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Prof. Pablo Rivera-Fuentes, University of Zurich, Switzerland: Chemigenetic Tools for Imaging and Sensing

Speaker Series. Abstract: The combination of genetically encoded tags and their cognate small-molecule fluorophores is a powerful way to image specific protein targets. In the past decade, a large palette of fluorogenic dyes that emit in the visible range (400-650 nm) has been developed for the self-labeling protein tags HaloTag and SNAP-tag. Probes with additional functions, such as biosensing, or that emit at longer wavelengths, which is essential for in vivo applications, are still in development. In this lecture, I will present our efforts to develop chemigenetic probes to sense small biomolecules and reach long wavelengths without compromising on the excellent contrast and specificity of fluorescent proteins.

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