Main Content

Chiral-at-Metal Catalysts Invented by the Meggers Lab

Chiral-at-Iridium Catalysts

• Chiral-at-Ir Lewis acid catalysis. Our first report: J. Am. Chem. Soc. 2014, 136, 2990.
• Asymmetric photoredox catalysis with chiral-at-Ir complex. Our first report: Nature 2014, 515, 100.
• Account article on this class of catalysts: Acc. Chem. Res. 2017, 50, 320.
• Detailed protocol for the synthesis of this class of catalysts: Nat. Protoc. 2018, 13, 605.
• Applications by other groups of this catalyst system: Peng-Fei Xu Lab (Lanzhou University).

Chiral-at-Rhodium Catalysts

• Chiral-at-Rh Lewis acid catalysis. Our first report: Chem. Sci. 2015, 6, 1094.
• Asymmetric photoredox catalysis with chiral-at-Rh catalyst. Our first report: J. Am. Chem. Soc. 2016, 138, 22.
• Asymmetric photocycloadditions with chiral-at-Rh catalyst: J. Am. Chem. Soc. 2017, 139, 27.
• Account article about chiral-at-Rh photocatalysis: Acc. Chem. Res. 2019, 52, 833.
• Electrochemistry merged with asymmetric catalysis: Nat. Catal. 2019, 2, 34.
• Applications of this catalyst by Qiang Kang (FIRSM). See, for example: Chem. Commun. 2017, 53, 7665.
• Applications of this catalyst by Yu Du (FIRSM). See, for example: Org. Chem. Front. 2019, 6, 3683.

Chiral-at-Ruthenium Catalysts

A) C₂-Symmetry with Two Chelating NHC Ligands

• Our first report: J. Am. Chem. Soc. 2017, 139, 12.
• Application to the synthesis of the drug Efavirenz: Org. Process Res. Dev. 2018, 22, 103.
• Application to enantioselective C(sp³)-H aminations. See, for example: Chem 2020, 6, 1851.

B) Non-C₂-Symmetry with Two Chelating rNHC Ligands

• Our first publication on this scaffold: J. Am. Chem. Soc. 2019, 141, 48.

Chiral-at-Iron Catalyst

• Our first report on chiral-at-Fe catalysts: J. Am. Chem. Soc. 2019, 141, 11.