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Meggers Group Publications

Complete list of publications (PDF)

2021

Catalytic Enantioselective Oxidative Homocoupling of 2-Acyl Imidazoles: N. Demirel, J. Qin. S. I. Ivlev, E. Meggers, Adv. Synth. Catal. 2021, Early View.

Enantioselective α-Fluorination and α-Chlorination of N-Acyl Pyrazoles Catalyzed by Non-C2-Symmetric Chiral-at-Rhodium Catalyst: Y. Grell, X. Xie, S. I. Ivlev, E. Meggers, ACS Catal. 2021, 11, 11396-11406.

Catalytic α-Deracemization of Ketones Enabled by Photoredox Deprotonation and Enantioselective Protonation: C. Zhang, A. Z. Gao, X. Nie, C.-X. Ye, S. I. Ivlev, S. Chen, E. Meggers, J. Am. Chem. Soc. 2021, 143, 13393-13400.

Understanding the mechanism of direct visible-light-activated [2 + 2] cycloadditions mediated by Rh and Ir photocatalysts: combined computational and spectroscopic studies: H. Jung, M. Hong, M. Marchini, M. Villa, P. S. Steinlandt, X. Huang, M. Hemming, E. Meggers, P. Ceroni, J. Park, M.-H. Baik, Chem. Sci. 2021, 12, 9673-9681.

Stereogenic-at-Iron Catalysts with a Chiral Tripodal Pentadentate Ligand: P. S. Steinlandt, X. Xie, S. Ivlev, E. Meggers, ACS Catal. 2021, 11, 7467-7476.

Chiral-at-Iron Catalyst for Highly Enantioselective and Diastereoselective Hetero-Diels-Alder Reaction: Y. Hong, T. Cui, S. Ivlev, E. Meggers, Chem. Eur. J. 2021, 8557-8563.

Chiral-at-Ruthenium Catalysts with Mixed Normal and Abnormal N-Heterocyclic Carbene Ligands: E. Winterling, S. Ivlev, E. Meggers, Organometallics 2021, 40, 1148-1155.

Bis-Cyclometalated Indazole and Benzimidazole Chiral-at-Iridium Complexes. Synthesis and Asymmetric Catalysis: S. Brunen, Y. Grell, P. S. Steinlandt, K. Harms, E. Meggers, Molecules 2021, 26, 1822.

Efficient Amination of Activated and Non-Activated C(sp3)-H Bonds with Simple Iron-Phenanthroline Catalyst: L. Jarrige, Z. Zhou, M. Hemming, E. Meggers, Angew. Chem. Int. Ed. 2021, 60, 6314-6319.

Catalytic enantioselective synthesis of β-amino alcohols by nitrene insertion: Z. Zhou, Y. Tan, X. Shen, S. Ivlev, E. Meggers, Sci. China Chem. 2021, 64, 452-458.

Ruthenium Pybox-Catalyzed Enantioselective Intramolecular C–H Amination of Sulfamoyl Azides en Route to Chiral Vicinal Diamines: X. Nie, Z. Yan, S. Ivlev, E. Meggers, J. Org. Chem. 2021, 86, 750-761.

2020

Intermolecular C(sp3)-H Bond Oxygenation by Transition-Metal Acylnitrenoids: Y. Tan, S. Chen, Z. Zhou, Y. Hong, S. Ivlev, K. N. Houk, E. Meggers, Angew. Chem. Int. Ed. 2020, 132, 21890-21894.

Asymmetric Ring-Closing Aminooxygenation of Alkenes en Route to 2-Amino-1,3-Diols with Vicinal Stereocenters: Y. Tan, F. Han, M. Hemming, J. Wang, K. Harms, X. Xie, E. Meggers, Org. Lett. 2020, 22, 6653-6656.

Asymmetric Catalysis with a Chiral-at-Osmium Complex. G. Wang, Z. Zhou, X. Shen, E. Meggers, Chem. Commun. 2020, 56, 7714-7717 ("HOT Article").

Enantioselective Ring-Closing C-H Amination of Urea Derivatives: Z. Zhou, Y. Tan, T. Yamahira, S. Ivlev, X. Xie, R. Riedel, M. Hemming, M. Kimura, E. Meggers, Chem 2020, 6, 2024-2034 (highlighted: N. P. van Leest, K. M. van Vliet, B. de Bruin, Chem 2020, 6, 1851-1853).

Atroposelective Synthesis of Axially Chiral N-Arylpyrroles by Chiral-at-Rhodium Catalysis: C.-X. Ye, S. Shen, F. Han, X. Xie, S. Ivlev, K. N. Houk, E. Meggers, Angew. Chem. Int. Ed. 2020, 59, 13552-13556.

Complementing Pyridine-2,6-bis(oxazoline) with Cyclometalated N-Heterocyclic Carbene for Asymmetric Ruthenium Catalysis: L. Li, F. Han, X. Nie, Y. Hong, S. Ivlev, E. Meggers, Angew. Chem. Int. Ed. 2020, 59, 12392-12395.

Ruthenacarboran-Phenanthroline Derivatives as Potential Metallodrugs: M. Kellert, I. Sárosi, R. Rajaratnam, E. Meggers, P. Lönnecke, E. Hey-Hawkins, Molecules 2020, 25, 2322.

Directed Evolution of an Fe(II)-Dependent Halogenase for Asymmetric C(sp3)-H Chlorination: S. Duewel, L. Schmermund, T. Faber, K. Harms, V. Srinivasan, E. Meggers, S. Hoebenreich, ACS Catal. 2020, 10, 1272-1277.

2019

Non-C2-Symmetric Chiral-at-Ruthenium Catalyst for Highly Efficient Enantioselective Intramolecular C(sp3)-H Amidation: Z. Zhou, S. Chen, Y. Hong, E. Winterling, Y. Tan, M. Hemming, K. Harms, K. N. Houk, E. Meggers, J. Am. Chem. Soc. 2019, 141, 19048-19057.

Asymmetric Synthesis of 1,4-Dicarbonyl Compounds from Aldehydes via the Marriage of Hydrogen Atom Transfer Photocatalysis with Chiral Lewis Acid Catalysis: Y. Kuang, K. Wang, X. Shi, X. Huang, E. Meggers, J. Wu, Angew. Chem. Int. Ed. 2019, 58, 16859-16863.

Bis-Cyclometalated Indazole Chiral-at-Rhodium Catalyst for Asymmetric Photoredox Cyanoalkylation: P. S. Steinlandt, W. Zuo, K. Harms, E. Meggers, Chem. Eur. J. 2019, 25, 15333-15340 ("Hot Paper").

Enantioconvergent Photoredox Radical−Radical Coupling Catalyzed by a Chiral-at-Rhodium Complex: Z. Zhou, X. Nie, K. Harms, R. Riedel, L. Zhang, E. Meggers, Sci. China Chem. 2019, 62, 1512-1518.

Chiral-at-Rhodium Catalyst Containing Two Different Cyclometalating Ligands: Y. Grell, Y. Hong, X. Huang, T. Mochizuki, X. Xie, K. Harms, E. Meggers, Organometallics 2019, 38, 3948-3954.

Chiral Bis(oxazoline) Ligands as C2-Symmetric Chiral Auxiliaries for the Synthesis of Enantiomerically Pure Bis-Cyclometalated Rhodium(III) Complexes: Y. Grell, N. Demirel, K. Harms, E. Meggers, Organometallics 2019, 38, 3852-3859.

