Main Content
Publications
| Lenz J, Brehm A. Conserved mechanisms of NuRD function in hematopoetic gene expression. Enzymes. 2023;53:7-32. doi: 10.1016/bs.enz.2023.07.006. Epub 2023 Aug 30. PMID: 37748838 |
| Ullah I, Thölken C, Zhong Y, John M, Rossbach O, Lenz J, Gößringer M, Nist A, Albert L, Stiewe T, Hartmann R, Vázquez O, Chung HR, Mackay JP, Brehm A. RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodeling. Cell Rep. 2022 May 31;39(9):110895. doi: 10.1016/j.celrep.2022.110895. PMID: 35649367 |
| Lenz J, Liefke R, Funk J, Shoup S, Nist A, Stiewe T, Schulz R, Tokusumi Y, Albert L, Raifer H, Förstemann K, Vázquez O, Tokusumi T, Fossett N, Brehm A. Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis. PLoS Genet. 2021 Feb 18;17(2):e1009318. doi: 10.1371/journal.pgen.1009318. PMID: 33600407 |
| Mačinković I, Theofel I, Hundertmark T, Kovač K, Awe S, Lenz J, Forné I, Lamp B, Nist A, Imhof A, Stiewe T, Renkawitz-Pohl R, Rathke C, Brehm A Distinct CoREST complexes act in a cell-type-specific manner Nucleic Acids Research, 2019 Dec 16;47(22):11649-11666. PMID: 31701127 |
| Hundertmark T, Kreutz S, Merle N, Nist A, Lamp B, Stiewe T, Brehm A, Renkawitz-Pohl R, Rathke C Drosophila melanogaster tPlus3a and tPlus3b ensure full male fertility by regulating transcription of Y-chromosomal, seminal fluid, and heat shock genes. PLoS One. 2019 Mar 7;14(3):e0213177. PMID: 30845228 |
| Kovač K, Sauer A, Mačinković M, Awe S, Finkernagel F, Hoffmeister H, Fuchs A, Müller R, Rathke C, Längst G, Brehm A Tumour-associated missense mutations in the dMi-2 ATPase alter nucleosome remodelling properties in a mutation-specific manner Nature Communications, 2018, 9:2112. PMID: 29844320 |
| Jox T, Buxa MK, Bohla D, Ullah I, Mačinković I, Brehm A, Bartkuhn M, Renkawitz R Drosophila CP190- and dCTCF-mediated enhancer blocking is augmented by SUMOylation Epigenetics & Chromatin, 2017, 10:32. PMID: 28680483 |
| Kim J, Lu C, Srinivasan S, Awe S, Brehm A, Fuller MT Blocking promiscuous activation at cryptic promoters directs cell type-specific gene expression. Science, 2017, 356:717-721. PMID: 28522526 |
| Kreher K, Kovač K, Bouazoune K, Mačinković K, Ernst AL, Engelen E, Pahl R, Finkernagel F, Murawska M, Ullah I, Brehm A EcR recruits dMi-2 and increases efficiency of dMi-2-mediated remodelling to constrain transcription of hormone-regulated genes. Nature Communications, 2017, 8:14806. PMID: 28378812 |
| Fritsch K, Mernberger M, Nist A, Stiewe T, Brehm A, Jacob R Galectin-3 interacts with components of the nuclear ribonucleoprotein complex. BMC Cancer. 2016 Jul 19;16:502. PMID: 27435226 |
| Delatte B, Wang F, Ngoc LV, Collignon E, Bonvin E, Deplus R, Calonne E, Hassabi B, Putmans P, Awe S, Wetzel C, Kreher J, Soin R, Creppe C, Limbach PA, Gueydan C, Kruys V, Brehm A, Minakhina S, Defrance M, Steward R, Fuks F Transcriptome-wide distribution and function of RNA hydroxymethylcytosine. Science, 2016, 351(6270):282-5. PMID: 26816380 |
| Meier K, Brehm A Chromatin regulation: How complex does it get? Epigenetics, 2014, 9(11): 1485-95. PMID: 25482055 |
| Bergs JW, Neuendorff N, van der Heijden G, Wassenaar E, Rexin P, Elsässer HP, Moll R, Baarends WM, Brehm A Differential expression and sex chromosome association of CHD3/4 and CHD5 during spermatogenesis. PLoS One, 2014, 9(5):e98203. PMID: 24849318 |
| Fasulo B, Deuring R, Murawska M, Gause M, Dorighi KM, Schaaf CA, Dorsett D, Brehm A, Tamkun JW. The Drosophila MI-2 chromatin-remodeling factor regulates higher-order chromatin structure and cohesin dynamics in vivo. PLoS Genet. 2012 Aug;8(8):e1002878. PMID: 22912596 |
| Wagner E, Brehm A Muscles and Tendons of a Nucleosome Remodeling Machine. J Mol Biol, 2012, 422(1): 1-2. PMID: 22664199 |
