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Publications of subproject TP5

Desmoglein-dependent signaling complexes in pemphigus

Original papers

Kugelmann D, Anders M, Sigmund A, Egu D, Eichkorn R, Yazdi A, Sárdy M, Hertl M, Didona D, Hashimoto T, Waschke J. (2022) Role of ADAM10 and ADAM17 in the Regulation of Keratinocyte Adhesion in Pemphigus Vulgaris. Front. Immunol. 13:884248. https://doi.org/10.3389/fimmu.2022.884248

Egu DT, Schmitt T, Sigmund AM, Waschke J. (2022) Electron microscopy reveals that phospholipase C and Ca2+ signaling regulate keratin filament uncoupling from desmosomes in Pemphigus. Ann Anat. 241:151904. https://doi.org/10.1016/j.aanat.2022.151904

Fuchs M, Kugelmann D, Schlegel N, Vielmuth F, Waschke J. (2022) Desmoglein 2 can undergo Ca2+-dependent interactions with both desmosomal and classical cadherins including E-cadherin and N-cadherin. Biophys J. 121(7):1322-1335. https://doi.org/10.1016/j.bpj.2022.02.023

Büchau F, Vielmuth F, Waschke J, Magin TM (2022) Bidirectional regulation of desmosome hyperadhesion by keratin isotypes and desmosomal components. Cell Mol Life Sci. 79(5):223. doi: 10.1007/s00018-022-04244-y

Hudemann C, Maglie R, Llamazares-Prada M, Beckert B, Didona D, Tikkanen R, Schmitt T, Hashimoto T, Waschke J, Hertl M, Eming R. J (2022) Human Desmocollin 3‒Specific IgG Antibodies Are Pathogenic in a Humanized HLA Class II Transgenic Mouse Model of Pemphigus. Invest Dermatol. 142(3 Pt B):915-923. https://doi.org/10.1016/j.jid.2021.06.017

Schmitt T, Egu DT, Walter E, Sigmund AM, Eichkorn R, Yazdi A, Schmidt E, Sárdy M, Eming R, Goebeler M, Waschke J (2021) Ca2+ signalling is critical for autoantibody-induced blistering of human epidermis in pemphigus. Br J Dermatol. 185(3):595-604. https://doi.org/10.1111/bjd.20091

Hiermaier M, Kliewe F, Schinner C, Stüdle C, Maly IP, Wanuske MT, Rötzer V, Endlich N, Vielmuth F, Waschke J, Spindler V (2020) The Actin-Binding Protein α-Adducin Modulates Desmosomal Turnover and Plasticity. J Invest Dermatol., 141(5):1219-1229. https://doi.org/10.1016/j.jid.2020.09.022

Wanuske MT, Brantschen D, Schinner C, Stüdle C, Walter E, Hiermaier M, Vielmuth F, Waschke J, Spindler V (2020) Clustering of desmosomal cadherins by desmoplakin is essential for cell-cell adhesion. Acta Physiol., 231(4):e13609. https://doi.org/10.1111/apha.13609

Sigmund AM, Steinert LS, Egu DT, Bayerbach FC, Waschke J, Vielmuth F (2020) Dsg2 Upregulation as a Rescue Mechanism in Pemphigus. Front Immunol. 28;11:581370. https://doi.org/10.3389/fimmu.2020.581370

Fuchs M, Sigmund AM, Waschke J, Vielmuth F. (2020) Desmosomal Hyperadhesion Is Accompanied with Enhanced Binding Strength of Desmoglein 3 Molecules. Biophys J. 119(8):1489-1500. https://doi.org/10.1016/j.bpj.2020.09.008

Egu DT, Sigmund AM, Schmidt E., Spindler V, Walter E, Waschke J (2020) A new ex vivo human oral mucosa model reveals that p38MAPK inhibition is not effective to prevent autoantibody-induced mucosal blistering in pemphigus. Br J Dermatol, 182(4):987-994. https://doi.org/10.1111/bjd.18237

  • Inhalt ausklappen Inhalt einklappen Published before 2020Published before 2020

    Pollmann R, Walter E, Schmidt T, Waschke J, Hertl M, Möbs C, Eming R (2019) Identification of Autoreactive B Cell Subpopulations in Peripheral Blood of Autoimmune Patients With Pemphigus Vulgaris. Front Immunol., 10:1375. https://doi.org/10.3389/fimmu.2019.01375

    Egu DT, Kugelmann D, Waschke J (2019) Role of PKC and ERK Signaling in Epidermal Blistering and Desmosome Regulation in Pemphigus. Front Immunol. 6;10:2883. https://doi.org/10.3389/fimmu.2019.02883

    Walter E, Vielmuth F, Wanuske MT, Seifert M, Pollmann R, Eming R, Waschke J (2019) Role of Dsg1- and Dsg3-mediated signaling in pemphigus autoantibody-induced loss of keratinocyte adhesion. Front Immunol., 10:1128. https://doi.org/10.3389/fimmu.2019.01128

