransferases. Archives of Microbiology, 194:589–595, DOI: 10.1007/s00203-012-0795-0.
Abstract
124. Jia-Xiang Sun, Xiao-Ya Zhao, Xiao-Fang Fu, Heng-Yi Yu, Xue Li, Shu-Ming Li, Han-Li Ruan (2012) Three new naphthalenyl glycosides from the root bark of Juglans cathayensis. Chemical and Pharmaceutical Bulletin, 60: 785-789, DOI: 10.1248/cpb.60.785.
Abstract
123. Beate Wollinsky, Lena Ludwig, Alexandra Hamacher, Xia Yu, Matthias Kassack and Shu-Ming Li (2012) Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides. Bioorganic and Medicinal Chemistry Letters, 22: 3866–3869, DOI: 10.1016/j.bmcl.2012.04.119.
Abstract
122. Christiane Wallwey, Christoph Heddergott, Xiulan Xie, Axel A. Brakhage and Shu-Ming Li (2012) Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae. Microbiology, 158: 1634 - 1644, DOI: 10.1099/mic.0.056796-0.
Abstract
121. Marco Matuschek, Christiane Wallwey, Beate Wollinsky, Xiulan Xie and Shu-Ming Li (2012) In vitro conversion of chanoclavine-I aldehyde to the stereoisomers festuclavine and pyroclavine was controlled by the second reduction step. RSC Advances, 2: 3662-3669, DOI: 10.1039/C2RA20104F.
Abstract
120. Xia Yu, Yan Liu, Xiulan Xie, Xiao-Dong Zheng and Shu-Ming Li (2012) Biochemical characterization of indole prenyltransferases: Filling the last gap of prenylation positions by a 5-dimethylallyltryptophan synthase from Aspergillus clavatus. Journal of Biological Chemistry, 287: 1371-1380, DOI: 10.1074/jbc.M111.317982.
Abstract
119. Viola Wohlgemuth und Shu-Ming Li (2012) Monoklonale Antikörper, die magischen Kugeln Paul Ehrlichs. Apotheken Magazin, 30(3): 7-14 (review article).
Abstract
118. Wen-Bing Yin and Shu-Ming Li (2012) Stereospecific synthesis of aszonalenins by using two recombinant prenyltransferases. Practical Methods for Biocatalysis and Biotransformations (Eds. John Whittall and Peter Sutton) Volume 2, pp 254-258 (book capital).
117. Xia Yu and Shu-Ming Li (2012) Prenyltransferases of the dimethylallyltryptophan synthase superfamily. Methods in Enzymology, Vol 516 (Natural Product Biosynthesis by Microorganisms and Plants, Part B), Ed.: D. A. Hopwood, pp 259-278 (book capital).
116. Christiane Wallwey and Shu-Ming Li (2012). Production, detection and purification of clavine-type ergot alkaloids. Methods in Molecular Biology, Vol.944 (Fungal Secondary Metabolism: Methods and Protocols) Eds.: Nancy Keller and Geoffrey Turner, pp 121-131 (book capital).
115. Beate Wollinsky and Shu-Ming Li (2012). Detection and purification of non-ribosomal peptide synthetase products in Neosartorya fischeri. Methods in Molecular Biology, Vol. 944 (Fungal Secondary Metabolism: Methods and Protocols), Eds.: N. Keller and G. Turner, pp 111-119 (book capital).
2011
114. Xia Yu, Xiulan Xie and Shu-Ming Li (2011) Substrate promiscuity of secondary metabolite enzymes: Prenylation of hydroxynaphthalenes by fungal indole prenyltransferases. Applied Microbiology and Biotechnology, 92: 237-248, DOI: 10.1007/s00253-011-3351-y.
Abstract
113. Xia Yu and Shu-Ming Li (2011) Prenylation of flavonoids by using a dimethylallyltryptophan synthase 7-DMATS from Aspergillus fumigatus. ChemBioChem, 12: 2280-2283, DOI: 10.1002/cbic.201100413.
Abstract
112. Xiulan Xie, Christiane Wallwey, Marco Matuschek, Klaus Steinbach, Shu-Ming Li (2011) Formyl migration product of chanoclavine-I aldehyde in the presence of the old yellow enzyme FgaOx3 from Aspergillus fumigatus: a NMR structure elucidation. Magnetic Resonance in Chemistry, 49: 678-681, DOI: 10.1002/mrc.2796.
Abstract
111. Chuan-Ling Si, Shu-Ming Li, Zhong Liu, Jin-Kyu Kim and Young-Soo Bae (2011) Antioxidant phenolic glycosides from the bark of Populus ussuriensis Kom. Natural Product Research, 25: 1396-1401, DOI: 10.1080/14786410802267700.
Abstract
110. Edyta Stec, Dominik Pistorius, Rolf Müller and Shu-Ming Li (2011) AuaA, a membrane-bound farnesyltransferase from Stigmatella aurantiaca, catalyzes the prenylation of 2-methyl-4-hydroxyquinoline in the biosynthesis of aurachins. ChemBioChem, 11: 1724-1730, DOI: 10.1002/cbic.201100188.
