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Die besten Publikationen der Grundlagenforschung 2012

 

Institut für Molekularbiologie und Tumorforschung (IMT)

Joost S, Almada LL, Rohnalter V, Holz PS, Vrabel AM, Fernandez-Barrena MG, McWilliams RR, Krause M, Fernandez-Zapico ME, Lauth M (2012): GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells. Cancer Res 72: 88-99

 

Seshire A, Rößiger T, Frech M, Beez S, Hagemeyer H, Puccetti E (2012): Direct interaction of PU.1 with oncogenic transcription factors reduces its serine phosphorylation and promoter binding. Leukemia 26: 1338-1347

 

Stein C, Riedl S, Rüthnick D, Nötzold RR, Bauer UM (2012): The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes. Nucleic Acids Res 40: 9522-9533

 

Mathieu EL, Finkernagel F, Murawska M, Scharfe M, Jarek M, Brehm A (2012): Recruitment of the ATP-dependent chromatin remodeler dMi-2 to the transcribed region of active heat shock genes. Nucleic Acids Res 40: 4879-4891

 

Meier K, Mathieu EL, Finkernagel F, Reuter LM, Scharfe M, Doehlemann G, Jarek M, Brehm A (2012): LINT, a novel dL(3)mbt-containing complex, represses malignant brain tumour signature genes. PLoS Genet 8: e1002676

 

Terrados G, Finkernagel F, Stielow B, Sadic D, Neubert J, Herdt O, Krause M, Scharfe M, Jarek M, Suske G (2012): Genome-wide localization and expression profiling establish Sp2 as a sequence-specific transcription factor regulating vitally important genes. Nucleic Acids Res 40 (16): 7844-57

 

Liu L, Ulbrich J, Müller J, Wüstefeld T, Aeberhard L, Kress TR, Muthalagu N, Rycak L, Rudalska R, Moll R, Kempa S, Zender L, Eilers M, Murphy DJ (2012): Deregulated MYC expression induces dependence upon AMPK-related kinase 5. Nature 483 (7391): 608-12

 

 

Institut für Medizinische Biometrie und Epidemiologie

Bradfield JP, Taal HR, Timpson NJ, Scherag A, Lecoeur C, Warrington NM, Hypponen E, Holst C, Valcarcel B, Thiering E, Salem RM, Schumacher FR, Cousminer DL, Sleiman PMA, Zhao J, Berkowitz RI, Vimaleswaran KS, Jarick I, Pennell CE, Evans DM, StPourcain B, Berry DJ, …. Jarvelin MR, Jaddoe VW, Smith GD, Hakonarson H, Grant SF, for the Early Growth Genetics (EGG) Consortium (2012): A genome-wide association metaanalysis identifies new childhood obesity loci. Nature Genetics 44 (5): 526-531




Institut für Medizinische Mikrobiologie und Krankenhaushygiene

Bollig N, Brüstle A, Kellner K, Ackermann W, Abass E, Raifer H, Camara B, Brendel C, Giel G, Bothur E, Huber M, Paul C, Elli A, Kroczek RA, Nurieva R, Dong C, Jacob R, Mak TW, Lohoff M (2012): Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation. Proc Natl Acad Sci USA 109 (22): 8664-9

 

 

Institut für Pathologie

Liu L, Ulbrich J, Müller J, Wüstefeld T, Aeberhard L, Kress TR, Muthalagu N, Rycak L, Rudalska R, Moll R, Kempa S, Zender L, Eilers M, Murphy DJ (2012): Deregulated MYC expression induces dependence upon AMPK-related kinase 5. Nature 483 (7391): 608-12


       

Institut für  Klinische Zytobiologie und Zytopathologie

Netz DJ, Stith CM, Stümpfig M, Köpf G, Vogel D, Genau HM, Stodola JL, Lill R#, Burgers PM#, Pierik AJ# (2012): Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes. Nat Chem Biol 8: 125-132, # joint last authors

 

Stehling O*, Vashisht AA*, Mascarenhas J, Jonsson ZO, Sharma T, Netz DJ, Pierik AJ, Wohlschlegel JA#, Lill R# (2012): MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. Science 337: 195-199, # joint last authors

 

 

Institut für Immunologie

Jöckel S, Nees G, Sommer R, Zhao Y, Cherkasov D, Hori H, Ehm G, Schnare M, Nain M, Kaufmann A, Bauer S (2012): The 2'-O-methylation status of a single guanosine controls transfer RNA-mediated Toll-like receptor 7 activation or inhibition. J Exp Med 13, 209(2): 235-41

 

Oldenburg M, Krüger A, Ferstl R, Kaufmann A, Nees G, Sigmund A, Bathke B, Lauterbach H, Suter M, Dreher S, Koedel U, Akira S, Kawai T, Buer J, Wagner H, Bauer S, Hochrein H, Kirschning CJ (2012): TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification. Science 337 (6098): 1111-5

 

Yu P, Lübben W, Slomka H, Gebler J, Konert M, Cai C, Neubrandt L, Prazeres da Costa O, Paul S, Dehnert S, Döhne K, Thanisch M, Storsberg S, Wiegand L, Kaufmann A, Nain M, Quintanilla-Martinez L, Bettio S, Schnierle B, Kolesnikova L, Becker S, Schnare M, Bauer S (2012): Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors. Immunity 37 (5): 867-79

 

 

Institut für Virologie

Groseth A, Marzi A, Hoenen T, Herwig A, Gardner D, Becker S, Ebihara H, Feldmann H (2012): The Ebola virus glycoprotein contributes to but is not sufficient for virulence in vivo. PLoS Pathog 8 (8): e1002847

 

Pichlmair A, Kandasamy K, Alvisi G, Mulhern O, Sacco R, Habjan M, Binder M, Stefanovic A, Eberle CA, Goncalves A, Bürckstümmer T, Müller AC, Fauster A, Holze C, Lindsten K, Goodbourn S, Kochs G, Weber F, Bartenschlager R, Bowie AG, Bennett KL, Colinge J, Superti-Furga G (2012): Viral immune modulators perturb the human molecular network by common and unique strategies. Nature 487(7408): 486-90

 

 

Institut für Humangenetik

Greif PA, Dufour A, Konstandin NP, Ksienzyk B, Zellmeier E, Tizazu B, Sturm J, Benthaus T, Herold T, Yaghmaie M, Dörge P, Hopfner KP, Hauser A, Graf A, Krebs S, Blum H, Kakadia PM, Schneider S, Hoster E, Schneider F, Stanulla M, Braess J, Sauerland MC, Berdel WE, Büchner T, Woermann BJ, Hiddemann W, Spiekermann K, Bohlander SK (2012): GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia. Blood 120: 395-403

 

Mulaw MA, Krause AJ, Deshpande AJ, Krause LF, Rouhi A, La Starza R, Borkhardt A, Buske C, Mecucci C, Ludwig WD, Lottaz C, Bohlander SK (2012): CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12. Leukemia 26: 1012-1019




Auswahlkriterien:
Originalarbeit, Erst- oder Letztautor und Journal Impact Faktor > 7,5 oder
Originalarbeit, Mitautorenschaft und Journal Impact Faktor > 14

Zuletzt aktualisiert: 12.09.2013 · Gerd Rinke

 
 
 
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