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1) Interactions of filoviruses with the unfolded protein response

Antagonistic effects of the MARV proteins GP and VP30 balance the IRE1-dependent UPR

In contrast, we found that EBOV infection leads to activation of the IRE1-dependent UPR. In this context, we would like to examine the molecular basis of this activation and its consequences in more detail. We are also interested in the relevance of the PERK-dependent UPR signaling pathway for the replication of both filoviruses. In our investigations, we use so-called virus-like particle assays under BSL1/2 conditions, with which we can mimic various aspects of viral infection. In order to be able to analyze the influence of specific inhibitors on the viruses, we use wild-type viruses under BSL4 conditions.

See also: pubmed.ncbi.nlm.nih.gov/?term=kraehling+V+UPR