Hauptinhalt

Publications:

Hermes J, Borisova V, Kockskämper J. (2023)
Store-operated calcium entry increases nuclear calcium in adult rat atrial and ventricular cardiomyocytes.
Cells 12(23):2690 
doi: 10.3390/cells12232690

Fender H, Walter K, Kiper AK, Plackic J, Kisko TM, Braun MD, Schwarting RKW, Rohrbach S, Wöhr M, Decher N, Kockskämper J. (2023)
Calcium handling remodelling underlies impaired sympathetic stress response in ventricular myocardium from Cacna1c haploinsufficient rats.
Int J Mol Sci. 24(12):9795
doi: 10.3390/ijms24129795

Kockskämper J, Pluteanu F. (2022)
Left atrial myocardium in arterial hypertension.
Cells 11(19):3157
doi: 10.3390/cells11193157

Bukowska A, Nikonova Y, Wolke C, Lendeckel U, Kockskämper J, Goette A (2022)
Anti-inflammatory effects of endothelin receptor blockade in left atrial tissue of spontaneously hypertensive rats.
Int J Cardiol Heart Vasc. 42:101088
doi: 10.1016/j.ijcha.2022.101088

Euler G, Kockskämper J, Schulz R, Parahuleva MS (2021)
JDP2, a novel molecular key in heart failure and atrial fibrillation?
Int J Mol. 22(8):4110
doi: 10.3390/ijms22084110

Niemann B, Li L, Simm A, Molenda N, Kockskämper J, Boening A, Rohrbach S (2021)
Caloric restriction reduces sympathetic activity similar to beta-blockers but conveys additional mitochondrio-protective effects in aged myocardium.
Sci Rep. 11(1):1931
doi: 10.1038/s41598-021-81438-7

Parahuleva MS, Kockskämper J, Heger J, Grimm W, Scherer A, Bühler S, Kreutz J, Schulz R, Euler G. (2020)
Structural, pro-inflammatory and calcium handling remodeling underlies spontaneous onset of paroxysmal atrial fibrillation in JDP2-overexpressing mice
Int J Mol Sci. 21(23):9095
doi: 10.3390/ijms21239095

Kiess TO, Kockskämper J (2019)
SERCA activity controls the systolic calcium increase in the nucleus of cardiac myocytes.
Front Physiol. 10:56
doi: 10.3389/fphys.2019.00056

Thomas D, Christ T, Fabritz L, Goette A, Hammwöhner M, Heijman J, Kockskämper J, Linz D, Odening KE, Schweizer PA, Wakili R, Voigt N (2019)
German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper: impact of molecular mechanisms on clinical arrhythmia management.
Clin Res Cardiol. 108:577-599
doi: 10.1007/s00392-018-1377-1

Olivares-Florez S, Czolbe M, Riediger F, Seidlmayer L, Williams T, Nordbeck P, Strasen J, Glocker C, Jänsch M, Eder-Negrin P, Arias-Loza P, Mühlfelder M, Plackic J, Heinze KG, Molkentin JD, Engelhardt S, Kockskämper J, Ritter O (2018)
Nuclear calcineurin is a sensor for detecting Ca2+ release from the nuclear envelope via IP3R.
J Mol Med. 96(11):1239-1249
doi: 10.1007/s00109-018-1701-2

Plackic J, Kockskämper J (2018)
Isolation of atrial and ventricular cardiomyocytes for in vitro studies.
Methods Mol Biol. 1816:39-54
doi: 10.1007/978-1-4939-8597-5_3

Pluteanu F, Nikonova Y, Holzapfel A, Herzog B, Scherer A, Preisenberger J, Plackic J, Scheer K, Ivanova T, Bukowska A, Goette A, Kockskämper J (2018)
Progressive impairment of atrial myocyte function during left ventricular hypertrophy and heart failure.
J Mol Cell Cardiol. 114:253-263
doi: 10.1016/j.yjmcc.2017.11.020

Decher N, Ortiz-Bonnin B, Friedrich C, Schewe M, Kiper AK, Rinné S, Seemann G, Peyronnet R, Zumhagen S, Bustos D, Kockskämper J, Kohl P, Just S, González W, Baukrowitz T, Stallmeyer B, Schulze-Bahr E (2017)
Sodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia.
EMBO Mol Med. 9:403-414
doi: 10.15252.emmm.201606690

Plackic J, Preissl S, Nikonova Y, Pluteanu F, Hein L, Kockskämper J (2016)
Enhanced nucleoplasmic Ca2+ signaling in ventricular myocytes from young hypertensive rats.
J Mol Cell Cardiol. 101:58-68
doi: 10.1016/j.yjmcc.2016.11.001