Asymmetric Photocatalysis by Intramolecular Hydrogen-Atom Transfer in Photoexcited Catalyst–Substrate Complex: C. Zhang, S. Chen, C.-X. Ye, K. Harms, L. Zhang, K. N. Houk, E. Meggers, Angew. Chem. Int. Ed. 2019, 58, 14462-14466.

Chiral-at-Iron Catalyst: Expanding the Chemical Space for Asymmetric Earth-Abundant Metal Catalysis: Y. Hong, L. Jarrige, K. Harms, E. Meggers, J. Am. Chem. Soc. 2019, 141, 4569-4572.

Enantioselective intramolecular C-H amination of aliphatic azides by dual ruthenium and phosphine catalysis: J. Qin, Z. Zhou, T. Cui, M. Hemming, E. Meggers, Chem. Sci. 2019, 10, 3202-3207.

Electricity-driven asymmetric Lewis acid catalysis: X. Huang, Q. Zhang, J. Lin, K. Harms, E. Meggers, Nat. Catal. 2019, 2, 34-40.

Catalytic enantioselective intramolecular C(sp3)-H amination of 2-azidoacetamides: Z. Zhou, S. Chen, J. Qin, X. Nie, X. Zheng, K. Harms, R. Riedel, K. N. Houk, E. Meggers, Angew. Chem. Int. Ed. 2019, 58, 1088-1093.

Kinetic resolution of epoxides with CO2 catalyzed by a chiral-at-iridium complex: J. Qin, V. A. Larionov, K. Harms, E. Meggers, ChemSusChem 2019, 12, 320-325.

Chiral-at-ruthenium catalyst with sterically demanding furo[3,2-b]pyridine ligands: T. Cui, J. Qin, K. Harms, E. Meggers, Eur. J. Inorg. Chem. 2019, 195-198 ("Very Important Paper").

2018

Visible-light-activated catalytic enantioselective β-alkylation of α,β-unsaturated 2-acyl imidazoles using Hantzsch esters as radical reservoirs: F. F. de Assis, X. Huang, M. Akiyama, R. A. Pilli, E. Meggers, J. Org. Chem. 2018, 83, 10922-10932.

A chiral-at-metal iridium catalyst with two simple but sterically demanding cyclometalated N-heterocyclic carbene ligands: Y. Tan, K. Harms, E. Meggers, Eur. J. Inorg. Chem. 2018, 2500-2504.

Synthesis of β-substituted gamma-aminobutyric acid derivatives via enantioselective photoredox catalysis: J. Ma, J. Lin, L. Zhao, K. Harms, M. Marsch, X. Xie, E. Meggers, Angew. Chem. Int. Ed. 2018, 57, 11193-11197.

Catalytic asymmetric dearomatization by visible-light-activated [2+2] photocycloaddition: N. Hu, H. Jung, Y. Zheng, J. Lee, L. Zhang, Z. Ullah, X. Xie, K. Harms, M.-H. Baik, E. Meggers, Angew. Chem. Int. Ed. 2018, 57, 6242-6246 (highlighted in Science Bulletin 2018, 63, 809-811).

Arylketone π-conjugation controls enantioselectivity in asymmetric alkynylations catalyzed by centrochiral ruthenium complexes: S. Chen, Y. Zheng, T. Cui, E. Meggers, K. N. Houk, J. Am. Chem. Soc. 2018, 140, 5146-5152.

Asymmetric Nazarov cyclizations catalyzed by chiral-at-metal complexes: T. Mietke, T. Cruchter, V. A. Larionov, T. Faber, K. Harms, E. Meggers, Adv. Synth. Catal. 2018, 360, 2093-2100 ("VIP").

Asymmetric [3+2] photocycloadditions of cyclopropanes with alkenes or alkynes via visible light excitation of catalyst-bound substrates: X. Huang, J. Lin, T. Shen, K. Harms, M. Marchini, P. Ceroni, E. Meggers, Angew. Chem. Int. Ed. 2018, 57, 5454-5458 ("Hot Paper").

Preparation of chiral-at-metal catalysts and their use in asymmetric photoredox chemistry: J. Ma, X. Zhang, X. Huang, S. Luo, E. Meggers, Nat. Protocols 2018, 13, 605-632.

Catalytic enantioselective synthesis of a key propargylic alcohol intermediates of the anti-HIV drug efavirenz: Y. Zheng, L. Zhang, E. Meggers, Org. Process Res. Dev. 2018, 22, 103-107 (Synfacts 2018, 0343).

One-pot sequential photoredox and asymmetric transfer hydrogenation with a single catalyst: X. Zhang, J. Qin, X. Huang, E. Meggers, Eur. J. Org. Chem. 2018, 571-577.

Sequential asymmetric hydrogenation and photoredox chemistry with a single catalyst: X. Zhang, J. Qin, X. Huang, E. Meggers, Org. Chem. Front. 2018, 5, 166-170.

Catalytic asymmetric synthesis of fluoroalkyl-containing compounds by three-component photoredox chemistry: J. Ma, X. Xie, E. Meggers, Chem. Eur. J. 2018, 24, 259-265.

2017

Catalytic asymmetric synthesis of a nitrogen heterocycle through stereocontrolled direct photoreaction from electronically excited state: X. Huang, X. Li, X. Xie, R. Riedel, E. Meggers, Nat. Commun. 2017, 8, 2245.

Visible-Light-Activated Asymmetric β-C–H Functionalization of Acceptor-Substituted Ketones with 1,2-Dicarbonyl Compounds: J. Ma, A. R. Rosales, X. Huang, K. Harms, R. Riedel, O. Wiest, E. Meggers, J. Am. Chem. Soc. 2017, 139, 17245-17248 (Synfacts 2018, 0157).

Origins of Enantioselectivity in Asymmetric Radical Additions to Octahedral Chiral-at-Rhodium Enolates: A Computational Study: S. Chen, X. Huang, E. Meggers, K. N. Houk, J. Am. Chem. Soc. 2017, 139, 17902-17907.

Combining the Catalytic Enantioselective Reaction of Visible-Light-Generated Radicals with a By-Product Utilization System: X. Huang, S. Luo, O. Burghaus, R. D. Webster, K. Harms, E. Meggers, Chem. Sci. 2017, 8, 7126-7131.

Suzuki Cross-Coupling for Post-Complexation Derivatization of Non-Racemic Bis-Cyclometalated Iridium(III) Complexes: T. Mietke, T. Cruchter, E. Winterling, M. Tripp, K. Harms, E. Meggers, Chem. Eur. J. 2017, 23, 12363-12371.

Asymmetric Alkylation of Remote C(sp3)-H Bonds by Combining Proton-Coupled Electron Transfer with Chiral Lewis Acid Catalysis: W. Yuan, Z. Zhou, L. Gong, E. Meggers, Chem. Commun. 2017, 53, 8964-8967.

Enantioselective Alkynylation of Aromatic Aldehydes Catalyzed by a Sterically Highly Demanding Chiral-at-Rhodium Lewis Acid: S. Luo, X. Zhang, Y. Zheng, K. Harms, L. Zhang, E. Meggers, J. Org. Chem. 2017, 82, 8995-9005.

An N-Heterocyclic Carbene Iridium Catalyst with Metal-Centered Chirality for Enantioselective Transfer Hydrogenation of Imines: Y. Li, M. Lei, W. Yuan, E. Meggers, L. Gong, Chem. Commun. 2017, 53, 8089-8092.

