Main Content
Publications
2023
58. Hirschhäuser A, Molitor D, Salinas G, Großhans J, Rust K, Bogdan S. Single-cell transcriptomics identifies new blood cell populations in Drosophila released at the onset of metamorphosis. Development. 150:dev201767. doi: 10.1242/dev.201767.
57. L Long, HS Beati, J Heras Chanes, F di Pietro, Y Bellaiche, HA Müller, J Großhans. Kinesin-1 patterns Par-1 and Rho signaling at the cortex of syncytial embryos of Drosophila. J Cell Biol (2023) in press
56. N Lenner, S Eule, J Großhans, F Wolf. "Reverse-time analysis uncovers universality classes in directional biological dynamics." arXiv preprint arXiv:2304.03226
55. N Lenner, M Häring, S Eule, J Großhans, F Wolf. "Reverse-time analysis and boundary classification of directional biological dynamics with multiplicative noise." arXiv preprint arXiv:2304.04279
54. N Lenner, M Häring, S Eule, J Großhans, F Wolf. "Signatures of heterogeneity in the statistical structure of target state aligned ensembles." arXiv preprint arXiv:2304.09719
53. Schmidt A, Finegan T, Häring M, Kong D, Fletcher AG, Alam Z, Grosshans J, Wolf F, Peifer M. Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins Mol Biol Cell (2023), in press
2022
52. D. Kong, J. Großhans. Optochemical Control of Cell Contractility in Drosophila Embryos. Methods Mol Biol. 2022;2540:285-299, doi: 10.1007/978-1-0716-2541-5_14
51. Z. Lv, N. Zhang, X. Zhang, J. Großhans, D. Kong. The lateral epidermis actively counteracts pulling by the amnioserose during dorsal closure. Front Cell Dev Biol 10 (2022) 865397. doi: 10.3389/fcell.2022.865397
50. A. Schmidt, L. Li, S. Yan, J. Großhans. Restriction of sub apical proteins during cellularization depends on the onset of zygotic transcription and the formin Dia. Dev Biology 487 (2022) 110–121. doi: 10.1016/j.ydbio.2022.04.012
49. F. Lehne, T. Rokrant, G. Salinas-Riester, J. Großhans, K. Rust, J. Faix, S. Bogdan. Calcium bursts allow rapid reorganisation of EFhD2/Swip-1 crosslinked actin networks in epithelial wound closure. Nat Comm 13 (2022) 2492. doi: 10.1038/s41467-022-30167-0
2021
48. A. Schmidt, L. Li, Z. Lv, S. Yan, J. Großhans. Dia- and Rok-dependent enrichment of capping proteins in a cortical region. J Cell Sci 134 (2021) jcs258973. doi: 10.1242/jcs.258973
2020
47. Z. Lv J. Rosenbaum, S. Mohr, X. Zhang, D. Kong, H. Preiß, S. Kruss, K. Alim, T. Aspelmeier, J, Großhans. The emergent Yo-yo movement of nuclei driven by cytoskeletal remodeling in pseudo-synchronous mitotic cycles. Curr Biol 30 (2020) 2564–2573.e5, doi: 10.1016/j.cub.2020.04.078
46. B. Liu, I. Gregor, HA. Müller, J. Großhans. Fluorescence fluctuation analysis reveals PpV dependent Cdc25 protein dynamics in living embryos. PLOS Gen 16 (2020) e1008735. doi: 10.1371/journal.pgen.1008735
45. Selvaggio G, Chizhik A, Nißler R, Kuhlemann L, Meyer D, Vuong L, Preiß H, Herrmann N, Mann FA, Lv Z, Oswald TA, Spreinat A, Erpenbeck L, Großhans J, Karius V, Janshoff A, Pablo Giraldo J, Kruss S. Exfoliated near infrared fluorescent silicate nanosheets for (bio)photonics. Nat Commun. 11 (2020) 1495. doi: 10.1038/s41467-020-15299-5
2019
44. B. Liu, HW Sung, J. Großhans. Multiple functions of the essential gene PpV in Drosophila early development. G3 (2019) doi: 10.1534/g3.119.400662
43. D. Kong, Z. Lv, M. Häring, B. Lin, F. Wolf, J. Großhans. In vivo optochemical control of cell contractility at single cell resolution. EMBO rep (2019) doi: 10.15252/embr.201947755
