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Publikationen der letzten Jahre

Originalarbeiten 2022

Alhyari A, Görg C, Dietrich CF, Trenker C, Strauch L, Safai Zadeh E. ARFI elastography of the omentum: feasibility and diagnostic performance in differentiating benign from malignant omental masses. BMJ Open Gastroenterol. 2022 May;9(1):e000901. doi: 10.1136/bmjgast-2022-000901.

Stathopoulos P, Zumblick M, Wächter S, Schiffmann L, Gress TM, Bartsch D, Seitz G, Denzer UW. Endoscopic vacuum therapy (EVT) for acute esophageal perforation: Could it replace surgery?. Endoscopy International Open 2022. doi: 10.1055/a-1781-0827

Alhyari, A.; Görg, C.; Dietrich, C.F.; Kawohl, S.; Safai Zadeh, E. Diagnostic Performance of Point ShearWave Elastography (pSWE) Using Acoustic Radiation Force Impulse (ARFI) Technology in Mesenteric Masses: A Feasibility Study. Diagnostics 2022, 12, 523. https://doi.org/10.3390/ diagnostics12020523

Krug, S.; Khosravian, M.; Weissbach, J.; George, K.; Damm, M.; Garbe, J.; Walldorf, J.; Reuken, P.A.; Amin, T.; Siebenhüner, A.; et al. The Patient’s Point of View: COVID-19 and Neuroendocrine Tumor Disease. Cancers 2022, 14, 613. https:// doi.org/10.3390/cancers14030613

Safai Zadeh, E.; Görg, C.; Kuttkat, P.; Dietrich, C.F.; Westhoff, C.C.; Rodepeter, F.; Trenker, C.; Görg, M.; Kirschbaum, A.; Alhyari, A. The Value of Contrast-Enhanced Ultrasound (CEUS) in the Detection of Perfusion Disturbances in Abdominal Wall Hernias Compared with Surgical and Histological Assessment. Diagnostics 2022, 12, 370. https://doi.org/10.3390/ diagnostics12020370

Alhyari A, Görg C, Dietrich CF, Trenker C, Ludwig M, Safai Zadeh E. Diagnostic Performance of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Technology in Peripheral Pulmonary Consolidations: A Feasibility Study Ultrasound Med Biol. 2022 May; 48(5):778-785. doi: 10.1016/j.ultrasmedbio.2021.12.015. Epub 2022 Feb 9.

Findeisen H, Görg C, Hartbrich R, Dietrich CF, Görg K, Trenker C, Safai Zadeh E. Contrast-enhanced ultrasound is helpful for differentiating benign from malignant parietal pleural lesions. J Clin Ultrasound. 2022 Jan;50(1):90-98. doi: 10.1002/jcu.23088. Epub 2021 Oct 19.

Safai Zadeh E, Keber CU, Dietrich CF, Westhoff CC, Günter C, Beutel B, Alhyari A, Trenker C, Görg C. Perfusion Patterns of Peripheral Pulmonary Granulomatous Lesions Using Contrast-Enhanced Ultrasound (CEUS) and Their Correlation with Immunohistochemically Detected Vascularization Patterns. J Ultrasound Med. 2022 Mar;41(3):565-574. doi: 10.1002/jum.15730. Epub 2021 May 6.

Wagener N, Buchholz M, Bertolino P, Zhang CX, Di Fazio P. Exploring the MEN1 dependent modulation of caspase 8 and caspase 3 in human pancreatic and murine embryo fibroblast cells Apoptosis. Apoptosis. 2022 Feb;27(1-2):70-79.doi: 10.1007/s10495-021-01700-1. Epub 2021 Dec 8.

Overbeek KA, Goggins MG, Dbouk M, Levink IJM, Koopmann BDM, Chuidian M, Konings ICAW, Paiella S, Earl J, Fockens P, Gress TM, Ausems MGEM, Poley JW, Thosani NC, Half E, Lachter J, Stoffel EM, Kwon RS, Stoita A, Kastrinos F, Lucas AL, Syngal S, Brand RE, Chak A, Carrato A, Vleggaar FP, Bartsch DK, van Hooft JE, Cahen DL, Canto MI, Bruno MJ; International Cancer of the Pancreas Screening Consortium. Timeline of development of pancreatic cancer and implications for successful early detection in high-risk individuals. Gastroenterology. 2022 Mar; 162(3):772-785.e4. doi: 10.1053/j.gastro.2021.10.014. Epub 2021 Oct 19.

Reviews 2022

Safai Zadeh E, Görg C, Prosch H, Jenssen C, Blaivas M, Laursen CB, Jacobsen N, Dietrich CF. WFUMB Technological Review: How to Perform Contrast-Enhanced Ultrasound of the Lung. Ultrasound Med Biol. 2022 Jan 20:S0301-5629(21)00493-2. doi: 10.1016/j.ultrasmedbio.2021.11.014. Online ahead of print.

Safai Zadeh E, Görg C, Dietrich CF, Görlach J, Alhyari A, Trenker C. Contrast-Enhanced Ultrasound for Evaluation of Pleural Effusion: A Pictorial Essay. J Ultrasound Med. 2022 Feb;41(2):485-503. doi: 10.1002/jum.15705. Epub 2021 Mar 29.

Safai Zadeh E, Baumgarten MA, Dietrich CF, Görg C, Neesse A, Trenker C, Alhyari A. Frequency of synchronous malignant liver lesions initially detected by ultrasound in patients with newly diagnosed underlying non-hematologic malignant disease: a retrospective study in 434 patients. Z Gastroenterol. 2022 Apr; 60(4):586-592. doi: 10.1055/a-1649-8857. Epub 2021 Oct 20.

Originalarbeiten 2021

Bartsch DK, Matthäi E, Mintziras I, Bauer C, Figiel J, Sina-Boemers M, Gress TM, Langer P, Slater EP. The German National Case Collection for Familial Pancreatic Carcinoma (FaPaCa)—Knowledge Gained in 20 Years. Dtsch Arztebl Int. 2021 Mar 5;118(Forthcoming):arztebl.m2021.0004. doi: 10.3238/arztebl.m2021.0004. Online ahead of print.

Fijalkowski R, Reher D, Rinke A, Gress TM, Schrader J, Baum RP, Kaemmerer D, Hörsch D. Clinical Features and Prognosis of Patients with Carcinoid Syndrome and Carcinoid Heart Disease - a Retrospective Multicentric Study of 276 Patients. Neuroendocrinology. 2021 Jul 26. doi: 10.1159/000518651. Online ahead of print.

Reher D, Fehrenbach U, Kayser A, Pape UF, Henes FO, Cremer B, Hörsch D, Izbicki J, Lohse AW, Rinke A, Schrader J. Localization defines streptozotocin/5-FU response in primary pancreatic neuroendocrine tumours. Neuroendocrinology. 2021 Aug 5. doi: 10.1159/000518895. Online ahead of print.

Safai Zadeh E, Huber KP, Dietrich CF, Trenker C, Martin E, Beutel B, Wollenberg B, Görg C. The Value of Lung Ultrasound to Detect the Early Pleural and Pulmonary Pathologies in Nonhospitalized COVID-19-Suspected Cases in a Population with a Low Prevalence of COVID-19 Infection. J Ultrasound Med . 2021 Sep 4.doi: 10.1002/jum.15822. Online ahead of print.

Al-Batran SE, Hofheinz RD, Reichart A, Pauligk C, Schönherr C, Schlag R, Siegler G, Dörfel S, Koenigsmann M, Zahn MO, Schubert J, Aldaoud A, Höffkes HG, Schulz H, Hahn L, Uhlig J, Blau W, Stauch M, Weniger J, Wolf M, Jacobasch L, Bildat S, Wehmeyer J, Homann N, Trojan J, Waidmann O, Fietz T, Feustel HP, Groschek M, Wierecky J, Waibel K, Mahlmann S, Schwindel U, Peters U, Schuch G, Pink D, Eschenburg H, Wörns MA, Harich HD, von Weikersthal LF, Däßler KU, Behringer DM, Messmann H, Kretzschmar A, Gallmeier E, Forstbauer H, Kunzmann V, Papke J, Büchner-Steudel P, Vehling-Kaiser U, Springfeld C, Vogel A, Ettrich TJ, Schaaf M, Hausen GZ, Götze TO; Arbeitsgemeinschaft Internistische Onkologie (AIO). Quality of life and outcome of patients with metastatic pancreatic cancer receiving first-line chemotherapy with nab-paclitaxel and gemcitabine: Real-life results from the prospective QOLIXANE trial of the Platform for Outcome, Quality of Life and Translational Research on Pancreatic Cancer registry. Int J Cancer. 2021 Mar 15;148(6):1478-1488. doi: 10.1002/ijc.33336. Epub 2020 Oct 23.

Apostolidis L, Schrader J, Jann H, Rinke A, Krug S. Leptomeningeal Carcinomatosis: A Clinical Dilemma in Neuroendocrine Neoplasms. Biology (Basel). 2021 Mar 28;10(4):277. doi: 10.3390/biology10040277.