Direct Visible-Light-Excited Asymmetric Lewis Acid Catalysis of Intermolecular [2+2] Photocycloadditions: X. Huang, T. R. Quinn, K. Harms, R. D. Webster, L. Zhang, O. Wiest, E. Meggers, J. Am. Chem. Soc. 2017, 139, 9120-9123 (highlighted in Science 2017, 357, 265; Synfacts 2017, 1061).

Asymmetric Nucleophilic Catalysis with an Octahedral Chiral-at-Metal Iridium(III) Complex: T. Cruchter, M. G. Medvedev, X. Shen, T. Mietke, K. Harms, M. Marsch, E. Meggers, ACS Catal. 2017, 7, 5151-5162 (Synfacts 2017, 0945).

Enantioselective Catalytic β-Amination Through Proton-Coupled Electron Transfer Followed by Stereocontrolled Radical-Radical Coupling: Z. Zhou, Y. Li, B.-W. Han, L. Gong, E. Meggers, Chem. Sci. 2017, 8, 5757-5763.

Understanding Rate Acceleration and Stereoinduction of an Asymmetric Giese Reaction Mediated by a Chiral Rhodium Catalyst: B. Tutkowski, E. Meggers, O. Wiest, J. Am. Chem. Soc. 2017, 139, 8062-8065.

Asymmetric Construction of 3,3-Disubstituted Oxindoles Bearing Vicinal Quaternary–Tertiary Carbon Stereocenters Catalyzed by a Chiral-at-Rhodium Complex: H. Lin, Z. Zhou, J. Cai, B. Han, L. Gong, E. Meggers, J. Org. Chem. 2017, 82, 6457-6467 (Synfacts 2017, 0946).

Octahedral Ruthenium Complex with Exclusive Metal-Centered Chirality for Highly Effective Asymmetric Catalysis: Y. Zheng, Y. Tan, K. Harms, M. Marsch, R. Riedel, L. Zhang, E. Meggers, J. Am. Chem. Soc. 2017, 139, 4322-4325 (Synfacts 2017, 0625).

Polymer-Supported Chiral-at-Metal Lewis Acid Catalysts: V. A. Larionov, T. Cruchter, T. Mietke, and E. Meggers, Organometallics 2017, 36, 1457-1460.

Chemical Activation in Blood Serum and Human Cell Culture: Improved Ruthenium Complex for Catalytic Uncaging of Alloc-Protected Amines: T. Völker, E. Meggers, ChemBioChem 2017, 18, 1083-1086.

Three-Component Asymmetric Mannich Reaction Catalyzed by a Lewis Acid with Rhodium-Centered Chirality: L. Feng, X. Dai, E. Meggers, L. Gong, Chem. Asian J. 2017, 12, 963-967.

Enantioselective 2-Alkylation of 3-Substituted Indoles with Dual Chiral Lewis Acid/Hydrogen-Bond-Mediated Catalyst: Z. Zhou, Y. Li, L. Gong, E. Meggers, Org. Lett. 2017, 19, 222-225.

Stereogenic-Only-at-Metal Asymmetric Catalysts: L. Zhang and E. Meggers, Chem. Asian J. 2017, 12, 2335-2342 (focus review).

Exploiting Octahedral Stereochemistry: From Enzyme Inhibition through to Asymmetric Photoredox Catalysis: E. Meggers, Angew. Chem. Int. Ed. 2017, 56, 5668-5675 (essay).

Steering Asymmetric Catalysis Exclusively with Octahedral Metal-Centered Chirality: L. Zhang and E. Meggers, Acc. Chem. Res. 2017, 50, 320-330 (account).

2016

Restricted Conformation of a Hydrogen Bond Mediated Catalyst Enables the Highly Efficient Enantioselective Construction of an All-Carbon Quaternary Stereocenter: W. Xu, X. Shen, Q. Ma, L. Gong, E. Meggers, ACS Catal. 2016, 6, 7641-7646.

Catalytic Asymmetric C(sp3)-H Functionalization under Photoredox Conditions by Radical Translocation and Stereocontrolled Alkene Addition: C. Wang, K. Harms, E. Meggers, Angew. Chem. Int. Ed. 2016, 55, 13495-13498.

Asymmetric Catalysis with Organic Azides and Diazo Compounds Initiated by Photoinduced Electron Transfer: X. Huang, R. D. Webster, K. Harms, E. Meggers, J. Am. Chem. Soc. 2016, 138, 12636-12642.

Progress in the Synthesis and Bioactivity of Hexacoordinate Silicon(IV) Complexes. J. Henker, J. Wirmer-Bartoschek, L. E. Bendel, Y. Xiang, C. Fu, K. Harms, H. Schwalbe, E. Meggers, Eur. J. Inorg. Chem. 2016, 5161-5170.

Enantioselective β-Alkylation of Pyrroles with the Formation of an All-Carbon-Quaternary Stereocenter: Q. Ma, L. Gong, E. Meggers, Org. Chem. Front. 2016, 3, 1319-1325.

Metal-​Templated Asymmetric Catalysis: (Z)​-​1-​Bromo-​1-​Nitrostyrenes as Versatile Substrates for Friedel-​Crafts Alkylation of Indoles: K. Huang, Q. Ma, X. Shen, L. Gong, E. Meggers, Asian J. Org. Chem. 2016, 5, 1198-1203.

PIM kinases as Therapeutic Targets Against Advanced Melanoma: B. Shannan, A. Watters, Q. Chen, S. Mollin, M. Dörr, E. Meggers, X. Xu, P. A. Gimotty, M. Perego, L. Li, J. Benci, C. Krepler, P. Brafford, J. Zhang, Z. Wei, G. Zhang, Q. Liu, X. Yin, K. L. Nathanson, M. Herlyn, A. Vultur, Oncotarget 2016, 7, 54897-54912.

Toward Anticancer Gold-based Compounds Targeting PARP-1. A New Case Study: A. Citta, V. Scalcon, P. Göbel, B. Bertrand, M. Wenzel, A. Folda, M. P. Rigobello, E. Meggers, A. Casini, RSC Adv. 2016, 6, 79147-79152.

Enantioselective Rhodium/ruthenium Photoredox Catalysis en Route to Chiral 1,2-Aminoalcohols: J. Ma, K. Harms, E. Meggers, Chem. Commun. 2016, 52, 10183–10186.

Enantioselective Alkynylation of 2-Trifluoroacetyl Imidazoles Catalyzed by Bis-Cyclometalated Rhodium(III) Complexes Containing Pinene-Derived Ligands: Y. Zheng, K. Harms, L. Zhang, E. Meggers, Chem. Eur. J. 2016, 22, 11977-11981 (Synfacts 2016, 1156).

Metal-Templated Design: Enantioselective Hydrogen-Bond-Driven Catalysis Requiring Only Parts-per-Million Catalyst Loading: W. Xu, M. Arieno, H. Löw, K. Huang, X. Xie, T. Cruchter, Q. Ma, J. Xi, B. Huang, O. Wiest, L. Gong, E. Meggers, J. Am. Chem. Soc. 2016, 138, 8774-8780.

Proline and α-Methylproline as Chiral Auxiliaries for the Synthesis of Enantiopure Bis-Cyclometalated Iridium(III) Complexes: M. Helms, C. Wang, B. Orth, K. Harms, E. Meggers, Eur. J. Inorg. Chem. 2016, 2896-2901.

Rhodium Catalyst Superior over Iridium Congeners for Enantioselective Radical Amination Activated by Visible Light: X. Shen, K. Harms, M. Marsch, E. Meggers, Chem. Eur. J. 2016, 22, 9102-9105 (Synfacts 2016, 0941).

