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Publications Carsten Culmsee

Selected Publications


2012

Dolga Am, Culmsee C (2012) Protective roles for potassium SK/K(Ca)2 channels in microglia and neurons. Front Pharmacol 3:196 Free PMC article

Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C (2012) Activation of KCNN3/SK3/K(Ca)2.3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia. Glia 60(12): 2050-64

Oxler EM, Dolga A, Culmsee C (2012) AIF depletion provides neuroprotection through a preconditioning effect. Apoptosis 17(10):1027-38

Grohm J, Kim SW, Mamrak U, Tobaben S, Cassidy-Stone A, Nunnari J, Plesnila N, Culmsee C (2012) Inhibition of Drp1 provides neuroprotection in vitro and in vivo. Cell Death Differ 19(9):1446-58

Diemert S, Dolga AM, Tobaben S, Grohm J, Pfeifer S, Öxler E, Culmsee C (2012) Impedance measurement for real time detection of neuronal cell death. J Neurosci Methods 203(1):69-77

2011

Tobaben S, Grohm J, Seiler A, Conrad M, Plesnila N, Culmsee C (2011) Bid-mediated mitochondrial damage is a key mechnism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons. Cell Death and Differentiation 18(2):282-292 [Epub 2010 Aug. 6]
 
Dolga AM, Terpolilli N, Kepura F, Nijholt IM, Knaus H-G, D’Orsi B, Prehn JHM, Eisel ULM, Plant T, Plesnila N, Culmsee C (2011) KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia. Cell Death Dis. 2, e:147

Dolga AM, Culmsee C, de Lau L, Winter Y, Oertel WH, Luiten PG, Eisel UL (2011) Statins - increasing or reducing the risk of Parkinson's disease? Exp Neurol. 228(1): 1-4 [Epub 2010 Nov. 24]

Nijboer CH, Heijnen CJ, van der Kooij MA, Zijlstra J, van Velthoven CT, Culmsee C, van Bel F, Hagberg H, Kavelaars A (2011)Targeting the p53 pathway to protect the neonatal ischemic brain. Ann Neurol. 2011 Aug;70(2):255-64.


2010

Hangen E, De Zio D, Bordi M, Zhu C, Dessen P, Caffin F, Lachkar S, Perfettini JL, Lazar V, Benard J, Fimia GM, Piacentini M, Harper F, Pierron G, Vicencio JM, Bénit P, de Andrade A, Höglinger G, Culmsee C, Rustin P, Blomgren K, Cecconi F, Kroemer G, Modjtahedi N (2010) A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2.Cell Death Differ. 17(7):1155-66  [Epub 2010 Jan 29.]

Grohm J, Plesnila N, Culmsee C (2010) Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death.
Brain Behav Immun. 24(5):831-8 [Epub 2009 Dec. 2]

2009

Cardoso AL, Costa P, de Almeida LP, Simões S, Plesnila N, Culmsee C, Wagner E, de Lima MC (2009) Tf-lipoplex-mediated c-jun silencing improves neuronal survival following excitotoxic damage in vivo. J Control Release. 2010 Mar 19;142(3):392-403

Culmsee C (2009) Targeting beta2-adrenoceptors for neuroprotection after cerebral ischemia: is inhibition or stimulation best? Anesth Analg. 2009 Jan;108(1):3-5.



2008

Slemmer JE, Zhu C, Landshamer S, Trabold R, Grohm J, Ardeshiri A, Wagner E, Sweeney MI, Blomgren K, Culmsee C, Weber JT, Plesnila N (2008) Causal role of apoptosis-inducing factor for neuronal cell death following traumatic brain injury. Am J Pathol. 2008 Dec;173(6):1795-805.

Cardoso AL, Simões S, de Almeida LP, Plesnila N, Pedroso de Lima MC, Wagner E, Culmsee C (2008) Tf-lipoplexes for neuronal siRNA delivery: a promising system to mediate gene silencing in the CNS. J Control Release. 2008 Dec 8;132(2):113-23.