Inside cover
Abstract
109. Eva Kranen, Nicola Steffan, Ruth Maas, Shu-Ming Li and Joachim Jose (2011) Development of a whole cell biocatalyst for the efficient prenylation of indole derivatives by Autodisplay of the aromatic prenyltransferase FgaPT2. ChemCatChem, 3, 1200-1207, DOI: 10.1002/cctc.201000429.
Abstract
108. Marco Matuschek, Christiane Wallwey, Xiulan Xie and Shu-Ming Li (2011) New insights into ergot alkaloid biosynthesis in Claviceps purpurea: An agroclavine synthase EasG catalyses, via a non-enzymatic adduct with reduced glutathione, the conversion of chanoclavine-I aldehyde to agroclavine. Organic and Biomolecular Chemistry, 9: 4328-4335, DOI: 10.1039/C0OB01215G.
Abstract
107. Fan-Yu Meng, Jia-Xiang Sun, Xue Li, Heng-Yi Yu, Shu-Ming Li and Han-Li Ruan (2011) Schiglautone A, a new tricyclic triterpenoid with a unique 6/7/9-fused skeleton from the stems of Schisandra glaucescens. Organic Letters, 13:1502–1505, DOI: 10.1021/ol200188n.
Abstract
106. Christiane Wallwey and Shu-Ming Li (2011) Ergot alkaloids: structure diversity, biosynthetic gene clusters and functional proof of biosynthetic genes. Natural product reports, 28: 496-510, DOI: 10.1039/C0NP00060D.
Abstract
105. Hui-Xi Zou, Xiulan Xie, Xiao-Dong Zheng and Shu-Ming Li (2011) The tyrosine O-prenyltransferase SirD catalyzes O-, N- and C prenylations. Applied Microbiology and Biotechnology, 89:1443-1451, DOI: 10.1007/s00253-010-2956-x.
Abstract
104. Shu-Ming Li (2011) Genome mining and biosynthesis of fumitremorgin-type alkaloids in ascomycetes. Journal of Antibiotics, 64:45-49 (review article), DOI: 10.1038/ja.2010.128.
Abstract
2010
103. Marco Jost, Georg Zocher, Sylwia Tarcz, Marco Matuschek, Xiulan Xie, Shu-Ming Li and Thilo Stehle (2010) Structure-function analysis of an enzymatic prenyl transfer reaction identifies a reaction chamber with modifiable specificity. Journal of the American Chemical Society, 132: 17849-17858, DOI: 10.1021/ja106817c.
Abstract
102. Christiane Wallwey, Marco Matuschek, Xiu-Lan Xie and Shu-Ming Li (2010) Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3. Organic and Biomolecular Chemistry, 8: 3500-3508, DOI: 10.1039/C003823G.
Abstract
101. Hui-Xi Zou, Xiu-Lan Xie, Uwe Linne, Xiao-Dong Zheng and Shu-Ming Li (2010) Simultaneous C7- and N1-prenylation of cyclo-L-Trp-L-Trp catalyzed by a prenyltransferase from Aspergillus oryzae. Organic and Biomolecular Chemistry, 8: 3037-3044, DOI: 10.1039/C002850A.
Abstract
100. Wen-Bing Yin, Xia Yu, Xiu-Lan Xie, and Shu-Ming Li (2010) Preparation of pyrrolo[2,3-b]indoles carrying a ß-configured reverse C3 dimethylallyl moiety by using a recombinant prenyltransferase CdpC3PT. Organic and Biomolecular Chemistry, 8, 2430-2438, DOI: 10.1039/C000587H.
Abstract
99. Anika Kremer and Shu-Ming Li (2010). A tyrosine O-prenyltransferase catalyses the first pathway-specific step in the biosynthesis of sirodesmin PL. Microbiology, 156: 278-286, DOI: 10.1099/mic.0.033886-0
Abstract
98. Christiane Wallwey, Marco Matuschek and Shu-Ming Li (2010) Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenaseFgaDH. Archives of Microbiology, 192: 127-134, DOI: 10.1007/s00203-009-0536-1.
Abstract
97. Wen-Bing Yin, Xiu-Lan Xie, Marco Matuschek and Shu-Ming Li (2010). Reconstruction of pyrrolo[2,3-b]indoles carrying an alpha-configured reverse C3-dimethylallyl moiety by using recombinant enzymes. Organic and Biomolecular Chemistry, 8: 1133-1141, DOI: 10.1039/B922440H.
Abstract
96. Shu-Ming Li (2010) Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis. Natural Product Reports, 27: 57-78 (Review article), DOI: 10.1039/B909987P.
Abstract
2009
95. Han-Li Ruan, Edyta Stec and Shu-Ming Li (2009). Production of diprenylated indole derivatives by tandem incubation of two recombinant dimethylallyltryptophan synthases. Archives of Microbiology, 191:791-795, DOI: 10.1007/s00203-009-0504-9.
