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Johannes Rebelein

Portrait Johannes Rebelein
Photo: Rolf K. Wegst

The microbial Metalloenzyme lab focuses on the unique properties of metal-containing enzymes and in particular nitrogenase and nitrogenase-like proteins, which activate nitrogen (N2), but also CO and CO2. Combining structural and biochemical approaches, we aim to elucidate the underlying principles and mechanisms of metalloenzyme catalysis and use this knowledge to developing new and improved catalysts for the conversion of CO and CO2. In M4C, we are interested in the evolution and engineering of CO2-activating metalloenzymes and their integration into novel metabolic pathways using these unique reactivities for new carbon capture and conversion reactions.

Research Focus:

Microbes as Drivers; Microbes providing Solutions

Key Publication(s):

Ernst L, Barayeu U, Hädeler J, Dick TP, Klatt JM, Keppler, F, *Rebelein JG. Methane formation driven by light and heat prior to the origin of life. Nature Communications 2023. doi: 10.17617/3.6X6JXR

Rebelein JG, Stiebritz MT, Lee CC, *Hu Y. Activation and reduction of carbon dioxide by nitrogenase iron proteins. Nature Chemical Biology 2017 13:147-149. doi: 10.1038/nchembio.2245

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