| Meier K, Mathieu EL, Finkernagel F, Reuter LM, Scharfe M, Doehlemann G, Jarek M, Brehm A LINT, a novel dL(3)mbt-containing complex, represses malignant brain tumour signature genes. PLoS Genet., 2012, May 8(5), e 1002676. PMID: 22570633 |
| Mathieu EL, Fingernagel F, Murawska M, Scharfe M, Jarek M, Brehm A Recruitment of the ATP-dependent chromatin remodeler dMi-2 to the transcribed region of active heat shock genes. Nucleic Acids Res, 2012, June 1, 40(11), 4879-91. PMID: 22362736 |
| Murawska M, Brehm A Immunostaining of Drosophila polytene chromosomes to investigate recruitment of chromatin-binding proteins. Methods Mol Biol, 2012, 809-267-77. PMID: 22113282 |
| Murawska M, Brehm A CHD chromatin remodelers and the transcription cycle. Transcription, 2011, 244-53. PMID: 22223048 |
| Murawska M, Hassler M, Renkawitz-Pohl R, Ladurner A, Brehm A Stress-induced PARP activation mediates recruitment of Drosophila Mi-2 to promote heat shock gene expression PLoS Genet, 2011, July 7, e 1002206. PMID: 21829383 |
| Kreher J, Brehm A SAYP: a bridge connecting specific and general transcription regulators Cell Cycle, 2011, August 1, e 2420. PMID: 21734455 |
| Kunert N, Brehm A Novel Mi-2 related ATP-dependent chromatin remodelers. Epigenetics, 2009, 4, 209-11. PMID: 19535903 |
| van Vugt JJ, de Jager M, Murawska M, Brehm A, van Noort J, Logie C Multiple aspects of ATP-dependent nucleosome translocation by RSC and Mi-2 are directed by the underlying DNA sequence. PLoS One, 2009, e6345. PMID: 19626125 |
| Kunert N, Wagner E, Murawska M, Klinker H, Kremmer E, Brehm A dMec: a novel Mi-2 chromatin remodelling complex involved in transcriptional repression. EMBO J., 2009, 28, 533-44. PMID: 19165147 |
| Scharf A.N, Meier K, Seitz V, Kremmer E, Brehm A, Imhof A Monomethylation of Lysine 20 on Histone H4 Facilitates Chromatin Maturation Mol Cell Biol, 2009, 29, 57–67. PMID: 19001096 |
| Murawska M, Kunert N, van Vugt J, Längst G, Kremmer E, Logie C and Brehm A dCHD3 - a novel ATP-dependent chromatin remodeler associated with sites of active transcription Mol Cell Biol, 2008, 28, 2745-2757. PMID: 18250149 |
| Stielow B, Sapetschnig A, Krüger I, Kunert N, Brehm A, Boutros M, and Suske G Identification of SUMO-dependent chromatin-associated transcriptional repression components by a genome-wide RNA interference screen. Mol. Cell., 2008, 28, 742-754. PMID: 18374648 |
| Schmit F, Korenjak M, Mannefeld M, Schmitt K, Franke C, Eyss BV, Gagrica S, Hanel F, Brehm A and Gaubatz S LINC, a human complex that is related to pRb containing complexes in invertebrates regulates the expression of G2/M genes Cell Cycle, 2007, 6, 1903-1913. PMID: 1767143 |
| Korenjak M and Brehm A The retinoblastoma tumour suppressor in model organisms--new insights from flies and worms. Curr Mol Med, 2006, 6, 705-711. PMID: 17100596 |
| Bouazoune K and Brehm A ATP-dependent chromatin remodeling complexes in Drosophila Chromosome Res., 2006, 14, 433-449. PMID: 16821138 |
| Bouazoune K and Brehm A dMi-2 chromatin binding and remodeling activities are regulated by dCK2 phosphorylation J. Biol. Chem., 2005, 280, 41912-41920. PMID: 16223721 |
| Korenjak M and Brehm A E2F-Rb complexes regulating transcription of genes important for differentiation and development Curr. Opin. Genet. Dev., 2005, 15, 520-527. PMID: 16081278 |
| Korenjak M, Taylor-Harding B, Binne UK, Satterlee JS, Stevaux O, Aasland R, White-Cooper H, Dyson N, Brehm A Native E2F/RBF Complexes Contain Myb-Interacting Proteins and Repress Transcription of Developmentally Controlled E2F Target Genes. Cell, 2004, 119, 181-193. PMID: 15479636 |
