Main Content

Publications    

  • Inhalt ausklappen Inhalt einklappen 20212021

    Characterization of a L136P mutation in Formin-like 2 (FMNL2) from a patient with chronic inflammatory bowel disease.
    Trefzer R, Elpeleg O, Gabrusskaya T, Stepensky P, Mor-Shaked H, Grosse R, Brandt DT.
    PLoS One 2021, 16(5):e0252428. https://doi.org/10.1371/journal.pone.0252428

    Mechanochemical control of epidermal stem cell divisions by B-plexins.
    Jiang C, Javed A, Kaiser L, Nava MM, Xu R, Brandt DT, Zhao D, Mayer B, Fernández-Baldovinos J, Zhou L, Höß C, Sawmynaden K, Oleksy A, Matthews D, Weinstein LS, Hahn H, Gröne HJ, Graumann P, Niessen CM, Offermanns S, Wickström SA, Worzfeld T.
    Nat Commun, 2021, 12(1):1308. https://doi.org/10.1038/s41467-021-21513-9

    TTL-expression modulates epithelial morphogenesis.
    Müller M, Ringer K, Hub F, Kamm K, Worzfeld T, Jacob R.
    Front Cell Dev Biol 2021. https://doi.org/10.3389/fcell.2021.635723

    Glycolipid-dependent and lectin-driven transcytosis in mouse enterocytes.
    Ivashenka A, Wunder C, Chambon V, Sandhoff R, Jennemann R, Dransart E, Podsypanina K, Lombard B, Loew D, Lamaze C, Poirier F, Gröne HJ, Johannes L, Shafaq-Zadah M.
    Commun Biol 2021, 4(1):173. https://doi.org/10.1038/s42003-021-01693-2

    CaM Kinase II-δ Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy.
    Chen J, Fleming T, Katz S, Dewenter M, Hofmann K, Saadatmand A, Kronlage M, Werner MP, Pokrandt B, Schreiter F, Lin J, Katz D, Morgenstern J, Elwakiel A, Sinn P, Gröne HJ, Hammes HP, Nawroth PP, Isermann B, Sticht C, Brügger B, Katus HA, Hagenmueller M, Backs J.
    Diabetes 2021, 70(2):616-626. https://doi.org/10.2337/db19-0659

  • Inhalt ausklappen Inhalt einklappen 20202020

    Congestive nephropathy: a neglected entity? Proposal for diagnostic criteria and future perspectives.
    Husain-Syed F, Gröne HJ, Assmus B, Bauer P, Gall H, Seeger W, Ghofrani A, Ronco C, Birk HW.
    ESC Heart Fail 2020, 8(1):183-203. https://doi.org/10.1002/ehf2.13118

    Development of a New Macrophage-Specific TRAP Mouse (Mac TRAP) and Definition of the Renal Macrophage Translational Signature.
    Hofmeister A, Thomaßen MC, Markert S, Marquardt A, Preußner M, Rußwurm M, Schermuly RT, Steinhoff U, Gröne HJ, Hoyer J, Humphreys BD, Grgic I.
    Sci Rep 2020, 10:7519. https://doi.org/10.1038/s41598-020-63514-6

    Endothelial Notch Signaling Controls Insulin Transport in Muscle.
    Hasan SS, Jabs M, Taylor J, Wiedmann L, Leibing T, Nordström V, Federico G, Roma LP, Carlein C, Wolff G, Ekim-Üstünel B, Brune M, Moll I, Tetzlaff F, Gröne HJ, Fleming T, Géraud C, Herzig S, Nawroth PP, Fischer A.
    EMBO Mol Med 2020, 12:e09271. https://doi.org/10.15252/emmm.201809271

    Gangliosides Modulate Insulin Secretion by Pancreatic Beta-Cells Under Glucose Stress.
    Jennemann R, Kaden S, Volz M, Nordström V, Herzer S, Sandhoff R, Gröne HJ.
    Glycobiology 2020, cwaa022. https://doi.org/10.1093/glycob/cwaa02

    TRPC1 Regulates the Activity of a Voltage-Dependent Nonselective Cation Current in Hippocampal CA1 Neurons.
    Kepura F, Braun E, Dietrich A, Plant TD.
    Cells 2020, 9:459. https://doi.org/10.3390/cells9020459

  • Inhalt ausklappen Inhalt einklappen 20192019

    Multi-platform Affinity Proteomics Identify Proteins Linked to Metastasis and Immune Suppression in Ovarian Cancer Plasma.
    Graumann J, Finkernagel F, Reinartz S, Stief T, Brödje D, Renz H, Jansen JM, Wagner U, Worzfeld T, Pogge von Strandmann E, Müller R.
    Front Oncol 2019, 9:1150. https://doi.org/10.3389/fonc.2019.01150