Abstract
94. Chuan-Ling Si, Jin-Kyu Kim, Young-Soo Bae and Shu-Ming Li (2009). Phenolic compounds in the leaves of Populus ussuriensis and their anti-oxidantactivities. Planta Medica, 75: 1165-1167, DOI: 10.1055/s-0029-1185476.
Abstract
93. Nicola Steffan, Alexander Grundmann, Shamil Afiyatullov, Hanli Ruan and Shu-Ming Li (2009). FtmOx1, a non heme Fe(II) and alpha-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus. Organic and Biomolecular Chemistry, 7: 4082 – 4087, DOI: 10.1039/B908392H.
Abstract
92. Xiaoqing Liu, Lu Wang, Nicola Steffan, Wen-Bing Yin and Shu-Ming Li (2009). Ergot alkaloid biosynthesis in Aspergillus fumigatus: FgaAT catalyses theacetylation of fumigaclavine B. ChemBioChem, 10: 2325-2328, DOI: 10.1002/cbic.200900395.
Abstract
91. Ute Metzger, Christoph Schall, Georg Zocher, Inge Unsöld, Edyta Stec, Shu-Ming Li, Lutz Heide, Thilo Stehle (2009). The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria. Proceedings of the National Acaddemy of Sciences USA, 106: 14309-14314, DOI: 10.1073/pnas.0904897106.
Abstract
90. Lu Wang, Wen-Bing Yin, Shu-Ming Li and Xiao-Qing Liu (2009) Chemoenzymatic synthesis of prenylated indole alkaloids. Chinese Journal of Biochemistryand Molecular Biology, 25: 580-584.
Abstract
89. Wen-Bing Yin, Jun Cheng and Shu-Ming Li (2009). Stereospecific synthesis of aszonalenins by using two recombinant prenyltransferases. Organic and Biomolecular Chemistry, 7: 2202-2207, DOI: 10.1039/B902413A.
Abstract
88. Nicola Steffan and Shu-Ming Li (2009). Increasing structure diversity of prenylated diketopiperazine derivatives by using a 4-dimethylallyltryptophan synthase. Archives of Microbiology, 191: 461-466, DOI: 10.1007/s00203-009-0467-x.
Abstract
87. Shubha Maiya, Alexander Grundmann, Shu-Ming Li and Geoffrey Turner (2009). Improved tryprostatin B production by heterologous gene expression in Aspergillus nidulans. Fungal Genetics and Biology, 46: 436-440, DOI: 10.1016/j.fgb.2009.01.003.
Abstract
86. Huixi Zou, Xiaodong Zheng and Shu-Ming Li (2009). Substrate promiscuity of the cyclic dipeptide prenyltransferases from Aspergillus fumigatus. Journal of Natural Products, 72: 44-52, DOI: 10.1021/np800501m.
Abstract
85. Wen-Bing Yin, Alexander Grundmann, Jun Cheng and Shu-Ming Li (2009). Acetylaszonalenin biosynthesis in Neosartorya fischeri. Identification of the biosynthetic gene cluster by genomic mining and functional proof of the genes by biochemical investigation. Journal of Biological Chemistry, 284, 100-109, DOI: 10.1074/jbc.M807606200.
Abstract
84. Shu-Ming Li (2009). Evolution of aromatic prenyltransferases in the biosynthesis of indole derivatives. Phytochemistry, 70: 1746-1757 (Review article), DOI: 10.1016/j.phytochem.2009.03.019.
Abstract
83. Nicola Steffan and Shu-Ming Li (2009) Gewinnung biologisch aktiver Substanzen aus Mikroorganismen durch Genomforschung. Apotheken Magazin, 27(9): 8-13 (Review article).
Abstract
82. Shu-Ming Li (2009). Applications of dimethylallyltryptophan synthases and other indole prenyltransferases for structural modification of natural products. Applied Microbiology and Biotechnology, 84: 631-639 (Review article), DOI:10.1007/s00253-009-2128-z.
Abstract
81. Nicola Steffan, Alexander Grundmann, Wenbing Yin, Anika Kremer and Shu-Ming Li (2009). Indole prenyltransferases from Aspergillus, a new enzyme group with high potential for the production of prenylated indole derivatives. Current Medicinal Chemistry, 16: 218-231 (Review article), DOI : 10.2174/092986709787002772.
Abstract
2008
80. Ole Rigbers and Shu-Ming Li (2008) Ergot alkaloid biosynthesis in Aspergillus fumigatus: overproduction and biochemical characterisation of a 4-dimethylallyltryptophan N-methyltransferase. Journal of Biological Chemistry, 283: 26859-26868, DOI: 10.1074/jbc.M804979200 (PHOENIX Pharmaceutics Science Award 2009).
Abstract
79. Alexander Grundmann, Tatyana Kuznetsova, Shamil Sh. Afiyatullov and Shu-Ming Li (2008) FtmPT2, an N-prenyltransferase from Aspergillus fumigatus, catalyses the last step in the biosynthesis of fumitremorgin B. ChemBioChem, 9: 2059-2063, DOI: 10.1002/cbic.200800240.