Bucher F, Görg C, Weber S, Peterlein CD. Paediatric hip ultrasound: uncertainties in examination and choice of treatment. J Child Orthop. 2021 Feb 1;15(1):42-47. doi: 10.1302/1863-2548.15.200084.

Chen Y, Lin J, Schlotterer A, Kurowski L, Hoffmann S, Hammad S, Dooley S, Buchholz M, Hu J, Fleming I, Hammes HP. MicroRNA-124 Alleviates Retinal Vasoregression via Regulating Microglial Polarization. Int J Mol Sci. 2021 Oct 14;22(20):11068. doi: 10.3390/ijms222011068.

Evers M, Rinke A, Rütz J, Ramaswamy A, Maurer E, Bartsch DK. Prognostic Factors in Curative Resected Locoregional Small Intestine Neuroendocrine Neoplasms. World J Surg. 2021 Apr;45(4):1109-1117. doi: 10.1007/s00268-020-05884-6. Epub 2021 Jan 8.

Gehring S, Stathopoulos P, Denzer UW. Upper Gastrointestinal Bleeding: Hemoclips Do Not Always Solve the Problem. Gastroenterology. 2021 Jun;160(7):e12-e13. doi: 10.1053/j.gastro.2020.10.052. Epub 2020 Nov 19.

Krug S, Kegel T, Gress TM, Rinke A, Apostolidis L, Jann H, König A, Hörsch D, Schrader J, Ettrich TJ, Richter M, Steighardt J, Michl P. Ramucirumab in combination with dacarbazine in patients with progressive well-differentiated metastatic pancreatic neuroendocrine tumors (RamuNET): study protocol for a multicenter single-arm trial. BMC Cancer. 2021 Nov 12;21(1):1206. doi: 10.1186/s12885-021-08900-7. Study Protocol

Krug S, Damm M, Garbe J, König S, Schmitz RL, Michl P, Schrader J, Rinke A. Finding the Appropriate Therapeutic Strategy in Patients with Neuroendocrine Tumors of the Pancreas: Guideline Recommendations Meet the Clinical Reality. J Clin Med. 2021 Jul 7;10(14):3023. doi: 10.3390/jcm10143023.

Leifeld L, Denzer U, Frieling T, Jakobs R, Koop H, van Leeuwen P, Madisch A, Rosien U, Stier A, Siegmund B, Tappe U, Lammert F, Lynen Jansen P. [Quality management in the field of gastroenterology - Proposals of the Quality Commission of the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS) for Outpatient and Inpatient Quality Assurance]. Z Gastroenterol. 2021 Jul;59(7):665-676. doi: 10.1055/a-1451-6350. Epub 2021 Jul 12.

López de Maturana E, Rodríguez JA, Alonso L, Lao O, Molina-Montes E, Martín-Antoniano IA, Gómez-Rubio P, Lawlor R, Carrato A, Hidalgo M, Iglesias M, Molero X, Löhr M, Michalski C, Perea J, O'Rorke M, Barberà VM, Tardón A, Farré A, Muñoz-Bellvís L, Crnogorac-Jurcevic T, Domínguez-Muñoz E, Gress T, Greenhalf W, Sharp L, Arnes L, Cecchini L, Balsells J, Costello E, Ilzarbe L, Kleeff J, Kong B, Márquez M, Mora J, O'Driscoll D, Scarpa A, Ye W, Yu J; PanGenEU Investigators, García-Closas M, Kogevinas M, Rothman N, Silverman DT; SBC/EPICURO Investigators, Albanes D, Arslan AA, Beane-Freeman L, Bracci PM, Brennan P, Bueno-de-Mesquita B, Buring J, Canzian F, Du M, Gallinger S, Gaziano JM, Goodman PJ, Gunter M, LeMarchand L, Li D, Neale RE, Peters U, Petersen GM, Risch HA, Sánchez MJ, Shu XO, Thornquist MD, Visvanathan K, Zheng W, Chanock SJ, Easton D, Wolpin BM, Stolzenberg-Solomon RZ, Klein AP, Amundadottir LT, Marti-Renom MA, Real FX, Malats N. A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer. Genome Med. 2021 Feb 1;13(1):15.doi: 10.1186/s13073-020-00816-4.

Luu M, Riester Z, Baldrich A, Reichardt N, Yuille S, Busetti A, Klein M, Wempe A, Leister H, Raifer H, Picard F, Muhammad K, Ohl K, Romero R, Fischer F, Bauer CA, Huber M, Gress TM, Lauth M, Danhof S, Bopp T, Nerreter T, Mulder IE, Steinhoff U, Hudecek M, Visekruna A. Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer. Nat Commun. 2021 Jul 1;12(1):4077. doi: 10.1038/s41467-021-24331-1.

Matrood S, Apostolidis L, Schrader J, Krug S, Lahner H, Ramaswamy A, Librizzi D, Kender Z, Kröcher A, Kreutzfeldt S, Gress TM, Rinke A. Multicenter Analysis of Presacral Neuroendocrine Neoplasms—Clinicopathological Characterization and Treatment Outcomes of a Rare Disease. Front. Endocrinol., 06 October 2021 | https://doi.org/10.3389/fendo.2021.709256

Matrood S, de Prisco N, Wissniowski TT, Wiese D, Jabari S, Griesmann H, Wanzel M, Stiewe T, Neureiter D, Klieser E, Mintziras I, Buchholz M, Bartsch DK, Gennarino VA, Di Fazio P. Modulation of Pancreatic Neuroendocrine Neoplastic Cell Fate by Autophagy-Mediated Death. Neuroendocrinology. 2021;111(10):965-985. doi: 10.1159/000512567. Epub 2020 Oct 27.

Molina-Montes E, Coscia C, Gómez-Rubio P, Fernández A, Boenink R, Rava M, Márquez M, Molero X, Löhr M, Sharp L, Michalski CW, Farré A, Perea J, O'Rorke M, Greenhalf W, Iglesias M, Tardón A, Gress TM, Barberá VM, Crnogorac-Jurcevic T, Muñoz-Bellvís L, Dominguez-Muñoz JE, Renz H, Balcells J, Costello E, Ilzarbe L, Kleeff J, Kong B, Mora J, O'Driscoll D, Poves I, Scarpa A, Yu J, Hidalgo M, Lawlor RT, Ye W, Carrato A, Real FX, Malats N; PanGenEU Study Investigators. Deciphering the complex interplay between pancreatic cancer, diabetes mellitus subtypes and obesity/BMI through causal inference and mediation analyses. Gut. 2021 Feb;70(2):319-329.doi: 10.1136/gutjnl-2019-319990. Epub 2020 May 14.

Manoharan J, Anlauf M, Albers MB, Denzer UW, Mintziras I, Wächter S, Di Fazio P, Bollmann C, Bartsch DK. Gastric enterochromaffin-like cell changes in multiple endocrine neoplasia type 1. Clin Endocrinol (Oxf). 2021 Sep;95(3):439-446. doi: 10.1111/cen.14430. Epub 2021 Feb 7.

Rinke A, Maintz C, Müller L, Weber MM, Lahner H, Pavel M, Saeger W, Houchard A, Ungewiss H, Petersenn S. Multicenter, Observational Study of Lanreotide Autogel for the Treatment of Patients with Neuroendocrine Tumors in Routine Clinical Practice in Germany and Austria. Exp Clin Endocrinol Diabetes. 2021 Jul;129(7):500-509. doi: 10.1055/a-1342-2755. Epub 2021 Jul 22.

Rosato V, Gómez-Rubio P, Molina-Montes E, Márquez M, Löhr M, O'Rorke M, Michalski CW, Molero X, Farré A, Perea J, Kleeff J, Crnogorac-Jurcevic T, Greenhalf W, Ilzarbe L, Tardón A, Gress T, Barberá VM, Domínguez-Muñoz E, Muñoz-Bellvís L, Balsells J, Costello E, Iglesias M, Kong B, Mora J, O'Driscoll D, Poves I, Scarpa A, Ye W, Hidalgo M, Sharp L, Carrato A, Real FX, La Vecchia C, Malats N; PanGenEU Study Investigators. Gallbladder disease and pancreatic cancer risk: a multicentric case-control European study. Eur J Cancer Prev. 2021 Nov 1;30(6):423-430.doi: 10.1097/CEJ.0000000000000588.

Safai Zadeh E, Beutel B, Dietrich CF, Keber CU, Huber KP, Görg C, Trenker C. Perfusion Patterns of Peripheral Pulmonary Lesions in COVID-19 Patients Using Contrast-Enhanced Ultrasound (CEUS): A Case Series. J Ultrasound Med. 2021 Nov;40(11):2403-2411. doi: 10.1002/jum.15624. Epub 2021 Jan 18.

Safai Zadeh E, Westhoff CC, Keber CU, Trenker C, Dietrich CF, Alhyari A, Mohr CGL, Görg C. Perfusion Patterns of Peripheral Organizing Pneumonia (POP) Using Contrast-Enhanced Ultrasound (CEUS) and Their Correlation with Immunohistochemically Detected Vascularization Patterns. Diagnostics (Basel). 2021 Sep 2;11(9):1601. doi: 10.3390/diagnostics11091601.