    Bacterial Immunogenic α-galactosylceramide Identified in the Murine Large Intestine: Dependency on Diet and Inflammation.
    von Gerichten J, Lamprecht D, Opálka L, Soulard D, Marsching C, Pilz R, Sencio V, Herzer S, Galy B, Nordström V, Hopf C, Gröne HJ, Trottein F, Sandhoff R.
    J Lipid Res 2019, 60(11):1892-1904. https://doi.org/10.1194/jlr.RA119000236

    Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment.
    Finkernagel F, Reinartz S, Schuldner M, Malz A, Jansen JM, Wagner U, Worzfeld T, Graumann J, von Strandmann EP, Müller R.
    Theranostics 2019, 9(22):6601-6617. https://doi.org/10.7150/thno.37549

    The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology.
    Simonetti M, Paldy E, Njoo C, Bali KK, Worzfeld T, Pitzer C, Kuner T, Offermanns S, Mauceri D, Kuner R.
    Mol Psychiatry 2019. https://doi.org/10.1038/s41380-019-0491-4

    O-GlcNAcylation of Histone Deacetylase 4 Protects the Diabetic Heart From Failure.
    Kronlage M, Dewenter M, Grosso J, Fleming T, Oehl U, Lehmann LH, Falcão-Pires I, Leite-Moreira AF, Volk N, Gröne HJ, Müller OJ, Sickmann A, Katus HA, Backs J.
    Circulation 2019, 140(7):580-594. https://doi.org/10.1161/CIRCULATIONAHA.117.031942

    Herniation of the Tuft With Outgrowth of Vessels Through the Glomerular Entrance in Diabetic Nephropathy Damages the Juxtaglomerular Apparatus.
    Löwen J, Gröne E, Gröne HJ, Kriz W.
    Am J Physiol Renal Physiol 2019, 317(2):F399-F410. https://doi.org/10.1152/ajprenal.00617.2018

    Renal Globotriaosylceramide Facilitates Tubular Albumin Absorption and Its Inhibition Protects Against Acute Kidney Injury.
    Morace I, Pilz R, Federico G, Jennemann R, Krunic D, Nordström V, von Gerichten J, Marsching C, Schießl IM, Müthing J, Wunder C, Johannes L, Sandhoff R, Gröne HJ.
    Kidney Int 2019, 96(2):327-341. https://doi.org/10.1016/j.kint.2019.02.010

    Cell type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment.
    Reinartz S, Lieber S, Pesek J, Brandt DT, Asafova A, Finkernagel F, Watzer B, Nockher WA, Nist A, Stiewe T, Jansen JM, Wagner U, Konzer A, Graumann J, Grosse R, Worzfeld T, Müller-Brüsselbach S, Müller R.
    Mol Oncol 2019, 13(2):185-201. https://doi.org/10.1002/1878-0261.12396                               

  • Inhalt ausklappen Inhalt einklappen 20182018

    A Rac1-FMNL2 signaling module affects cell-cell contact formation independent of Cdc42 and membrane protrusions.
    Grobe H, Wüstenhagen A, Baarlink C, Grosse R, Grikscheit K.
    PLoS One 2018, 13(3):e0194716. https://doi.org/10.1371/journal.pone.0194716

    Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis.
    Jelinek A, Heyder L, Daude M, Plessner M, Krippner S, Grosse R, Diederich WE, Culmsee C.
    Free Radic Biol Med 2018, 117:45-57. https://doi.org/10.1016/j.freeradbiomed.2018.01.019

    Prognosis of ovarian cancer is associated with effector memory CD8+ T cell accumulation in ascites, CXCL9 levels and activation-triggered signal transduction in T cells.
    Lieber S, Reinartz S, Raifer H, Finkernagel F, Dreyer T, Bronger H, Jansen JM, Wagner U, Worzfeld T, Müller R, Huber M.
    Oncoimmunology 2018, 7(5):e1424672. https://doi.org/10.1080/2162402X.2018.1424672

    Proteotranscriptomics Reveal Signaling Networks in the Ovarian Cancer Microenvironment.
    Worzfeld T, Finkernagel F, Reinartz S, Konzer A, Adhikary T, Nist A, Stiewe T, Wagner U, Looso M, Graumann J, Müller R.
    Mol Cell Proteomics 2018, 17(2):270-289. https://doi.org/10.1074/mcp.RA117.000400

    Dynamizing nuclear actin filaments.
    Plessner M, Grosse R.
    Curr Opin Cell Biol 2018, 56:1-6. https://doi.org/10.1016/j.ceb.2018.08.005