Expanding the Family of Bis-Cyclometalated Chiral-at-Metal Rhodium(III) Catalysts with a Benzothiazole Derivative: J. Ma, X. Shen, K. Harms, E. Meggers, Dalton Trans. 2016, 45, 8320-8323.

Asymmetric Dual Catalysis via Fragmentation of a Single Rhodium Precursor Complex. L. Song, L. Gong, E. Meggers, Chem. Commun. 2016, 52, 7699-7702 (Synfacts 2016, 0809).

Catalytic, Enantioselective Addition of Alkyl Radicals to Alkenes via Visible-Light-Activated Photoredox Catalysis with a Chiral Rhodium Complex: H. Huo, K. Harms, E. Meggers, J. Am. Chem. Soc. 2016, 138, 6936-6939.

Chiral-at-Metal Iridium Complex for Efficient Enantioselective Transfer Hydrogenation of Ketones: C. Tian, L. Gong, E. Meggers, Chem. Commun. 2016, 52, 4207-4210 (Synfacts 2016, 0495).

Tuning the Basicity of a Metal-Templated Brønsted Base to Facilitate the Enantioselective Sulfa-Michael Addition of Aliphatic Thiols to α,β-Unsaturated N-Acylpyrazoles: X. Ding, C. Tian, Y. Hu, L. Gong, E. Meggers, Eur. J. Org. Chem. 2016, 887-890.

Visible-Light-Activated Enantioselective Perfluoroalkylation with a Chiral Iridium Photoredox Catalyst: H. Huo, X. Huang, X. Shen, K. Harms, E. Meggers, Synlett 2016, 27, 749-753.

Asymmetric Radical-Radical Cross-Coupling through Visible-Light Activated Iridium Catalysis: C. Wang, J. Qin, X. Shen, R. Riedel, K. Harms, E. Meggers, Angew. Chem. Int. Ed. 2016, 55, 685-688 (highlight article in Angew. Chem. Int. Ed. 2016, 55, 2304-2306, Synfacts 2016, 0156).

Cooperative Photoredox and Asymmetric Catalysis: H. Huo, E. Meggers, Chimia 2016, 70, 186-190 (review).

2015

Bioorthogonal Enzymatic Activation of Caged Compounds: C. Ritter, N. Nett, C. G. Acevedo-Rocha, R. Lonsdale, K. Kräling, F. Dempwolff, S. Hoebenreich, P. L. Graumann, M. T. Reetz, E. Meggers, Angew. Chem. Int. Ed. 2015, 54, 13440-13443.

Aerobic Asymmetric Dehydrogenative Cross-Coupling between two Csp3-H Groups Catalyzed by a Chiral-at-Metal Rhodium Complex: Y. Tan, W. Yuan, L. Gong, E. Meggers, Angew. Chem. Int. Ed. 2015, 54, 13045-13048 (Synfacts 2016, 0155).

Enantioselective, Catalytic Trichloromethylation through Visible-Light-Activated Photoredox Catalysis with a Chiral Iridium Complex: H. Huo, C. Wang, K. Harms, E. Meggers, J. Am. Chem. Soc. 2015, 137, 9551-9556 (Synfacts 2015, 1071 and Synform 2015, A172-A174).

Asymmetric Synthesis of Hydrocarbazoles Catalyzed by an Octahedral Chiral-at-Metal Lewis Acid: Y. Huang, L. Song, L. Gong, E. Meggers, Chem. Asian J. 2015, 10, 2738-2743 (Synfacts 2016, 0157).

Asymmetric Friedel-​Crafts Alkylation of Indoles with 2-​Nitro-​3-​Arylacrylates Catalyzed by a Metal-​Templated Hydrogen Bonding Catalyst: J. Liu, L. Gong, E. Meggers, Tetrahedron Lett. 2015, 46, 4653-4656.

Correlation between the Stereochemistry and Bioactivity in Octahedral Rhodium Prolinato Complexes: R. Rajaratnam, E. K. Martin, M. Dörr, K. Harms, A. Casini, E. Meggers, Inorg. Chem. 2015, 54, 8111-8120.

Asymmetric Aza-Henry Reaction to Provide Oxindoles with Quaternary Carbon Stereocenter Catalyzed by a Metal-Templated Chiral Brønsted Base, Y. Hu, Z. Zhou, L. Gong, E. Meggers, Org. Chem. Front. 2015, 2, 968-972.

Octahedral Chiral-at-Metal Iridium Catalysts: Versatile Chiral Lewis Acids for Asymmetric Conjugate Additions, X. Shen, H. Huo, C. Wang, B. Zhang, K. Harms, E. Meggers, Chem. Eur. J. 2015, 21, 9720-9726.

Octahedral Rhodium(III) Complexes as Kinase Inhibitors: Control of Relative Stereochemistry with Acyclic Tridentate Ligands: S. Mollin, R. Riedel, K. Harms, E. Meggers, J. Inorg. Biochem. 2015, 148, 11-21.

Merger of Visible Light Induced Oxidation and Enantioselective Alkylation with Chiral Iridium Catalyst: C. Wang, Y. Zheng, H. Huo, P. Röse, L. Zhang, K. Harms, G. Hilt, E. Meggers, Chem. Eur. J. 2015, 21, 7355-7359.

Enantioselective Sulfa-Michael Addition to α,β-Unsaturated g-Oxoesters Catalyzed by a Metal-Templated Chiral Brønsted Base: X. Ding, H. Lin, L. Gong, E. Meggers, Asian J. Org. Chem. 2015, 4, 434-437.

Probing the Chiral Recognition of Enzyme Active Sites with Octahedral Iridium(III) Propeller Complexes: P. Göbel, F. Ritterbusch, M. Helms, M. Bischof, K. Harms, M. Jung, E. Meggers, Eur. J. Inorg. Chem. 2015, 1654-1659.

Asymmetric Lewis Acid Catalysis Directed by Octahedral Rhodium Centrochirality: C. Wang, L.-A. Chen, H. Huo, X. Shen, K. Harms, L. Gong, E. Meggers, Chem. Sci. 2015, 6, 1094-1100.

Development of Organometallic S6K1 Inhibitors: J. Qin, R. Rajaratnam, L. Feng, J. Salami, J. S. Barber-Rotenberg, J. Domsic, P. Reyes-Uribe, H. Liu, W. Dang, S. L. Berger, J. Villanueva, E. Meggers, R. Marmorstein, J. Med. Chem. 2015, 58, 305-314.

Asymmetric Catalysis Activated by Visible Light: E. Meggers, Chem. Commun. 2015, 51, 3290-3301 (feature).

Transition-Metal-Mediated Uncaging in Living Human Cells – An Emerging Alternative to Photolabile Protecting Groups: T. Völker, E. Meggers, Curr. Opin. Chem. Biol. 2015, 25, 48-54 (review).

2014

Visible Light Activated Asymmetric Photoredox Transition Metal Catalysis: H. Huo, X. Shen, C. Wang, L. Zhang, P. Röse, L.-A. Chen, K. Harms, M. Marsch, G. Hilt, E. Meggers, Nature 2014, 515, 100-103 (highlighted in Nature 2014, 515, 45-46; Synfacts 2015, 0153; Chem. Eng. News 2014, Nov. 10, p. 9; Nachrichten aus der Chemie 2015, No. 2, p. 108 and No. 3, p. 283).

