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Prof. Hauke Hillen, University Medical Centre Göttingen: Structural basis of organellar and viral RNA biogenesis

Speaker Series. Abstract: RNA biogenesis in eukaryotic cells is not confined to the nucleus, but also takes place in other parts of the cell. For example, mitochondria and chloroplasts contain organellar genomes that are expressed by specialized machineries, and many RNA viruses replicate and transcribe their genomes in the cytoplasm. However, the molecular mechanisms of these gene expression systems remain relatively poorly understood. In our group, we use a combination of structural biology and biochemical as well as cellular methods to study organellar and viral gene expression, with a particular focus on RNA biogenesis and maturation. In my talk, I will provide an overview of our research and highlight recent advances in our understanding of mitochondrial, chloroplast and viral RNA biogenesis.

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