    Interplay of cell-cell contacts and RhoA/MRTF-A signaling regulates cardiomyocyte identity.
    Dorn T, Kornherr J, Parrotta EI, Zawada D, Ayetey H, Santamaria G, Iop L, Mastantuono E, Sinnecker D, Goedel A, Dirschinger RJ, My I, Laue S, Bozoglu T, Baarlink C, Ziegler T, Graf E, Hinkel R, Cuda G, Kääb S, Grace AA, Grosse R, Kupatt C, Meitinger T, Smith AG, Laugwitz KL, Moretti A.
    EMBO J 2018, 37(12):e98133. https://doi.org/10.15252/embj.201798133

  • Inhalt ausklappen Inhalt einklappen 20172017

    Actin visualization at a glance.
    Melak M, Plessner M, Grosse R.
    J Cell Sci. 2017 Feb 1;130(3):525-530. doi: 10.1242/jcs.189068. Epub 2017 Jan 12. Review. Erratum in: J Cell Sci. 2017 May 1;130(9):1688. 
    PMID:28082420                                                                                          

    A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib.
    Sun T, Yang L, Kaur H, Pestel J, Looso M, Nolte H, Krasel C, Heil D, Krishnan RK, Santoni MJ, Borg JP, Bünemann M, Offermanns S, Swiercz JM, Worzfeld T.
    J Cell Biol. 2017 Jan 2;216(1):199-215. doi: 10.1083/jcb.201602002. Epub 2016 Dec 22.
    PMID:28007914                                                                                          

    The Unique Molecular and Cellular Microenvironment of Ovarian Cancer.
    Worzfeld T, Pogge von Strandmann E, Huber M, Adhikary T, Wagner U, Reinartz S, Müller R.
    Front Oncol. 2017 Feb 22;7:24. doi: 10.3389/fonc.2017.00024. eCollection 2017. Review.
    PMID:28275576                                                                                                    

    Report: MRTF transcription and Ezrin-dependent plasma membrane blebbing are required for entotic invasion.
    Soto Hinojosa L, Holst M, Baarlink C, Grosse R.
    J Cell Biol. 2017 DOI: 10.1083/jcb.201702010 | Published August 3, 2017            

    A Tri-part Protein Complementation System Using Antibody-Small Peptide Fusions Enables Homogeneous Immunoassays.
    Dixon AS, Kim SJ, Baumgartner BK, Krippner S, Owen SC.
    Scientific Reports, 7:8186, Doi:10.1038/s41598-017-07569-y. published online 15. August 2017                                                                                                                      

    Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain.
    Paldy E, Simonetti M, Worzfeld T, Bali KK, Vicuña L, Offermanns S, Kuner R.
    Nat Commun. 2017 Aug 2;8(1):176. doi: 10.1038/s41467-017-00341-w.                                                                                                                         

    Immunosuppression in Honeybee Queens by the Neonicotinoids Thiacloprid and Clothianidin
    Brandt A, Grikscheit K, Siede R, Grosse R, Meixner MD, Büchler R.
    Scientific Reports, 7:4673/DOI:1k0.1038/s41598-017-04734-1                                                                                                                           

    A transient pool of nuclear F-actin at mitotic exit controls chromatin organization.
    Baarlink C, Plessner M, Sherrard A, Morita K, Misu S, Virant D, Kleinschnitz EM, Harniman R, Alibhat D, Baumeister S, Miyamoto K, Endesfelder U, Kaidi A, Grosse R.
    Nature Cell Biology        DOI: 10.1038/ncb3641                                      

  • Inhalt ausklappen Inhalt einklappen 20162016

    Formins at the Junction
    Grikscheit K, Grosse R.
    Trends Biochem Sci, 2016 Feb;41(2):148-159. Review                        

    SCAI promotes DNA double-strand break repair in distinct chromosomal contexts
    Kring Hansen R, Mund A, Lund Poulsen S, Sandoval M, Klement K, Tsouroula K, Tollenaere M A X, Mäschle M, Soria R, Offermanns S, Worzfeld T, Grosse R, Brandt D T, Rozell B, Mann M, Cole F, Soutoglou E, Goodarzi A A, Daniel J A, Mailand N, Bekker-Jensen S.
    Nature Cell Biology, 2016; 18(12), 1357-1366.                                      

    Semaphorins and Plexins in Kidney Disease
    Xia J, Worzfeld T.
    Nephron. 2016;132(2):93-100.                      

    Apicobasal polarity of brain endothelial cells.
    Worzfeld T, Schwaninger M.
    J Cereb Blood Flow Metab. 2016 Feb;36(2):340-362.                             

    Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5
    Vogiatzi F, Brandt DT, Schneikert J, Fuchs J, Grikscheit K, Wanzel M, Pavlakis E, Charles JP, Timofeev O, Nist A, Mernberger M, Kantelhardt EJ, Siebolts U, Bartel F, Jacob R, Rath A, Moll R, Grosse R, Stiewe T.
    Proc Natl Acad Sci USA. 2016 Dec 27;113(52):E8433-E8442.                