Progress Towards Bioorthogonal Catalysis with Organometallics: T. Völker, F. Dempwolff, P. L. Graumann, E. Meggers, Angew. Chem. Int. Ed. 2014, 53, 10536-10540.

Metal-Templated Chiral Brønsted Base Organocatalysis: J. Ma, X. Ding, Y. Hu, Y. Huang, L. Gong, E. Meggers, Nat. Commun. 2014, 5, 5531.

Asymmetric Catalysis with Substitutionally Labile yet Stereochemically Stable Chiral-at-Metal Iridium(III) Complex: H. Huo, C. Fu, K. Harms, E. Meggers, J. Am. Chem. Soc. 2014, 136, 2990-2993 ("ACS Editors’ Choice", JACS Spotlights; Synfacts 2014, 0487).

Metal-Templated Enantioselective Enamine/H-Bonding Dual Activation Catalysis: H. Huo, C. Fu, C. Wang, K. Harms, E. Meggers, Chem. Commun. 2014, 50, 10409-10411.

Synthesis and Anticancer Activity of Ruthenium Half-Sandwich Complexes Comprising Combined Metal Centrochirality and Planar Chirality: E. K. Martin, N. Pagano, M. E. Sherlock, K. Harms, E. Meggers, Inorg. Chim. Acta 2014, 423, 530-539.

Synthesis and Functionalization of Hexacoordinate (Arenediolato)bis(polypyridyl)silicon(IV) Complexes: T. Breiding, J. Henker, C. Fu, Y. Xiang, S. Glöckner, P. Hofmann, K. Harms, E. Meggers, Eur. J. Inorg. Chem. 2014, 2924-2933.

DNA Mismatch Recognition by a Hexacoordinate Silicon Sandwich Ruthenium Hybrid Complex: C. Fu, K. Harms, L. Zhang, E. Meggers, Organometallics 2014, 33, 3219-3222.

Novel Metal-Coordinated 1,10-Phenanthroline Ligands Functionalized with a Lactam or Imide: H. Yao, L. Zhang, Y. Peng, P. J. Carroll, L. Gong, E. Meggers, Inorg. Chim. Acta 2014, 421, 489-495.

Rhenium Complexes with Red-Light-Induced Anticancer Activity: K. Wähler, A. Ludewig, P. Szabo, K. Harms, E. Meggers, Eur. J. Inorg. Chem. 2014, 807-811.

Organometallic Inhibitor for the Human Repair Enzyme 7,8-Dihydro-8-Oxoguanosine Triphosphatase: M. Streib, K. Kräling, K. Richter, X. Xie, H. Steuber, E. Meggers, Angew. Chem. Int. Ed. 2014, 53, 305-309.

Asymmetric Catalysis Mediated by the Ligand Sphere of Octahedral Chiral-at-Metal Complexes: L. Gong, L.-A. Chen, E. Meggers, Angew. Chem. Int. Ed. 2014, 53, 10868-10874 (review).

Author Profile, Angew. Chem. Int. Ed. 2014, 53, 10280.

Metal Complexes as Structural Templates for Targeting Proteins: M. Dörr, E. Meggers, Curr. Opin. Chem. Biol. 2014, 19, 76-81 (review).

2013

Chiral-at-Metal Octahedral Iridium Catalyst for the Asymmetric Construction of an All-Carbon Quaternary Stereocenter: L.-A. Chen, X. Tang, J. Xi, W. Xu, L. Gong, E. Meggers, Angew. Chem. Int. Ed. 2013, 52, 14021-14025 (Synfacts 2014, 0396).

Reductive Labilization of a Cyclometalating Ligand Applied to Auxiliary-Mediated Asymmetric Coordination Chemistry: M. Kraack, K. Harms, E. Meggers, Organometallics 2013, 32, 5103-5113.

Strain-Promoted Azide-Alkyne Cycloaddition with Ruthenium(II) Azido Complexes: T. Cruchter, K. Harms, E. Meggers, Chem. Eur. J. 2013, 19, 16882-16689.

Continuous Synthesis of Pyridocarbazoles and Initial Photophysical and Bioprobe Characterization: D. T. McQuade, A. G. O'Brien, M. Dörr, R. Rajaratnam, U. Eisold, B. Monnanda, T. Nobuta, H.-G. Löhmannsröben, E. Meggers, P. H. Seeberger, Chem. Sci. 2013, 4, 4067-4070.

Non-ATP-Mimetic Organometallic Protein Kinase Inhibitor: K. Wähler, K. Krähling, H. Steuber, E. Meggers, ChemistryOpen 2013, 2, 180-185.

Chiral Enol Oxazolines and Thiazolines as Auxiliary Ligands for the Asymmetric Synthesis of Ruthenium-Polypyridyl Complexes: B. Huang, L. Wang, L. Gong, E. Meggers, Chem. Asian J. 2013, 8, 2274-2280.

Method for the Preparation of Non-Racemic Bis-Cyclometalated Iridium(III) Complexes: M. Helms, Z. Lin, L. Gong, K. Harms, E. Meggers, Eur. J. Inorg. Chem. 2013, 4164-4172 (cover picture).

Nonfitting Protein-Ligand Interaction Scoring Function Based on First-Principles Theoretical Chemistry Methods: Development and Application to Kinase Inhibitors: L. Rao, I. Y. Zhang, W. Guo, L. Feng, E. Meggers, X. Xu, J. Comput. Chem. 2013, 34, 1636-1646.

Asymmetric Catalysis with Inert Chiral-at-Metal Iridium Complex: L.-A. Chen, W. Xu, B. Huang, J. Ma, L. Wang, J. Xi, K. Harms, L. Gong, E. Meggers, J. Am. Chem. Soc. 2013, 135, 10598-10601 (cover picture, JACS Spotlights, Synfacts 2013, 1079).

Rhenium Complexes with Visible-Light-Induced Anticancer Activity: A. Kastl, S. Dieckmann, K. Wähler, T. Völker, L. Kastl, A. L. Merkel, A. Vultur, B. Shannan, K. Harms, M. Ocker, M. Herlyn, E. Meggers, ChemMedChem 2013, 8, 924-927.

Thioether-Based Anchimeric Assistance for Asymmetric Coordination Chemistry with Ruthenium(II) and Osmium(II): L.-A. Chen, X. Ding, L. Gong, E. Meggers, Dalton Trans. 2013, 42, 5623-5626.

Chiral-Auxiliary-Mediated Asymmetric Synthesis of Ruthenium Polypyridyl Complexes: L. Gong, M. Wenzel, E. Meggers, Acc. Chem. Res. 2013, 46, 2635-2644 (account). 

Metal Complex Catalysis in Living Biological Systems: P. K. Sasmal, C. N. Streu, E. Meggers, Chem. Commun. 2013, 49, 1581-1587 (feature).

2012

GSK3β inhibition Blocks Melanoma Cell/Host Interactions by Downregulating N-Cadherin Expression and Decreasing FAK Phosphorylation: J. K. John, K. H.T. Paraiso, V. W. Rebecca, L. P. Cantini, E. V. Abel, N. Pagano, E. Meggers, R. Mathew, C. Krepler, V. Izumi, B. Fang, J. M. Koomen, J. L. Messina, M. Herlyn, K. S. M. Smalley, J. Investig. Dermatology 2012, 132, 2818-2827.

Cyclometalated Phenylquinoline Rhodium Complexes as Protein Kinase Inhibitors: S. Mollin, S. Blanck, K. Harms, E. Meggers, Inorg. Chim. Acta 2012, 393, 261-268.

