Main Content

Publications of subproject TP1

Human leukocyte antigen (HLA)-transgenic mice as a pre-clinical model of pemphigus vulgaris

Original papers

Polakova A, Kauter L, Ismagambetova A, Didona D, Solimani F, Ghoreschi K, Hertl M, Möbs C, Hudemann C. Detection of rare autoreactive T cell subsets in patients with pemphigus vulgaris. Front Immunol. 2022, 13:979277. https://doi.org/10.3389/fimmu.2022.979277. eCollection 2022

Hudemann C, Exner Y, Pollmann R, Schneider K, Zakrzewicz A, Feldhoff S, Schmidt T, Spindler V, Rafei-Shamsabadi D, Völlner F, Waschke J, Tikkanen R, Hertl M, Eming R. IgG against the Membrane-Proximal Portion of the Desmoglein 3 Ectodomain Induces Loss of Keratinocyte Adhesion, a Hallmark in Pemphigus Vulgaris. J Invest Dermatol. 2022, S0022-202X(22)01901-7. https://doi.org/10.1016/j.jid.2022.07.030. Online ahead of print.

Hudemann C, Maglie R, Llamazares-Prada M, Beckert B, Didona D, Tikkanen R, Schmitt T, Hashimoto T, Waschke J, Hertl M, Eming R. Human Desmocollin 3‒Specific IgG Antibodies Are Pathogenic in a Humanized HLA Class II Transgenic Mouse Model of Pemphigus. J Invest Dermatol. 2022; 142(3B), 915-923. https://doi.org/10.1016/j.jid.2021.06.017.

Boch K, Dräger S, Zillikens D, Hudemann C, Hammers CM, et al. Immunization with desmoglein 3 induces non-pathogenic autoantibodies in mice. PLOS ONE. 2021. 16(11):e0259586. https://doi.org/10.1371/journal.pone.0259586

Sliwiak P, Folwarczny E, Didona D, Fink S, Wiegand C, Hanschmann E M, Hertl M, Hudemann C. Redox Enzymes of the Thioredoxin Family as Potential and Novel Markers in Pemphigus. Oxidative Medicine and Cellular Longevity. 2021. https://doi.org/10.1155/2021/6672693

Pollmann R, Walter E, Schmidt T, Waschke J, Hertl M, Möbs C, Eming R. Identification of Autoreactive B cell Subpopulations in Peripheral Blood of Autoimmune Patients with Pemphigus vulgaris. Front Immunol. 2019. https://doi.org/10.3389/fimmu.2019.01375

Walter E, Vielmuth F, Wanuske MT, Seifert M, Pollmann R, Eming R, Waschke J. Role of Dsg1- and Dsg3-Mediated Signaling in Pemphigus Autoantibody-Induced Loss of Keratinocyte Cohesion. Front Immunol. 2019. https://doi.org/10.3389/fimmu.2019.01128

Kugelmann D, Rötzer V, Walter E, Egu DT, Fuchs MT, Vielmuth F, Vargas-Robles H, Schnoor M, Hertl M, Eming R, Rottner K, Schmidt A, Spindler V, Waschke J. Role of Src and Cortactin in Pemphigus Skin Blistering. Front Immunol. 2019;10:626. https://doi.org/10.3389/fimmu.2019.00626

• Inhalt ausklappen Inhalt einklappen Published before 2019

  Amber KT, Maglie R, Solimani F, Eming R, Hertl M. Targeted Therapies for Autoimmune Bullous Diseases: Current Status. Drugs. 2018;78(15):1527-1548

  Pollmann R, Eming R. Research Techniques Made Simple: Mouse Models of Autoimmune Blistering Diseases. J Invest Dermatol. 2017;137(1):e1-e6. https://doi.org/10.1016/j.jid.2016.11.003

  Walter E, Vielmuth F, Rotkopf L, Sárdy M, Horváth ON, Goebeler M, Schmidt E, Eming R, Hertl M, Spindler V, Waschke. Different signaling patterns contribute to loss of keratinocyte cohesion dependent on autoantibody profile in pemphigus. Sci Rep. 2017;7(1): 3579

  Purath U., Ibrahim R., Zeitvogel J., Renz H., Runkel F., Schmidts T., Dobler D., Werfel T., Müller A., Garn H. Efficacy of T cell transcription factor-specific DNAzymes in murine skin inflammation models. J. Allergy Clin. Immunol. 2015. https://doi.org/10.1016/j.jaci.2015.09.022