42. FA. Mann, Z. Lv, J. Großhans, F. Opazo, S. Kruss. Nanobody conjugated nanotubes for targeted near-infrared in vivo imaging and sensing. Ange Chem Int Ed (2019) doi: 10.1002/anie.201904167
41. B. Liu, F. Winkler, M. Herde, HP. Witte, J. Großhans. A link between deoxyribonucleotide metabolites and embryonic cell-cycle control. Curr Biol 29 (2019) 1187–1192, doi: 10.1016/j.cub.2019.02.021
2018
40. S. Yan, J. Großhans. Localization and translation control of slam in Drosophila cellularization. Fly (2018) dot: 10.1080/19336934.2018.1520574
39. F Kaiser, Z Lv, DM Rodrigues, J Rosenbaum, T Aspelmeiser, J Großhans, K Alim. Mechanical model of nuclei ordering in Drosophila embryos reveals dilution of stochastic forces". Biophys J 114 (2018) 1730–1740 doi: 10.1016/j.bpj.2018.02.018
38. R Petrovski, G Krohne, J Großhans. Overexpression of the lamina proteins Lamin and Kugelkern induces specific ultrastructural alterations in the morphology of the nuclear envelope of intestinal stem cells and enterocytes. EJCB 97 (2018) 102–113 doi: 10.1016/j.ejcb.2018.01.002
37. Z. Lv, J Rosenbaum, T Aspelmeier, J Großhans. A “molecular guillotine” reveals an interphase function of Kinesin-5. J Cell Sci 131 (2018) jcs210583 doi: 10.1242/jcs.210583
36. A Schmidt, Z Lv, J Großhans. ELMO and Sponge specify subapical restriction of Canoe and formation of the subapical domain in early Drosophila embryos. Development 145 (2018) dev157909 doi: 10.1242/dev.157909
35. R Petrovski, J Großhans. Expression of lamina proteins suppresses stem cell proliferation. Nucleus 9 (2018) 104–118. doi: 10.1080/19491034.2017.1412028
2017
34. S Yan, S Acharya, S Gröning, J Großhans. Slam dictates subcellular localization and expression of it own mRNA. Plos Biol 15 (2017) e2003315. doi: 10.1371/journal.pbio.2003315
33. S Karsch, D Kong, J Großhans, A Janshoff. Single cell defects cause a collective and remote mechanical response in a confluent cell layer. Biophys J 113 (2017) 2601–2608. doi: 10.1016/j.bpj.2017.10.025
32. I Gregor, M Spiecker, R Petrovsky, J Großhans, R Ros, J Enderlein. Rapid non-linear image scanning microscopy, Nat Meth 14 (2017) 1087–1089. doi: 10.1038/nmeth.4467
31. A Prahlad, C Spalthoff, D Kong, J Grosshans, M Göpfert, CF Schmidt. Mechanical properties of a Drosophila larval chordotonal organ. Biophys J 113 (2017) 2796–2804. doi: 10.1016/j.bpj.2017.08.061
30. F Winkler, M Kriebel, M Clever, S Gröning, J Großhans. Essential function of the Serine hydroxymethyl transferase (SHMT) gene during rapid syncytial cell cycle in Drosophila, G3 7 (2017) 2305–2314. doi: 10.1534/g3.117.043133
2015
29. F Winkler, M Gummalla, L Küneke, Z Lv, A Zippelius, T Aspelmeier, J Großhans. Fluctuation analysis of centrosomes reveals a cortical function of Kinesin-1. Biophys J 109 (2015) 856-868. doi: 10.1016/j.bpj.2015.07.044
28. AD Wessel, M Gummalla, J Grosshans, CF Schmidt. The mechanical properties of early Drosophila embryos measured by high- speed video microrheology. Biophys J 108 (2015) 1899-1907. doi: 10.1016/j.bpj.2015.02.032
2014
27. C Koke, T Kanesaki, J Großhans, US Schwarz, CM Dunlop. A computational model of nuclear self-organisation in syncytial embryos. J Theor Biol 359 (2014) 92-100. doi: 10.1016/j.jtbi.2014.06.001