Safai Zadeh, E.;Weide, J.; Dietrich, C.F.; Trenker, C.; Koczulla, A.R.; Görg, C. Diagnostic Accuracy of B-Mode- and Contrast-Enhanced Ultrasound in Differentiating Malignant from Benign Pleural Effusions. Diagnostics 2021, 11, 1293. https://doi.org/10.3390/diagnostics 11071293

Ehsan Safai Zadeh, Christoph Frank Dietrich, Corinna Trenker, Amjad Alhayri, Christian Görg. Transcutaneous B-mode ultrasound (TUS) and contrast-enhanced ultrasound (CEUS) pattern of mediastinal tumors: a pictorial essay. J Ultrason 2021; 21: e340–e347. doi: 10.15557/JoU.2021.0056

Trenker C, Dietrich CF, Holland A, Schulte F, Michel C, Görg C. Mediastinal Masses in Contrast-Enhanced Ultrasound - Retrospective Analysis of 58 Cases. J Ultrasound Med. 2021 May;40(5):1023-1030. doi: 10.1002/jum.15479. Epub 2020 Sep 22.

Werle SD†, Schwab JD†, Tatura M†, Kirchhoff S, Szekely R, Diels R, Ikonomi N, Sipos B, Sperveslage J, Gress TM, Buchholz M‡, Kestler HA‡. Unraveling the Molecular Tumor-Promoting Regulation of Cofilin-1 in Pancreatic Cancer. Cancers (Basel). 2021 Feb 10;13(4):725.doi:10.3390/cancers13040725.

Zadeh ES, Kindermann J, Dietrich CF, Görg C, Bleyl T, Alhyari A, Trenker C. Clinical Awareness and Acceptance of Sonographically Diagnosed Epiploic Appendagitis (EA): A Retrospective Analysis of EA in a Single Tertiary Academic Referral Center. Ultrasound Int Open. 2020 Dec;6(3):E87-E93. doi: 10.1055/a-1371-9359. Epub 2021 Mar 12.

Adelmeyer J, Goebel JN, Kann PH. [Spontaneous Hypoglycemia: A Diagnostic Challenge]. Dtsch Med Wochenschr. 2021 Oct;146(19):1294-1297. doi: 10.1055/a-1581-4724. Epub 2021 Sep 22.

Kann PH, Scheunemann A, Dorzweiler P, Adelmeyer J, Bergmann S, Goebel JN, Mann V, Bartsch DK, Holzer K, Albers MB, Manoharan J, Scheunemann LM. Pancreatic Neuroendocrine Neoplasias in Multiple Endocrine Neoplasia Type 1 Are Predominantly Located in the Dorsal Anlage: An Endoscopic Ultrasound Study. Pancreas. 2021 Sep 1;50(8):1169-1172. doi: 10.1097/MPA.0000000000001890.

Koenig AM, Koehler U, Hildebrandt O, Schwarzbach H, Hannemann L, Boneberg R, Heverhagen JT, Mahnken AH, Keller M, Kann PH, Deigner HP, Laur N, Kinscherf R, Hildebrandt W. The Effect of Obstructive Sleep Apnea and Continuous Positive Airway Pressure Therapy on Skeletal Muscle Lipid Content in Obese and Nonobese Men. J Endocr Soc. 2021 May 6;5(8):bvab082. doi: 10.1210/jendso/bvab082. eCollection 2021 Aug 1.

Özkul N, Kann PH. Pheochromocytoma and Adrenocortical Carcinoma: Morphological Characteristics in Endoscopic Ultrasound Imaging. Ultrasound Int Open. 2021 Nov 17;7(2):E64-E70. doi: 10.1055/a-1626-1678. eCollection 2021 Aug.

Hupfer, A., Brichkina, A., Adhikary, T., and Lauth, M. The mammalian Hedgehog pathway is modulated by ANP32 proteins. Biochem Biophys Res Commun. 2021 May 14;553:78-84. doi: 10.1016/j.bbrc.2021.03.027. Epub 2021 Mar 21.

Ivanova E, Sharma SD, Brichkina A, Pfefferle P, Keber U, Pagenstecher A, Lauth M. DYRK3 contributes to differentiation and hypoxic control in neuroblastoma. Biochem Biophys Res Commun. 2021 Aug 27;567:215-221. doi: 10.1016/j.bbrc.2021.06.053. Epub 2021 Jun 22.

Koeniger, A., Brichkina, A., Nee, I., Dempwolff, L., Hupfer, A., Galperin, I., Finkernagel, F., Nist, A., Stiewe, T., Adhikary, T., Diederich, W., and Lauth, M. Activation of Cilia-Independent Hedgehog/GLI1 Signaling as a Novel Concept for Neuroblastoma Therapy. Cancers (Basel). 2021 Apr 15;13(8):1908. doi: 10.3390/cancers13081908.

Reviews 2021

Elisabeth Hessmann, Günter Schneider,  Corinne Bousquet, Channing Der, Stephan Dreyer, Nelson Dusetti, Martin Eilers, Volker Ellenrieder, Elisa Espinet, Chiara Falcomatà, Karin Feldmann, Anneli Gebhardt, Thomas Gress, Feda Hamdan, Magdalena Huber, Steven A Johnsen, Alexander Kleger, Bastian Krenz, Gwen Lomberk, Pawel Mazur, Patrick Michl, Jennifer Morton, Marina Pasca di Magliano, Felix Picard, Maximilian Reichert, Dieter Saur, Roland Schmid, Susanne Sebens, Shiv K Singh, Jens Siveke, Andreas Trumpp. New Insights Into Pancreatic Cancer: Notes from a Virtual Meeting. Gastroenterology. 2021 Sep;161(3):785-791. doi: 10.1053/j.gastro.2021.04.082. Epub 2021 Jun 2.

Rinke A, Auernhammer CJ, Bodei L, Kidd M, Krug S, Lawlor R, Marinoni I, Perren A, Scarpa A, Sorbye H, Pavel ME, Weber MM, Modlin I, Gress TM. Treatment of advanced gastroenteropancreatic neuroendocrine neoplasia, are we on the way to personalised medicine? Gut . 2021 Sep;70(9):1768-1781. doi: 10.1136/gutjnl-2020-321300. Epub 2021 Mar 10.

Xu Z, Hu K, Bailey P, Springfeld C, Roth S, Kurilov R, Brors B, Gress T, Buchholz M, An J, Wei K, Peccerella T, Büchler MW, Hackert T, Neoptolemos JP. Clinical Impact of Molecular Subtyping of Pancreatic Cancer. Front. Cell Dev. Biol. 9:743908. doi: 10.3389/fcell.2021.743908

Findeisen H, Trenker C, Zadeh ES, Görg C. Further aspects concering peripheral lung carcinoma in CEUS. Ultraschall Med. 2021 Jun;42(3):323. doi: 10.1055/a-1090-4327. Epub 2020 Feb 10.

Trenker C, Dietrich CF, Klein S, Safai Zadeh E, Sohlbach K, Neubauer A, Burchert A, Görg C. [Potential of ultrasound in allogeneic stem cell transplantation and transplant-related complications]. Z Gastroenterol. 2021 Apr;59(4):336-344. doi: 10.1055/a-1374-4192. Epub 2021 Feb 25.

Trenker C, Görg C, Freeman S, Jenssen C, Dong Y, Caraiani C, Ioanițescu ES, Dietrich CF. WFUMB Position Paper-Incidental Findings, How to Manage: Spleen. Ultrasound Med Biol. 2021 Aug;47(8):2017-2032. doi: 10.1016/j.ultrasmedbio.2021.03.032. Epub 2021 May 26.

Safai Zadeh E, Dietrich CF, Görg C, Bleyl T, Alhyari A, Ignee A, Jenssen C, Trenker C. [Spleen biopsy: "pros and cons" or better "when and when not?"]. Z Gastroenterol. 2021 Aug;59(8):879-885. doi: 10.1055/a-1404-3926. Epub 2021 Mar 22.

Originalarbeiten 2020

Int J Mol Sci. 2020 Nov 14;21(22):8602. doi: 10.3390/ijms21228602. IL-18 but Not IL-1 Signaling Is Pivotal for the Initiation of Liver Injury in Murine Non-Alcoholic Fatty Liver Disease Hohenester S, Kanitz V, Schiergens T, Einer C, Nagel J, Wimmer R, Reiter FP, Gerbes AL, De Toni EN, Bauer C, Holdt L, Mayr D, Rust C, Schnurr M, Zischka H, Geier A, Denk G.

J Clin Med. 2020 Nov 11;9(11):3633. doi: 10.3390/jcm9113633. Professional Assessment of the Impact of COVID-19 on Handling NET Patients. Krug S, Garbe J, König S, Ungewiss H, Michl P, Rinke A, Schrader J.

Med Ultrason. 2020 Sep 5;22(3):2634. doi: 10.11152/mu-2634. Does lymph node morphology using ultrasound reflect aetiology? A pictorial essay, part I Trenker C, Görg C, Hollerweger A, Jenssen C, Dong Y, Cui XW, Dietrich CF.