Abstract
78. Edyta Stec, Nicola Steffan, Anika Kremer, Huixi Zou, Xiaodong Zheng and Shu-Ming Li (2008) Two lysine residues are responsible for the enzymatic activities of indole prenyltransferases from fungi. ChemBioChem, 9: 2055-2058, DOI: 10.1002/cbic.200800237.
Abstract
77. Anika Kremer and Shu-Ming Li (2008). Tryptophan aminopeptidase activity of the indole prenyltransferases from Aspergillus fumigatus. Chemistry and Biology, 15: 729-738, DOI: 10.1016/j.chembiol.2008.05.019.
Abstract
76. Anika Kremer and Shu-Ming Li (2008). Potential of a 7-dimethylallyltryptophan synthase as a tool for production of prenylated indole derivatives. Applied Microbiology and Biotechnology, 79: 951-961, DOI: 10.1007/s00253-008-1505-3.
Abstract
75. Anne Markert, Nicola Steffan, Kerstin Ploss, Sabine Hellwig, Ulrike Steiner, Christel Drewke, Shu-Ming Li, Wilhelm Boland, and Eckhard Leistner (2008). Biosynthesis and accumulation of ergoline alkaloids in a mutualistic association between Ipomoea asarifolia (Convolvulaceae) and a Clavicipitalean fungus. Plant Physiology, 147: 296-305, DOI: 10.1104/pp.108.116699.
Abstract
74. Han-Li Ruan, Wen-Bing Yin, Ji-Zhou Wu and Shu-Ming Li (2008). Reinvestigation on a cyclic dipeptide N-prenyltransferase reveals rearrangement of N1-prenylated indole derivatives. ChemBioChem, 9: 1044-1047, DOI: 10.1002/cbic.200700723.
Abstract
73. L. Heide, B. Gust, C. Anderle and S.-M. Li (2008). Combinatorial biosynthesis, metabolic engineering and mutasynthesis for the generation of new aminocoumarin antibiotics. Current Topics in Medicinal Chemistry, 8: 667-679 (Review article), DOI: 10.2174/156802608784221505.
Abstract
2007
72. Christine Anderle, Shu-Ming Li, Bernd Kammerer, Bertolt Gust and Lutz Heide (2007). New aminocoumarin antibiotics derived from 4-hydroxycinnamic acid are formed after heterologous expression of a modified clorobiocin biosynthetic gene cluster. Journal of Antibiotics, 60: 504 - 10, DOI: 10.1038/ja.2007.64.
Abstract
71. Christine Anderle, Susanne Hennig, Bernd Kammerer, Shu-Ming Li, Ludger Wessjohann, Bertolt Gust and Lutz Heide (2007). Improved mutasynthetic approaches for the production of modified aminocoumarin antibiotics. Chemistry and Biology, 14: 955-967, DOI: 10.1016/j.chembiol.2007.07.014.
Abstract
70. Shubha Maiya, Alexander Grundmann, Xiang Li, Shu-Ming Li and Geoffrey Turner (2007). Identification of a hybrid PKS/NRPS required for pseurotin A biosynthesis in the human pathogen, Aspergillus fumigatus. ChemBioChem, 8: 1736-1743, DOI: 10.1002/cbic.200700202.
Abstract
69. Anika Kremer, Lucia Westrich and Shu-Ming Li (2007). A 7-dimethylallyltryptophan synthase from Aspergillus fumigatus. Overproduction, purification and biochemical characterization. Microbiology, 153: 3409-3416, DOI:10.1099/mic.0.2007/009019-0.
Abstract
68. Nicola Steffan, Inge A. Unsöld and Shu-Ming Li (2007). Chemoenzymatic synthesis of indole derivatives using a dimethylallyltryptophan synthases from Aspergillus fumigatus. ChemBioChem, 8: 1298-1307, DOI: 10.1002/cbic.200700107.
Abstract
67. Wen-Bing Yin, Han-Li Ruan, Lucia Westrich, Alexander Grundmann and Shu-Ming Li (2007). CdpNPT, an N-prenyltransferase from Aspergillus fumigatus: Overproduction, purification and biochemical characterization. ChemBioChem, 8: 1154-1161, DOI: 10.1002/cbic.200700079.
Abstract
2006
66. Anja Freitag , Carmen Méndez, José A. Salas, Bernd Kammerer, Shu-Ming Li and Lutz Heide (2006). Metabolic engineering of the heterologous production of clorobiocin derivatives and elloramycin in Streptomyces coelicolor M512. Metabolic Engineering, 8:653-661, DOI: 10.1016/j.ymben.2006.07.003.
Abstract
65. Anja Freitag, Shu-Ming Li and Lutz Heide (2006). Biosynthesis of the unusual 5,5-gem-dimethyl-deoxysugar noviose: investigation of the C-methyltransferase gene cloU. Microbiology, 152:2433-2442, DOI: 10.1099/mic.0.28931-0.
Abstract
64. Shubha Maiya, Alexander Grundmann, Shu-Ming Li and Geoffrey Turner (2006). The fumitremorgin gene cluster of Aspergillus fumigatus: Identification of a gene encoding brevianamide F synthetase. ChemBioChem, 7: 1062-1069, DOI: 10.1002/cbic.200600003.
