Main Content

Research profile

The common research goal of the working groups is the development of new therapeutics in the field of bacterially caused infectious diseases. The expertise and methodological approaches include:

  • the development of new efficient synthesis methods of molecular libraries, which are provided as test substances for drug screening;
  • methods for ligand "fishing" from complex natural substance libraries;
  • organic chemical syntheses of chemotherapeutic agents against pathogenic bacteria and fungi;
  • the development of small ligands that inhibit or modulate protein function by combining protein crystallography, protein/ligand functional studies, molecular modelling and structure-based design and chemical synthesis of ligands;
  • Evaluation of natural ribozymes, RNA/protein complexes and protein enzymes of RNA metabolism as drug targets as well as the application and further development of RNA technologies (antisense, aptamers, RNA interference);
  • Physicochemical characterisation of macromolecule/ligand interactions and development of biosensory methods.