26. Y Zhang, D Kong, L Reichl, N Vogt, F Wolf, J Großhans. The glucosyltransferase Xiantuan of the endoplasmic reticulum specifically affects E-Cadherin expression and is required for gastrulation movements in Drosophila. Dev Biol 390 (2014) 208-220. doi: 10.1016/j.ydbio.2014.03.007
25. S Acharya, P Laupsien, C Wenzl, S Yan, J Großhans. Function and dynamics of slam in furrow formation in early Drosophila embryo. Dev Biol, 386 (2014) 371-384. doi: 10.1016/j.ydbio.2013.12.022
2013
24. O Schulz, C Pieper, D Hähnel, M Clever, J Pfaff, RH Kehlenbach, FS Wouters, J Großhans, G Bunt, J Enderlein. Resolution-doubling in fluorescence microscopy with Confocal Spinning-Disk Image Scanning Microscopy. PNAS 110 (2013) 21000-21005. doi: 10.1073/pnas.1315858110
23. S Yan, Z Lv, M Winterhoff, C Wenzl, T Zobel, J Faix, S Bogdan, J Großhans. The F-BAR protein Cip4/Toca-1 antagonizes the formin Diaphanous in membrane stabilization and compartmentalization. J Cell Sci 126 (2013) 1796-1805. doi: 10.1242/jcs.118422.
22. H.-w Sung, S. Spangenberg, N. Vogt, J Großhans. Number of nuclear divisions in the Drosophila blastoderm controlled by onset of zygotic transcription. Curr Biol 23 (2013) 133-138. doi: 10.1016/j.cub.2012.12.013.
21. T Kanesaki, S Hirose, J Großhans, N Fuse. Heterotrimeric G protein signaling governs the cortical stability during apical constriction in Drosophila gastrulation. Mech Dev 130 (2013) 132-142. doi: 10.1016/j.mod.2012.10.001
2011
20. SC Albrecht, A Barata, J Großhans, AA Teleman, TP Dick. In vivo mapping of hydrogen peroxide and oxidaized glutathione reveals chemical and regional specificity of redox homeostasis. Cell metabolism 14 (2011) 819-829. doi: 10.1016/j.cmet.2011.10.010
19. T. Kanesaki, C. Edwards, U. Schwarz, J. Großhans. Dynamic ordering of nuclei in syncytial embryos: a quantitative analysis of the role of cytoskeletal networks. Integ Biol 3 (2011) 1112-1119. doi: 10.1039/c1ib00059d
2010
18. M Polychronidou, A Hellwig, J Großhans. The farnesylated nuclear proteins Kugelkern and LaminDmO affect nuclear morphology by directly interacting with the nuclear membrane. Mol Biol Cell 21 (2010) 3409-3420. doi: 10.1091/mbc.E10-03-0230
17. A Haghayeghi, A Sarac, J Großhans, F Schöck. Pellino is required for Toll pathway activation in Drosophila innate immunity. Mech Dev 127 (2010) 301-307. doi: 10.1016/j.mod.2010.01.004
16. C. Wenzl, S. Yan, P. Laupsien, J. Großhans. Localization of RhoGEF2 during Drosophila cellularization is developmentally controlled by slam. Mech Dev 127 (2010) 371-384. doi: 10.1016/j.mod.2010.01.001
2009
15. A. van Impel, S. Schumacher, M. Draga, H.-M. Herz, J. Großhans, H. A. Müller. Regulation of the RacGTPase pathway by the multi-functional RhoGEF Pebble is essential for mesoderm migration in the Drosophila gastrula. Development 136 (2009) 813-822. doi: 10.1242/dev.026203
2008
14. A. Brandt, G. Krohne, J. Großhans. The farnesylated nuclear proteins Kugelkern and Lamin B promote aging-like phenotypes in Drosophila flies. Aging Cell, 7 (2008) 541-551. doi: 10.1111/j.1474-9726.2008.00406.x
13. Y. Wang, P. Janicki, I. Köster, CD. Berger, C. Wenzl, J. Großhans, H. Steinbeisser. Xenopus paraxial protocadherin regulates morphogenesis by antagonizing sprouty. Genes Dev. 22 (2008) 878-883. doi: 10.1101/gad.452908
2007
12. T. Kitzing, A. S. Sahadevan, D. T. Brandt, H. Knieling, S. Hannemann, O. T. Fakler, J. Großhans, R. Grosse. Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion. Genes Dev. 21 (2007) 1478-1483.