Med Ultrason. 2020 Nov 18;22(4):476-484. doi: 10.11152/mu-2635. Epub 2020 Jun 13. Does lymph node morphology using ultrasound reflect aetiology? A pictorial essay, part II, malignant lymphadenopathy Trenker C, Görg C, Hollerweger A, Jenssen C, Dong Y, Cui XW, Dietrich CF.

Pancreatology. 2020 Jul;20(5):910-918. doi: 10.1016/j.pan.2020.05.011. Epub 2020 May 31. International consensus guidelines on surveillance for pancreatic cancer in chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club William Greenhalf, Philippe Lev, Thomas Gres, Vinciane Rebours,Randall E. Brand, Steve Pando, Suresh Charif, Maiken Thyregod Jørgensen, Julia Mayerle, Markus M. Lerch, P eter Hegyi, J€org Kleeff, Carlos Fern andez-del Castillo, Shuiji Isaji, Tooru Shimosegawa, Andrea Sheel, Christopher M Halloran, Pramod Garg, Kyoichi Takaori, Marc G. Besselink, Chris E. Forsmark, C.Mel Wilcox, Patrick Maisonneuve, Dhiraj Yadav, David Whitcomb, John Neoptolemos v, *, for the Working group for the International (IAP e APA e JPS e EPC) Consensus Guidelines for Chronic Pancreatitis

Neuroendocrinology. 2020 Oct 27. doi: 10.1159/000512567. Online ahead of print. Modulation of pancreatic neuroendocrine neoplastic cell fate by autophagy mediated death. Matrood S, de Prisco N, Wissniowski T, Wiese D, Jabari S, Griesmann H, Wanzel M, Stiewe T, Neureiter D, Klieser E, Mintziras I, Buchholz M, Bartsch DK, Gennarino V, Di Fazio P.

Cancers (Basel). 2020 Jul 20;12(7):1978. doi: 10.3390/cancers12071978. Depletion of Macrophages Improves Therapeutic Response to Gemcitabine in Murine Pancreas Cancer. Soeren M Buchholz, Robert G Goetze, Shiv K Singh, Christoph Ammer-Herrmenau, Frances M Richards, Duncan I Jodrell, Malte Buchholz, Patrick Michl, Volker Ellenrieder, Elisabeth Hessmann, Albrecht Neesse

Cancers (Basel) 2020 Jul; 12(7): 1957. Published online 2020 Jul 19. doi: 10.3390/cancers12071957 PMCID: PMC7409270 CUX1—Transcriptional Master Regulator of Tumor Progression in Pancreatic Neuroendocrine Tumors Sebastian Krug, Julia Weissbach, Annika Blank, Aurel Perren, Johannes Haybaeck, Volker Fendrich, Anja Rinke, Thomas Mathias Gress, Jonas Rosendahl, Patrick Michl

PLoS One. 2020; 15(2): e0228905. Published online 2020 Feb 4. doi: 10.1371/journal.pone.0228905 Corrects: PLoS One. 2019; 14(6): e0218953. PMCID: PMC6999902 Correction: Interaction between somatostatin analogues and targeted therapies in neuroendocrine tumor cells Sebastian Krug, Jan-Philipp Mordhorst, Fabian Moser, Katharina Theuerkorn, Claudia Ruffert, Maren Egidi, Anja Rinke, Thomas M. Gress, Patrick Michl

Sci Rep. 2020; 10: 18924. Published online 2020 Nov 3. doi: 10.1038/s41598-020-76033-1 PMCID: PMC7641191 The POLD1R689W variant increases the sensitivity of colorectal cancer cells to ATR and CHK1 inhibitors Albert Job, Marina Tatura, Cora Schäfer, Veronika Lutz, Hanna Schneider, Brigitte Lankat-Buttgereit, Alexandra Zielinski, Kerstin Borgmann, Christian Bauer, Thomas M. Gress, Malte Buchholz, Eike Gallmeier

Int J Mol Sci. 2020 Oct; 21(19): 7307. Published online 2020 Oct 3. doi: 10.3390/ijms21197307 PMCID: PMC7583843 The Immune Microenvironment in Pancreatic Cancer Magdalena Huber, Corinna U. Brehm, Thomas M. Gress, Malte Buchholz, Bilal Alashkar Alhamwe, Elke Pogge von Strandmann, Emily P. Slater, Jörg W. Bartsch, Christian Bauer, Matthias Lauth

World J Gastroenterol. 2020 Oct 7; 26(37): 5693–5704. Published online 2020 Oct 7. doi: 10.3748/wjg.v26.i37.5693 PMCID: PMC7545386 Endoscopic ultrasound-fine needle biopsies of pancreatic lesions: Prospective study of histology quality using Franseen needle Petros Stathopoulos, Anika Pehl, Lutz Philipp Breitling, Christian Bauer, Tobias Grote, Thomas Mathias Gress, Carsten Denkert, Ulrike Walburga Denzer

Pancreatology. 2020 Sep;20(6):1045-1055. doi: 10.1016/j.pan.2020.05.022. Epub 2020 Jul 10. PMID: 32792253 International consensus guidelines on interventional endoscopy in chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club. Kitano M, Gress TM, Garg PK, Itoi T, Irisawa A, Isayama H, Kanno A, Takase K, Levy M, Yasuda I, Lévy P, Isaji S, Fernandez-Del Castillo C, Drewes AM, Sheel ARG, Neoptolemos JP, Shimosegawa T, Boermeester M, Wilcox CM, Whitcomb DC.

Cancer Epidemiol Biomarkers Prev. 2020 Feb 12. pii: cebp.1027.2019. doi: 10.1158/1055-9965.EPI-19-1027. [Epub ahead of print] Pancreatic cancer risk in relation to lifetime smoking patterns, tobacco type, and dose-response relationships. Molina-Montes E, Van Hoogstraten L, Gomez-Rubio P, Löhr M, Sharp L, Molero X, Márquez M, Michalski CW, Farré A, Perea J, O'Rorke M, Greenhalf W, Ilzarbe L, Tardon A, Gress TM, Barberá VM, Crnogorac-Jurcevic T, Muñoz-Bellvis L, Domínguez-Muñoz E, Balsells J, Costello E, Iglesias M, Kleeff J, Kong B, Mora J, O'Driscoll D, Poves I, Scarpa A, Yu J, Ye W, Hidalgo M, Carrato A, Lawlor R, Real FX, Malats N.

Anticancer Res. 2020 Feb;40(2):1167-1173. doi: 10.21873/anticanres.14059. Safety of Prophylactic Gastrostomy Tube Placement and Gastrostomy Tube Usage in Patients Treated by Radio(chemo)therapy for Head and Neck Cancer. Sieron HL, Eberle F, Gress TM, Mahnken AH, Wiegand S.

Neuroendocrinology. 2020;110(1-2):23-34. doi: 10.1159/000500541. Epub 2019 Apr 25. PLAC8 is overexpressed and regulates cell proliferation in low-grade human PanNET. Tatura M, Schmidt H, Haijat M, Stark M, Rinke A, Diels R, Lawlor R, Scarpa A, Schrader J, Hackert T, Schimmack S, Gress TM, Buchholz M.

Physiol Rev. 2020 Apr 16. doi: 10.1152/physrev.00042.2019. Online ahead of print. PMID: 32297835 Microenvironmental Determinants of Pancreatic Cancer. Hessmann E, Buchholz SM, Demir IE, Singh SK, Gress TM, Ellenrieder V, Neesse A

Neuroendocrinology. 2020;110(3-4):225-233. doi: 10.1159/000500883. Epub 2019 May 13. PMID: 31079108 Recent Survival Trends in High-Grade Neuroendocrine Neoplasms and Lung Cancer. Breitling LP, Rinke A, Gress TM.

Ann Surg Oncol. 2020 May;27(5):1348-1355. doi: 10.1245/s10434-019-08049-5. Epub 2019 Nov 12. PMID: 31720931 Surgery with Radical Intent: Is There an Indication for G3 Neuroendocrine Neoplasms? Merola E, Rinke A, Partelli S, Gress TM, Andreasi V, Kollár A, Perren A, Christ E, Panzuto F, Pascher A, Jann H, Arsenic R, Cremer B, Kaemmerer D, Kump P, Lipp RW, Agaimy A, Wiedenmann B, Falconi M, Pavel ME.

Gut. 2020 May 14:gutjnl-2019-319990. doi: 10.1136/gutjnl-2019-319990. Online ahead of print. PMID: 32409590 Deciphering the complex interplay between pancreatic cancer, diabetes mellitus subtypes and obesity/BMI through causal inference and mediation analyses. Molina-Montes E, Coscia C, Gómez-Rubio P, Fernández A, Boenink R, Rava M, Márquez M, Molero X, Löhr M, Sharp L, Michalski CW, Farré A, Perea J, O'Rorke M, Greenhalf W, Iglesias M, Tardón A, Gress TM, Barberá VM, Crnogorac-Jurcevic T, Muñoz-Bellvís L, Dominguez-Muñoz JE, Renz H, Balcells J, Costello E, Ilzarbe L, Kleeff J, Kong B, Mora J, O'Driscoll D, Poves I, Scarpa A, Yu J, Hidalgo M, Lawlor RT, Ye W, Carrato A, Real FX, Malats N; PanGenEU Study Investigators.

