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Our lab focuses on cellular plasticity in intestinal inflammation and inflammation-associated intestinal tumorigenesis. A central point of our research is the signaling crosstalk between different intestinal epithelial cell types, as well as between intestinal epithelial cells and non-epithelial cells in their microenvironment during inflammatory responses. By this we want to better understand regenerative processes in intestinal tissues in order to reveal novel targets for the treatment of inflammatory bowel diseases. Furthermore, we want to get a deeper understanding about the contribution of inflammation to intestinal cancer development with the aim to identify new strategies for the prevention and treatment of colitis-associated colorectal cancers.