Main Content

Publications of subproject TP2

T-cell-dependent regulation of autoreactive B cells in pemphigus

Original papers

Solimani F, Pollmann R, Schmidt T, Schmidt A, Savai R, Zheng X, Mühlenbein S, Pickert J, Eubel V, Möbs C, Eming R, Hertl M. Therapeutic targeting of Th17/Tc17 cells leads to clinical improvement of lichen planus. Front Immunol 2019. 10. https://doi.org/10.3389/fimmu.2019.01808

Solimani F, Maglie R, Pollmann R, Schmidt T, Schmidt A, Ishii N, Tackenberg B, Pickert J, Kirschbaum A, Eming R, Hashimoto T, Hertl M. Thymoma-associated paraneoplastic autoimmune multiorgan syndrome – from pemphigus to lichenoid dermatitis. Front Immunol 2019. 10. https://doi.org/10.3389/fimmu.2019.01413

Pollmann R, Walter E, Schmidt T, Waschke J, Hertl M, Möbs C, Eming R. Identification of Autoreactive B cell Subpopulations in Peripheral Blood of Autoimmune Patients with Pemphigus vulgaris. Front Immunol 2019. 10. https://doi.org/10.3389/fimmu.2019.01375

• Inhalt ausklappen Inhalt einklappen Published before 2019

  Eckardt J, Eberle FC, Ghoreschi K. Diagnostic value of autoantibody titres in patients with bullous pemphigoid. Eur J Dermatol. 2018;28(1):3–12.

  Forster M, Chaikuad A, Dimitrov T, Döring E, Holstein J, Berger BT, Gehringer M, Ghoreschi K, Müller S, Knapp S, Laufer S. Development, optimization, and structure-activity relationships of covalent-reversibel JAK3 inhibitors based on a tryciclic imidazo[5,4-d]pyrrolo[2,3-b]pyridine scaffold. J Med Chem 2018. 61, 5350-5366. https://doi.org/10.1021/acs.jmedchem.8b00571

  Vizzardelli C, Gindl M, Roos S, Möbs C, Nagl B, Zimmann F, Sexl V, Kenner L, Neunkirchner A, Zlabinger GJ, Pickl WF, Pfützner W, Bohle B. Blocking antibodies induced by allergen-specific immunotherapy ameliorate allergic airway disease in a human/mouse chimeric model. Allergy 2018. 73(4):851-861. https://doi.org/10.1111/all.13363

  Hennerici T, Pollmann R, Schmidt T, Seipelt M, Tackenberg B, Möbs C, Ghoreschi K, Hertl M, Eming R. Increased Frequency of T Follicular Helper Cells and Elevated Interleukin-27 Plasma Levels in Patients with Pemphigus. Plos One. 2016 Feb 12;11(2):e0148919. https://doi.org/10.1371/journal.pone.0148919

  Nagel A, Möbs C, Raifer H, Wiendl H, Hertl M, Eming R. CD3-positive B cells: a storage-dependent phenomenon. Plos One. 2014 Oct 16;9(10):e110138. https://doi.org/10.1371/journal.pone.0110138

  Onda M, Ghoreschi K, Steward-Tharp S, Thomas C, O’Shea JJ, Pastan I, Fitzgerald DJ. Tofacitinib suppresses antibody responses to protein therapeutics in murine hosts. J Immunol. 2014 Jul 1, 193(1):48-55. https://doi.org/10.4049/jimmunol.1400063

  Möbs C, Ipsen H, Mayer L, Slotosch C, Petersen A, Würtzen PA, Hertl M, Pfützner W. Birch pollen immunotherapy results in long-term loss of Bet v 1-specific TH2 responses, transient TR1 activation, and synthesis of IgE-blocking antibodies. J Allergy Clin Immunol. 2012 Nov;130(5):1108-1116. https://doi.org/10.1016/j.jaci.2012.07.056

  Hirahara K, Ghoreschi K, Yang XP, Takahashi H, Laurence A, Vahedi G, Sciumè G, Hall AO, Dupont CD, Francisco LM, Chen Q, Tanaka M, Kanno Y, Sun HW, Sharpe AH, Hunter CA, O'Shea JJ. Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1. Immunity. 2012 Jun 29;36(6):1017-30. https://doi.org/10.1016/j.immuni.2012.03.024

  Behzad M, Möbs C, Kneisel A, Möller M, Hoyer J, Hertl M, Eming R. Combined treatment with immunoadsorption and rituximab leads to fast and prolonged clinical remission in difficult-to-treat pemphigus vulgaris. Br J Dermatol. 2012 Apr;166(4):844-52. https://doi.org/10.1111/j.1365-2133.2011.10732.x

  Ghoreschi K, Jesson MI, Li X, Lee JL, Ghosh S, Alsup JW, Warner JD, Tanaka M, Steward-Tharp SM, Gadina M, Thomas CJ, Minnerly JC, Storer CE, LaBranche TP, Radi ZA, Dowty ME, Head RD, Meyer DM, Kishore N, O'Shea JJ. Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol. 2011 Apr 1;186(7):4234-43. https://doi.org/10.4049/jimmunol.1003668

  Ghoreschi K, Laurence A, Yang XP, Tato CM, McGeachy MJ, Konkel JE, Ramos HL, Wei L, Davidson TS, Bouladoux N, Grainger JR, Chen Q, Kanno Y, Watford WT, Sun HW, Eberl G, Shevach EM, Belkaid Y, Cua DJ, Chen W, O'Shea JJ. Generation of pathogenic T(H)17 cells in the absence of TGF-β signaling. Nature. 2010 Oct 21;467(7318):967-71. 

  Möbs C, Slotosch C, Löffler H, Jakob T, Hertl M, Pfützner W. Birch pollen immunotherapy leads to differential induction of regulatory T cells and delayed helper T cell immune deviation. J Immunol. 2010 Feb 15;184(4):2194-203. https://doi.org/10.4049/jimmunol.0901379

  Feliciani C, Caldarola G, Kneisel A, Podstawa E, Pfütze M, Pfützner W, Hertl M. IgG autoantibody reactivity against bullous pemphigoid (BP) 180 and BP230 in elderly patients with pruritic dermatoses. Br J Dermatol. 2009 Aug;161(2):306-12. https://doi.org/10.1111/j.1365-2133.2009.09266.x

  Ghoreschi K, Thomas P, Breit S, Dugas M, Mailhammer R, van Eden W, van der Zee R, Biedermann T, Prinz J, Mack M, Mrowietz U, Christophers E, Schlöndorff D, Plewig G, Sander CA, Röcken M. Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease. Nat Med. 2003 Jan;9(1):40-6. 

Review articles

Sabat R, Wolk K, Loyal L, Döcke WD, Ghoreschi K. T cell pathology in skin inflammation. Semin Immunopathol 2019. 41(3):359-377.

Welsch K, Holstein J, Laurence A, Ghoreschi K. Targeting JAK/STAT signalling in inflammatory skin diseases with small molecule inhibitors. Eur J Immunol. 2017;47(7):1096–1107. https://doi.org/10.1002/eji.201646680