Langenbecks Arch Surg. 2020 Mar;405(2):145-154. doi: 10.1007/s00423-020-01868-1. Epub 2020 May 5. PMID: 32372309 Long-term outcome of surgical resection in patients with gastroenteropancreatic neuroendocrine neoplasia: results from a German nation-wide multi-centric registry. Begum N, Maasberg S, Pascher A, Plöckinger U, Gress TM, Wurst C, Weber F, Raffel A, Krausch M, Holzer K, Bartsch DK, Musholt TJ, Keck T, Anlauf M, Rinke A, Pape UF, Goretzki PE; German NET-Registry.

Am J Surg. 2020 Mar 14:S0002-9610(20)30151-3. doi: 10.1016/j.amjsurg. 2020.03.009. Online ahead of print. PMID: 32209239 Radical intended surgery for highly selected stage IV neuroendocrine neoplasms G3. Merola E, Falconi M, Rinke A, Staettner S, Krendl F, Partelli S, Andreasi V, Gress TM, Pascher A, Arsenic R, Doglioni C, Kaemmerer D, Wiedenmann B, Pavel ME

PLoS One. 2020 Feb 4;15(2):e0228905. doi: 10.1371/journal.pone.0228905. eCollection 2020. PMID: 32017803 Correction: Interaction between somatostatin analogues and targeted therapies in neuroendocrine tumor cells. Krug S, Mordhorst JP, Moser F, Theuerkorn K, Ruffert C, Egidi M, Rinke A, Gress TM, Michl P.

Rofo. 2020 Feb;192(2):171-182. doi: 10.1055/a-1001-2412. Epub 2019 Sep 11. PMID: 31509861 Update Regarding Imaging of Neuroendocrine Neoplasms. Figiel JH, Viniol SG, Görlach J, Rinke A, Librizzi D, Mahnken AH.

Originalarbeiten 2019

Gut. 2020 Jan;69(1):7-17. doi: 10.1136/gutjnl-2019-319352. Epub 2019 Oct 31. Management of patients with increased risk for familial pancreatic cancer updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium. Goggins M, Overbeek KA, Brand R, Syngal S, Del Chiaro M, Bartsch DK, Bassi C, Carrato A, Farrell J, Fishman E, Fockens P, Gress TM, van Hooft JE, Hruban RH, Kastrinos F, Klein A, Lennon AM, Lucas A, Park W, Rustgi A, Simeone D, Stoffel E, Vasen HFA, Cahen DL, Canto MI, Bruno M; International Cancer of the Pancreas Screening (CAPS) consortium.

Z Gastroenterol. 2019 Aug;57(8):945-951. doi: 10.1055/a-0893-6872. Epub 2019 Aug 9. B-mode ultrasound and contrast-enhanced ultrasound (CEUS) of histological confirmed omental lesions: retrospective analysis of n = 44 patients. Trenker C, Dietrich CF, Ziegler E, Neesse A, Görg C

Ultraschall Med. 2019 Oct;40(5):603-608. doi: 10.1055/a-0725-7865. Epub 2018 Oct 17. Vascularization of Primary, Peripheral Lung Carcinoma in CEUS - A Retrospective Study (n = 89 Patients). Findeisen H, Trenker C, Figiel J, Greene BH, Görg K, Görg C.

J Clin Ultrasound. 2019 Oct;47(8):461-465. doi: 10.1002/jcu.22755. Epub 2019 Jul 22. Histological validation of pulmonary infarction detected with contrast-enhanced ultrasound in patients with negative computed tomography pulmonary angiogram: A case series. Trenker C, Dohse M, Ramaswamy A, Michel C, Görg C.

Nat Commun. 2019 Aug 14;10(1):3738. doi: 10.1038/s41467-019-11752-2. Author Correction: TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. Ottaviani S, Stebbing J, Frampton AE, Zagorac S, Krell J, de Giorgio A, Trabulo SM, Nguyen VTM, Magnani L, Feng H, Giovannetti E, Funel N, Gress TM, Jiao LR, Lombardo Y, Lemoine NR, Heeschen C, Castellano L.

Digestion. 2019 Jun 19:1-5. doi: 10.1159/000501270. [Epub ahead of print] Testing of Helicobacter pylori by Endoscopic Biopsy: The Clinical Dilemma of Suppressive Conditions. Knoop RF, Petzold G, Amanzada A, Bremer SCB, Gress TM, Ellenrieder V, Neesse A, Kunsch S

PLoS One. 2019 Jun 25;14(6):e0218953. doi: 10.1371/journal.pone.0218953. eCollection 2019. Interaction between somatostatin analogues and targeted therapies in neuroendocrine tumor cells. Krug S, Mordhorst JP, Moser F, Theuerkorn K, Ruffert C, Egidi M, Rinke A, Gress TM, Michl P.

Biosci Rep. 2019 Jun 20;39(6). pii: BSR20182361. doi: 10.1042/BSR20182361. Print 2019 Jun 28. Molecular profiling of the tumor microenvironment in glioblastoma patients: correlation of microglia/macrophage polarization state with metalloprotease expression profiles and survival. Gjorgjevski M, Hannen R, Carl B, Li Y, Landmann E, Buchholz M, Bartsch JW, Nimsky C

BMC Cancer. 2019 Apr 16;19(1):362. doi: 10.1186/s12885-019-5559-7. Brain metastases in patients with neuroendocrine neoplasms: risk factors and outcome. Krug S, Teupe F, Michl P, Gress TM, Rinke A.

Neuroendocrinology. 2019;108(1):26-36. doi: 10.1159/000494258. Epub 2018 Oct 3. Neuroendocrinology. Unmet Needs in Functional and Nonfunctional pancreatic neuroendocrine neoplasms (PanNENs). Jensen RT, Bodei L, Capdevila J, Couvelard A, Falconi M, Grozinsky-Glasberg S, Klöppel G, Lamberts SWJ, Peeters M, Rindi G, Rinke A, Rothmund M, Sundin A, Welin S, Fazio N.

Cell Mol Life Sci. 2019 Jan;76(1):193-207. doi: 10.1007/s00018-018-2942-5. Epub 2018 Oct 13. DYRK1B regulates Hedgehog-induced microtubule acetylation. Singh R, Holz PS, Roth K, Hupfer A, Meissner W, Müller R, Buchholz M, Gress TM, Elsässer HP, Jacob R, Lauth M.

Int J Cancer. 2019 Apr 1;144(7):1540-1549. doi: 10.1002/ijc.31866. Epub 2018 Oct 26. Pancreatic cancer and autoimmune diseases: An association sustained by computational and epidemiological case-control approaches. Gomez-Rubio P, Piñero J, Molina-Montes E, Gutiérrez-Sacristán A, Marquez M, Rava M, Michalski CW, Farré A, Molero X, Löhr M, Perea J, Greenhalf W, O'Rorke M, Tardón A, Gress T, Barberá VM, Crnogorac-Jurcevic T, Muñoz-Bellvís L, Domínguez-Muñoz E, Balsells J, Costello E, Yu J, Iglesias M, Ilzarbe L, Kleeff J, Kong B, Mora J, Murray L, O'Driscoll D, Poves I, Lawlor RT, Ye W, Hidalgo M, Scarpa A, Sharp L, Carrato A, Real FX, Furlong LI, Malats N; PanGenEU Study Investigators

Endocr Relat Cancer. 2019 Feb 1;26(2):227-239. doi: 10.1530/ERC-18-0424. Peptide receptor radionuclide therapy in gastroenteropancreatic NEN G3: a multicenter cohort study. Carlsen EA, Fazio N, Granberg D, Grozinsky-Glasberg S, Ahmadzadehfar H, Grana CM, Zandee WT, Cwikla J, Walter MA, Oturai PS, Rinke A, Weaver A, Frilling A, Gritti S, Arveschoug AK, Meirovitz A, Knigge U, Sorbye H

Theranostics. 2019 Feb 12;9(5):1280-1287. doi: 10.7150/thno.29247. eCollection 2019. A Blood-Based Multi Marker Assay Supports the Differential Diagnosis of Early-Stage Pancreatic Cancer. Berger AW, Schwerdel D, Reinacher-Schick A, Uhl W, Algül H, Friess H, Janssen KP, König A, Ghadimi M, Gallmeier E, Bartsch DK, Geissler M, Staib L, Tannapfel A, Kleger A, Beutel A, Schulte LA, Kornmann M, Ettrich TJ, Seufferlein T.

Cancer Biol Ther. 2019;20(5):633-641. doi: 10.1080/15384047.2018.1550566. Epub 2019 Jan 13. Functional evaluation of variants of unknown significance in the BRCA2 gene identified in genetic testing. Heczkova M, Machackova E, Macinga P, Gallmeier E, Cahova M, Spicak J, Jirsa M, Foretova L, Hucl T

Liver Int. 2019 Jun;39(6):1155-1164. doi: 10.1111/liv.13995. Epub 2019 Feb 21. Endoscopic retrograde cholangiography and percutaneous transhepatic cholangiodrainage in biliary strictures after liver transplantation: Long-term outcome predictors and influence on patient survival. Heinemann M, Tafrishi B, Pischke S, Fischer L, Rösch T, Lohse AW, Sterneck M, Denzer UW.

