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Selected publications

1.      Xu R, Höß C, Swiercz JM, Brandt DT, Lutz V, Petersen N, Li R, Zhao D, Oleksy A, Creigh-Pulatmen T, Trokter M, Fedorova M, Atzberger A, Strandby RB, Olsen AA, Achiam MP, Matthews D, Huber M, Gröne HJ, Offermanns S, Worzfeld T. A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin expression and protects against peptic ulcers. Sci Transl Med. 2022 Jul 20;14(654):eabf1922. doi: 10.1126/scitranslmed.abf1922. Epub 2022 Jul 20. PMID: 35857828.IF=17.9

2.      Kandra P, Nandigama R, Eul B, Huber M, Kobold S, Seeger W, Grimminger F, Savai R. Utility and Drawbacks of Chimeric Antigen Receptor T Cell (CAR-T) Therapy in Lung Cancer. Front Immunol. 2022 Jun 2;13:903562. doi: 10.3389/fimmu.2022.903562. PMID: 35720364; PMCID: PMC9201083.IF=8.7

3.      Arnold C, Demuth P, Seiwert N, Wittmann S, Boengler K, Rasenberger B, Christmann M, Huber M, Brunner T, Linnebacher M, Fahrer J. The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner. Mol Cancer Ther. 2022 Jan;21(1):100-112. doi: 10.1158/1535-7163.MCT-21-0393. Epub 2021 Nov 8. PMID: 34750196.IF=6.0

4.      Raifer H, Schulz AR, Theodorou J, Romero-Olmedo AJ, Böck A, Bertrams W, Schmeck BT, Chung HR, Lohoff M, Chang HD, Schaub B, Mei HE, Huber M. Mass cytometry-based identification of a unique T-cell signature in childhood allergic asthma.

Allergy. 2022 Jan;77(1):313-316. doi: 10.1111/all.15110.IF=13.1

5.      Churin Y, Irungbam K, Imiela CS, Schwarz D, Mollenkopf HJ, Drebber U, Odenthal M, Pak O, Huber M, Glebe D, Roderfeld M, Roeb E. Lipid Storage and Interferon Response Determine the Phenotype of Ground Glass Hepatocytes in Mice and Humans. Cell Mol Gastroenterol Hepatol. 2021;12(2):383-394. doi: 10.1016/j.jcmgh.2021.03.009.IF=9.2

6.      New Insights Into Pancreatic Cancer: Notes from a Virtual Meeting. Hessmann E, Schneider G; 1(st) Virtual Göttingen-Munich-Marburg Pancreatic Cancer Meeting. Gastroenterology. 2021 Sep;161(3):785-791. doi: 10.1053/j.gastro.2021.04.082. IF=22.7

7.      Luu M, Riester Z, Baldrich A, Reichardt N, Yuille S, Busetti A, Klein M, Wempe A, Leister H, Raifer H, Picard F, Muhammad K, Ohl K, Romero R, Fischer F, Bauer CA, Huber M, Gress TM, Lauth M, Danhof S, Bopp T, Nerreter T, Mulder IE, Steinhoff U, Hudecek M, Visekruna A. Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer.              Nat Commun. 2021 Jul 1;12(1):4077. doi: 10.1038/s41467-021-24331-1.  IF=14.9

8.      Arnold C, Demuth P, Seiwert N, Wittmann S, Boengler K, Rasenberger B, Christmann M, Huber M, Brunner T, Linnebacher M, Fahrer J. The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner. Mol Cancer Ther. 2021 Nov 8. doi: 10.1158/1535-7163.MCT-21-0393.IF=6.3

9.      Carbó JM, León TE, Font-Díaz J, De la Rosa JV, Castrillo A, Picard FR, Staudenraus D, Huber M, Cedó L, Escolà-G JC, Campos L, Bakiri L, Wagner EF, Caelles C, Stratmann T, Ginderachter JV, Valledor AF. LXR activation modulates the expression profile of tumor-associated macrophages and the abundance of regulatory T cells in the tumor microenvironment.Cancer Res. 2021 Feb 15;81(4):968-985. doi: 10.1158/0008-5472.CAN-19-3360.IF=12.7.

10.  Romero-Olmedo AJ, Schulz AR, Huber M, Brehm CU, Chang HD, Chiarolla C, Bopp T, Skevaki C, Berberich-Siebelt F, Radbruch A, Mei HE, Lohoff M. Deep phenotypical characterization of human CD3+CD56+ T cells by mass cytometry.Eur. J. Immunol. 2020. Nov 24. doi: 10.1002/eji.202048941.IF=5.5

11.  Huber M, Brehm CU, Gress TM, Buchholz M, Alashkar Alhamwe B, von Strandmann EP, Slater EP, Bartsch JW, Bauer C, Lauth M. The Immune Microenvironment in Pancreatic Cancer.Int J Mol Sci. 2020 Oct 3;21(19):7307.IF=4.5

12.  Stelmach P, Pütz M, Pollmann R, Happel M, Stei S, Schlegel K, Seipelt M, Eienbröker C, Eming R, Mandic R, Huber M, Tackenberg B. Alternative splicing of the TNFSF13B (BAFF) pre-mRNA and expression of the BAFFX1 isoform in human immune cells.Gene. 2020 Nov 15;760:145021.IF=2.9

13.  Matthias J, Heink S, Picard F, Zeiträg J, Kolz A, Chao YY, Soll D, de Almeida GP, Glasmacher E, Jacobsen ID, Riedel T, Peters A, Floess S, Huehn J, Baumjohann D, Huber M, Korn T, Zielinski CE. Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments.J Clin Invest. 2020 Sep 1;130(9):4587-4600.IF=14.8