| Taylor-Harding B, Binne U, Korenjak M, Brehm A and Dyson NJ p55/CAF1 is required for the repression of dE2F2/RBF regulated genes in Drosophila MCB, 2004, 24, 9124-9136. PMID: 15456884 |
| Sutcliffe JE, Brehm A Of flies and men; p53, a tumour suppressor. FEBS Letters, 2004, 567, 86-91. PMID: 15165898 |
| Brehm A, Tufteland KR, Aasland R and Becker PB The many colours of chromodomains. Bioessays, 2004, 26, 133-140. PMID: 14745831 |
| Sutcliffe JE, Korenjak M, Brehm A Tumour suppressors - a fly's perspective. Eur J Cancer, 2003, 39, 1355-62. PMID: 12826037 |
| Bouazoune K, Mitterweger A, Längst G, Imhof A, Akhtar A, Becker PB and Brehm A The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilisation EMBO J., 2002, 21, 2430-2440. PMID: 12006495 |
| Murawsky CM, Brehm A, Badenhorst P, Lowe N, Becker PB, Travers AA Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex EMBO Rep., 2001, 2, 1089-1094. PMID: 11743021 |
| Czermin B, Schotta G, Hulsmann BB, Brehm A, Becker PB, Reuter G, Imhof A Physical and functional association of Su(VAR)3-9 and HDAC1 in Drosophila EMBO Rep., 2001, 2, 915-919. PMID: 11571273 |
| Yang SH, Vickers E, Brehm A, Kouzarides T, Sharrocks AD Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1 Mol Cell Biol, 2001, 21, 2802-2814. PMID: 11283259 |
| Brehm A, Längst G, Kehle J, Clapier CR, Imhof A, Eberharter A, Muller J, Becker PB dMi-2 and ISWI chromatin remodelling factors have distinct nucleosome binding and mobilization properties EMBO J., 2000, 15, 4332-4341. PMID: 10944116 |
| Lutz M, Burke LJ, Barreto G, Goeman F, Greb H, Arnold R, Schultheiss H, Brehm A, Kouzarides T, Lobanenkov V, Renkawitz R Transcriptional repression by the insulator protein CTCF involves histone deacetylases Nucleic Acids Res., 2000, 15; 1707-1713. PMID: 10734189 |
| Martinez-Balbas MA, Bauer UM, Nielsen SJ, Brehm A, Kouzarides T Regulation of E2F1 activity by acetylation EMBO J., 2000, 19, 662-671. PMID: 10675335 |
| Fuks F, Burgers WA, Brehm A, Hughes-Davies L, Kouzarides T DNA methyltransferase dnmt1 associates with histone deacetylase activity Nat. Genet., 2000, 24, 88-91. PMID: 10615135 |
| Brehm A, Miska E, Reid J, Bannister A, Kouzarides T The cell cycle-regulating transcription factors E2F-RB Br. J. Cancer, 1999, 80, 38-41. PMID: 10466760 |
| Radkov SA, Touitou R, Brehm A, Rowe M, West M, Kouzarides T, Allday MJ Epstein-Barr virus nuclear antigen 3C interacts with histone deacetylase to repress transcription J. Virol., 1999, 73, 5688-5697. PMID: 10364319 |
| Brehm A, Nielsen JN, Miska EA, McCance DJ, Reid JL, Bannister AJ and Kouzarides T The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth EMBO J., 1999, 18, 2449-2458. PMID: 10228159 |
| Brehm A and Kouzarides T Retinoblastoma protein meets chromatin Trends Biochem. Sci., 1999, 24, 142-145. PMID: 10322419 |
| Brehm A, Ohbo K, Zwerschke W, Botquin V, Jansen-Dürr P and Schöler H Synergism with germ line transcription factor Oct-4: Viral oncoproteins share the ability to mimic a stem cell-specific activity Mol.Cell.Biol., 1999, 19, 2635-2643. PMID: 10082529 |
| Brehm A, Ovitt CE and Schöler HR Oct-4: more than just a POUerful marker of the mammalian germline? APMIS, 1998, 106, 114-124. PMID: 9524569 |
| Brehm A, Miska EA, McCance DJ, Reid JL, Bannister AJ and Kouzarides T Retinoblastoma protein recruits histone deacetylase to repress transcription Nature, 1998, 391, 597-601. PMID: 9468139 |
| Brehm A, Ohbo K, Schöler H The carboxy-terminal transactivation domain of Oct-4 acquires cell specificity through the POU domain Mol.Cell.Biol., 1997, 17, 154-162. PMID: 8972195 |
| Yeom YI, Fuhrmann G, Ovitt CE, Brehm A, Ohbo K, Gross M, Hübner K, Schöler HR Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells Development, 1996, 122, 881-894. PMID: 8631266 |