Main Content


Lenz J, Brehm A.
Conserved mechanisms of NuRD function in hematopoetic gene expression.
Enzymes. 2023;53:7-32. doi: 10.1016/bs.enz.2023.07.006. Epub 2023 Aug 30. PMID: 37748838.
Ullah I, Thölken C, Zhong Y, John M, Rossbach O, Lenz J, Gößringer M, Nist A, Albert L, Stiewe T, Hartmann R, Vázquez O, Chung HR, Mackay JP, Brehm A.
RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodeling.
Cell Rep. 2022 May 31;39(9):110895. doi: 10.1016/j.celrep.2022.110895. PMID: 35649367.
Lenz J, Liefke R, Funk J, Shoup S, Nist A, Stiewe T, Schulz R, Tokusumi Y, Albert L, Raifer H, Förstemann K, Vázquez O, Tokusumi T, Fossett N, Brehm A.
Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis. 
PLoS Genet. 2021 Feb 18;17(2):e1009318. doi: 10.1371/journal.pgen.1009318. PMID: 33600407.
Mačinković I, Theofel I, Hundertmark T, Kovač K, Awe S, Lenz J, Forné I, Lamp B, Nist A, Imhof A, Stiewe T, Renkawitz-Pohl R, Rathke C, Brehm A
Distinct CoREST complexes act in a cell-type-specific manner
Nucleic Acids Research, 2019 Dec 16;47(22):11649-11666
Hundertmark T, Kreutz S, Merle N, Nist A, Lamp B, Stiewe T, Brehm A, Renkawitz-Pohl R, Rathke C
Drosophila melanogaster tPlus3a and tPlus3b ensure full male fertility by regulating transcription of Y-chromosomal, seminal fluid, and heat shock genes.
PLoS One. 2019 Mar 7;14(3):e0213177
Kovač K, Sauer A, Mačinkovič M, Awe S, Finkernagel F, Hoffmeister H, Fuchs A, Müller R, Rathke C, Längst G, Brehm A
Tumour-associated missense mutations in the dMi-2 ATPase alter nucleosome remodelling properties in a mutation-specific manner
Nature Communications, 2018, 9:2112
Jox T, Buxa MK, Bohla D, Ullah I, Mačinkovič́ I, Brehm A, Bartkuhn M, Renkawitz R
Drosophila CP190- and dCTCF-mediated enhancer blocking is augmented by SUMOylation
Epigenetics & Chromatin, 2017, 10:32
Kim J, Lu C, Srinivasan S, Awe S, Brehm A, Fuller MT
Blocking promiscuous activation at cryptic promoters directs cell type-specific gene expression.
Science, 2017, 356:717-721
Kreher K, Kovač K, Bouazoune K, Mačinković K, Ernst AL, Engelen E, Pahl R, Finkernagel F, Murawska M, Ullah I, Brehm A
EcR recruits dMi-2 and increases efficiency of dMi-2-mediated remodelling to constrain transcription of hormone-regulated genes.
Nature Communications, 2017, 8:14806.
Fritsch K, Mernberger M, Nist A, Stiewe T, Brehm A, Jacob R
Galectin-3 interacts with components of the nuclear ribonucleoprotein complex.
BMC Cancer. 2016 Jul 19;16:502
Delatte B, Wang F, Ngoc LV, Collignon E, Bonvin E, Deplus R, Calonne E, Hassabi B, Putmans P, Awe S, Wetzel C, Kreher J, Soin R, Creppe C, Limbach PA, Gueydan C, Kruys V, Brehm A, Minakhina S, Defrance M, Steward R, Fuks F
Transcriptome-wide distribution and function of RNA hydroxymethylcytosine.
Science, 2016, 351(6270):282-5
Meier K, Brehm A
Chromatin regulation: How complex does it get?
Epigenetics, 2014, 9(11): 1485-95
Bergs JW, Neuendorff N, van der Heijden G, Wassenaar E, Rexin P, Elsässer HP, Moll R, Baarends WM, Brehm A
Differential expression and sex chromosome association of CHD3/4 and CHD5 during spermatogenesis.
PLoS One, 2014, 9(5):e98203
Fasulo B, Deuring R, Murawska M, Gause M, Dorighi KM, Schaaf CA, Dorsett D, Brehm A, Tamkun JW.
The Drosophila MI-2 chromatin-remodeling factor regulates higher-order chromatin structure and cohesin dynamics in vivo.
PLoS Genet. 2012 Aug;8(8):e1002878
Wagner E, Brehm A
Muscles and Tendons of a Nucleosome Remodeling Machine.
J Mol Biol, 2012, 422(1): 1-2
Meier K, Mathieu EL, Finkernagel F, Reuter LM, Scharfe M, Doehlemann G, Jarek M, Brehm A
LINT, a novel dL(3)mbt-containing complex, represses malignant brain tumour signature genes.
PLoS Genet., 2012, May 8(5), e 1002676
Mathieu EL, Fingernagel F, Murawska M, Scharfe M, Jarek M, Brehm A
Recruitment of the ATP-dependent chromatin remodeler dMi-2 to the transcribed region of active heat shock genes.
Nucleic Acids Res, 2012, June 1, 40(11), 4879-91

