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Gert Bange

Portrait Gert Bange
Photo: Rolf K. Wegst

Our lab investigates the response of microbes to various biotic and abiotic stress conditions. A central research theme are nucleotide-based second messengers, which enable the translation of intra- and extracellular stress signals into a cellular and/or metabolic response. We use a combination of structural biochemistry with systems and cell biological approaches to study these relevant questions. In M4C, we are especially interested in understanding the stress response of microbes in climate change at the structural and molecular level. 

Research Focus:

Microbes as Drivers; Microbes as Responders 

Key Publication(s):

Giammarinaro PI, Young MKM, Steinchen W, Mais CN, Hochberg G, Yang J, Stevenson DM, Amador-Noguez D, Paulus A, Wang JD, *Bange G. Diadenosine tetraphosphate regulates biosynthesis of GTP in Bacillus subtilis. Nature Microbiology 2022 7:1442-1452. doi: 10.1038/s41564-022-01193-x. Epub 2022 Aug 11.

*Czech L, Mais CN, Kratzat H, Sarmah P, Giammarinaro P, Freibert SA, Esser HF, Musial J, Berninghausen O, Steinchen W, Beckmann R, Koch HG, *Bange G. Inhibition of SRP-dependent protein secretion by the bacterial alarmone (p)ppGpp. Nature Communications 2022 13:1069. doi: 10.1038/s41467-022-28675-0.

Osorio-Valeriano M, Altegoer F, Steinchen W, Urban S, Liu Y, *Bange G, *Thanbichler M. ParB-type DNA Segregation Proteins Are CTP-Dependent Molecular Switches. Cell 2019 179:1512-1524.e15. doi: 10.1016/j.cell.2019.11.015

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