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AG Graumann

Prof. Dr. Peter Graumann

SYNMIKRO Research Center
Molecular and cellular biochemistry of microorganisms
Karl-von-Frisch-Straße 14, 35032 Marburg

Fachbereich Chemie, Biochemie
Hans-Meerwein-Straße 4, 35032 Marburg
Room: +2/2470
Phone: +49-6421 28 22210
Mail:

Research Area

We are studying dynamic processes in bacteria, with a focus on chromosome dynamics, organization of metabolic enzymes and cell shape maintenance. We are interested in several questions that involve the spatial organization and biochemistry of the cell: how is the shape of a bacterium established? How is the cell cycle regulated and driven, and how is DNA transferred between bacteria? As a model for Gram positive bacteria, we use Bacillus subtilis cells, which offer a superb genetic and cell biological system. We are using a combination of state of the art biochemical tools and super resolution fluorescence microscopy to understand how the bacterial cell is organized in 3D, and how cytosolic and membrane proteins are dynamically positioned within a non-compartmentalized cell. Our studies also focus on bacterial physiological and morphologic responses to environmental stress, such as subcellular dynamics of metabolic enzymes during adaptation to changes in the environment, assembly of membrane-protective structures and cyclic-di-GMP signaling. 

Expertise

  • synthetic microbiology
  • microbial genetics
  • bacterial cell biology
  • single molecule tracking
  • super resolution fluorescence microscopy
  • cell cycle
  • biofilms
  • genome organization
  • DNA repair