Murawska M, Brehm A
Immunostaining of Drosophila polytene chromosomes to investigate recruitment of chromatin-binding proteins.
Methods Mol Biol, 2012, 809-267-77

Murawska M, Brehm A
CHD chromatin remodelers and the transcription cycle.
Transcription, 2011, 244-53

Murawska M, Hassler M, Renkawitz-Pohl R, Ladurner A, Brehm A
Stress-induced PARP activation mediates recruitment of Drosophila Mi-2 to promote heat shock gene expression
PLoS Genet, 2011, July 7, e 1002206

Kreher J, Brehm A
SAYP: a bridge connecting specific and general transcription regulators
Cell Cycle, 2011, August 1, e 2420

Kunert N., Brehm A.
Novel Mi-2 related ATP-dependent chromatin remodelers.
Epigenetics, 2009, 4, 209-11

van Vugt JJ, de Jager M, Murawska M, Brehm A, van Noort J, Logie C.
Multiple aspects of ATP-dependent nucleosome translocation by RSC and Mi-2 are directed by the underlying DNA sequence.
PLoS One, 2009, e6345

Kunert N, Wagner E, Murawska M, Klinker H, Kremmer E, Brehm A.
 dMec: a novel Mi-2 chromatin remodelling complex involved in transcriptional repression.
 EMBO J., 2009, 28, 533-44

Scharf A.N., Meier K., Seitz V., Kremmer E., Brehm A., Imhof A.
Monomethylation of Lysine 20 on Histone H4 Facilitates Chromatin Maturation
Mol Cell Biol, 2009, 29, 57–67

Murawska M., Kunert N., van Vugt J., Längst G., Kremmer E., Logie C. and Brehm A.
dCHD3 - a novel ATP-dependent chromatin remodeler associated with sites of active transcription
Mol Cell Biol, 2008, 28, 2745-2757.

Stielow B, Sapetschnig A, Krüger I, Kunert N, Brehm A, Boutros M., and Suske G
Identification of SUMO-dependent chromatin-associated transcriptional repression components by a genome-wide RNA interference screen.
Mol. Cell., 2008, 28, 742-754.

Schmit F., Korenjak M., Mannefeld M., Schmitt K., Franke C., Eyss B.V., Gagrica S., Hanel F., Brehm A. and Gaubatz S.
LINC, a human complex that is related to pRb containing complexes in invertebrates regulates the expression of G2/M genes
Cell Cycle, 2007, 6, 1903-1913.

Korenjak M. and Brehm A.
The retinoblastoma tumour suppressor in model organisms--new insights from flies and worms.
Curr Mol Med, 2006, 6, 705-711.

Bouazoune K. and Brehm A.
ATP-dependent chromatin remodeling complexes in Drosophila
Chromosome Res., 2006, 14, 433-449.

Bouazoune K. and Brehm A.
dMi-2 chromatin binding and remodeling activities are regulated by dCK2 phosphorylation
J. Biol. Chem., 2005, 280, 41912-41920.

Korenjak M. and Brehm A.
E2F-Rb complexes regulating transcription of genes important for differentiation and development
Curr. Opin. Genet. Dev., 2005, 15, 520-527.

Korenjak M., Taylor-Harding B., Binne U.K., Satterlee J.S., Stevaux O., Aasland R., White-Cooper H., Dyson N.,
Brehm A.
Native E2F/RBF Complexes Contain Myb-Interacting Proteins and Repress Transcription of Developmentally Controlled E2F Target Genes.
Cell, 2004, 119, 181-193

Taylor-Harding B., Binne U., Korenjak M., Brehm A. and Dyson N.J.
p55/CAF1 is required for the repression of dE2F2/RBF regulated genes in Drosophila
MCB, 2004, 24, 9124-9136

Sutcliffe J.E., Brehm, A.
Of flies and men; p53, a tumour suppressor.
FEBS Letters, 2004, 567, 86-91

Brehm, A., Tufteland, K.R., Aasland, R. and Becker, P.B.
The many colours of chromodomains.
Bioessays, 2004, 26, 133-140.