Seiler A, Schneider M, Förster H, Roth S, Wirth EK, Culmsee C, Plesnila N, Kremmer E, Rådmark O, Wurst W, Bornkamm GW, Schweizer U, Conrad M (2008) Glutathione peroxidase 4 senses  and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab. 2008 Sep;8(3):237-48.

Beck H, Semisch M, Culmsee C, Plesnila N, Hatzopoulos AK (2008) Egr-1 regulates expression of the glial scar component phosphacan in astrocytes after experimental stroke. Am J Pathol. 2008 Jul;173(1):77-92.

Landshamer S, Hoehn M, Barth N, Duvezin-Caubert S, Schwake G, Tobaben S, Kazhdan I, Becattini B, Zahler S, Vollmar A, Pellecchia M, Reichert A, Plesnila N, Wagner E, Culmsee C (2008) Bid-induced release of  AIF from mitochondria causes immediated neuronal cell death. Cell Death Differ. 2008 Oct;15(10):1553-63


2007

Gaedtke L, Thoenes L, Culmsee C, Mayer B, Wagner E (2007) Proteomic analysis reveals differences in spheroid versus monolayer cultures of low passage colon cancer cells. J Proteome Res , Epub ahead of print,  PubMed / Reprint request

Culmsee C, Junker V, Thal S, Kremers W, Schneider H, Plesnila N, Krieglstein J (2007) Enantio-selective effects of clenbuterol in cultured neurons and astrocytes, and in a mouse model of cerebral ischemia. Epub ahead of print EurJ Pharm. PubMed / Reprint request

Plesnila N, von Baumgarten L, Retiounskaia M, Engel D, Ardeshiri A, Zimmermann R, Hofmann F, Landshamer S, Wagner E, Culmsee C (2007). Delayed neuronal death after brain trauma involves p53-dependent inhibition of NF-kB transcriptional activity. Cell Death Diff., 14: 1529-1541. PubMed / Reprint request

Tarcha PJ, Pelisek J,Merdan t,Waters J, Cheung K, v Gersdorff K, Culmsee C, Wagner E (2007) Synthesis and Characterization of Chemically Condensed Oligoethyleneimine Containing Beta-Aminopropionamide Linkages for siRNA Delivery. Biomaterials 28: 3731-40. PubMed / Reprint request

Isele NB, Lee HS, Landshamer S, Straube A, Padovan CS, Plesnila N, Culmsee C (2007) Bone marrow stromal cells mediate protection through stimulation of PI3-K/Akt and MAPK signaling in neurons. NeurochemInt. 50: 243-250. PubMed / Reprint request

Ameri K, Hammond EM, Culmsee C, Raida M, Katschinski DM, Wenger RH, Wagner E, Davis RJ, Hai T, Denko N, Harris AL (2007) Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway. Oncogene. 26: 284-289. PubMed / Reprint request

Henn IH, Bouman L, Schlehe JS, Schlierf A, Schramm JE, Wegener E, Nakaso K, Culmsee C, Berninger B, Krappmann D, Tatzelt J, Winklhofer KF (2007) Parkin mediates neuroprotection through activation of IKK/NF-kB signalling. J. Neuroscience 27: 1868-1878. PubMed / Reprint request

Zhu C, Wang X, Huang Z, Qiu L, Xu F, Vahsen N, Nilsson M, Eriksson PS, Hagberg H, Culmsee C, Plesnila N, Kroemer G, Blomgren K. (2007) Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia. Cell Death Differ. 14: 775-784. PubMed / Reprint request

Cardoso AL, Simões S, Almeida LP, Pelisek J., Culmsee C, Wagner E, Pedroso de Lima MC (2007) siRNA delivery by Transferrin associated Lipoplexes: a non-viral strategy to mediate gene silencing. J Gene Med 9: 170-183. PubMed / Reprint request

Culmsee C, Krieglstein J. (2007) Ischaemic brain damage after stroke: new insights into efficient therapeutic strategies. International Symposium on Neurodegeneration and Neuroprotection. EMBO Rep. 8, 129 – 133. PubMed / Reprint request