Abstract
63. Ruth H. Flatman, Alessandra Eustaquio, Shu-Ming Li, Lutz Heide and Anthony Maxwell (2006). Structure-activity relationships of aminocoumarin-type gyrase and topoisomerase IV inhibitors obtained by combinatorial biosynthesis. Antimicrobial Agents and Chemotherapy, 50:1136-1142, DOI: 10.1128/AAC.50.4.1136-1142.2006.
Abstract
62. Inge A. Unsöld and Shu-Ming Li (2006). Reverse prenyltransferase in the biosynthesis of fumigaclavine C in Aspergillus fumigatus. gene expression, purification and characterization of fumigaclavine C synthase FgaPT1. ChemBioChem, 7:158-164, DOI: 10.1002/cbic.200500318.
Abstract
61. Shu-Ming Li and Inge A. Unsöld (2006). Post genome research in the biosynthesis of ergot alkaloids. Planta Medica, 72:1117-1120 (Review article), DOI:10.1055/s-2006-947195.
Abstract
60. Shu-Ming Li and Lutz Heide (2006). The biosynthetic gene clusters of aminocoumarin antibiotics. Planta Medica, 72:1093-1099 (Review article), DOI:10.1055/s-2006-946699.
Abstract
2005
59. Anja Freitag, Emmanuel Wemakor, Shu-Ming Li and Lutz Heide (2005) Acyl transfer in clorobiocin biosynthesis: Involvement of several proteins in the transfer of the pyrrole-2-carboxyl moiety to the deoxysugar. ChemBioChem, 6: 2316-2325, DOI: 10.1002/cbic.200500252
Abstract
58. Alexander Grundmann and Shu-Ming Li (2005). Overproduction, purification and characterization of FtmPT1, a brevianamide F prenyltransferase from Aspergillus fumigatus. Microbiology, 151: 2199-2207, DOI:10.1099/mic.0.27962-0.
Abstract
57. Anja Freitag, Heike Rapp, Lutz Heide and Shu-Ming Li (2005). Metabolic engineering of aminocoumarins: Inactivation of the methyltransferase gene cloP and generation of new clorobiocin derivatives in a heterologous host. ChemBioChem, 6: 1411-1418, DOI: 10.1002/cbic.200500019.
Abstract
56. Inge A. Unsöld und Shu-Ming Li (2005). Overproduction, purification and characterization of FgaPT2, a dimethylallyltryptophan synthase from Aspergillus fumigatus. Microbiology, 151: 1499-1505, DOI:10.1099/mic.0.27759-0
Abstract
55. Thomas Luft, Shu-Ming Li, Holger Scheible, Bernd Kammerer, Lutz Heide (2005). Overexpression, purification and characterization of SimL, an amide synthetase involved in simocyclinone biosynthesis. Archives of Microbiology, 183:277-285, DOI: 10.1007/s00203-005-0770-0.
Abstract
54. Alessandra S. Eustáquio, Shu-Ming Li and Lutz Heide (2005). NovG, a DNA-binding protein acting as a positive regulator of novobiocin biosynthesis. Microbiology, 151:1949-1961, DOI:
10.1099/mic.0.27669-0.
Abstract
53. Alessandra S. Eustáquio, Bertolt Gust, Ute Galm, Shu-Ming Li, Keith F. Chater and Lutz Heide (2005). Heterologous expression of biosynthetic gene clusters. Applied and Environmental Microbiology, 71: 2452-2459.
Abstract
52. Shu-Ming Li and Lutz Heide (2005). New aminocoumarin antibiotics from genetically engineered Streptomyces strains. Current Medicinal Chemistry, 12 (3): 763-771 (review article).
Abstract
2004
51. Hui Xu, Lutz Heide and Shu-Ming Li (2004). New aminocoumarin antibiotics formed by a combined mutational and chemoenzymatic approach, utilizing the carbamoyltransferase NovN. Chemistry and Biology, 11: 655-662, DOI: 10.1016/j.chembiol.2004.02.028.
Abstract
50. Elisabeth Schmutz, Susanne Hennig, Shu-Ming Li and Lutz Heide (2004). Identification of a topoisomerase IV in actinobacteria: Purification and characterization of ParYR and GyrBR from the coumermycin A1 producer Streptomyces rishiriensis DSM 40489. Microbiology, 150: 641-647, DOI: 10.1099/mic.0.26867-0.
Abstract
49. Alessandra S. Eustáquio, Bertolt Gust, Shu-Ming Li, Stefan Pelzer, Wolfgang Wohlleben, Keith F. Chater, and Lutz Heide (2004). Production of 8´-halogenated and 8´-unsubstituted novobiocin derivatives in genetically engineered Streptomyces coelicolor strains. Chemistry and Biology, 11: 1561-1572, DOI: 10.1016/j.chembiol.2004.09.009.
