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Helge Bode

Portrait Helge Bode
Photo: Chris Kettner

Interaction between any organisms depends on metabolites as chemical cues acting as attractants, repellents, or toxins. Microorganisms provide a huge repertoire of these molecules, which has been studied only to a very limited extend, so that several of such "communication signals“ still await their identification. In our lab, we aim at the understanding of microbial metabolite function in the environment. We additionally use our knowledge of the underlying biosynthetic pathways to manipulate them in detail and even generate new-to-nature microbial metabolites. In M4C, we aim at identifying relevant molecules in bacteria-environment interactions and produce new compounds with defined activity through synthetic biology.

Research Focus:

Microbes as Responders; Microbes providing solutions

Key Publication(s):

Shi YM, Crames JJ, Czech L, Bozhüyük KAJ, Shi YN, Hirschmann M, Lamberth S, Claus P, Paczia N, Rückert C, Kalinowski J, Bange G, *Bode HB. Genome Mining Enabled by Biosynthetic Characterization Uncovers a Class of Benzoxazolinate-Containing Natural Products in Diverse Bacteria. Angewandte Chemie International Edition 2022 61:e202206106. doi: 10.1002/anie.202206106.

Bozhüyük KAJ, Linck A, Tietze A, Kranz J, Wesche F, Nowak S, Fleischhacker F, Shi YN, Grün P, *Bode HB. Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains. Nature Chemistry 2019 11:653-661. doi: 10.1038/s41557-019-0276-z

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