2006

Culmsee C, Gasser E, Hansen S, Tonn JC, Wagner E, Goldbrunner R (2006) Effects of Raf-1 siRNA on human microvascular endothelial cells: A potential therapeutic strategy for inhibition of tumor angiogenesis. Brain Res 1125: 147-154. PubMed / Reprint request

Becattini B, Culmsee C, Leone M, Zhai D, Zhang X, Crowell KJ, Rega MF, Landshamer S, Reed JC, Plesnila N, Pellecchia M (2006) Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid. Proc Natl Acad Sci U S A. 103: 12602-12606. PubMed / Reprint request

Culmsee C, Plesnila N (2006) Targeting Bid to prevent programmed cell death in neurons. Biochem Soc Trans 34: 1334-1340. PubMed / Reprint request

Culmsee C, Landshamer S (2006) Molecular insights into mechanisms of the cell death program: role in the progression of neurodegenerative disorders. CurrAlzheimer Res 3: 269-283. PubMed / Reprint request

Culmsee C, Krieglstein J (2006) Emerging pharmacotherapeutic strategies for the treatment of ischemic stroke. Drug Discovery Today.Therapeutic strategies. 621-628.



2005

Culmsee C, Zhu C, Landshamer S, Becattini B, Wagner E, Pellecchia M, Blomgren K, Plesnila N (2005) Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia. J Neurosci. 25:10262-10272. PubMed / Reprint request

Culmsee C, Gerling N, Landshamer S, Rickerts B, Duchstein HJ, Umezawa K, Klumpp S, Krieglstein J (2005)  Nitric oxide donors induce neurotrophin-like survival signaling and protect neurons against apoptosis. Mol Pharmacol. 68:1006-1017. PubMed / Reprint request

Culmsee C, Krieglstein J (2005). Mechanisms of neuronal degeneration after ischemic stroke – emerging targets for novel therapeutic strategies. Drug Discovery Today.Disease Mechanisms. 2:463-470.

Culmsee C, Mattson MP (2005) The role of p53 in neuronal apoptosis. BiochemBiophys Res Com. 331:761-777. PubMed / Reprint request



2004

Culmsee C, Junker V, Kremers W, Thal S, Plesnila N, Krieglstein J (2004) Combination therapy in ischemic stroke. Synergistic neuroprotective effects of memantine and clenbuterol. Stroke, 35:1197-1202. PubMed / Reprint request

Plesnila N, Zhu C, Culmsee C, Gröger M, Moskowitz MA, Blomgren K (2004) Nuclear Translocation of Apoptosis-Inducing Factor (AIF) after Focal Cerebral Ischemia. J Cereb Blood Flow Metab, 24:458-466. PubMed / Reprint request

Zhu Y, Culmsee C, Klumpp S, Krieglstein J (2004) Activation of NF-kB through PI3K/Akt and MAPK/Erk1,2 signaling contributes to the neuroprotective effect of TGFß1 in hippocampal neurons. Neuroscience 123:897-906. PubMed / Reprint request

Gerling N, Culmsee C, Klumpp S, Krieglstein J (2004) The tyrosine phosphatase inhibitor orthovanadate mimics NGF-induced neuroprotective signaling in rat hippocampal neurons. NeurochemInt, 44:505-520. PubMed / Reprint request

Boeckle S, v. Gersdorff K, V.d. Piepen S, Culmsee C, Wagner E, Ogris M (2004) Purification of polyethyleneimine polyplexes highlights the role of free polycation in gene transfer. J Gene Med 6:1102-1111. PubMed / Reprint request



2003

Culmsee C, Siewe J, Junker V, Retiounskaia m, Schwarz S, Camandola S, El-Metainy S, Behnke H, Mattson MP, Krieglstein J (2003) Reciprocal inhibition of p53 and NF-kappa B transcriptional activities determines cell survival or death in neurons. J Neuroscience, 18:8586-8595. PubMed / Reprint request