Abstract
48. Bernd Kammerer, Rainer Kahlich, Stefan Laufer, Shu-Ming Li, Lutz Heide and Christoph H. Gleiter (2004). Mass spectrometric pathway monitoring of secondary metabolites: Systematic analysis of culture extracts of Streptomyces species. Analytical Biochemistry, 335: 17-29, DOI: 10.1016/j.ab.2004.08.018.
Abstract
47. Ute Galm, Stefanie Heller, Stuart Shapiro, Malcolm Page, Shu-Ming Li and Lutz Heide (2004). Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis. Antimicrobial Agents and Chemotherapy, 48: 1307-1312, DOI: 10.1128/AAC.48.4.1307-1312.2004.
Abstract
46. Anja Freitag, Ute Galm, Shu-Ming Li and Lutz Heide (2004). New aminocoumarin antibiotics from a cloQ-defective mutant of the clorobiocin producer Streptomyces roseochromogenes DS12.976. Journal of Antibiotics, 57: 205-209, DOI: 10.7164/antibiotics.57.205.
Abstract
45. Karin Räth, Katja Taxis, Gitta Walz, Christoph H. Gleiter, Shu-Ming Li and Lutz Heide (2004). Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (Annual Wormwood). American Journal of Tropical Medicine & Hygiene, 70: 128-132, DOI: 10.4269/ajtmh.2004.70.128.
Abstract
44. Shu-Ming Li (2004). Abenteuer Genomsequenz und Naturstoffforschung. Pharmazeutische Zeitung, 149 (43): 3760-3766 (review article).
Abstract
43. Shu-Ming Li and Lutz Heide (2004). Functional analysis of biosynthetic genes of aminocoumarins and production of hybrid antibiotics. Current Medicinal Chemistry Anti-infective Agents, 3 (4): 279-295 (review article), DOI: 10.2174/1568012043353801.
Abstract
42. Shu-Ming Li (2004). Molekulares Farming: Produktion rekombinanter Proteine in Pflanzen. Deutsche Apotheker Zeitung, 144 (26): 2969-2973 (review article).
Abstract
2003
41. Elisabeth Schmutz, Marion Steffensky, Jürgen Schmidt, Andera Porzel, Shu-Ming Li and Lutz Heide (2003). An unusual amide synthetase (CouL) from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis DSM 40489. European Journal of Biochemistry, 270: 4413-4419, DOI: 10.1046/j.1432-1033.2003.03830.x.
Abstract
40. Lucia Westrich, Lutz Heide and Shu-Ming Li (2003). CloN6, a novel methyltransferase catalysing the methylation of the pyrrole-2-carboxyl moiety of clorobiocin. ChemBioChem, 4: 268-773, DOI:10.1002/cbic.200300609.
Abstract
39. Hui Xu, Rainer Kahlich, Bernd Kammerer, Lutz Heide and Shu-Ming Li (2003). CloN2, a novel acyltransferase involved in the attachment of the pyrrole-2-carboxyl moiety to the deoxysugar of clorobiocin. Microbiology, 149: 2183-2191, DOI 10.1099/mic.0.26314-0.
Abstract
38. Florence Pojer, Rainer Kahlich, Bernd Kammerer, Shu-Ming Li and Lutz Heide (2003). CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis. Journal of Biological Chemistry, 278: 30661-30668, DOI: 10.1074/jbc.M303190200.
Abstract
37. Alessandra S. Eustáquio, Thomas Luft, Zhao-Xin Wang, Bertolt Gust, Keith F. Chater, Shu-Ming Li and Lutz Heide (2003). Novobiocin biosynthesis: Inactivation of the putative regulatory gene novE and heterologous expression of genes involved in aminocoumarin ring formation. Archives of Microbiology, 180: 25-32, DOI: 10.1007/s00203-003-0555-2.
Abstract
36. Alessandra S. Eustáquio, Bertolt Gust, Thomas Luft, Shu-Ming Li, Keith F. Chater, and Lutz Heide (2003). Clorobiocin biosynthesis in Streptomyces. Identification of the halogenase and generation of structural analogs. Chemistry and Biology, 10: 279-288, DOI: 10.1016/S1074-5521(03)00051-6.
Abstract
35. Florence Pojer, Emmanuel Wemakor, Bernd Kammerer, Huawei Chen, Christopher T. Walsh, Shu-Ming Li and Lutz Heide (2003). CloQ, a novel prenyltransferase involved in clorobiocin biosynthesis. Proc. Natl. Acad. Sci. USA, 100: 2316-2321, DOI: 10.1073/pnas.0337708100 (PHOENIX Pharmaceutics Science Award 2004).
Abstract
34. Elisabeth Schmutz, Agnes Mühlenweg, Shu-Ming Li and Lutz Heide (2003). Resistance genes of aminocoumarin producers: Two type II topoisomerase genes confer resistance against coumermycin A1 and clorobiocin. Antimicrobial Agents and Chemotherapy, 47: 869-877, DOI: 10.1128/AAC.47.3.869-877.2003.
