Main Content

Publications of subproject TP4

Flotillins in the regulation of desmosomal adhesion in pemphigus

Original papers

Zakrzewicz A, Würth C, Beckert B, Feldhoff S, Vanderheyden K, Foss S, Andersen JT, de Haard H, Verheesen P, Bobkov V, Tikkanen R (2022) Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with efgartigimod: Novel Treatment Paradigm for Pemphigus? Cells, 11, 942. https://doi.org/10.3390/cells11060942

Hudemann C, Maglie R, Llamazares-Prada M, Beckert B, Didona D, Tikkanen R, Schmitt T, Hashimoto T, Waschke J, Hertl M, Eming R. J (2022) Human Desmocollin 3‒Specific IgG Antibodies Are Pathogenic in a Humanized HLA Class II Transgenic Mouse Model of Pemphigus. J Invest Dermatol. 142(3 Pt B):915-923. https://doi.org/10.1016/j.jid.2021.06.017

Beckert B, Panico F, Pollmann R, Eming R, Banning A, Tikkanen R (2019) Immortalized human hTert/KER-CT keratinocytes as a model system for research on desmosomal adhesion and pathogenesis of Pemphigus Vulgaris. Int J Mol Sci, 20, 3113. https://doi.org/10.3390/ijms20133113

Kessler EA, van Stuijvenberg L, van Bavel JJA, van Bennekom J, Zwartsen A, Rivaud MA, Vink A, Efimov IA, van Tintelen JP, Remme CA, Marc A. Vos MA, Banning A, de Boer TP, Tikkanen R, van Veen TAB. (2019) Flotillins in the intercalated disc are potential modulators of cardiac excitability. J Mol Cell Cardiol, 126:86-95. https://doi.org/10.1016/j.yjmcc.2018.11.007

• Inhalt ausklappen Inhalt einklappen Published before 2019

  Banning A, Babuke T, Kurrle N, Meister M, Ruonala MO, Tikkanen R. (2018) Flotillins regulate focal adhesions by interacting with α-actinin and by influencing the activation of Focal Adhesion Kinase. Cells, 7, 28. https://doi.org/10.3390/cells7040028

  Meister M, Baenfer S, Gärtner U, Koskimies J, Amaddii M, Jacob R, Tikkanen R. (2017) Regulation of cargo transfer between ESCRT-0 and ESCRT-I complexes by flotillin-1 during endosomal sorting of ubiquitinated cargo. Oncogenesis 6, e344. doi:10.1038/oncsis.2017.47

  Völlner F, Ali J, Kurrle N, Exner Y, Eming R, Hertl M, Banning A, Tikkanen R. (2016) Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes. Sci Rep, 6, 28820. 

  Kühne S, Ockenga W, Banning A, Tikkanen R. (2015) Cholinergic Transactivation of the EGFR in HaCaT Keratinocytes Stimulates a Flotillin-1 Dependent MAPK-Mediated Transcriptional Response. Int J Mol Sci, 16, 6447-6463. https://doi.org/10.3390/ijms16036447

  Fork C, Hitzel J, Nichols BJ, Tikkanen R, Brandes RP. (2014) Flotillin-1 facilitates Toll-like receptor 3 signaling in human endothelial cells. Basic Res Cardiol, 109:439. doi: 10.1007/s00395-014-0439-4.

  Meister M, Zuk A, Tikkanen R. (2014) Role of dynamin and clathrin in cellular trafficking of flotillins. FEBS J. Jul;281(13):2956-76. https://doi.org/10.1111/febs.12834

  John BA, Meister M, Banning A, Tikkanen R. (2014) Flotillins bind to the Dileucine Sorting Motif of BACE1 and influence its endosomal Sorting. FEBS J. Apr;281(8):2074-87. https://doi.org/10.1111/febs.12763

  Banning A, Regenbrecht CRA, Tikkanen R. (2014) Increased activity of mitogen activated protein kinase pathway in flotillin-2 knockout mouse. Cell Signal. b Feb;26(2):198-207. https://doi.org/10.1016/j.cellsig.2013.11.001

  Kurrle N, Völlner F, Eming R, Hertl M, Banning A, Tikkanen R. (2013) Flotillins directly interact with γ-catenin and regulate cell-cell adhesion. PLoS One. Dec 31;8(12):e84393. https://doi.org/10.1371/journal.pone.0084393

  Amaddii M*, Meister M*, Banning A, Tomasovic A, Mooz J, Rajalingam K, Tikkanen R. (2012) Flotillin-1/reggie-2 plays a dual role in the activation of receptor tyrosine kinase/MAP kinase signaling. J Biol Chem. Mar 2;287(10):7265-78. https://doi.org/10.1074/jbc.M111.287599

  Babuke T, Ruonala MO, Meister M, Amaddii M, Genzler C, Esposito A, Tikkanen R. (2009) Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis. Cell Signal. Aug;21(8):1287-97. https://doi.org/10.1016/j.cellsig.2009.03.012

  Neumann-Giesen C, Fernow I, Amaddii M, Tikkanen R. (2007) Role of EGF-induced Tyrosine Phosphorylation of Reggie-1/Flotillin-2 in Cell Spreading and Signaling to Actin Cytoskeleton. J Cell Sci. Feb 1;120(Pt 3):395-406. https://doi.org/10.1242/jcs.03336

Review articles

Banning A, Kurrle N, Meister M, Tikkanen R. 2014) Flotillins in receptor tyrosine kinase signaling and cancer. Cells. a Feb 19;3(1):129-49. https://doi.org/10.3390/cells3010129