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Project B3:  Function of Protein Arginine Methyltransferases in tumor-stroma interactions of PDAC

Participants: 

Prof. Dr. rer. nat. Uta-Maria Bauer
Institute of Molecular Biology & Tumor Research
Philipps-Universität Marburg

Prof. Dr. Detlef Bartsch
VTG Surgery
Hospital Philipps-Universität Marburg

Project aims:

PRMTs (Protein Arginine Methyltransferases) are epigenetic modifiers that are frequently deregulated in human tumors. In this project proposal, we will investigate the role of PRMTs in tumor cells (cell-autonomous effects) as well as in tumor-microenvironment interactions of human and murine PDAC. Diagnostic efforts will analyze extracellular PRMT-induced end-products (ADMA serum levels) as possible biomarkers. Novel specific PRMT1 antagonists will be developed and characterized for their potential in PDAC therapy.

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