Visc Med. 2019 Apr;35(2):71-72. doi: 10.1159/000499632. Epub 2019 Apr 3. Editorial An Interdisciplinary Approach to Acute and Chronic Pancreatitis: Is There Anything New? Denzer UW, Besselink MG.

Neuroendocrinology. 2019;109(2):141-151. doi: 10.1159/000499469. Epub 2019 Mar 11. Health-Related Quality of Life for Long-Acting Octreotide versus Placebo in Patients with Metastatic Midgut Neuroendocrine Tumors in the Phase 3 PROMID Trial. Rinke A, Neary MP, Eriksson J, Hunger M, Doan T, Karli D, Arnold R.

Neuroendocrinology. 2019;108(1):37-44. doi: 10.1159/000493894. Epub 2018 Sep 20. Unmet Needs in Appendiceal Neuroendocrine Neoplasms. Toumpanakis C, Fazio N, Tiensuu Janson E, Hörsch D, Pascher A, Reed N, O Apos Toole D, Nieveen van Dijkum E, Partelli S, Rinke A, Kos-Kudla B, Costa F, Pape UF, Grozinsky-Glasberg S, Scoazec JY; The ENETS 2016 Munich Advisory Board Participants; ENETS 2016 Munich Advisory Board Participants.

Gut. 2019 Apr;68(4):581. doi: 10.1136/gutjnl-2018-317735. Epub 2018 Dec 7. Commentary Immunosuppressive βig-h3 links tumour stroma and dysfunctional T cells in pancreatic cancer. Bauer CA.

PLoS One. 2019 Nov 21;14(11):e0224893. doi: 10.1371/journal.pone.0224893. eCollection 2019. The effects of prolonged single night session of videogaming on sleep and declarative memory. Hartmann M, Pelzl MA, Kann PH, Koehler U, Betz M, Hildebrandt O, Cassel W.

Exp Clin Endocrinol Diabetes. 2019 Aug 14. doi: 10.1055/a-0950-9892. [Epub ahead of print] Single Centre Experience in Patients with Primary Hyperparathyroidism: Sporadic, Lithium-associated and in Multiple Endocrine Neoplasia. Dillenberger S, Bartsch DK, Maurer E, Kann PH.

J Clin Endocrinol Metab. 2019 Dec 1;104(12):6129-6138. doi: 10.1210/jc.2019-01204. Surgical Management, Preoperative Tumor Localization, and Histopathology of 80 Patients Operated on for Insulinoma. Andreassen M, Ilett E, Wiese D, Slater EP, Klose M, Hansen CP, Gercke N, Langer SW, Kjaer A, Maurer E, Federspiel B, Kann PH, Bartsch DK, Knigge U

J Clin Endocrinol Metab. 2019 Nov 1;104(11):5053-5055. doi: 10.1210/jc.2019-00954. Commentary Turning Up the Heat: Endoscopic Ablation of Pancreatic Neuroendocrine Neoplasms. Hofland J, de Herder WW, Kann PH.

Reviews 2019

Gut. 2019 Jan;68(1):159-171. doi: 10.1136/gutjnl-2018-316451. Epub 2018 Sep 3. Stromal biology and therapy in pancreatic cancer: ready for clinical translation? Neesse A, Bauer CA, Öhlund D, Lauth M, Buchholz M, Michl P, Tuveson DA, Gress TM.

Gut. 2019 Aug;68(8):1343-1351. doi: 10.1136/gutjnl-2019-318742. Epub 2019 May 25. Controversies on the endoscopic and surgical management of pain in patients with chronic pancreatitis: pros and cons! Drewes AM, Kempeneers MA, Andersen DK, Arendt-Nielsen L, Besselink MG, Boermeester MA, Bouwense S, Bruno M, Freeman M, Gress TM, van Hooft JE, Morlion B, Olesen SS, van Santvoort H, Singh V, Windsor J.

Dtsch Med Wochenschr. 2019 Oct;144(21):1509-1521. doi: 10.1055/a-0865-0061. Epub 2019 Oct 21. German. [Gastroenteropancreatic neuroendocrine tumors]. Breitling LP, Rinke A, Gress TM.

Int J Mol Sci. 2019 Oct 23;20(21). pii: E5266. doi: 10.3390/ijms20215266. The Crosstalk of miRNA and Oxidative Stress in the Liver: From Physiology to Pathology and Clinical Implications. Klieser E, Mayr C, Kiesslich T, Wissniowski T, Fazio PD, Neureiter D, Ocker M.

Originalarbeiten 2018

Z Gastroenterol. 2018 Oct;56(10):1237-1246. doi: 10.1055/a-0661-6099. Epub 2018 Oct 10. [Neuroendocrine Neoplasia within the German NET Registry]. Sebastian Maasberg, Ulrich-Frank Pape, Christian Fottner, Peter E. Goretzki, Martin Anlauf, Dieter Hörsch, Birgit Cremer, Dominik M. Schulte, Detlef Quietzsch, Frank Scheerer, Gabriele Pöpperl, Thorsten D. Poeppel, Nehara Begum, Christian Grohé, Anja Rinke

Z Gastroenterol. 2018 Jan;56(1):e1. doi: 10.1055/s-0035-1567241. Epub 2017 Dec 1. [The revised version of standard terminology in gastroenterological endoscopy - result of a consensus project of the german society for gastroenterology, digestive and metabolic diseases]. Meining A, Schmidbaur W, Schumacher B, Toermer T, Keuchel M, Baltes P, Denzer U, Götz M, Hochberger J, Jakobs R, Klaus J, Moog G, Rosien U, von Delius S, Wehrmann T, Lerch MM, Lammert F.

Circ Cardiovasc Qual Outcomes. 2018 Mar;11(3):e004226. doi: 10.1161/CIRCOUTCOMES.117.004226. A Novel Tool for Visualizing Composite Endpoint Associations. Breitling LP

Neuroendocrinology. 2018;106(1):30-37. doi: 10.1159/000457954. Epub 2017 Feb 3. Bone Metastases in Patients with Neuroendocrine Neoplasm: Frequency and Clinical, Therapeutic, and Prognostic Relevance Scharf M, Petry V, Daniel H, Rinke A, Gress TM.

Gut. 2018 May;67(5):789-804. doi: 10.1136/gutjnl-2018-316027. Epub 2018 Mar 24. European evidence-based guidelines on pancreatic cystic neoplasms. European Study Group on Cystic Tumours of the Pancreas.

Gut. 2018 Mar;67(3):497-507. doi: 10.1136/gutjnl-2016-311954. Epub 2017 Jan 10. Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer. Hessmann E, Patzak MS, Klein L, Chen N, Kari V, Ramu I, Bapiro TE, Frese KK, Gopinathan A, Richards FM, Jodrell DI, Verbeke C7, Li X, Heuchel R, Löhr JM, Johnsen SA, Gress TM, Ellenrieder V, Neesse A.

Neoplasia. 2018 Nov;20(11):1135-1143. doi: 10.1016/j.neo.2018.08.009. Epub 2018 Sep 23. Inactivation of PRIM1 Function Sensitizes Cancer Cells to ATR and CHK1 Inhibitors. Job A, Schmitt LM, von Wenserski L, Lankat-Buttgereit B, Gress TM, Buchholz M, Gallmeier E.

J Neurooncol. 2018 May;137(3):463-468. doi: 10.1007/s11060-018-2749-0. Epub 2018 Jan 11. MicroRNA-30c as a novel diagnostic biomarker for primary and secondary B-cell lymphoma of the CNS. Baraniskin A, Chomiak M, Ahle G, Gress T, Buchholz M, Turewicz M, Eisenacher M, Margold M, Schlegel U, Schmiegel W, Hahn S, Schroers R.

Oncotarget. 2018 Aug 31;9(68):32997-33010. doi: 10.18632/oncotarget.26038. eCollection 2018 Aug 31. Panobinostat mediated cell death: a novel therapeutic approach for osteosarcoma. Wirries A, Jabari S, Jansen EP, Roth S, Figueroa-Juárez E, Wissniowski TT, Neureiter D, Klieser E, Lechler P, Ruchholtz S, Bartsch DK, Boese CK, Di Fazio P.

Int J Epidemiol. 2018 Apr 1;47(2):473-483. doi: 10.1093/ije/dyx269. Risk of pancreatic cancer associated with family history of cancer and other medical conditions by accounting for smoking among relatives. Molina-Montes E, Gomez-Rubio P, Márquez M, Rava M, Löhr M, Michalski CW, Molero X, Farré A, Perea J, Greenhalf W, Ilzarbe L, O'Rorke M, Tardón A, Gress T, Barberà VM, Crnogorac-Jurcevic T, Domínguez-Muñoz E, Muñoz-Bellvís L, Balsells J, Costello E, Huang J, Iglesias M, Kleeff J, Kong B, Mora J, Murray L, O'Driscoll D, Poves I, Scarpa A, Ye W, Hidalgo M, Sharp L, Carrato A, Real FX, Malats N; PanGenEU Study Investigators.

