Hannah Klinkhammer Ph. D.
Research Fellow
Contact information
+49 6421 28-26429 hannah.klinkhammer@ 1 Hans-Meerwein-Straße 635032 Marburg
H|04 Institutsgebäude (Room: 04B07)
Organizational unit
Philipps-Universität Marburg Medizin (Fb20) Zentrum für Methodenwissenschaften und Gesundheitsforschung (Methodenwissenschaften und Gesundheitsforschung) Institut für Medizinische Biometrie und Statistik (Medizinische Biometrie und Statistik)Research Interests
- Statistical genetics
- Polygenic scores
- Prediction modeling
- Statistical boosting
- Variable selection for high-dimensional data
Selected Publications
- Strömer Annika, Klein Nadja, Staerk Christian, Faschingbauer Florian, Klinkhammer Hannah and Mayr Andreas (2025). Enhanced variable selection for boosting sparser and less complex models in distributional copula regression. Statistics in Bioscience (2025).
- Mak Christopher C.Y., Klinkhammer Hannah, […], Hsieh Tzung-Chien, Chung Brian H.Y. “Artificial intelligence-driven genotype–epigenotype–phenotype approaches to resolve challenges in syndrome diagnostics“. In: eBioMedicine 115 (2025), 105677.
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Klinkhammer Hannah, Staerk Christian, Maj Carlo, Krawitz Peter M., Mayr Andreas. “Genetic Prediction Modeling in Large Cohort Studies via Boosting Targeted Loss Functions”. In: Statistics in Medicine 43 (2024), pp. 5412–5430
- Schmidt Axel, Danyel Magdalena, Grundmann Kathrin, Brunet Theresa, Klinkhammer Hannah, [...], Krawitz Peter M., Haack Tobias, Ehmke Nadja, Wagner Matias. “Next-generation phenotyping integrated in a national framework for patients with ultrarare disorders improves genetic diagnostics and yields new molecular findings”. In: Nature Genetics 56.8 (2024), pp. 1644–1653
- Staerk Christian, Klinkhammer Hannah, Wistuba Tobias, Maj Carlo, Mayr Andreas. “Generalizability of polygenic prediction models: how is the R2 defined on test data?” In: BMC Medical Genomics 17.1 (2024), p. 132.
- Dueñas Nuria, Klinkhammer Hannah, Bonifaci Nuria, Spier Isabel, Mayr Andreas, Hassanin Emadeldin, Diez-Villanueva Anna, Moreno Victor, Pineda Marta, Maj Carlo, Capellà Gabriel, Aretz Stefan, Brunet Joan. “Ability of a polygenic risk score to refine colorectal cancer risk in Lynch syndrome”. In: Journal of Medical Genetics 60.11 (2023), pp. 1044–1051.
- Klinkhammer Hannah, Staerk Christian, Maj Carlo, Krawitz Peter Michael, Mayr Andreas. “A statistical boosting framework for polygenic risk scores based on large-scale genotype data”. In: Frontiers in Genetics 13 (2023), p. 1076440.
Profiles
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1 The email addresses are only selectable in the intranet. To complete an email address, merge following string ".uni-marburg.de" or "uni-marburg.de" to the end of the email address.