    Radeva MY, Walter E, Stach RA, Yazdi AS, Schlegel N, Sarig O, Sprecher E, Waschke J (2019) ST18 enhances PV-IgG-induced loss of keratinocyte cohesion in parallel to increased ERK activation. Front Immunol., 10:770. https://doi.org/10.3389/fimmu.2019.00770

    Kugelmann D, Rötzer V, Walter E, Egu DT, Fuchs M, Vielmuth F, Vargas-Robles H, Schnoor M, Hertl M, Eming R, Rottner K, Schmidt A, Spindler V, Waschke J (2019) Role of Src and cortactin in pemphigus skin blistering. Front Immunol. 10:626. https://doi.org/10.3389/fimmu.2019.00626

    Fuchs M, Foresti M, Radeva M, Kugelmann D, Keil R, Hatzfeld M, Spindler V, Waschke J*, Vielmuth F*  (2019) Plakophilin 1 but not Plakophilin 3 regulates desmoglein clustering. Cell. Mol. Life Sci., 76(17):3465-3476. * co-corresponding.  https://doi.org/10.1007/s00018-019-03083-8

    Kugelmann D, Radeva MY, Spindler V, Waschke J (2019) Dsg1 deficiency causes lethal skin blistering. J Invest Dermatol., 139(7):1596-1599. https://doi.org/10.1016/j.jid.2019.01.002

    Schlögl E, Radeva MY, Vielmuth F, Schinner S, Waschke J, Spindler V, (2018) Keratin retraction and desmoglein 3 Internalization independently contribute to autoantibody-induced cell dissociation in pemphigus vulgaris. Front Immunol., 9:858.

    Vielmuth F, Walter E, Fuchs M, Radeva MY, Buechau F, Magin TM, Spindler V, Waschke J (2018) Keratins regulate p38MAPK-dependent desmoglein binding properties in pemphigus. Front Immunol., 9:528.

    Vielmuth F, Wanuske MT, Radeva MY, Hiermaier M, Kugelmann D, Walter E, Buechau F, Magin TM, Waschke J*, Spindler V* (2018) Keratins Regulate the Adhesive Properties of Desmosomal Cadherins through Signaling. J Invest Dermatol. 138(1):121-131. * co-corresponding.

    Schinner C, Vielmuth F, Rötzer, V, Hiermaier M, Radeva M, Co TK, Hartlieb E, Schmidt A, Imhof A, Messoudi A, Horn A, Schlipp A, Spindler V, Waschke J  (2017) Adrenergic signaling strengthens cardiac myocyte cohesion. Circ Res. 120(8):1305-1317.

    Walter E, Vielmuth F, Rotkopf L, Sárdy M, Horváth ON, Goebeler M, Schmidt E, Eming R, Hertl M, Spindler V, Waschke J (2017) Different signaling patterns contribute to loss of keratinocyte cohesion dependent on autoantibody profile in pemphigus. Sci Rep., 7(1): 3579.

    Egu DT, Walter E, Spindler V, Waschke J (2017) Inhibition of p38MAPK signaling prevents epidermal blistering and alterations of desmosome structure induced by pemphigus autoantibodies in human epidermis. Br J Dermatol, 177(6):1612-1618.

Review articles

Schmitt T, Waschke J. (2020) Autoantibody-Specific Signalling in Pemphigus. Front Med, 9;8:701809. https://doi.org/10.3389/fmed.2021.701809

Waschke J (2018) Desmogleins as signaling hubs regulating cell cohesion and tissue/organ function in skin and heart- EFEM lecture 2018. Ann Anat., 226:96-100. https://doi.org/10.1016/j.aanat.2018.11.006

Vielmuth F, Spindler V, Waschke J (2018) Atomic force microscopy provides new mechanistic insights into the pathogenesis of pemphigus. Front. Immunol. 9: 485. https://doi.org/10.3389/fimmu.2018.00485

Spindler V, Waschke J (2018) Pemphigus-A Disease of Desmosome Dysfunction Caused by Multiple Mechanisms. Front. Immunol. 1;9:136. https://doi.org/10.3389/fimmu.2018.00136

Spindler V, Eming R, Schmidt E, Amagai M, Grando S, Jonkman MF, Kowalczyk AP, Müller EJ, Payne AS, Pincelli C, Sinha AA, Sprecher E, Zillikens D, Hertl M, Waschke J (2018) Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus. J. Invest. Dermatol. 138(1):32-37. https://doi.org/10.1016/j.jid.2017.06.022

Schmidt E, Spindler V, Eming R, Amagai M, Antonicelli F, Baines JF, Belheouane M, Bernard P, Borradori L, Caproni M, Di Zenzo G, Grando S, Harman K, Jonkman MF, Koga H, Ludwig RJ, Kowalczyk AP, Müller EJ, Nishie W, Pas H, Payne AS, Sadik CD, Seppänen A, Setterfield J, Shimizu H, Sinha AA, Sprecher E, Sticherling M, Ujiie H, Zillikens D, Hertl M, Waschke J (2017). Meeting Report of the Pathogenesis of Pemphigus and Pemphigoid Meeting in Munich. J. Invest. Dermatol. 137(6):1199-1203. https://doi.org/10.1016/j.jid.2017.01.028