Z Gastroenterol. 2018 Jun;56(6):583-681. doi: 10.1055/a-0604-2924. Epub 2018 Jun 11. S2k-Leitlinie Neuroendokrine Tumore Anja Rinke  *, Bertram Wiedenmann  *, Christoph Auernhammer, Peter Bartenstein, Detlef K. Bartsch, Nehara Begum, Siegbert Faiss, Christian Fottner, Bernhard Gebauer, Peter Goretzki, Petra Lynen Jansen, Gabriele Pöpperl, Hans Scherübl, Matthias M. Weber, Thomas Mathias Gress  **, Marianne Pavel  **, **= gleichberechtigte 1st oder Letztautorschaft

Arch Osteoporos. 2018 Mar 3;13(1):16. doi: 10.1007/s11657-018-0426-8. Smoking and bone mineral density: comprehensive analyses of the third National Health and Nutrition Examination Survey (NHANES III). Strozyk D, Gress TM, Breitling LP

Nat Commun. 2018 May 10;9(1):1845. doi: 10.1038/s41467-018-03962-x. TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. Ottaviani S, Stebbing J, Frampton AE, Zagorac S, Krell J, de Giorgio A, Trabulo SM, Nguyen VTM, Magnani L, Feng H, Giovannetti E, Funel N, Gress TM, Jiao LR, Lombardo Y, Lemoine NR, Heeschen C, Castellano L

J Clin Med. 2018 Sep 20;7(10). pii: E295. doi: 10.3390/jcm7100295. The Combination of MiRNA-196b, LCN2, and TIMP1 is a Potential Set of Circulating Biomarkers for Screening Individuals at Risk for Familial Pancreatic Cancer. Bartsch DK, Gercke N, Strauch K, Wieboldt R, Matthäi E, Wagner V, Rospleszcz S, Schäfer A, Franke FS, Mintziras I, Bauer C, Grote T, Figiel J, Di Fazio P, Burchert A, Reinartz S, Pogge von Strandmann E, Klöppel G, Slater EP

Int J Cancer. 2018 Oct 1;143(7):1806-1816. doi: 10.1002/ijc.31562. Therapeutic targeting of tumor-associated macrophages in pancreatic neuroendocrine tumors Krug S, Abbassi R, Griesmann H, Sipos B, Wiese D, Rexin P, Blank A, Perren A, Haybaeck J, Hüttelmaier S, Rinke A, Gress TM, Michl P.

Digestion. 2018 Nov 13:1-6. doi: 10.1159/000494755. [Epub ahead of print] Contrast-Enhanced Sonography in Patients with Hyposplenia: A Retrospective Analysis in Forty-Three Patients. Trenker C, May L, Librizzi D, Neesse A, Görg C.

Liver Int. 2018 Oct 26. doi: 10.1111/liv.13995. [Epub ahead of print] ERC and PTCD in biliary strictures after liver transplantation: long-term outcome predictors and influence on patient survival. Heinemann M, Tafrishi B, Pischke S, Fischer L, Rösch T, Lohse AW, Sterneck M, Denzer UW.

Digestion. 2018 Nov 14:1-6. doi: 10.1159/000494718. [Epub ahead of print] High Prevalence of Pathological Hydrogen Breath Tests in Patients with Functional Dyspepsia. Petzold G, Amanzada A, Gress TM, Ellenrieder V, Neesse A, Kunsch S.

JCI Insight. 2018 Mar 8;3(5). pii: 96322. doi: 10.1172/jci.insight.96322. Nlrp3-dependent IL-1β inhibits CD103+ dendritic cell differentiation in the gut. Mak'Anyengo R, Duewell P, Reichl C, Hörth C, Lehr HA, Fischer S, Clavel T, Denk G, Hohenester S, Kobold S, Endres S, Schnurr M, Bauer C.

BMC Endocr Disord. 2018 Feb 13;18(1):10. doi: 10.1186/s12902-018-0237-3 Design of the Growth hormone deficiency and Efficacy of Treatment (GET) score and non-interventional proof of concept study. Kann PH, Bergmann S, Bidlingmaier M, Dimopoulou C, Pedersen BT, Stalla GK, Weber MM, Meckes-Ferber S

Digestion. 2018;98(2):112-118. doi: 10.1159/000487939. Epub 2018 Apr 26. Endoscopic Ultrasound Features of Multiple Endocrine Neoplasia Type 1-Related versus Sporadic Pancreatic Neuroendocrine Tumors: A Single-Center Retrospective Study. Tamagno G, Scherer V, Caimo A, Bergmann SR, Kann PH

World J Surg. 2018 May;42(5):1440-1447. doi: 10.1007/s00268-017-4317-8. Preoperative Imaging Overestimates the Tumor Size in Pancreatic Neuroendocrine Neoplasms Associated with Multiple Endocrine Neoplasia Type 1. Polenta V, Slater EP, Kann PH, Albers MB, Manoharan J, Ramaswamy A, Mahnken AH, Bartsch DK

Bone. 2018 Sep;114:109-115. doi: 10.1016/j.bone.2018.06.007. Epub 2018 Jun 13. Prevention of breast cancer treatment-induced bone loss in premenopausal women treated with zoledronic acid: Final 5-year results from the randomized, double-blind, placebo-controlled ProBONE II trial. Kyvernitakis I, Kann PH, Thomasius F, Hars O, Hadji P

Exp Clin Endocrinol Diabetes. 2018 Jul 26. doi: 10.1055/a-0654-5134. [Epub ahead of print] Risk and Relevance of Insulin Pump Therapy in the Aetiology of Ketoacidosis in People with Type 1 Diabetes. Giessmann LC, Kann PH

Exp Clin Endocrinol Diabetes. 2018 Oct 17. doi: 10.1055/a-0600-9649. [Epub ahead of print] Cardivascular Risk Profile in Patients with Diabetes and Acromegaly or Cushing's Disease - Analysis from the DPV Database. Warncke K, Kummer S, Kann PH, Bergis D, Bollow E, Hummel M, Zoicas F, Wernert S, Holl RW

Reviews 2018

Gut. 2019 Jan;68(1):159-171. doi: 10.1136/gutjnl-2018-316451. Epub 2018 Sep 3. Stromal biology and therapy in pancreatic cancer: ready for clinical translation? Neesse A, Bauer CA, Öhlund D, Lauth M, Buchholz M, Michl P, Tuveson DA, Gress TM

Rev Endocr Metab Disord. 2018 Jun;19(2):133-137. doi: 10.1007/s11154-018-9464-1. Is endoscopic ultrasonography more sensitive than magnetic resonance imaging in detecting and localizing pancreatic neuroendocrine tumors? Kann PH

Originalarbeiten 2017

Pancreatology 17, 139-145 Relevance of dihydropyrimidine-dehydrogenase and thymidylatesynthase in patients with pancreatic neuroendocrine neoplasms treated with 5-FU-based chemotherapy  S. Krug, M. Boch, W. Nimphius, T.M. Gress, P. Michl, A. Rinke

Clinics in Oncology, Volume 2, Article 1198 Autophagy: From Liver to Pancreas Tumor Pathogenesis Pietro Di Fazio and Thaddeus Till Hippokrates Wissniowski

Oncotarget,  Vol. 8, (No. 39), pp: 66215-66225 "The deubiquitinating enzyme USP5 promotes pancreatic cancer via modulating cell cycle regulators" Brajesh P. Kaistha, Anja Krattenmacher, Johannes Fredebohm, Harald Schmidt, Diana Behrens, Miriam Widder, Thilo Hackert, Oliver Strobel, Jörg D. Hoheisel, Thomas M. Gress and Malte Buchholz

Oncotarget, "Combined microRNA and mRNA microfluidic TaqMan array cards for the diagnosis of malignancy of multiple types of pancreaticobiliary tumors in fine-needle aspiration material" Thomas M. Gress, Ludwig Lausser, Lyn-Rouven Schirra, Lisa Ortmüller, Ramona Diels, Bo Kong, Christoph W. Michalski, Thilo Hackert, Oliver Strobel, Nathalia A. Giese, Miriam Schenk, Rita T. Lawlor, Aldo Scarpa, Hans A. Kestler and Malte Buchholz

PLoS One. 2017 Dec 12;12(12):e0188876. doi: 10.1371/journal.pone.0188876. eCollection 2017. Clinicopathological hallmarks and biomarkers of colorectal neuroendocrine neoplasms Koenig A, Krug S, Mueller D, Barth PJ, Koenig U, Scharf M, Ellenrieder V, Michl P, Moll R, Homayunfar K, Kann PH, Stroebel P, Gress TM, Rinke A.

Anticancer Res. 2017 May;37(5):2491-2500. Impact of Therapy Sequence with Alkylating Agents and MGMT Status in Patients with Advanced Neuroendocrine Tumors. Krug S, Boch M, Rexin P, Gress TM, Michl P, Rinke A.

