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Screening and Automation Technologies (SAT)

Laboratory Automation, Next Generation Sequencing, and Fermentation

Dr. Javier Serrania

Microbial Comparative Genomics, AG Becker
Karl-von-Frisch-Str. 14, 35032 Marburg
Phone: +49-6421 28 24452

Dipl. Ing. Patrick Manz

Microbial Comparative Genomics, AG Becker
Karl-von-Frisch-Str. 14, 35032 Marburg
Phone: +49-6421 28 22001


In synthetic biology, high-throughput screens and combinatorial experiments are powerful strategies to support the design–build–test engineering process of gene circuits and biosynthetic pathways. However, manual execution of such experiments is error-prone and often not feasible because of the required throughput. Only recently, advances in computer-aided design and laboratory automation technologies enable such innovative and highly complex experiments: Instead of building and testing of a handful of genetic constructs manually, hundreds to thousands of constructs can now be generated and characterized in an automated way. To tap the potential of these approaches, SYNMIKRO established a Laboratory Automation Unit at its Department of Microbial Comparative Genomics which has been operational since summer 2013. The unit provides access to this technology to the members of the center and is a competent partner both for the design and the execution of automated experiments. In addition, the unit’s mission is the development and application of novel experimental methods and processes in the field.

Recent Publications

Korfhage N, Mühling M, Ringshandl S, Becker A, Schmeck B, Freisleben B (2020) Detection and segmentation of morphologically complex eukaryotic cells in fluorescence microscopy images via feature pyramid fusion. PLoS Comput Biol. 16: e1008179

Jung A, Raßbach A, Pulpetta RL, van Teeseling MCF, Heinrich K, Sobetzko P, Serrania J, Becker A, Thanbichler M (2019) Two-step chromosome segregation in the stalked budding bacterium Hyphomonas neptunium. Nat Commun. 10: 3290

Kemter FS, Schallopp N, Sperlea T, Serrania J, Sobetzko P, Fritz G, Waldminghaus T (2019) Stringent response leads to continued cell division and a temporal restart of DNA replication after initial shutdown in Vibrio cholerae. Mol Microbiol. 111: 1617-1637

Cooperation Partners