11. P. Gawlinski, R. Nikolay,C. Goursot, S. Lawo, B. Chaurasia, H.-M. Herz, Y. Kußler-Schneider, T. Ruppert, M. Mayer, J. Großhans. The Drosophila mitotic inhibitor Frühstart specifically binds to the hydrophobic patch of Cyclins. EMBO rep. 8 (2007) 490-496.
2006
10. A. Brandt, F. Papagiannouli, N. Wagner, M. Wilsch-Bräuninger, M. Braun, E. E. Furlong, S. Loserth, C. Wenzl, F. Pilot, N. Vogt, T. Lecuit, G. Krohne, J. Großhans. Developmental control of nuclear size and shape by Kugelkern and Kurzkern. Curr. Biol. 16 (2006) 543--552.
2005
9. J. Großhans*, C. Wenzl, H.-M. Herz, S. Bartoszewski, F. Schnorrer, N. Vogt, H. Schwarz, A. Müller. RhoGEF2 and the formin Dia control the formation of the furrow canal by directed actin assembly during Drosophila cellularisation. Development 132 (2005) 1009-1020. * corresponding author
2004
8. S. Bartoszewski, S. Luschnig, I. Desjeux, J. Großhans, and C. Nüsslein-Volhard. Drosophila p24 homologues eclair and baiser are necessary for the activity of the maternally expressed TKV receptor during early embryogenesis. Mech. Dev. 121 (2004) 1259-1273.
2003
7. J. Großhans*, A. Müller, and E. Wieschaus. Control of cleavage cycles in Drosophila embryos by frühstart. Dev. Cell 5 (2003) 285-294. * corresponding author
2001
6. N. Q. Fernandez, J. Großhans, J. S. Goltz, and D. Stein. Redundant regulatory determinants mediate Drosophila dorsal group dependent degradation of Cactus. Development 128 (2001) 2963-2974.
5. S. Bacher, J. Großhans, W. Dröge, and L. Schmitz. The Drosophila proteins Pelle and Tube induce JNK/AP-1 activity in mammalian cells. FEBS Letters 497 (2001) 153-158.
2000
4. J. Großhans* and E. Wieschaus. A genetic link between morphogenesis and cell division during formation of the ventral furrow in Dorsophila. Cell 101 (2000) 523-531. DOI:10.1016/s0092–8674(00)80862–4* corresponding author
1999
3. J. Großhans*, F. Schnorrer, and C. Nüsslein-Volhard. Oligomerisation of Tube and Pelle leads to nuclear localisation of Dorsal. Mech. Devel. 81 (1999) 139-150. * corresponding author
1994
2. J. Großhans*, A. Bergmann, P. Haffter, and C. Nüsslein-Volhard. Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo. Nature 372 (1994) 563-566. DOI:10.1038/372563a0 * corresponding author
1993
1. J. Großhans and R. Wolfenden. Transition-state discrimination by adenosine deaminase from Aspergillus oryzae, Biochem. Biophy. Acta 1161 (1993) 28-32.