Publications 2026

Pörschke J, Heidemann S, Nehring HP, Lluch A, Szymański W, Finkernagel F, Preußer C, Bhagwat AM, Stamm TJ, Sommerfeld L, Helmprobst F, Müller R, Reinartz S, Graumann J, Pogge von Strandmann E, Gómez-Serrano M. Tumor-associated macrophages display differential protein cargo sorting in extracellular vesicles associated with poor survival in ovarian cancer. Mol Med. 2026 Jan 30;32(1):16. doi: 10.1186/s10020-025-01416-x 

von Wichert L, Stroh A, Witt M, Wanzel M, Mernberger M, Griewing S, Wündisch T, Pfitzner BM, Teply-Szymanski J, Litmeyer AS, Denkert C, Wagner U, Stiewe T, Gremke N. mTOR-driven autophagy suppression defines metabolic vulnerability in CDK4/6 inhibitor-resistant HR+/HER2- breast cancer. Cell Death Dis. 2026 Feb 19;17(1):235. doi: 10.1038/s41419-026-08496-5.

Burchert A, Nicolini FE, le Coutre P, Saussele S, Hochhaus A, Tuere E, Metzelder SK, Pauck K, Garn H, Raifer H, Huber M, Gattermann N, Crysandt M, Schafhausen P, Bormann M, Radsak MP, Guerci-Bresler A, Illmer T, Goebeler ME, Herhaus P, Teichmann LL, Franke GN, Lang F, Krause SW, Möhle R, Klausmann M, Stegelmann F, Lutz C, Etienne G, Stoltefuß A, Göthert JR, Ernst T, Abu-Samra M, Höffkes HG, Neubauer A, Wang Y, Weiland P, Otto C, Kiessler L, Weber T, Kroning L, Nist A, Stiewe T, Hehlmann R, Aminossadati B, Wittenberg M, Winterstein K, Oellerich T, Lechner M, Pfirrmann M, Schade-Brittinger C, Klemm P, Michel C. Randomized phase 3 trial of Ropeginterferon alfa-2b versus surveillance after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia (ENDURE/CML-IX). Leukemia. 2026 Feb;40(2):410-417. doi: 10.1038/s41375-025-02859-1. 

Nguyen TT-P, Weiland P, Loi VV, Kiontke S, Burchert F, Zegarra V, Kern A, Fritsch VN, Baranov D, Bronowska AK, Bange G, Antelmann H. Structural basis of quinone sensing by the MarR-type repressor MhqR in Staphylococcus aureus. mBio. 2026 Feb 11;17(2):e0329225. doi: 10.1128/mbio.03292-25.

Merle N, Bullwinkel I, Timofeev O, Elmshäuser S, Stiewe S. Secreted luciferases as a minimally invasive 3R-compliant tool for accurate monitoring of tumor burden. Nat Protoc . 2026 Aug;21(8):3580-3613. doi: 10.1038/s41596-025-01315-9.

Dreute J, Schmitz ML. iBiT: A vector system allowing stable genome integration and scalable expression of NanoLuc fusion proteins to monitor dynamic protein-protein interactions in intact cells. Plasmid. 2026 May 23:135:102772. doi: 10.1016/j.plasmid.2026.102772.

Alashkar Alhamwe B, Alhamdan F, Ponath V, Hoffmann N, Meena C, Fingernagel F, Garn H, Pauk K, Keber C, Denkert C, Reinartz S, Pogge von Strandmann E. Ascites reprograms innate lymphoid immune cells in ovarian cancer by promoting ILC2 enrichment and dysfunctional NK-cell states. J Immunother Cancer. 2026 Aug 26;14(8):e015396. doi: 10.1136/jitc-2026-015396.

Heidemann S, Finkernagel F, Steitz AM, Koennecke J, Werner F, Beutgen VM, Szymanski W, Graumann J, Teply-Szymanski J, Nist A, Stiewe T, Keber CU, Gremke N, Wagner U, Denkert C, Gómez-Serrano M, Pogge von Strandmann E, Müller R, Reinartz S. A pro-inflammatory metastasis-associated macrophage subset induces tumor-promoting mesothelial cell conversion in ovarian cancer via IL-1α secretion. Cell Death Dis. 2026 Sep 12;17(1):794. doi: 10.1038/s41419-026-09280-1.

Kersten MC, Witt M, Stiewe T, Gremke N, Taudte RV. 2-deoxy-d-ribose: A multifaceted player at the crossroads of cancer metabolism. Biomed Pharmacother. 2026 Sep:202:119800. doi: 10.1016/j.biopha.2026.119800.

Chaurasiya V, Li L, Lluch A, Fernández-Sánchez A, Harju J, Pham DD, Sanni Perttunen, Keskitalo S, Varjosalo M, Pietiläinen KH, Haridas PAN, Moreno-Navarrete JM, Rodríguez-Hermosa JI, Piedrafita-Serra E, Kar A, Pajukanta P, Laakso M, Männistö V, Pihlajamäki J, Kaikkonen MU, Frühbeck G, Rangel-Zúñiga OA, Tinahones FJ, Diéguez C, Burkhardt R, Höring M, Liebisch G, Pörschke J, Gómez-Serrano M, Graumann J, Szymanski W, Fernández-Real JM, Zhou Y, Olkkonen VM, Ortega FJ. An adipocyte-endothelial framework linking adipose tissue inflammation to cardiometabolic vulnerability in obesity. Res Sq [Preprint]. 2026 Aug 12:rs.3.rs-10603589. doi: 10.21203/rs.3.rs-10603589/v1.

*Ems M, Lindberg MF, Adhikary T, Meijer L, Lauth M. Small-Molecule-Mediated Depletion of the Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1B (DYRK1B) Protein Scaffold. ACS Pharmacol Transl Sci. 2026 Aug 29;9(9):2419-2425. doi: 10.1021/acsptsci.6c00238.

*Ashford AL, Ber S, Ems MS, Duncan E, Balmanno K, Reeves H, Huntly R, Cassidy MA, Johnston HE, Oxley D, Nthiga TM, Johansen T, Kluge M, Jacob R, Lauth M, Cook SJ. Phosphoproteomics identifies the DYRK1B protein kinase as a regulator of processing bodies. J Cell Sci. 2026 Sep 1;139(17):jcs265054. doi: 10.1242/jcs.265054.