Dr. Aida Shahraki

Aida Shahraki

Postdoctoral Research Fellow

Contact information

+49 6421 28-21359 +49 6421 28-28994 aida.shahraki@pharmazie 1 Marbacher Weg 8
35032 Marburg
M|04 Institutsgebäude A (Room: 02A18)

Organizational unit

Philipps-Universität Marburg Pharmazie (Fb16) Institut für Pharmazeutische Chemie AG Kolb

Following my academic journey in Physics and Biophysics at the Kharazmi University and University of Tehran, I pursued my Ph.D. in Molecular Biology and Genetics at Bogazici (Bosphorus) University in Turkey. My doctoral research focused on characterizing the orthosteric binding pocket of a G protein-coupled receptor (GPCR) in Thaumetopoea pityocampa, a Mediterranean pest. I utilized both in silico and in vitro methods to design agonists for the Allatostatin receptor in this organism, with potential applications as next-generation pesticides.

During my Ph.D., I sought additional knowledge and skills by visiting various laboratories. In 2016, I undertook an internship in Jana Selent's lab at the University Pompeu Fabra to learn about molecular dynamic simulations and docking calculations. In 2019, I joined Martin J. Lohse's group at MDC Berlin to gain expertise in signaling assays, particularly FRET/BRET techniques. These opportunities were made possible through short-term scientific mission grants from GLISTEN (CM1207) and ERNEST (CA18133). In the final two years of my Ph.D., I strengthened my Computational Chemistry skills at Serdar Durdagi's group in Istanbul.

Upon completing my Ph.D., I became a postdoctoral researcher in Peter Kolb's lab at the University of Marburg and got involved in multiple studies on human GPCRs, employing both computational and wet-lab techniques. My passion lies in GPCRs and drug development for these remarkable receptors, making Kolb lab the ideal environment for my scientific pursuits.

List of publications:

(1) Bresinsky M, Shahraki A, Kolb P, Pockes S, Schihada H. Development of Fluorescent AF64394 Analogues Enables Real-Time Binding Studies for the Orphan Class A GPCR GPR3. J. Med. Chem. (2023) doi: 10.1021/acs.jmedchem.3c01707.

(2) Shahraki A, Selent J, Kolb P. On the construction of LIECE models for the serotonin receptor 5-HT2AR. J. Comput. Aided. Mol. Des. (2023) 1:11. doi: 10.1007/s10822-023-00507-3.

(3) Durdagi S, Orhan MD, Aksoydan B, Calis S, Dogan B, Sahin K, Shahraki A, Iyison NB, Avsar T. Screening of clinically approved and investigation drugs as potential inhibitors of SARSCoV2: A combined in silico and in vitro study. Mol. Inform. (2022) 41:2100062. Mol. Inform. doi: 10.1002/minf.202100062.

(4) Birgül N, Shahraki A, Kahveci K, Düzgün MB, Gün G. Are insect GPCRs ideal nextgeneration pesticides: opportunities and challenges. FEBS J. (2021) 288:272. doi: 10.1111/febs.15708.

(5) Shahraki A, Isbilir A, Dogan B, Lohse MJ, Durdagi S, Birgul-Iyison N. Structural and functional characterization of allatostatin receptor type-C of thaumetopoea pityocampa, a potential target for next-generation pest control agents. J. Chem. Inf. Model. (2021) 61:715. doi: 10.1021/acs.jcim.0c00985.

(6) Shahraki A, Yu Y, Gul ZM, Liang C, Iyison NB. Whole genome sequencing of Thaumetopoea pityocampa revealed putative pesticide targets. Genomics. (2020) 112:4203. doi: 10.1016/j.ygeno.2020.07.017. [Open Access]

(7) Iyison NB, Sinmaz MG, Sahbaz BD, Shahraki A, Aksoydan B, Durdagi S. In silico characterization of adipokinetic hormone receptor and screening for pesticide candidates against stick insect, Carausius morosus. J. Mol. Graph. Model. (2020) 101:107720. doi: 10.1016/j.jmgm.2020.107720.

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