Proline as Chiral Auxiliary for the Economical Asymmetric Synthesis of Ruthenium(II) Polypyridyl Complexes: C. Fu, M. Wenzel, E. Treutlein, K. Harms, E. Meggers, Inorg. Chem. 2012, 51, 10004-10011.

Active versus Passive Substituent Participation in the Auxiliary-Mediated Asymmetric Synthesis of an Octahedral Metal Complex: L.-A. Chen, J. Ma, M. A. Celik, H.-L. Yu, Z. Cao, G. Frenking, L. Gong, E. Meggers, Chem. Asian J. 2012, 7, 2523-2526.

Bioactive Cyclometalated Phthalimides: Design, Synthesis and Kinase Inhibition: S. Blanck, Y. Geisselbrecht, K. Kräling, S. Middel, T. Mietke, K. Harms, L.-O. Essen, E. Meggers, Dalton Trans. 2012, 41, 9337-9348.

Hydrolytically Stable Octahedral Silicon Complexes as Bioactive Scaffolds: Application to the Design of DNA Intercalators: Y. Xiang, C. Fu, T. Breiding, P. K. Sasmal, H. Liu, Q. Shen, K. Harms, L. Zhang, E. Meggers, Chem. Commun. 2012, 48, 7173-7133 (cover picture).

Light-Triggered Ruthenium-Catalyzed Allylcarbamate Cleavage in Biological Environments: P. K. Sasmal, S. Carregal-Romero, W. J. Parak, E. Meggers, Organometallics 2012, 31, 5968-5970.

Chiral 2-Mercaptophenyloxazolines as Auxiliaries for Asymmetric Coordination Chemistry: M. Wenzel, E. Meggers, Eur. J. Inorg. Chem. 2012, 3168-3175.

Catalytic Azide Reduction in Biological Environments: P. K. Sasmal, S. Carregal-Romero, C. N. Streu, Z. Lin, K. Namikawa, S. L. Elliott, R. W. Köster, W. J. Parak, E. Meggers, ChemBioChem 2012, 13, 1116-1120.

About the Art of Filling Protein Pockets Efficiently with Octahedral Metal Complexes: S. Blanck, J. Maksimoska, J. Baumeister, K. Harms, R. Marmorstein, E. Meggers, Angew. Chem. Int. Ed. 2012, 51, 5244-5246.

Rhodium(III)-Pyridocarbazole Complexes as Protein Kinase Inhibitors: S. Dieckmann, R. Riedel, K. Harms, E. Meggers, Eur. J. Inorg. Chem. 2012, 813-821.

Dual Anticancer Activity in a Single Compound: Visible Light-Induced Apoptosis by an Antiangiogenic Iridium Complex: A. Kastl, A. Wilbuer, A. L. Merkel, L. Feng, P. Di Fazio, M. Ocker, E. Meggers, Chem. Commun. 2012, 48, 1863-1865 (backside cover picture).

Sixty Years Young: The Diverse Biological Activities of Metal Polypyridyl Complexes Pioneered by Francis P. Dwyer: N. L. Kilah, E. Meggers, Aust. J. Chem. 2012, 65, 1325-1332 (review).

PIM1 Kinase as a Target for Cancer Therapy: A. L. Merkel, E. Meggers, M. Ocker, Expert Opin. Investig. Drugs 2012, 21, 425-436 (review).

2011

N-Sulfinylcarboximidates as a Novel Class of Chiral Bidentate Ligands: Application to Asymmetric Coordination Chemistry: Z. Lin, M. A. Celik, C. Fu, K. Harms, G. Frenking, E. Meggers, Chem. Eur. J. 2011, 17, 12602-12605.

On the Structure and Dynamics of Duplex GNA: A. T. Johnson, M. K. Schlegel, E. Meggers, L.-O. Essen, O. Wiest, J. Org. Chem. 2011, 76, 7964-7974.

P-Donor Ligand Containing Ruthenium Half-Sandwich Complexes as Protein Kinase Inhibitors: C. Streu, L. Feng, P. J. Carroll, J. Maksimoska, R. Marmorstein, E. Meggers, Inorg. Chim. Acta 2011, 377, 34-41.

Organometallic Pyridylnaphthalimide Complexes as Protein Kinase Inhibitors: S. Blanck, T. Cruchter, A. Vultur, R. Riedel, K. Harms, M. Herlyn, E. Meggers, Organometallics 2011, 30, 4598-4606 (cover picture).

Size Does Matter. Sterically Demanding Metallocene-Substituted 3-Methylidene-Oxindoles Exhibit Poor Kinase Inhibitory Action: J. Spencer, J. Amin, P. Coxhead, J. McGeehan, C. J. Richards, G. J. Tizzard, S. J. Coles, J. P. Bingham, J. A. Hartley, L. Feng, E. Meggers, M. Guille, Organometallics 2011, 30, 3177-3181.

Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors: L. Feng, Y. Geisselbrecht, S. Blanck, A. Wilbuer, G. E. Atilla-Gokcumen, P. Filippakopoulos, K. Kräling, M. A. Celik, K. Harms, J. Maksimoska, R. Marmorstein, G. Frenking, S. Knapp, L.-O. Essen, E. Meggers, J. Am. Chem. Soc. 2011, 133, 5976-5986.

2-Diphenylphosphino-2′-Hydroxy-1,1′-Binaphthyl as a Chiral Auxiliary for Asymmetric Coordination Chemistry: L. Gong, C. Müller, M. A. Celik, G. Frenking, E. Meggers, New. J. Chem. 2011, 35, 788-793.

Asymmetric Coordination Chemistry by Chiral-Auxiliary-Mediated Dynamic Resolution under Thermodynamic Control: Z. Lin, L. Gong, M. A. Celik, K. Harms, G. Frenking, E. Meggers, Chem. Asian J. 2011, 6, 474-481.

Structure of Anticancer Ruthenium Half-Sandwich Complex Bound to Glycogen Synthase Kinase 3b: G. E. Atilla-Gokcumen, L. Di Costanzo, E. Meggers, J. Biol. Inorg. Chem. 2011, 16,  45-50.

Asymmetric Synthesis of Octahedral Coordination Complexes: E. Meggers, Eur. J. Inorg. Chem. 2011, 2911-2926 (microreview) (cover picture).

From Conventional to Unusual Enzyme Inhibitor Scaffolds: The Quest for Target Specificity: E. Meggers, Angew. Chem. Int. Ed. 2011, 50, 2442-2448 (minireview).

2010

Isomerization-Induced Asymmetric Coordination Chemistry: From Auxiliary Control to Asymmetric Catalysis: L. Gong, Z. Lin, K. Harms, E. Meggers, Angew. Chem. Int. Ed. 2010, 49, 7955-7957 (cover picture, highlighted in Nat. Chem. 2010, 2, 796).

Iridium Complex with Antiangiogenic Properties: A. Wilbuer, D. H. Vlecken, D. J. Schmitz, K. Kräling, K. Harms, C. P. Bagowski, E. Meggers, Angew. Chem. Int. Ed. 2010, 49, 3839-3842 (inside cover picture, highlighted in Angew. Chem. Int. Ed. 2010, 49, 5226).

Chiral Salicyloxazolines as Auxiliaries for the Asymmetric Synthesis of Ruthenium Polypyridyl Complexes: L. Gong, S. P. Mulcahy, D. Devarajan, K. Harms, G. Frenking, E. Meggers, Inorg. Chem. 2010, 49, 7692-7699.