Abstract
33. Annegret Köhle, Susanne Sommer, Shu-Ming Li, Lieselotte Schilde-Rentschler, Helga Ninnemann and Lutz Heide (2003). Secondary metabolites in transgenic tobacco and potato: High accumulation of 4-hydroxybenzoic acid glucosides results from high expression of the bacterial gene ubiC. Molecular Breeding, 11: 15-24, DOI: 10.1023/A:1022211521390.
Abstract
2002
32. Florence Pojer, Shu-Ming Li and Lutz Heide (2002). Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: New insights into the biosynthesis of aminocoumarin antibiotics. Microbiology, 148: 3901-3911, DOI:10.1099/00221287-148-12-3901.
Abstract
31. H. Xu, Z.-X.Wang, J. Schmidt, L. Heide and S.-M. Li (2002). Genetic analysis of the biosynthesis of the pyrrole and carbamoyl moieties of coumermycin A1 and novobiocin. Molecular Genetics and Genomics, 268: 387-396, DOI: 10.1007/s00438-002-0759-1.
Abstract
30. Shu-Ming Li, Lucia Westrich, Jürgen Schmidt, Christine Kuhnt and Lutz Heide (2002). Methyltransferase genes in Streptomyces rishiriensis: New coumermycin derivatives from gene-inactivation experiments. Microbiology, 148: 3317-3326, DOI: 10.1099/00221287-148-10-3317.
Abstract
29. Annegret Köhle, Susanne Sommer, Kazufumi Yazaki, Albert Ferrer, Albert Boronat, Shu-Ming Li and Lutz Heide (2002). High level expression of chorismate pyruvate-lyase (UbiC) and HMG-CoA reductase in hairy root cultures of Lithospermum erythrorhizon. Plant and Cell Physiology, 43: 894-902, DOI: 10.1093/pcp/pcf106.
Abstract
28. Ute Galm, Judith Schimana, Hans-Peter Fiedler, Jürgen Schmidt, Shu-Ming Li, and Lutz Heide (2002). Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tü 6040. Archives of Microbiology, 178: 102-114, DOI: 10.1007/s00203-002-0429-z.
Abstract
27. Lutz Heide and Shu-Ming Li (2002). Aminocoumarin antibiotics. Microbial Secondary Metabolites: Biosynthesis, Genetics and Regulation (Eds: J.F. Martin and F. Fierro), pp 63-83 (book article).
2001
26. Shu-Ming Li, Emmanuel Wemakor and Lutz Heide (2001). PCR amplification of 1-deoxy-D-xylulose 5-phosphate synthase (dxs) genes from different Streptomyces species: Evidence for the existence of two dxs gene families. Molecular Biology Today, 2: 61-66.
2000
25. Robert Boehm, Susanne Sommer, Klaus Severin, Shu-Ming Li and Lutz Heide (2000). Active expression of the ubiA gene from E. coli in tobacco: Influence of plant ER-specific signal peptides on the expression of a membrane-bound prenyltransferase in plant cells. Transgenic Research, 9: 477-486, DOI: 10.1023/A:1026507803067.
Abstract
24. Zhao-Xin Wang, Shu-Ming Li and Lutz Heide (2000). Identification of the coumermycin A1 biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489. Antimicrobial Agents and Chemotherapy, 44: 3040-3048, DOI: 10.1128/AAC.44.11.3040-3048.2000.
Abstract
23. Robert Boehm, Susanne Sommer, Shu-Ming Li, Lutz Heide (2000). Genetic engineering on shikonin biosynthesis: Expression of the bacterial ubiA gene in Lithospermum erythrorhizon. Plant and Cell Physiology, 41: 911-919, DOI: 10.1093/pcp/pcd013.
Abstract
22. Marion Steffensky, Shu-Ming Li and Lutz Heide (2000). Cloning, overexpression, and purification of novobiocic acid synthetase from Streptomyces spheroides NCIMB 11891. Journal of Biological Chemistry, 275: 21754-21760, DOI: 10.1074/jbc.M003066200.
Abstract
21. Marion Steffensky, Agnes Mühlenweg, Zhao-Xin Wang, Shu-Ming Li and Lutz Heide (2000). Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891. Antimicrobial Agents and Chemotherapy, 44: 1214-1222, DOI: 10.1128/AAC.44.5.1214-1222.2000.
Abstract
20. Hirobumi Yamamoto, Kenichiro Inoue, Shu-Ming Li and Lutz Heide (2000). Geranylhydroquinone 3”-hydroxylase, a cytochrome P-450 monooxygenase from Lithospermum erythrorhizon cell suspension cultures. Planta, 210: 312-317, DOI: 10.1007/PL00008139.
Abstract
1998
19. Shu-Ming Li, Andreas Bechthold and Lutz Heide (1998). Putative retrotransposon polyprotein. Plant Molecular Biology, 38: 505.
18. Agnes Mühlenweg, Martin Melzer, Shu-Ming Li and Lutz Heide (1998). 4-Hydroxybenzoate 3-geranyltransferase from Lithospermum erythrorhizon. Purification of a plant membrane-bound prenyltransferase. Planta, 205: 407-413, DOI: 10.1007/s004250050337.