  • Inhalt ausklappen Inhalt einklappen 20152015

    Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα.
    Wang Y, Arjonen A, Pouwels J, Ta H, Pausch P, Bange G, Engel U, Pan X, FacklerOT, Ivaska J, Grosse R.
    Dev Cell. 2015 Aug 24;34(4):475-483. pii: S1534-5807(15)00422-0. doi: 10.1016/j.devcel.2015.06.015. [Epub ahead of print]                                

    Extracellular signaling cues for nuclear actin polymerization.
    Plessner M, Grosse R.
    Eur J Cell Biol. 2015 Jun 1. pii: S0171-9335(15)00055-2. doi: 10.1016/j.ejcb.2015.05.009. [Epub ahead of print]                                                                                                  

    Junctional actin assembly is mediated by Formin-like 2 downstream of Rac1.
    Grikscheit K, Frank T, Wang Y, Grosse R.
    J Cell Biol. 2015 May 11;209(3):367-76. doi: 10.1083/jcb.201412015.  

    Nuclear F-actin formation and reorganization upon cell spreading.
    Plessner M, Melak M, Chinchilla P, Baarlink C, Grosse R.
    J. Biol Chem. 2015 May 1;290(18):11209-16. doi: 10.1074/jbc.M114.627166. Epub 2015 Mar 10.                                                                                                                            

    LOV is all we need.
    Grosse R.
    Nat Rev Mol Cell Biol. 2015 Apr;16(4):206. doi: 10.1038/nrm3950. Epub 2015 Jan 29. No abstract available.                                                                                                         

    Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair.
    Xia, J., Swiercz, J.M., Bañón-Rodríguez, I., Matković, I., Federico, G., Sun, T., Franz, T., Brakebusch, C.H., Kumanogoh, A., Friedel, R.H., Martín-Belmonte, F., Gröne, H.J., Offermanns, S., Worzfeld, T. (2015).
    Dev. Cell 33, 299-313.                                                                                  

    RanBP3 Regulates Melanoma Cell Proliferation via Selective Control of Nuclear Export.
    Pathria G, Garg B, Wagner C, Garg K, Gschaider M, Jallili A, Wagner SN
    J Invest Dermatol 2015 Oct 8 doi: 10.1038/jid.2015.401. [Epub ahead of print]                                                                                                                            

    Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration.
    Kircher P, Hermanns C, Nossek M, Drexler MK, Grosse R, Fischer M, Sarikas A, Penkava J, Lewis T, Prywes R, Gudermann T, Muehlich S.
    Sci Signal. 2015 Nov 10;8(402):ra112. doi: 10.1126/scisignal.aad2959.        

  • Inhalt ausklappen Inhalt einklappen 20142014

    Pharmacological Inhibition of Actin Assembly to Target Tumor Cell Motility.
    Nürnberg A, Kollmannsperger A, Grosse R.
    Rev Physiol Biochem Pharmacol. 2013 Nov 6. [Epub ahead of print]
    Published 2014                                                                                                                                

    G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion.
    Purvanov V, Holst M, Khan J, Baarlink C, Grosse R.
    Elife. 2014 Jun 20;3. doi: 10.7554/eLife.02786.                                                                                                                                

    Formin' actin in the nucleus.
    Baarlink C, Grosse R.
    Nucleus. 2014 Jan-Feb;5(1):15-20.                                                                                                                                

    Dynamics of Gαq-protein-p63RhoGEF interaction and its regulation by RGS2.
    Bodmann EL, Rinne A, Brandt D, Lutz S, Wieland T, Grosse R, Bünemann M.
    Biochem J. 2014 Feb 15;458(1):131-40.                                                                                                                                

    Specific Phosphorylations Transmit Signals from Leukocyte ß2- to ß1-Ingegrins and Regulate Adhesion.
    Uotila LM, Jahan F, Soto Hinojosa L, Melandry E, Grönholm M, Gahmberg CG.
    J Bio Chem doi: 10.1074/jbc.M114.588111                                                                                                                                

    TRPs in mechanosensing and volume regulation.
    Plant TD.
    Handb Exp Pharmacol. 2014;223:743-66. doi: 10.1007/978-3-319-05161-1_2.

    Genetic dissection of plexin signaling in vivo.
    Worzfeld T*, Swiercz JM, Sentürk A, Genz B, Korostylev A, Deng S, Xia J, Hoshino M, Epstein JA, Chan AM, Vollmar B, Acker-Palmer A, Kuner R, Offermanns S.
    Proc. Natl. Acad. Sci. USA 111:2194-2199 (2014)
    * corresponding author                                                                                                                                

    Semaphorins and plexins as therapeutic targets.
    Worzfeld T, Offermanns S.
    Nat Rev Drug Discov. 2014 Aug;13(8):603-21.                                                                                                                               

-