Mederle K, Gess B, Pluteanu F, Plackic J, Tiefenbach KJ, Grill A, Kockskämper J, Castrop H (2016)
The angiotensin receptor-associated protein Atrap is a simulator of the cardiac Ca2+-ATPase SERCA2a.
Cardiovasc Res. 110(3):359-370
doi: 10.1093/cvr/cvw064

Schipke J, Grimm C, Arnstein G, Kockskämper J, Sedej S, Mühlfeld C (2016)
Cardiomyocyte loss is not required for the progression of left ventricular hypertrophy induced by pressure overload in female mice.
J Anat. 229(1):75-81
doi: 10.1111/joa.12463

Schotten U, Hatem S, Ravens U, Jais P, Müller FU, Goette A, Rohr S, Antoons G, Pieske B, Scherr D, Oto A, Casadei B, Verheule S, Cartlidge D, Steinmeyer K, Götsche T, Dobrev D, Kockskämper J, Lendeckel U, Fabritz L, Kirchhof P, Camm AJ. EUTRAF Investigators (2015)
The European Network for Translational Research in Atrial Fibrillation (EUTRAF): Objectives and initial results.
Europace 17(10):1457-1466
doi: 10.1093/europace/euv252

Pluteanu F, Heß J, Plackic J, Nikonova Y, Preisenberger J, Buckowska A, Schotten U, Rinne A, Kienitz MC, Schäfer MK, Weihe E, Goette A, Kockskämper J (2015)
Early subcellular Ca2+ remodelling and increased propensity for Ca2+ alternans in left atrial myocytes from hypertensive rats.
Cardiovasc Res. 106(1):87-97
doi: 10.1093/cvr/cvv045

Walther S, Pluteanu F, Renz S, Nikonova J, Maxwell JT, Yang LZ, Schmidt K, Edwards JN, Wakula P, Groschner K, Maier LS, Spiess J, Blatter LA, Pieske B, Kockskämper J (2014)
Urocortin 2 stimulates nitric oxide production in ventricular myocytes via Akt- and PKA-mediated phosphorlyation of eNOS at serine 1177.
Am J Physiol Heart Circ Physiol. 307(5):H689-700
doi: 10.1152/ajpheart.00694.2013

Ljubojevic S, Radulovic S, Leitinger G, Sedej S, Sacherer M, Holzer M, Winkler C, Pritz E, Mittler T, Schmidt A, Sereinigg M, Wakula P, Zissimopoulos S, Bisping E, Post H, Marsche G, Bossuyt J, Bers DM, Kockskämper J, Pieske B (2014)
Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure.
Circulation 130(3):244-255
doi: 10.1161/CIRCULATIONAHA.114.008927

Sedej S, Schmidt A, Denegri M, Walther S, Matovina M, Arnstein G, Gutschi EM, Windhager I, Ljubojevic S, Negri S, Heinzel FR, Bisping E, Vos MA, Napolitano C, Priori SG, Kockskämper J, Pieske B (2014)
Subclinical abnormalities in sarcoplasmic reticulum Ca2+ release promote eccentric myocardial remodeling and pump failure death in response to pressure overload.
J Am Coll Cardiol. 63(15):1569-1579
doi: 10.1016/j.jacc.2013.11.010

Kockskämper A, von Lewinski D, Zhu D, Kockskämper J, Khafaga M, Schmidt AG, Post H, Pieske B (2013)
Relevance of stretch-induced phosphorylation of MAPK and p90rsk in human myocardium.
Front Biosci. (Elite Ed.) 5:883-892
doi: 10.2741/e667

Sacherer M, Sedej S, Wakula P, Wallner M, Vos MA, Kockskämper J, Stiegler P, Sereinigg M, von Lewinski D, Antoons G, Pieske BM, Heinzel FR - CONTICA investigators (2012)
JTV519 (K201) reduces sarcoplasmic reticulum Ca2+ leak and improves diastolic function in vitro in murine and human non-failing myocardium.
Br J Pharmacol. 167(3):493-504
doi: 10.1111/j.1476-5381.2012.01995.x

Ljubojevic S, Walther S, Asgarzoei M, Sedej S, Pieske B, Kockskämper J (2011)
In situ calibration of nucleoplasmic versus cytoplasmic Ca2+ concentration in adult cardiomyocytes.
Biophys J 100(10):2356-2366. Erratum in: Biophys J 100(12):3055
doi: 10.1016/j.bpj.2011.03.060

Dybkova N, Sedej S, Napolitano C, Neef S, Rokita AG, Hünlich M, Heller Brown J, Kockskämper J, Priori SG, Pieske B, Maier LS (2011)
Overexpression of CaMKIIδc in RyR2R4496C knock-in mice leads to altered intracellular Ca2+-handling and increased mortality.
J Am Coll Cardiol. 57:469-479
doi: 10.1016/j.jacc.2010.08.639