2002

Culmsee C, Junker V, Gerling N, Lehmann M, Nikolova-Karakashian M, Prehn JHM, Mattson MP, Krieglstein J (2002) NGF-induced neuroprotection in hippocampal neurons requires the common neurotrophin receptor p75NTR. Neuroscience, 115:1089-1108. PubMed / Reprint request

Zhu Y, Yang GY, Ahlemeyer B, Pang L, Che XM, Culmsee C, Klumpp S, Krieglstein J (2002) Transforming growth factor-beta 1 increases bad phosphorylation and protects neurons against damage. J Neurosci 22:3898-3909. PubMed / Reprint request

Zhu X, Yu QS, Cutler R, Culmsee C, Holloway HW, Mattson MP, Greig NH. (2002) Design and synthesis of novel p53 inhibitors as neuroprotective agents. J Med Chem 45:5090-5097. PubMed / Reprint request

Van Ess PJ, Pedersen WA, Culmsee C, Mattson MP, Blouin RA (2002) Elevated hepatic and depressed renal cytochrome P450 activity in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurochem 80:571-578. PubMed / Reprint request

Junker V, Becker A, Hühne R, Zembatov M, Ravati A, Culmsee C, Krieglstein J (2002) Stimulation of ß-adrenoceptors activates astrocytes and provides neuroprotection. Eur J Pharm 446:25-36. PubMed / Reprint request

Chan SL, Culmsee C, Haughey N, Klapper W, Mattson MP (2002) Presinilin-1 mutations sensitize neurons to DNA-damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12. NeurobiolDis, 11:2-19. PubMed / Reprint request

Bui TN, König, HG, Culmsee C, Bauerbach E, Poppe M, Krieglstein J, Prehn JHM (2002) p75 neurotrophin receptor is required for constitutive and NGF survival signalling in PC12 cells and rat hippocampal neurons. J Neurochem 81:594-605. PubMed / Reprint request

Stumm R, Rummel, J, Junker V, Culmsee C, Pfeiffer M, Krieglstein J, Höllt V, Schulz S (2002) A dual role for the SDF-1/CXCR4 chemokine receptor system in adult brain: isoform selective regulation of SDF-1 expression and cerebral leukocyte recruitment after focal ischemia. J Neurosci 22:5865-5878. PubMed / Reprint request



2001

Culmsee C, Zhu Y, Krieglstein J, Mattson MP (2001) Evidence for the involvement of Par-4 in ischemic cell death. J Cereb Blood Flow Metab 21:334-343.

Culmsee C, Zhu X, Yu Q, Chan SL, Camandola S, Guo Z, Greig N, Mattson MP (2001) A synthetic inhibitor of p53 protects neurons in the brain against ischemic and excitotoxic injury. J Neurochem 77:220-228.

Culmsee C, Bondada S, Mattson MP (2001) Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity. Brain Res Mol Brain Res 87:257-262.

Culmsee C, Monnig J, Kemp B, Mattson MP (2001) Evidence that AMP activated protein kinase protects against metabolic, excitotoxic and oxidative insults in embryonic hippocampal neurons. J Mol Neurosci 17:45-58.

Stumm R, Culmsee C, Schafer MK, Krieglstein J, Weihe E (2001) Adaptive plasticity in tachykinin and tachykinin receptor expression after focal cerebral ischemia is differentially linked to gabaergic and glutamatergic cerebrocortical circuits and cerebrovenular endothelium. J Neurosci 21:798-811.

Zhu Y, Culmsee C, Roth-Eichhorn S, Krieglstein J (2001) ß2-Adrenoceptor stimulation enhances latent TGF-ß1 binding protein-1 and TGF-ß1 expression in rat hippocampus after transient forebrain ischemia. Neuroscience 107:593-602.



2000

Fu W, Killen M, Culmsee C, Dhar S, Pandita TK, Mattson MP (2000) The catalytic subunit of telomerase protects developing brain neurons against apoptosis. J Mol Neurosci, 14:3-15.