Abstract
17. Shu-Ming Li, Susanne Hennig and Lutz Heide (1998) Shikonin: A geranyl diphosphate-derived plant hemiterpenoid formed via the mevalonate pathway. Tetrahedron Letters, 39: 2121-2124.
Abstract
16. Shu-Ming Li, Susanne Hennig and Lutz Heide (1998) Biosynthesis of the dimethylallyl moiety of novobiocin via a non-mevalonate pathway. Tetrahedron Letters, 39: 2717-2720, DOI: 10.1016/S0040-4039(98)00386-4
Abstract
15. Marion Steffensky, Shu-Ming Li, Bernhard Vogler and Lutz Heide (1998). Novobiocin biosynthesis in Streptomyces spheroides. Identification of a dimethylallyl diphosphate: 4-hydroxyphenylpyruvate dimethylallyl transferase. FEMS Microbiology Letters, 161: 69-74, DOI: 10.1111/j.1574-6968.1998.tb12930.x
Abstract
1997
14. Zhao-Xin Wang, Shu-Ming Li, Ralf Löscher and Lutz Heide (1997). 4-Coumaroyl coenzyme A 3-hydroxylase activity from cell cultures of Lithospermum erythrorhizon and its relationship to polyphenol oxidase. Archives of Biochemistry and Biophysics, 347: 249-255, DOI: 10.1006/abbi.1997.0337
Abstract
13. Shu-Ming Li, Zhao-Xin Wang and Lutz Heide (1997). Purification of UDP-glucose: 4-hydroxybenzoate glucosyltransferase from cell cultures of Lithospermum erythrorhizon. Phytochemistry, 46: 27-32, DOI: 10.1016/S0031-9422(97)00212-4
Abstract
12. Shu-Ming Li, Zhao-Xin Wang, Emmanuel Wemakor and Lutz Heide (1997). Metabolization of the artificial secondary metabolite 4-hydroxybenzoate in ubiC-transformed tobacco. Plant and Cell Physiology, 38: 844-850, DOI: 10.1093/oxfordjournals.pcp.a029243
Abstract
11. Robert Boehm, Shu-Ming Li, Martin Melzer and Lutz Heide (1997). 4-Hydroxybenzoate prenyltransferases in cell-free extracts of Lithospermum erythrorhizon cell cultures. Phytochemistry, 44: 419-424, DOI: 10.1016/S0031-9422(96)00458-X
Abstract
1996
10. Marion Siebert, Susanne Sommer, Shu-Ming Li, Zhao-Xin Wang, Klaus Severin and Lutz Heide (1996). Genetic engineering of plant secondary metabolism: Accumulation of 4-hydroxybenzoate glucosides as a result of the expression of the bacterial ubiC gene in tobacco. Plant Physiology, 112: 811-819 (PHOENIX Pharmaceutics Science Award 1997).
Abstract
9. Shu-Ming Li, Zhao-Xin Wang and Lutz Heide (1996). Purification and characterization of an alcohol dehydrogenase from Lithosperrmum erythrohrizon cell cultures. Plant Cell Reports, 15: 786-790.
Abstract
1991
8. S.-M. Li and K-W. Glombitza (1991). Phlorotannins from the brown alga Landsburgia quercifolia (Hook. fil. et Harv.) Harv. Botanica Marina, 34: 455-457, DOI: 10.1515/botm.1991.34.5.455.
Abstract
7. Karl-Werner Glombitza and Shu-Ming Li (1991). Fucophlorethols from the brown alga Carpophyllum maschalocarpum. Phytochemistry, 30: 3423-3427, DOI: 10.1016/0031-9422(91)83221-6.
Abstract
6. Shu-Ming Li and Karl-Werner Glombitza (1991). Carmalols and phlorethofuhalols from the brown alga Carpophyllum maschalocarpum. Phytochemistry, 30: 3417-3421, DOI: 10.1016/0031-9422(91)83220-F.
Abstract
5. Karl-Werner Glombitza and Shu-Ming Li (1991). Hydroxyphlorethols from the brown alga Carpophyllum maschalocarpum. Phytochemistry, 30: 2741-2745, DOI: 10.1016/0031-9422(91)85135-M.
Abstract
1987
4. Chang-Ling Li, Jian Ma, Yin-Ye Wang, Gui-Qiu Han and Shu-Ming Li (1987). Preliminary investigation of activity of the ethanolic extract from Piper hancei against platelet-activating factor. Physiological Sciences, 7: 316-317.
3. Shu-Ming Li and Gui-Qiu Han (1987). Studies on the chemical constituents of Piper hancei Maxim (III). Acta Botanica Sinica, 29: 293-296.
Abstract
2. Shu-Ming Li, Gui-Qiu Han, B.H. Arison and M.N. Chang (1987). Studies on chemical constituents of Piper hancei Maxim (II). Acta Pharmaceutica Sinica, 22: 196-202.
Abstract
1986
1. Gui-Qiu Han, Shu-Ming Li, Chang-Ling Li, J.P. Springer, S.B. Hwang and M.N. Chang (1986). Neolignans from Piper hancei Maxim. Acta Pharmaceutica Sinica, 21: 361-365.
Abstract