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SP3 Function of Protein Arginine Methyltransferases in tumor-stroma interactions of PDAC

Prof. Uta-Maria Bauer

Prof. Detlef Bartsch

PRMT1 is indicative for clinical prognosis and chemotherapy response of pancreatic tumor cells (Repenning et al., EMBO J., 2021). Furthermore, PRMT1 as well as PRMT4 are highly expressed in tumor-infiltrating immune cells (T cells, macrophages) and fibroblasts. In the second funding period we plan to (i) investigate the cell-autonomous tumor-suppressive function of PRMT1 in PDAC tumor cells and the synergism between PRMT1 and conventional chemotherapy in vivo, (ii) to determine the effects of PRMT1 and PRMT4 on immune cell / stromal cell functions and validate options for immunotherapy and (iii) to establish the detection of PRMT1-dependent PDAC biomarkers.