  Homburg, U., Renz H, Timmer W, Hohlfeld JM, Seitz F, Lüer K, Mayer A, Wacker A, Schmidt O, Kuhlmann J, Turowska A, Roller J, Kutz K, Schlüter G, Krug N, Garn H. Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma. J. Allergy Clin. Immunol. 2015. https://doi.org/10.1016/j.jaci.2015.02.018

  Krug N., Hohlfeld JM, Kirsten AM, Kornmann O, Beeh KM, Kappeler D, Korn S, Ignatenko S, Timmer W, Rogon C, Zeitvogel J, Zhang N, Bille J, Homburg U, Turowska A, Bachert C, Werfel T, Buhl R, Renz J, Garn H*, Renz H*. Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme. N. Engl. J. Med. 2015, 372,1987-95. DOI: 10.1056/NEJMoa1411776

  Eming R, Hennerici T, Bäcklund J, Feliciani C, Visconti KC, Willenborg S, Schmidt J, Holmdahl R, Sonderstrup G, Hertl M. Pathogenic IgG antibodies against desmoglein 3 in pemphigus vulgaris are regulated by HLA-DRB1*04:02-restricted T cells. J Immunol. 2014 193(9):4391-9. https://doi.org/10.4049/jimmunol.1401081

  Nagel A, Möbs C, Raifer H, Wiendl H, Hertl M, Eming R. CD3-positive B cells: a storage-dependent phenomenon. Plos One. 2014, Oct 16;9(10):e110138. doi: 10.1371/journal.pone.0110138. eCollection 2014. https://doi.org/10.1371/journal.pone.0110138

  Dicke T, Pali-Schöll I, Kaufmann A, Bauer S, Renz H, Garn H. Absence of unspecific innate immune cell activation by GATA-3-specific DNAzymes. Nucleic Acid Ther. 2012 Apr;22(2):117-26. https://doi.org/10.1089/nat.2011.0294

  Rafei D, Müller R, Ishii N, Llamazares M, Hashimoto T, Hertl M, Eming R. IgG autoantibodies against desmocollin 3 in pemphigus sera induce loss of keratinocyte adhesion. Am J Pathol. 2011;178:718-23. https://doi.org/10.1016/j.ajpath.2010.10.016

  Nagel A, Podstawa E, Eickmann M, Müller HH, Hertl M, Eming R. Rituximab mediates a strong elevation of B-cell-activating factor associated with increased pathogen-specific IgG but not autoantibodies in pemphigus vulgaris. J Invest Dermatol. 2009;129:2202-10. https://doi.org/10.1038/jid.2009.27

  Sel S, Wegmann M, Dicke T, Sel S, Henke W, Yildirim AO, Renz H, Garn H. Effective prevention and therapy of experimental allergic asthma using a GATA-3-specific DNAzyme. J Allergy Clin Immunol. 2008 Apr;121(4):910-916. https://doi.org/10.1016/j.jaci.2007.12.1175

  Eming R, Nagel A, Wolff-Franke S, Podstawa E, Debus D, Hertl M. Rituximab exerts a dual effect in pemphigus vulgaris. J Invest Dermatol. 2008; 128: 2850–8. https://doi.org/10.1038/jid.2008.172

  Eming R, Büdinger L, Riechers R, Christensen O, Bohlen H, Kalish R, Hertl M. Frequency analysis of autoreactive T-helper 1 and 2 cells in bullous pemphigoid and pemphigus vulgaris by enzyme-linked immunospot assay. Br J Dermatol. 2000;143:1279-82.  https://doi.org/10.1046/j.1365-2133.2000.03901.x

Review articles

Spindler V, Eming R, Schmidt E, Amagai M, Grando S, Jonkman MF, Kowalczyk AP, Müller EJ, Payne AS, Pincelli C, Sinha AA, Sprecher E, Zillikens D, Hertl M, Waschke J. Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus. J Invest Dermatol. 2018; 138(1): 32-37. https://doi.org/10.1016/j.jid.2017.06.022

Pollmann R, Schmidt T, Eming R, Hertl M. Pemphigus: a Comprehensive Review on Pathogenesis, Clinical Presentation and Novel Therapeutic Approaches. Clin Rev Allergy Immunol. 2018;54(1):1-25

Garn, H., H. Renz. GATA-3-specific DNAzyme - A novel approach for stratified asthma therapy. Eur J Immunol 2017; 47: 22-30. https://doi.org/10.1002/eji.201646450

Potaczek. D.P., H. Garn, S.D. Unger, H. Renz. Antisense molecules: A new class of drugs. J Allergy Clin Immunol 2016; 137: 1334-1346. https://doi.org/10.1016/j.jaci.2015.12.1344