14.  Lückel C, Picard FSR, Huber M. Tc17 biology and function: Novel concepts.Eur J Immunol. 2020 Jul 22.IF=5.5

15.                  Salazar Y, Zheng X, Brunn D, Raifer H, Picard F, Zhang Y, Winter H, Guenther S, Weigert A, Weigmann B, Dumoutier L, Renauld JC, Waisman A, Schmall A, Tufman A, Fink L, Brüne B, Bopp T, Grimminger F, Seeger W, Pullamsetti SS*, Huber M*, Savai R*. Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer.J Clin Invest. 2020 Jul 1;130(7):3560-3575. * equal contributionIF=14.8

16.  Lang J, Bohn P, Bhat H, Jastrow H, Walkenfort B, Cansiz F, Fink J, Bauer M, Olszewski D, Ramos-Nascimento A, Duhan V, Friedrich SK, Becker KA, Krawczyk A, Edwards MJ, Burchert A, Huber M, Friebus-Kardash J, Göthert JR, Hardt C, Probst HC, Schumacher F, Köhrer K, Kleuser B, Babiychuk EB, Sodeik B, Seibel J, Greber UF, Lang PA, Gulbins E, Lang KS. Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease.Nat Commun. 2020 Mar 12;11(1):1338 IF=14.9

17.                  Lückel C, Picard F, Raifer H, Campos Carrascosa L, Guralnik A, Zhang Y, Klein M, Bittner S, Steffen F, Moos S, Marini F, Gloury R, Kurschus FC, Chao YY, Bertrams W, Sexl V, Schmeck B, Bonetti L, Grusdat M, Lohoff M, Zielinski CE, Zipp F, Kallies A, Brenner D, Berger M, Bopp T, Tackenberg B, Huber M. IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis.      Nat Commun. 2019 Dec 16;10(1):5722. IF=12.1

18.  Bohn T, Rapp S, Luther N, Klein M, Bruehl TJ, Kojima N, Aranda Lopez P, Hahlbrock J, Muth S, Endo S, Pektor S, Brand A, Renner K, Popp V, Gerlach K, Vogel D, Lueckel C, Arnold-Schild D, Pouyssegur J, Kreutz M, Huber M, Koenig J, Weigmann B, Probst HC, von Stebut E, Becker C, Schild H, Schmitt E, Bopp T. Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages.   Nat Immunol. 2018 19(12):1319-1329.      IF=23.5

19.  Inselmann S, Wang Y, Saussele S, Fritz L, Schütz C, Huber M, Liebler S, Ernst T, Cai D, Botschek S, Brendel C, Calogero RA, Pavlinic D, Benes V, Liu ET, Neubauer A, Hochhaus A, Burchert A. Development, Function, and Clinical Significance of Plasmacytoid Dendritic Cells in Chronic Myeloid Leukemia.                           Cancer Res. 2018 78(21):6223-6234.          IF=8.4

20.  Lieber S, Reinartz S, Raifer H, Finkernagel F, Dreyer T, Bronger H, Jansen JM, Wagner U, Worzfeld T, Müller R, Huber M. Prognosis of ovarian cancer is associated with effector memory CD8+ T cell accumulation in ascites, CXCL9 levels and activation-triggered signal transduction in T cells.                           Oncoimmunology 2018, 7(5):e1424672.    IF=5.3

21.  Campos Carrascosa L, Klein M, Kitagawa Y, Lückel Ch, Marini F, König A, Guralnik A, Raifer H, Hagner-Benes S, Rädler D, Böck A, Kang Ch, Lohoff M, Garn H, Schaub B, Berberich-Siebelt F, Sakaguchi S, Bopp T, Huber M. Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4.   Nat. Commun. 2017, 12;8: 15366. IF=12.3

22.  Huber M, Suprunenko T, Ashhurst T, Marbach F, Raifer H, Wolff S, Strecker T, Viengkhou B, Jung SR, Obermann HL, Bauer S, Xu HC, Lang P, Tom A, Lang KS, King NJC, Campbell IL, Hofer MJ. IRF9 prevents CD8+ T cell exhaustion in an extrinsic manner during acute LCMV infection. J Virol. 2017. doi: 10.1128/JVI.01219-17.     IF=4.4

23.  Schütz Ch, Inselmann S, Saussele S, Dietz Ch, Müller M, Eigendorff E, Brendel C, Metzelder S, Bruemmendorf T, Waller C, Dengler J, Goebeler M, Herbst R, Freunek G, Hanzel S, Illmer T, Wang Y, Lange T, Finkernagel F, Hehlmann R, Huber M, Neubauer A, Hochhaus A, Guilhot J, Mahon FX, Pfirrmann M, Burchert A. Expression of the CTLA-4 ligand CD86 on plasmacytoid dendritic cells (pDC) predicts risk of disease recurrence after treatment discontinuation in CML.         Leukemia. 2017, 31:829.              IF=12.1

24.        Ribechini E, Hutchinson JA, Hergovits S, Heuer M, Lucas J, Schleicher U, Jordán Garrote A-L, Potter SJ, Riquelme P, Brackmann H, Müller N, Raifer H, Berberich I, Huber M, Beilhack A, Lohoff M, Bogdan Ch, Eyrich M, Hermanns HM, Geissler EK and Lutz MB. Novel GM-CSF signals via IFN-γR/IRF-1 and AKT/mTOR license monocytes for suppressor function.       Blood Adv. 2017, 1:947-960.             IF=4.9

25.  Worzfeld T, Pogge von Strandmann E, Huber M, Adhikary T, Wagner U, Reinartz S, Müller R. The Unique Molecular and Cellular Microenvironment of Ovarian Cancer.       Front Oncol. 2017, 7:24.        IF=4.7