Sutcliffe JE, Korenjak M, Brehm A.
Tumour suppressors - a fly's perspective.
Eur J Cancer, 2003, 39, 1355-62.

Bouazoune, K., Mitterweger, A., Längst, G., Imhof, A., Akhtar, A., Becker, P.B. and Brehm, A.
The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilisation
EMBO J., 2002, 21, 2430-2440.

Murawsky C.M., Brehm A., Badenhorst P., Lowe N., Becker P.B., Travers A.A.
Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex
EMBO Rep., 2001, 2, 1089-1094.

Czermin B., Schotta G., Hulsmann B.B., Brehm A., Becker P.B., Reuter G., Imhof A.
Physical and functional association of Su(VAR)3-9 and HDAC1 in Drosophila
EMBO Rep., 2001, 2, 915-919.

Yang S.H., Vickers E., Brehm A., Kouzarides T., Sharrocks A.D.
Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1
Mol Cell Biol, 2001, 21, 2802-2814.

Brehm A., Langst G., Kehle J., Clapier C.R., Imhof A., Eberharter A., Muller J., Becker P.B.
dMi-2 and ISWI chromatin remodelling factors have distinct nucleosome binding and mobilization properties
EMBO J., 2000, 15, 4332-4341.

Lutz M., Burke L.J., Barreto G., Goeman F., Greb H., Arnold R., Schultheiss H., Brehm A., Kouzarides T., Lobanenkov V., Renkawitz R.
Transcriptional repression by the insulator protein CTCF involves histone deacetylases
Nucleic Acids Res., 2000, 15; 1707-1713.

Martinez-Balbas, M.A., Bauer, U.M., Nielsen, S.J., Brehm, A., Kouzarides, T.
Regulation of E2F1 activity by acetylation
EMBO J., 2000, 19, 662-671.

Fuks, F., Burgers, W. A., Brehm, A., Hughes-Davies, L., Kouzarides, T.
DNA methyltransferase dnmt1 associates with histone deacetylase activity
Nat. Genet., 2000, 24, 88-91.

Brehm, A., Miska, E., Reid, J., Bannister, A., Kouzarides, T.
The cell cycle-regulating transcription factors E2F-RB
Br. J. Cancer, 1999, 80, 38-41.

Radkov, S.A., Touitou, R., Brehm, A., Rowe, M., West, M., Kouzarides, T., Allday, M.J.
Epstein-Barr virus nuclear antigen 3C interacts with histone deacetylase to repress transcription
J. Virol., 1999, 73, 5688-5697

Brehm, A., Nielsen, J.N., Miska, E.A., McCance, D.J., Reid, J.L., Bannister, A.J. and Kouzarides, T.
The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth
EMBO J., 1999, 18, 2449-2458

Brehm, A. and Kouzarides, T.
Retinoblastoma protein meets chromatin
Trends Biochem. Sci., 1999, 24, 142-145

Brehm, A., Ohbo, K., Zwerschke, W., Botquin, V., Jansen-Dürr, P. and Schöler, H.
Synergism with germ line transcription factor Oct-4: Viral oncoproteins share the ability to mimic a stem cell-specific activity
Mol.Cell.Biol., 1999, 19, 2635-2643

Brehm, A., Ovitt, C.E. and Schöler, H.R.
Oct-4: more than just a POUerful marker of the mammalian germline?
APMIS, 1998, 106, 114-124

Brehm, A., Miska, E.A., McCance, D.J., Reid, J.L., Bannister, A.J. and Kouzarides, T.
Retinoblastoma protein recruits histone deacetylase to repress transcription
Nature, 1998, 391, 597-601

Brehm, A., Ohbo, K., Schöler, H.
The carboxy-terminal transactivation domain of Oct-4 acquires cell specificity through the POU domain
Mol.Cell.Biol., 1997, 17, 154-162

Yeom, Y.I., Fuhrmann, G., Ovitt, C.E., Brehm, A., Ohbo, K., Gross, M., Hübner, K., Schöler, H.R.
Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells
Development, 1996, 122, 881-894