Kruman II, Culmsee C, Chan S, Kruman Y, Penix L, Mattson MP (2000) Homocysteine induces apoptosis and accelerates oxidative and excitotoxic damage in hippocampal neurons. J Neurosci 20:6920-6926.

Schaper C, Zhu Y, Kouklei M, Culmsee C, Krieglstein J (2000) Stimulation of 5-HT(1A) receptors reduces apoptosis after transient forebrain ischemia in the rat. Brain Res 883:41-50.

Zhu Y, Roth-Eichhorn S, Braun N, Culmsee C, Rami A, Krieglstein J (2000) The expression of transforming growth factor-beta1 (TGF-beta1) in hippocampal neurons: a temporary upregulated protein level after transient forebrain ischemia in the rat. Brain Res 866:286-298.

Pedersen WA, McCullers D, Culmsee C, Haughey NJ, Kasarskis E, Herman JP, Mattson MP (2000) Neuroprotective effects of corticotropin releasing hormone against amyloid-beta peptide toxicity in experimental models of Alzheimer’s disease. NeurobiolDis 8:492-503.

Mattson MP, Culmsee C, Yu ZF, Camandola S (2000) Roles of NF-kB in neuronal survival and plasticity. J Neurochem, 74:443-456.

Mattson MP, Culmsee C, Yu ZF (2000) Apoptosis and anti-apoptotic mechanisms in stroke. Cell Tiss Research, 301:173-187.



1999

Culmsee C, Pedersen WA, Ziegler D, Herman J, Mattson MP (1999) Aberrant stress response associated with severe hypoglycemia in a transgenic mouse model of Alzheimer’s disease. J Mol Neurosci, 13: 159-165.

Culmsee C, Vedder H, Ravati A, Junker V, Otto D, Ahlemeyer B, Krieg JC, Krieglstein J (1999) Neuroprotection by estrogens in a mouse model of focal cerebral ischemia and in cultured neurons: Evidence for a receptor independent antioxidative mechanism. J Cereb Blood Flow Metab, 19:1263-1269.

Culmsee C, Semkova I, Krieglstein J (1999) NGF mediates the neuroprotective effect of the b2-adrenoceptor agonist clenbuterol in vitro and in vivo: Evidence from a NGF-antisense study. NeurochemInt, 35: 47-57.

Culmsee C, Stumm R K, Schaefer MKH, Weihe E, Krieglstein J (1999) Clenbuterol induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage. EurJ Pharmacol, 379: 33-45.

Ravati A, Junker V, Kouklei M, Ahlemeyer B, Culmsee C, Krieglstein J (1999) Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats. EurJ Pharmacol 373: 21-33.

Zhu Y, Prehn JHM, Culmsee C, Krieglstein J (1999) The b2-adrenoceptor agonist clenbuterol modulates bcl-2, bcl-xl and bax protein expression following transient forebrain ischemia. Neuroscience 90: 1255-1263.

Mattson MP, Pedersen WA, Duan W, Culmsee C, Camandola S. (1999) Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases. Ann N Y Acad Sci, 893:154-75.



1998

Culmsee C, Junker V, Wolz P, Semkova I, Krieglstein J (1998) Lubeluzole protects hippocampal neurons from excitotoxicity in vitro and reduces brain damage caused by ischemia. Eur J Pharmacol, 342: 193-201.

Braun N, Zhu Y, Culmsee C, Krieglstein J, Zimmermann H (1998) Upregulation of the enzyme chain hydrolizing extracellular ATP following transient forebrain ischemia in the rat. J Neurosci, 18: 4891-4900.

Zhu Y, Culmsee C, Semkova I, Krieglstein J (1998) Stimulation of b2-adrenoceptors inhibits apoptosis in rat brain after transient forebrain ischemia. J Cereb Blood Flow Metab, 18: 1032-1039.


Zuletzt aktualisiert: 18.01.2013 · Frank Balzer

 
 
 
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