Yang L-Z, Kockskämper J, Khan S, Suarez J, Walther S, Doleschal B, Unterer G, Khafaga M, Mächler M, Heinzel FR, Dillmann WH, Pieske B, Spiess J (2011)
Inotropic, lusitropic, and arrhythmogenic effects of urocortin 2 in mouse ventricular myocytes are mediated by cAMP- and Ca2+/calmodulin-dependent protein kinases.
Brit J Pharmacol. 162:544-556
doi: 10.1111/j.1476-5381.2010.01067.x

Wakula P, Bisping E, Kockskämper J, Post H, Brauer S, Deuter M, Oehlmann R, Besenfelder U, Lai FA, Brem G, Pieske B (2011)
CMV promoter is inadequate for expression of mutant human RyR2 in transgenic rabbits.
J Pharmacol Toxicol Meth. 63:180-185
doi: 10.1016/j.vascn.2010.09.007

Sedej S, Heinzel FR, Walther S, Dybkova N, Wakula P, Groborz J, Gronau P, Maier LS, Vos MA, Lai FA, Napolitano C, Priori SG, Kockskämper J, Pieske B (2010)
Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.
Cardiovasc Res. 87:50-59
doi: 10.1093/cvr/cvq007

Yang L-Z, Tovote P, Rayner M, Kockskämper J, Pieske B, Spiess J (2010)
Corticotropin-releasing factor receptors and urocortins, links between brain and heart.
Eur J Pharmacol. 632:1-6
doi: 10.1016/j.ejphar.2010.01.027

Suckau L, Fechner H, Chemaly E, Krohn S, Hadri L, Kockskämper J, Westermann D, Bisping E, Ly H, Wang X, Kawase Y, Chen J, Liang L, Sipo I, Vetter R, Weger S, Kurreck J, Erdmann V, Pieske B, Lebeche D, Schultheiss H-P, Hajjar R, Poller W (2009)
Chronic cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy.
Circulation 119:1241-1252
doi: 10.1161/CIRCULATIONAHA.108.783852

von Lewinski D, Kockskämper J, Zhu D, Post H, Elgner A, Pieske B (2009)
Reduced stretch-induced force response in failing human myocardium caused by impaired Na+-contraction coupling.
Circ Heart Fail. 2:47-55
doi: 10.1161/CIRCHEARTFAILURE.108.794065

von Lewinski D, Kockskämper J, Rübertus S-U, Zhu D, Schmitto J, Schöndube FA, Hasenfuss G, Pieske B (2008)
Direkt pro-arrhythmogenic effects of angiotensin II can be suppressed by AT1 receptor blockade in human atrial myocardium.
Eur J Heart Fail. 10:1172-1176
doi: 10.1016/j.ejheart.2008.09.014

Kockskämper J, Khafaga M, Grimm M, Elgner A, Walther S, Kockskämper A, von Lewinski D, Post H, Grossmann M, Dörge H, Gottlieb PA, Sachs F, Eschenhagen T, Schöndube FA, Pieske B (2008)
Angiotensin II and myosin light chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardium.
Cardiovasc Res. 79:642-651
doi: 10.1093/cvr/cvn126

Kockskämper J, Zima AV, Roderick L, Pieske B, Blatter LA, Bootman MD (2008)
Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes.
J Mol Cell Cardiol. 45:128-147
doi: 10.1016/j.yjmcc.2008.05.014

Kockskämper J, von Lewinski D, Khafaga M, Elgner A, Grimm M, Eschenhagen T, Gottlieb PA, Sachs F, Pieske B (2008)
The slow force response to stretch in atrial and ventricular myocardium from human heart – functional relevance and subcellular mechanisms.
Prog Biophys Mol Biol. 97:250-267
doi: 10.1016/j.pbiomolbio.2008.02.026

Heinzel FR, Kockskämper J, Pieske B (2008)
Ionenhomöostase im insuffizienten Herzen (Ion homeostasis in heart failure).
Der Kardiologe 2:93-99

von Lewinski D, Zhu D, Khafaga M, Kockskämper J, Maier LS, Hasenfuss G, Pieske B (2008)
Frequency-dependence of the slow force response.
Front Biosci. 13:7202-7209
doi: 10.2741/3222

Kockskämper J, Seidlmayer L, Walther S, Hellenkamp K, Maier LS, Pieske B (2008)
Endothelin-1 enhances nuclear Ca2+ transients in atrial myocytes through Ins(1,4,5)P3-dependent Ca2+ release from perinuclear Ca2+ stores.
J Cell Sci. 121:186-195
doi: 10.1242/jcs.021386