Ann Oncol. 2017 Jul 1;28(7):1618-1624. doi: 10.1093/annonc/mdx167 A systems approach identifies time-dependent associations of multimorbidities with pancreatic cancer risk. Gomez-Rubio P, Rosato V, Márquez M, Bosetti C, Molina-Montes E, Rava M, Piñero J, Michalski CW, Farré A, Molero X, Löhr M, Ilzarbe L, Perea J, Greenhalf W, O'Rorke M, Tardón A, Gress T, Barberá VM, Crnogorac-Jurcevic T, Muñoz-Bellvís L, Domínguez-Muñoz E, Gutiérrez-Sacristán A, Balsells J, Costello E, Guillén-Ponce C, Huang J, Iglesias M, Kleeff J, Kong B, Mora J, Murray L, O'Driscoll D, Peláez P, Poves I, Lawlor RT, Carrato A, Hidalgo M, Scarpa A, Sharp L, Furlong L, Real FX, La Vecchia C, Malats N; PanGenEU Study Investigators.

J Clin Endocrinol Metab. 2017 May 1;102(5):1486-1494. doi: 10.1210/jc.2016-3732. Functional Imaging in the Follow-Up of Enteropancreatic Neuroendocrine Tumors: Clinical Usefulness and Indications. Merola E, Pavel ME, Panzuto F, Capurso G, Cicchese N, Rinke A, Gress TM, Iannicelli E, Prosperi D, Pizzichini P, Prasad V, Kump P, Lipp R, Partelli S, Falconi M, Wiedenmann B, Delle Fave G

Oncologist. 2017 Apr;22(4):409-415. doi: 10.1634/theoncologist.2016-0351. Epub 2017 Feb 23   Stage IV Gastro-Entero-Pancreatic Neuroendocrine Neoplasms: A Risk Score to Predict Clinical Outcome. Panzuto F, Merola E, Pavel ME, Rinke A, Kump P, Partelli S, Rinzivillo M, Rodriguez-Laval V, Pape UF, Lipp R, Gress T, Wiedenmann B, Falconi M, Delle Fave G.

Neuroendocrinology. 2017;104(1):26-32. Epub 2016 Jan 6 Placebo-Controlled, Double-Blind, Prospective, Randomized Study on the Effect of Octreotide LAR in the Control of Tumor Growth in Patients with Metastatic Neuroendocrine Midgut Tumors (PROMID): Results of Long-Term Survival. Rinke A, Wittenberg M, Schade-Brittinger C, Aminossadati B, Ronicke E, Gress TM, Müller HH, Arnold R; PROMID Study Group.

Neuroendocrinology. 2017;104(3):302-312. doi: 10.1159/000446917. Epub 2016 May 25. Loss of Chromosome 18 in Neuroendocrine Tumors of the Small Intestine: The Enigma Remains. Nieser M, Henopp T, Brix J, Stoß L, Sitek B, Naboulsi W, Anlauf M, Schlitter AM, Klöppel G, Gress T, Moll R, Bartsch DK, Heverhagen AE, Knoefel WT, Kaemmerer D, Haybaeck J, Fend F, Sperveslage J, Sipos B.

Gut. 2017 Jul;66(7):1278-1285. doi: 10.1136/gutjnl-2015-310049. Epub 2016 Mar 24. Pharmacological macrophage inhibition decreases metastasis formation in a genetic model of pancreatic cancer. Griesmann H, Drexel C, Milosevic N, Sipos B, Rosendahl J, Gress TM, Michl P

Gut. 2017 Feb;66(2):314-322. doi: 10.1136/gutjnl-2015-310442. Epub 2015 Dec 1 Reduced risk of pancreatic cancer associated with asthma and nasal allergies. Gomez-Rubio P, Zock JP, Rava M, Marquez M, Sharp L, Hidalgo M, Carrato A, Ilzarbe L, Michalski C, Molero X, Farré A, Perea J, Greenhalf W, O'Rorke M, Tardón A, Gress T, Barberà V, Crnogorac-Jurcevic T, Domínguez-Muñoz E, Muñoz-Bellvís L, Alvarez-Urturi C, Balcells J, Barneo L, Costello E, Guillén-Ponce C, Kleeff J, Kong B, Lawlor R, Löhr M, Mora J, Murray L, O'Driscoll D, Peláez P, Poves I, Scarpa A, Real FX, Malats N; PanGenEU Study Investigators.

Thromb Res. 2017 Sep;157:9-15. doi: 10.1016/j.thromres.2017.06.021. Epub 2017 Jun 20 Incidence, outcome and risk stratification tools for venous thromboembolism in advanced pancreatic cancer - A retrospective cohort study. Kruger S, Haas M, Burkl C, Goehring P, Kleespies A, Roeder F, Gallmeier E, Ormanns S, Westphalen CB, Heinemann V, Rank A, Boeck S

Journal of Travel Medicine, 2017, 1–8 doi: 10.1093/jtm/tax073 Case report of the patient source of the Babesia microti R1 reference strain and implications for travelers Philipp Stahl, Yves Poinsignon, Pascal Pouedras,Vasilica Ciubotaru, Laurence Berry, Brinda Emu, Peter J. Krause,Choukri Ben Mamoun, and Emmanuel Cornillot

Gynecol Endocrinol. 2017 Jul;33(7):564-569. doi: 10.1080/09513590.2017.1296130. Epub 2017 Mar 5. Gender-, age- and time-dependent dosing of growth hormone in adults - real-world data from a decade of clinical practice in Germany. Kann PH, Bergmann S, Stalla GK, Dimopoulou C, Weber MM, Pedersen BT, Meckes-Ferber S.

Biomaterials. 2017 Apr;123:48-62. doi: 10.1016/j.biomaterials.2017.01.035. Epub 2017 Jan 28. Effect of sex-hormone levels, sex, body mass index and other host factors on human craniofacial bone regeneration with bioactive tricalcium phosphate grafts. Knabe C, Mele A, Kann PH, Peleska B, Adel-Khattab D, Renz H, Reuss A, Bohner M, Stiller M.

World J Surg. 2017 Jun;41(6):1521-1527. doi: 10.1007/s00268-017-3907-9. Limited Value of Ga-68-DOTATOC-PET-CT in Routine Screening of Patients with Multiple Endocrine Neoplasia Type 1. Albers MB, Librizzi D, Lopez CL, Manoharan J, Apitzsch JC, Slater EP, Bollmann C, Kann PH, Bartsch DK.

Gynecol Endocrinol. 2017 Apr;33(4):292-296. doi: 10.1080/09513590.2016.1266475. Epub 2016 Dec 23. Bone health of the Ovahimba people of north-western Namibia in the context of urbanization and a change of the sociocultural environment.   Wilhelm A, Hadji P, Münzel M, Daniel H, Flache S, Nyarango P, Kann PH.

Endocrine. 2017 Apr;56(1):158-163. doi: 10.1007/s12020-016-1179-z. Epub 2016 Nov 30. Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNA) in insulinomas: Indications and clinical relevance in a single investigator cohort of 47 patients. Kann PH, Moll R, Bartsch D, Pfützner A, Forst T, Tamagno G, Goebel JN, Fourkiotis V, Bergmann SR, Collienne M.

J Diabetes Sci Technol. 2017 Mar;11(2):278-283. doi: 10.1177/1932296816663745. Epub 2016 Sep 25. Clinical and Laboratory Evaluation of a New Specific Point-of-Care Test for Intact Proinsulin. Pfützner A, Pfützner AH, Kann PH, Burgard G.

Neurosurgery. 2017 Apr 1;80(4):525-533. doi: 10.1227/NEU.0000000000001319. Ectopic Adrenocorticotropic Hormone-Secreting Pituitary Adenomas: An Underestimated Entity. Knappe UJ, Jaspers C, Buschsieweke D, Reinbold WD, Alomari A, Saeger W, Ehlenz K, Mann WA, Kann PH, Feldkamp J.

Ultraschall Med. 2017 Aug;38(4):411-419. doi: 10.1055/s-0041-107996. Epub 2015 Nov 3. Adrenal Incidentaloma and Subclinical Cushing's Syndrome: A Longitudinal Follow-Up Study by Endoscopic Ultrasound. Collienne M, Timmesfeld N, Bergmann SR, Goebel J, Kann PH.

Reviews 2017

Digestion, 95, 109–114  2017 Neuroendocrine Cancer, Therapeutic Strategies in G3 Cancers Anja Rinke Thomas M. Gress

Nat Rev Dis Primers. 2017 Sep 7;3:17060. doi: 10.1038/nrdp.2017.60. Chronic pancreatitis Kleeff J, Whitcomb DC, Shimosegawa T, Esposito I, Lerch MM, Gress T, Mayerle J, Drewes AM, Rebours V, Akisik F, Muñoz JED, Neoptolemos JP

Digestion. 2017;96(2):67-75. doi: 10.1159/000477800. Epub 2017 Jul 21 The Role of Cytotoxic Chemotherapy in Advanced Pancreatic Neuroendocrine Tumors Krug S, Gress TM, Michl P, Rinke A.