ORGANOMETALLICS FOR LIFE SCIENCES AND ASYMMETRIC CATALYSIS
Our research group is exploring organometallics as tools in chemical biology, lead structures for the development of future medicines, and scaffolds for the design of highly efficient asymmetric catalysts. Key focus of the Meggers lab is to exploit the unique structural opportunities provided by chemically inert metal complexes, in particular octahedral coordination geometries (up to 30 stereoisomers possible!), and apply them to difficult problems of biomolecular recognition and asymmetric catalysis.
LOEWE Research Cluster "SynChemBio": Link to ProLOEWE
- J. Am. Chem. Soc. 2014, 2990-2993. Selected as "ACS Editors' Choice". Sought-after realization of a substitutionally labile (reactive) yet configurationally stable chiral-only-at-metal high performance asymmetric catalyst:
It is organometallic: First inhibitor for human repair enzyme 7,8-dihydro-8-oxoguanosine triphosphatase: Angew. Chem. Int. Ed. 2014, 53, 305-309.
- Highly efficient asymmetric catalyst relying exclusively on
octahedral metal-centered chirality! J. Am. Chem. Soc.
2013, 135, 10598-10601. Featured in JACS
- Asymmetric construction of all-carbon quaternary stereocenter: Angew.
Chem. Int. Ed. 2013, 52, 14021-14025.
- Gold standard for the design of structurally sophisticated metal-based enzyme inhibitors: J. Am. Chem. Soc. 2011, 133, 5976-5986.
- First example of catalytic asymmetric coordination chemistry!
Featured in Nature Chemistry.
Link to article.
Link to cover picture.
Atomic resolution structure of a GNA duplex containing solely Watson–Crick hydrogen bonded base pairs solved in collaboration with Prof. Dr. L.-O. Essen: Helical twist due to alternating syn & anti conformations of the vicinal CO bonds: Chem. Commun.2010, 46, 1094-1096.
Chiral auxiliaries as emerging tools for the asymmetric synthesis of octahedral metal complexes: Chem. Eur. J. 2010, 16, 752-758 (minireview).
- First iridium complex as kinase inhibitor: Angew. Chem. Int. Ed. 2010, 49, 3839-3842.
Asymmetric coordination chemistry! First example of asymmetric synthesis of enantiopure ruthenium complex with the help of a chiral auxiliary: J. Am. Chem. Soc. 2009, 131, 9602-9603.
Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein
Strasse, D-35032 Marburg
Phone: ++49 6421 282 1534 Fax.: ++49 6421 282 2189 firstname.lastname@example.org