Project Overview 1. period

• Project A1 Project A1: Overcoming T-cell exhaustion in PDAC: Mechanisms of CD8+ cytotoxic T cell dysfunction in pancreatic carcinoma
• Project A2 Toll-like receptors in tumor progression and as treatment targets in PDAC
• Project A3 The role of PDAC-derived extracellular vesicles in tumor immune evasion
• Project B1 Small molecule-induced reprogramming of pancreatic tumor and stroma compartments
• Project B2 Role of ADAM8 in TAMs in PDAC tumor progression and therapy resistance
• Project B3 Function of Protein Arginine Methyltransferases in tumor-stroma interactions of PDAC
• Project B4 Exploiting tumor-stroma Hedgehog signal transduction heterogeneity
• Central Project Z Z-Biobanking – Z-Imaging – Z-MedChem