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Research and Publications

Our research has been funded by the Deutsche Forschungsgemeinschaft (DFG), the Volkswagenstiftung, the Thyssen-Stiftung, EMBO, Boehringer Ingelheim Fonds (BIF), Deutscher Akademischer Austauschdienst (DAAD) and Chinese Scholarship Council (CSC). We have participated in several collaborative research concortia, including DFG/SPP1782 “Epithelial junctions”, DFG/SPP1464 “Dynamics and function of actin nucleator complexes”, DFG/FOR1756 “Functional dynamics of cell contacts”, DFG/GRK2213 “Membrane plasticity”, VW/CIDBN Göttingen “Big Data/Deep learning techniques…”.

Selected recent publications

A Schmidt, J Großhans. Dynamics of cortical domains in early Drosophila development, J Cell Sci 131 (2018) jcs212795. doi:10.1242/jcs.212795 (review)

D Kong, F Wolf, J Großhans. Forces directing germ-band extension in Drosophila embryo (review). Mech Dev 144 (2017) 11–22 doi: 10.1016/j.mod.2016.12.001

S Bogdan, J Schulz, J Großhans. Formin' cellular structures - physiological roles of Diaphanous (Dia) in actin dynamics. (review). Comm Integ Biol, 6 (2013) e27634. doi: 10.4161/cib.27634

Z. Lv J. Rosenbaum, S. Mohr, X. Zhang, D. Kong, H. Preiß, S. Kruss, K. Alim, T. Aspelmeier, J, Großhans. The emergent Yo-yo movement of nuclei driven by cytoskeletal remodeling in pseudo-synchronous mitotic cycles. Curr Biol (2020)

D. Kong, Z. Lv, M. Häring, B. Lin, F. Wolf, J. Großhans. In vivo optochemical control of cell contractility at single cell resolution. EMBO rep (2019) doi: 10.15252/embr.201947755

B Liu*, F Winkler*, M Herde, CP Witte, J Grosshans. A link between deoxyribonucleotide metabolites and embryonic cell cycle control. Curr Biol 29 (2019) 1187-1192

F Kaiser, Z Lv, DM Rodrigues, J Rosenbaum, T Aspelmeiser, J Großhans, K Alim. Mechanical model of nuclei ordering in Drosophila embryos reveals dilution of stochastic forces". Biophys J 114 (2018) 1730-1740

S Yan, S Acharya, S Gröning, J Großhans. Slam dictates subcellular localization and expression of it own mRNA. Plos Biol 15 (2017) e2003315

I Gregor, M Spiecker, R Petrovsky, J Großhans, R Ros, J Enderlein. Rapid non-linear image scanning microscopy, Nat Meth 14 (2017) 1087-1089

AD Wessel, M Gummalla, J Grosshans, CF Schmidt. The mechanical properties of early Drosophila embryos measured by high-speed video microrheology. Biophysical Journal 108 (2015) 1899-1907


Research publications