Publications:
2011
Ljubojevic S, Walther S, Asgarzoei M, Sedej S, Pieske B, Kockskämper J. In situ calibration of nucleoplasmic versus cytoplasmic Ca2+ concentration in adult cardiomyocytes. Biophys J. 2011. (accepted).
Dybkova N, Sedej S, Napolitano C, Neef S, Rokita AG, Hünlich M, Heller Brown J, Kockskämper J, Priori SG, Pieske B, Maier LS. Overexpression of CaMKIIδc in RyR2R4496C knock-in mice leads to altered intracellular Ca2+-handling and increased mortality. J Am Coll Cardiol. 57:469-479. 2011.
Yang L-Z, Kockskämper J, Khan S, Suarez J, Walther S, Doleschal B, Unterer G, Khafaga M, Mächler M, Heinzel FR, Dillmann WH, Pieske B, Spiess J. Inotropic, lusitropic, and arrhythmogenic effects of urocortin 2 in mouse ventricular myocytes are mediated by cAMP- and Ca2+/calmodulin-dependent protein kinases. Brit J Pharmacol. 162:544-556. 2011.
Wakula P, Bisping E, Kockskämper J, Post H, Brauer S, Deuter M, Oehlmann R, Besenfelder U, Lai FA, Brem G, Pieske B. CMV promoter is inadequate for expression of mutant human RyR2 in transgenic rabbits. J Pharmacol Toxicol Meth. 63:180-185. 2011.
2010
Sedej S, Heinzel FR, Walther S, Dybkova N, Wakula P, Groborz J, Gronau P, Maier LS, Vos MA, Lai FA, Napolitano C, Priori SG, Kockskämper J, Pieske B. Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation. Cardiovasc Res. 87:50-59. 2010.
Yang L-Z, Tovote P, Rayner M, Kockskämper J, Pieske B, Spiess J. Corticotropin-releasing factor receptors and urocortins, links between brain and heart. Eur J Pharmacol. 632:1-6. 2010.
2009
Suckau L, Fechner H, Chemaly E, Krohn S, Hadri L, Kockskämper J, Westermann D, Bisping E, Ly H, Wang X, Kawase Y, Chen J, Liang L, Sipo I, Vetter R, Weger S, Kurreck J, Erdmann V, Pieske B, Lebeche D, Schultheiss H-P, Hajjar R, Poller W. Chronic cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy. Circulation 119:1241-1252. 2009.
von Lewinski D, Kockskämper J, Zhu D, Post H, Elgner A, Pieske B. Reduced stretch-induced force response in failing human myocardium caused by impaired Na+-contraction coupling. Circ Heart Fail 2:47-55. 2009.
2008
von Lewinski D, Kockskämper J, Rübertus S-U, Zhu D, Schmitto J, Schöndube FA, Hasenfuss G, Pieske B. Direct pro-arrhythmogenic effects of angiotensin II can be suppressed by AT1 receptor blockade in human atrial myocardium. Eur J Heart Fail. 10:1172-1176. 2008.
Kockskämper J, Khafaga M, Grimm M, Elgner A, Walther S, Kockskämper A, von Lewinski D, Post H, Grossmann M, Dörge H, Gottlieb PA, Sachs F, Eschenhagen T, Schöndube FA, Pieske B. Angiotensin II and myosin light chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardium. Cardiovasc Res. 79:642-651. 2008.
Kockskämper J, Zima AV, Roderick L, Pieske B, Blatter LA, Bootman MD. Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes. J Mol Cell Cardiol. 45:128-147. 2008.
Kockskämper J, von Lewinski D, Khafaga M, Elgner A, Grimm M, Eschenhagen T, Gottlieb PA, Sachs F, Pieske B. The slow force response to stretch in atrial and ventricular myocardium from human heart – functional relevance and subcellular mechanisms. Prog Biophys Mol Biol. 97:250-267. 2008.
Heinzel FR, Kockskämper J, Pieske B. Ionenhomöostase im insuffizienten Herzen (Ion homeostasis in heart failure). Der Kardiologe 2:93-99. 2008.
von Lewinski D, Zhu D, Khafaga M, Kockskämper J, Maier LS, Hasenfuss G, Pieske B. Frequency-dependence of the slow force response. Front Biosci. 13:7202-7209. 2008.
Kockskämper J, Seidlmayer L, Walther S, Hellenkamp K, Maier LS, Pieske B. Endothelin-1 enhances nuclear Ca2+ transients in atrial myocytes through Ins(1,4,5)P3-dependent Ca2+ release from perinuclear Ca2+ stores. J Cell Sci. 121:186-195. 2008.
2007
von Lewinski D, Bisping E, Elgner A, Kockskämper J, Pieske B. Mechanistic insight into the functional and toxic effects of Strophanthidin in the failing human myocardium. Eur J Heart Fail. 9:1086-1094. 2007.
Nakipova OV, Zakharova NM, Andreeva LA, Chumaeva NA, Averin A, Kosarskii LS, Anufriev AI, von Lewinski D, Kockskämper J, Pieske B. The seasonal peculiarities of force-frequency relationships in active ground squirrel Spermophilis undulatus ventricle. Cryobiology 55:173-181. 2007.
Schillinger W, Teucher N, Sossalla S, Kettlewell S, Werner C, Raddatz D, Elgner A, Tenderich G, Pieske B, Schöndube FA, Kögler H, Kockskämper J, Maier LS, Schwörer H, Smith GL, Hasenfuss G. Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits. Evaluation of mechanisms. Circulation 116:57-66. 2007.
2006
Zima AV, Kockskämper J, Blatter LA. Cytosolic energy reserves determine the effect of glycolytic sugar phosphates on sarcoplasmic reticulum Ca2+ release in cat ventricular myocytes. J Physiol. 577:283-291. 2006.
Yang L-Z, Kockskämper J, Heinzel FR, Hauber M, Walther S, Spiess J, Pieske B. Urocortin II enhances contractility in rabbit ventricular myocytes via CRF2 receptor-mediated stimulation of protein kinase A. Cardiovasc Res. 69:402-411. 2006.
2005
Luers C, Fialka F, Elgner A, Zhu D, Kockskämper J, von Lewinski D, Pieske B. Stretch-dependent modulation of [Na+]i, [Ca2+]i and pHi in rabbit myocardium – a mechanism for the slow force response. Cardiovasc Res. 68:454-463. 2005.
Kockskämper J, Zima AV, Blatter LA. Modulation of cardiac sarcoplasmic reticulum Ca2+ release by glycolysis. J Physiol. 564:697-714. 2005.
