Main Content

Regulation of chromatin function by arginine methylation

Red cell background, medicine scientific, molecular research dna
Foto: Colourbox.de

Our research focusses on posttranslational modifications by the enzyme family of protein arginine methyltransferases (PRMTs). Arginine methylation of histones and other chromatin proteins regulates DNA-dependent processes, such as transcription and DNA repair. Similar to other epigenetic regulators, PRMTs are mis-expressed in cancer and other diseases. Therefore we are interested in characterizing

  • gene regulatory pathways controlled by PRMTs and their substrates.
  • molecular mechanisms, by which arginine methylation affects gene regulation and cross-talks with other epigenetic regulators.
  • how the enzymatic activity and the chromatin recruitment of PRMTs is regulated.
  • how PRMTs and their methylation substrates contribute to diseases, which show mutation, mis-expression or deregulation of the enzymes.
nucleus.jpg




For background information and more detailed description of our research please click the "Research" button on the right.

Funding:

  • DFG (Deutsche Forschungsgemeinschaft)
  • BMBF (Bundesministerium für Forschung und Bildung)
  • Land Hessen (LOEWE)
  • José Carrera Leukämie Stiftung (DJCLS)