Atomic Resolution Duplex Structure of the Simplified Nucleic Acid GNA: M. K. Schlegel, L.-O. Essen, E. Meggers, Chem. Commun. 2010, 46, 1094-1096.

Discovery of a Strongly Apoptotic Ruthenium Complex through Combinatorial Coordination Chemistry: S. P. Mulcahy, K. Gründler, C. Frias, L. Wagner, A. Prokop, E. Meggers, Dalton Trans. 2010, 39, 8177-8182.

Unusual Eta2-Allene Osmacycle with Apoptotic Properties: X. He, L. Gong, K. Kräling, K. Gründler, C. Frias, R. D. Webster, E. Meggers, A. Prokop, H. Xia, ChemBioChem 2010, 11, 1607-1613. 

Chiral Auxiliaries as Emerging Tools for the Asymmetric Synthesis of Octahedral Metal Complexes: E. Meggers, Chem. Eur. J. 2010, 16, 752-758 (minireview).

Organometallics as Structural Scaffolds for Enzyme Inhibitor Design: S. P. Mulcahy, E. Meggers, Topics Organomet. Chem. 2010, 32, 141-153 (review).

Synthesis and Properties of the Simplified Nucleic Acid GNA: E. Meggers, L. Zhang, Acc. Chem. Res. 2010, 43, 1092-1102 (account).

2009

Chiral Auxiliary-Mediated Asymmetric Synthesis of Tris-Heteroleptic Ruthenium Polypyridyl Complexes: L. Gong, S. P. Mulcahy, K. Harms, E. Meggers, J. Am. Chem. Soc. 2009, 131, 9602-9603.

From Imide to Lactam Metallo-Pyridocarbazoles: Distinct Scaffolds for the Design of Selective Protein Kinase Inhibitors: N. Pagano, E. Y. Wong, T. Breiding, H. Liu, A. Wilbuer, H. Bregman, Q. Shen, S. L. Diamond, E. Meggers, J. Org. Chem. 2009, 74, 8997-9009.

The Crystal Structure of BRAF in Complex with an Organoruthenium Inhibitor Reveals a Mechanism for Inhibition of an Active Form of BRAF Kinase: P. Xie, C. Streu, J. Qin, H. Bregman, N. Pagano, E. Meggers, R. Marmorstein, Biochemistry 2009, 48, 5187-5198.

Improved Phosphoramidite Building Blocks for the Synthesis of the Simplified Nucleic Acid GNA: M. K. Schlegel, E. Meggers, J. Org. Chem. 2009, 74, 4615-4618.

Toward the Development of a Potent and Selective Organoruthenium Mammalian Sterile 20 Kinase Inhibitor: R. Anand, J. Maksimoska, N. Pagano, E. Y. Wong, P. A. Gimotty, S. L. Diamond, E. Meggers, R. Marmorstein, J. Med. Chem. 2009, 52, 1602-1611. 

Inert Ruthenium Half-Sandwich Complexes with Anticancer Activity: E. Meggers, G. E. Atilla-Gokcumen, K. Gründler, C. Frias, A. Prokop, Dalton. Trans. 2009, 10882-10888.

Strategy for the Stereochemical Assignment of Tris-Heteroleptic Ru(II) Complexes by NMR Spectroscopy: X. Xie, S. P. Mulcahy, E. Meggers, Inorg. Chem. 2009, 48, 1053-1061.

Metal-Mediated Base Pairing within the Simplified Nucleic Acid GNA: M. K. Schlegel, L. Zhang, N. Pagano, E. Meggers, Org. Biomol. Chem. 2009, 7, 476-482.

Insight into the High Duplex Stability of the Simplified Nucleic Acid GNA: M. K. Schlegel, X. Xie, L. Zhang, E. Meggers, Angew. Chem. Int. Ed. 2009, 48, 960-963.

Crystal Structure of the PIM2 Kinase in Complex with an Organoruthenium Inhibitor: A. N. Bullock, S. Russo, A. Amos, N. Pagano, H. Bregman, J. É. Debreczeni, W. H. Lee, F. von Delft, E. Meggers, S. Knapp, PLoS One 2009, 4, e7112.

Targeting Proteins with Metal Complexes: E. Meggers, Chem. Commun. 2009, 1001-1010 (feature).

2008

Targeting Large Kinase Active Site with Rigid and Bulky Octahedral Ruthenium Complexes: J. Maksimoska, L. Feng, K. Harms, C. Yi, J. Kissil, R. Marmorstein, E. Meggers, J. Am. Chem. Soc. 2008, 130, 15764-15765.

Extremely Tight Binding of Ruthenium Complex to Glycogen Synthase Kinase 3: G. E. Atilla-Gokcumen, N. Pagano, C. Streu, J. Maksimoska, P. Filippakopoulos, S. Knapp, E. Meggers, ChemBioChem 2008, 9, 2933-2936 (cover picture).

Duplex Structure of a Minimal Nucleic Acid: M. K. Schlegel, L.-O. Essen, E. Meggers, J. Am. Chem. Soc. 2008, 130, 8158-8159.

Structure-Based Design of an Organoruthenium Phosphatidyl-inositol-3-kinase Inhibitor Reveals a Switch Governing Lipid Kinase Potency and Selectivity: P. Xie, D. S. Williams, G. E. Atilla-Gokcumen, L. Milk, M. Xiao, K. S. M. Smalley, M. Herlyn, E. Meggers, R. Marmorstein, ACS Chem. Biol. 2008, 3, 305-316.

Similar Biological Activities of Two Isostructural Ruthenium and Osmium Complexes: J. Maksimoska, D. S. Williams, G. E. Atilla-Gokcumen, K. S. M. Smalley, P. J. Carroll, R. D. Webster, P. Filippakopoulos, S. Knapp, M. Herlyn, E. Meggers, Chem. Eur. J. 2008, 14, 4816-4822. 

Solid Phase Synthesis of Tris-Heteroleptic Ru(II) Complexes and Application to Acetylcholinesterase Inhibition: S. P. Mulcahy, S. Li, R. Korn, X. Xie, E. Meggers, Inorg. Chem. 2008, 47, 5030-5032 (cover picture).

Synthesis of Cyclopentadienyl Ruthenium Complexes Bearing Pendant Chelating Picolinates through an Electrophilic Precursor: C. Streu, P. J. Carroll, R. K. Kohli, E. Meggers, J. Organomet. Chem. 2008, 693, 551-556.      

2007

Duplex Formation of the Simplified Nucleic Acid GNA: M. K. Schlegel, A. E. Peritz, K. Kittigowittana, L. Zhang, E. Meggers, ChemBioChem 2007, 8, 927-932.

Platinum Complex as Nanomolar Protein Kinase Inhibitor: D. S. Williams, P. J. Carroll, E. Meggers, Inorg. Chem. 2007, 46, 2944-2946.

Ruthenium Half-Sandwich Complexes as Protein Kinase Inhibitors: Derivatization of the Pyridocarbazole Pharmacophore Ligand: N. Pagano, J. Maksimoska, H. Bregman, D. S. Williams, R. D. Webster, F. Xue, E. Meggers, Org. Biomol. Chem. 2007, 5, 1218-1227.

An Organometallic Protein Kinase Inhibitor Pharmacologically Activates p53 and Induces Apoptosis in Human Melanoma Cells: K. S. M. Smalley, R. Contractor, N. K. Haass, A. N. Kulp, G. E. Atilla-Gokcumen, D. S. Williams, H. Bregman, K. T. Flaherty, M. S. Soengas, E. Meggers, M. Herlyn, Cancer Res. 2007, 67, 209-217.

