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Die besten Publikationen der Grundlagenforschung 2015

 

Institut für Molekularbiologie und Tumorforschung (IMT)

Schneider P, Miguel Bayo-Fina J, Singh R, Kumar Dhanyamraju P, Holz P, Baier A, Fendrich V, Ramaswamy A, Baumeister S, Martinez ED, Lauth M (2015) Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1. Nature communications 6: 8023

Adhikary T, Wortmann A, Schumann T, Finkernagel F, Lieber S, Roth K, Toth PM, Diederich WE, Nist A, Stiewe T, Kleinesudeik L, Reinartz S, Müller-Brüsselbach S, Müller R (2015) The transcriptional PPARβ/δ network in human macrophages defines a unique agonist-induced activation state. Nucleic Acids Research 43: 5033-5051

Volkel S, Stielow B, Finkernagel F, Stiewe T, Nist A, Suske G (2015) Zinc finger independent genome-wide binding of Sp2 potentiates recruitment of histone-fold protein Nf-y distinguishing it from Sp1 and Sp3. PLoS Genetics 11: e1005102

Institut für Physiologische Chemie

Störchel PH, Thümmler J, Siegel G, Aksoy-Aksel A, Zampa F, Sumer S, Schratt G (2015) A large-scale functional screen identifies Nova1 and Ncoa3 as regulators of neuronal miRNA function. EMBO J 34(17):2237-54

Peykov S, Berkel S, Schoen M, Weiss K, Degenhardt F, Strohmaier J, Weiss B, Proepper C, Schratt G, Nöthen MM, Boeckers TM, Rietschel M, Rappold G (2015) Identification and functional characterization of rare SHANK2 variants in schizophrenia. Mol Psychiatry 20(12):1489-98
                                                                                                                
Valluy J, Bicker S, Aksoy-Aksel A, Lackinger M, Sumer S, Fiore R, Wüst T, Seffer D, Metge F, Dieterich C, Wöhr M, Schwarting R, Schratt G (2015) A coding-independent function of an alternative Ube3a transcript during neuronal development. Nat Neurosci 18(5):666-73

Wolf M, Zimmermann AM, Görlich A, Gurniak CB, Sassoè-Pognetto M, Friauf E, Witke W, Rust MB (2015) ADF/cofilin controls synaptic actin dynamics and regulates synaptic vesicle mobilization and exocytosis. Cereb Cortex 25(9):2863-75

Zimmermann AM, Jene T, Wolf M, Görlich A, Gurniak CB, Sassoè-Pognetto M, Witke W, Friauf E, Rust MB (2015) ADHD-like phenotype in a mouse model with impaired synaptic actin dynamics. Biol Psychiatry 78(2):95-106

Institut für Klinische Zytobiologie und Zytpathologie

Paul VD, Mühlenhoff U, Stümpfig M, Seebacher J, Kugler KG, Renicke C, Taxis C, Gavin A-C, Pierik J, Lill R (2015) The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein  Rli1 for iron-sulfur cluster insertion. eLife 4:e08231

Lossos A, Stümpfig C, Stevanin G, Gaussen M, Zimmerman Bat-EL, Mundwiller E, Asulin M,  Chamma L, Sheffer R, Misk A, Dotan S, Gomori JM, Ponger P, Brice A, Lerer I, Meiner V,  Lill R (2015) Fe/S protein assembly gene IBA57 mutation causes hereditary spactic paraplegia. Neurology 84(7): 659-667

Pharmakologische Institut

Grikscheit K, Frank T, Wang Y, Grosse R (2015) Junctional actin assembly is mediated by Formin-like 2 downstream by Rac1. J Cell Biol 209(3):367-376

Wang Y, Arionen A, Pouwels J,Ta H, Pausch P, Bange G, Engel U, Pan X, Fackler OT, Ivaska J, Grosse R (2015) Formin-l.ike 2 Promotes ß1-Integrin Trafficking and Invasive Motility Downstream of PKCa. Dev Cell 34(4):475-483

Xia J, Swiercz JM, Bañón-Rodríguez I, Matković I, Federico G, Sun T, Franz T, Brakebusch CH, Kumanogoh A, Friedel RH, Martín-Belmonte F, Gröne HJ, Offermanns S, Worzfeld T (2015) Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair. Dev Cell 33:299-313

Institut für Virologie

Carroll MW, Matthews DA, Hiscox JA, Elmore MJ, Pollakis G, Rambaut A, Hewson R, Garcia-Dorival I, Bore JA, Koundouno R, Abdellati S, Afrough B, Aiyepada J, Akhilomen P, Asogun D, Atkinson B, Badusche M, Bah A, Bate S, Baumann J, Becker D, Becker-Ziaja B, Bocquin A…, …Kelterbaum A,… …Kis Z, Kloth S, Kohl C, …Schudt G, Strecker T, Thom R, Thomas S, Tobin E,Tolley H, Trautner J, Vermoesen T, Vitoriano I, Wagner M, Wolff S, Yue C, Capobianchi MR, Kretschmer B, Hall Y, Kenny JG, Rickett NY, Dudas G, Coltart CE, Kerber R, Steer D, Wright C, Senyah F, Keita S, Drury P, Diallo B, de Clerck H, Van Herp M, Sprecher A, Traore A, Diakite M, Konde M, Koivogui L, Magassouba N, Avsic-Zupanc T, Nitsche A, Strasser M, Ippolito G, Becker S, Stoecker K, Gabriel M, Raoul H, Di Caro A, Wolfel R, Formenty P, Gunther S (2015) Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa. Nature 524:97-101
 
Weber M, Sediri H, Felgenhauer U, Binzen I, Banfer S, Jacob R, Brunotte L, Garcia-Sastre A, Schmid-Burgk JL, Schmidt T, Hornung V, Kochs G, Schwemmle M, H. D. Klenk HD, Weber F (2015) Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I. Cell Host Microbe 17:309-19 Strecker T, Palyi B, Ellerbrok H, Jonckheere S, de Clerck H, Bore JA, Gabriel M, Stoecker K, Eickmann M, van Herp M, Formenty P, Di Caro A, Becker S (2015) Field Evaluation of Capillary Blood Samples as a Collection Specimen for the Rapid Diagnosis of Ebola Virus Infection During an Outbreak Emergency. Clin Infect Dis 61: 669-75 Wolf T, Kann G, Becker S, Stephan C, Brodt HR, de Leuw P, Grunewald T, Vogl T, Kempf VA, Keppler OT, Zacharowski K (2015) Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care. Lancet 385: 1428-35 Huttner A, Dayer JA, Yerly S, Combescure C, Auderset F, Desmeules J, Eickmann M, Finckh A, Goncalves AR, Hooper JW, Kaya G, Kraehling V, Kwilas S, Lemaitre B, Matthey A, Silvera P, Becker S, Fast PE, Moorthy V, Kieny MP, Kaiser L, Siegrist CA (2015) The effect of dose on the safety and immunogenicity of the VSV Ebola candidate vaccine: a randomised double-blind, placebo-controlled phase 1/2 trial. Lancet Infect Dis 15:1156-66


Auswahlkriterien: Originalarbeit, Erst- oder Letztautor und Journal Impact Faktor > 7,5 oder Originalarbeit, Mitautorenschaft und Journal Impact Faktor > 14

Zuletzt aktualisiert: 07.06.2016 · Gerd Rinke

 
 
 
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