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  • Foto: S. Bogdan

Department of Molecular Cell Physiology - Bogdan lab

The actin cytoskeleton provides mechanical support for cells and generates forces to drive cell shape changes, cell fusion and cell migration in tissue morphogenesis and remodeling. Molecular understanding of actin dynamics requires a genetically traceable model system that allows interdisciplinary experimental approaches to elucidate the regulatory network of cytoskeletal proteins in vivo. We use Drosophila as a model system that allows combining genetics, high-resolution live-imaging techniques with cell biological and biochemical approaches to identify new actin regulators and actin functions, signaling pathways and mechanisms of actin regulation in vivo.



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