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Publications 2023

Brichkina A, Suezov R and Huber M. Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy. Signal Transduction and Targeted Therapy (2023)8:448. doi: 10.1038/s41392-023-01696-x 
Steitz AM, Schröder C, Knuth I, Keber CU, Sommerfeld L, Finkernagel F, Jansen JM, Wagner U, Müller-Brüsselbach S, Worzfeld T, Huber M, Beutgen VM, Graumann J, Pogge von Strandmann E, Müller R, Reinartz S. TRAIL-dependent apoptosis of peritoneal mesothelial cells by NK cells promotes ovarian cancer invasion. iScience. 2023 Dec 15; 26(12): 108401. doi: 10.1016/j.isci.2023.108401
Weber LM, Jia Y, Stielow B, Gisselbrecht SS, Cao Y, Ren Y, Rohner I, King J, Rothmann E, Fischer S, Simon C, Forné I, Nist A, Stiewe T, Bulyk ML, Wang Z, Liefke R. The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain. Nucleic Acids Research, 20213, Vol. 51, No. 2. doi: 10.1093/nar/gkac1188
Fischer S, Trinh, VT, Simon C, Weber LM, Forné I, Nist A, Bange G, Abendroth F, Stiewe T, Steinchen W, Liefke R, Vázquez O. Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells. Cell Chemical Biology 30, 766-779, July 20, 2023. doi: 10.1016.j.chembiol.2023.05.012
Enukashvily N, Ponomartsev N, Ketkar A, Suezov R, Chubar A, Prjibelski A, DShafranskaya D, Elmshäuser S, Keber C, Stefanova V, Akopov A, Klingmüller U, Pfefferle P, Stiewe T, Lauth M, Brichkina A. Pericentromeric satellite lncRNAs are induced in cancer-associated fibroblasts and regulate their functions in lung tumorigenesis. Cell Death Disease (2023)14:19. doi: 10.1038/s41449-023-05553-1
de Pedro MA, López E, González-Nuño FM, Pulido M, Álvarez V, Marchena AM, Preusser C, Szymanski W, Pogge von Strandmann E, Graumann J, Sanchez-Margallo FM, Gómez-Serrano M (2023) Menstrual blood-derived mesenchymal stromal cells: impact of preconditioning on the extracellular vesicle cargo and potential therapeutics. Stem Cell Research & Therapy (2023) 14:187. doi: 10.1186/s13287-023-03413-5
Ojasalu K, Lieber S, Sokol AM, Nist A, Stiewe T, Bullwinkel I, Finkernagel F, Reinartz S, Müller-Brüsselbach S, Grosse R, Graumann J & Müller R. The lysophosphatidic acid-regulated signal transduction network in ovarian cancer cells and its role in actomyosin dynamics, cell migration and entosis. Theranostics 13, 1921–1948; doi: 10.7150/thno.81656 (2023)
Pavlakis E, Neumann M, Merle N, Wieboldt R, Wanzel M, Ponath V, Pogge von Strandmann E, Elmshäuser E, Stiewe T. Mutant p53-ENTPD5 control of the calnexin/calreticulin cycle: a druggable target for inhibiting integrin-a5-driven metastasis. J Exp Clin Cancer Res 2023, 42, 203. doi: 10.1186/s13046-023-02785-z
Belapurkar R, Pfisterer M, Dreute J, Werner S, Zukunft S, Fleming I, Kracht M, Schmitz L. A transient increase of HIF-1α during the G1 phase (G1-HIF) ensures cell survival under nutritional stress. Cell Death & Disease (2023)14:477. doi: 10.1038/s41419-023-06012-7
Picard FSR, Lutz V, Brichkina A, Neuhaus F, Ruckenbrod T, Hupfer A, Raifer H, Klein M, Bopp T, Pfefferle PI, Savai R, Prinz I, Waisman A, Moos S, Chang HD, Heinrich S, Bartsch DK, Buchholz M, Singh S, Tu M, Klein L, Bauer C, Liefke R, Burchert A, Chung HR, Mayer P, Gress TM, Lauth M, Gaida M, Huber M. IL-17A-producing CD8+ T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts. Gut 2023;0:1-13. doi:10.1136/gutjnl-2022-327855
Lutz V, Hellmund VM, Picard FSR, Raifer H, Ruckenbrod T, Klein M, Bopp T, Savai R, Duewell P, Keber CU, Weigert A, Chung HR, Buchholz M, Menke A, Gress TM, Huber M & Bauer C. IL-18 receptor signaling regulates tumor-reactive CD8+ T-cell exhaustion via activation of the IL-2/STAT5/mTOR pathway in a pancreatic cancer model. Cancer immunology research (2023) 11 (4): 421-434. doi: 10.1158/2326-6066.CIR-22-0398
Shearer HL, van Loi V, Weiland P, Bange G, Altegoer F, Hampton MB, Antelmann H, Dickerhof N. MerA functions as a hypothiocyanous acid reductase and defense mechanism in Staphylococcus aureus. Molecular Microbiology.2023;119:456-470. doi:10.1111/mmi.15035
Priester J, Meier-Soelch J, Heylmann D, Weber A, Linne U, Kracht M. Metabolic labeling and LC-MS/MS-based identification of interleukin-1alpha-induced secreted proteomes from epithelial cells in the presence or absence of serum. STAR Protocols 4, 102195, June 16, 2023. doi: 10.1016/j.xpro.2023.102195
Alkhayer R, Ponath V, Frech M, Adhikary T, Graumann J, Neubauer A and Pogge von Strandmann E. KLF4‑mediated upregulation of the NKG2D ligand MICA in acute myeloid leukemia: a novel therapeutic target identified by enChIP. Cell Communication and Signaling (2023) 21:94. doi: 0.1186/s12964-023-01118-z