Exploring Chemical Space with Organometallics: Ruthenium Complexes as Protein Kinase Inhibitors: E. Meggers, G. E. Atilla-Gokcumen, H. Bregman, J. Maksimoska, S. P. Mulcahy, N. Pagano, D. S. Williams, Synlett 2007, 8, 1177-1189 (account).

Exploring Biologically Relevant Chemical Space with Metal Complexes: E. Meggers, Curr. Opin. Chem. Biol. 2007, 11, 287-292 (review).       

Book review of "Concepts and Models in Bioinorganic Chemistry", H.-B. Kraatz, N. Metzler-Nolte (Eds.), Wiley-VCH, published in ChemBioChem, 2007, 8, 145.

2006

Synthesis and Cyclometalation of a Pyrido[3,2-e]-2,10b-diazacyclopenta[c]fluorene-1,3-dione Scaffold: S. P. Mulcahy, P. J. Carroll, E. Meggers, Tetrahedron Lett. 2006, 47, 8877-8880.

Ruthenium Half-Sandwich Complexes as Protein Kinase Inhibitors: An N-Succinimidyl Ester for Rapid Derivatizations of the Cyclopentadienyl Moiety: H. Bregman, E. Meggers, Org. Lett. 2006, 8, 5465-5468.

Ruthenium-Induced Allylcarbamate Cleavage in Living Cells: C. Streu, E. Meggers, Angew. Chem. Int. Ed. 2006, 45, 5645-5648.

Organometallic Compounds with Biological Activity: A Very Selective and Highly Potent Cellular Inhibitor for Glycogen Synthase Kinase 3: G. E. Atilla, D. S. Williams, H. Bregman, N. Pagano, E. Meggers, ChemBioChem 2006, 7, 1443-1450.

Synthesis of Glycol Nucleic Acids: L. Zhang, A. E. Peritz, E. Meggers, Synthesis 2006, 645-653.

Ruthenium Half-Sandwich Complexes Bound to Protein Kinase Pim-1: J. É. Debreczeni, A. N. Bullock, G. E. Atilla, D. S. Williams, H. Bregman, S. Knapp, E. Meggers, Angew. Chem. Int. Ed. 2006, 45, 1580-1585.

Rapid Access to Unexplored Chemical Space by Ligand Scanning Around a Ruthenium Center: Discovery of Potent and Selective Protein Kinase Inhibitors: H. Bregman, P. J. Carroll, E. Meggers, J. Am. Chem. Soc. 2006, 128, 877-884.

2005

A Simple Glycol Nucleic Acid: L. Zhang, A. Peritz, E. Meggers, J. Am. Chem. Soc. 2005, 127, 4174-4175 (highlighted in Chem. Eng. News 2005, March 21, p. 13).

An Extremely Stable and Orthogonal DNA-Base Pair with a Simplified Three-Carbon Backbone: L. Zhang, E. Meggers, J. Am. Chem. Soc. 2005, 127, 74-75.

Switching On a Signaling Pathway with an Organometallic Ruthenium Complex: D. S. Williams, G. Ekin Atilla, H. Bregman, A. Arzoumanian, P. S. Klein, E. Meggers, Angew. Chem. Int. Ed. 2005, 44, 1984-1987 (highlighted in Angew. Chem. Int. Ed. 2006, 45, 1504; Mol. BioSyst. 2005, 1, 109; Chem. Eng. News 2005, Sept. 12, p. 40).

Pyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-diones: Synthesis, Cyclometalation, and Protein Kinase Inhibition: H. Bregman, D. S. Williams, E. Meggers, Synthesis 2005, 1521-1527.

2004

An Organometallic Inhibitor for Glycogen Synthase Kinase 3: H. Bregman, D. S. Williams, G. E. Atilla, P. J. Carroll, E. Meggers, J. Am. Chem. Soc. 2004, 126, 13594-13595.

Ruthenium Complexes as Protein Kinase Inhibitors: L. Zhang, P. J. Carroll, E. Meggers, Org. Lett. 2004, 6, 521-523.

A Second Generation Copper(II)-Mediated Metallo-DNA-Base Pair: N. Zimmermann, E. Meggers, P. G. Schultz, Bioorg. Chem. 2004, 32, 13-25.

2003

Progress Toward an Expanded Eukaryotic Genetic Code: J. W. Chin, T. A. Cropp, S. Chu, E. Meggers, P. G. Schultz, Chemistry & Biology 2003, 10, 511-519.   

2002

A Novel Silver(I)-Mediated DNA Base Pair: N. Zimmermann, E. Meggers, P. G. Schultz, J. Am. Chem. Soc. 2002, 124, 13684-13685.

2001

Structure of a Copper-Mediated Base Pair in DNA: S. Atwell, E. Meggers, G. Spraggon, P. G. Schultz, J. Am. Chem. Soc. 2001, 123, 12364-12367.

2000

A Novel Copper-Mediated DNA Base Pair: E. Meggers, P. L. Holland, W. B. Tolman, F. E. Romesberg, P. G. Schultz, J. Am. Chem. Soc. 2000, 122, 10714-10715.

Electron Transfer in DNA from Guanine and 8-Oxoguanine to a Radical Cation of the Carbohydrate Backbone: E. Meggers, A. Dussy, T. Schäfer, B. Giese, Chem. Eur. J. 2000, 6, 485-492.

DNA as a Supramolecule for Long-Distance Charge Transport: B. Giese, E. Meggers, S. Wessely, M. Spormann, A. Biland, Chimia 2000, 54, 547-551 (review).

1999

On the Mechanism of Long-Range Electron Transfer through DNA: B. Giese, S. Wessely, M. Spormann, U. Lindemann, E. Meggers, M. E. Michel-Beyerle, Angew. Chem. Int. Ed. Engl. 1999, 38, 996-998.

Hole Transport between G Bases in DNA: E. Meggers, B. Giese, Nucleosides & Nucleotides 1999, 18, 1317-1318.

1998

Sequence Dependent Hole Transfer in DNA: E. Meggers, M. E. Michel-Beyerle, B. Giese, J. Am. Chem. Soc. 1998, 120, 12950-12955.

Spontaneous Cleavage of 4’-DNA Radicals under Aerobic Conditions: Apparent Discrepancy between Trapping Rate Coefficients and Cleavage Products: A. Dussy, E. Meggers, B. Giese, J. Am. Chem. Soc. 1998, 120, 7399-7403.

Electron Transfer through DNA in the Course of Radical-Induced Strand Cleavage: E. Meggers, D. Kusch, M. Spichty, U. Wille, B. Giese, Angew. Chem. Int. Ed. 1998, 37, 460-462.

1997

Conformation, Lifetime and Repair of 4’-DNA Radicals: B. Giese, A. Dussy, E. Meggers, M. Petretta, U. Schwitter, J. Am. Chem. Soc. 1997, 119, 11130-11131.

An Efficient Synthesis of Enantiomerically Pure D- and L-Ruthenium(II)-Labelled Oligonucleotides: E. Meggers, D. Kusch, B. Giese, Helv. Chim. Acta 1997, 80, 640-652.

1995

Radical C-C Bond Formation by Photoinduced Electron Transfer Addition of a-Silyl Carbamates to Acceptor-Substituted Alkenes: E. Meggers, E. Steckhan, S. Blechert, Angew. Chem. Int. Ed. 1995, 34, 2137-2139.

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