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Our Publications

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2021

  • Müller M, Ringer K, Hub F, Kamm N, Worzfeld T, Jacob R (2021). TTL-Expression Modulates Epithelial Morphogenesis. Front Cell Dev Biol 9:635723 doi: 10.3389/fcell.2021.635723. eCollection 2021.

2020

  • Kratzer M C, Becker S F S, Grund A, Merks A, Harnos J, Bryja V, Giehl K, Kashef J, Borchers A (2020). The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled. Development 147 (10), doi: 10.1242/dev.186338

  • Schwenty-Lara J, Nehl D, Borchers A (2020). The histone methyltransferase KMT2D, mutated in Kabuki syndrome patients, is required for neural crest cell formation and migration. Hum Mol Genet 29, 305-319 doi: 10.1093/hmg/ddz284. 

  • Ufartes R, Berger H, Till K, Salinas G, Sturm M, Altmuller J, Nurnberg P, Thiele H, Funke R, Apeshiotis N, Langen H, Wollnik B, Borchers A, Pauli S (2020). De novo mutations in FBRSL1 cause a novel recognizable malformation and intellectual disability syndrome. Hum Genet 139(11):1363-1379. doi: 10.1007/s00439-020-02175-x.

  • Breuer M, Berger H, Borchers A (2020) Caveolin 1 is required for axonal outgrowth of motor neurons and affects Xenopus neuromuscular development. Sci Rep. 10(1):16446. doi: 10.1038/s41598-020-73429-x

  • Bänfer S, Jacob R (2020) Galectins in Intra- and Extracellular Versicles. Biomolecules 10 E1232. doi: 10.3390/biom10091232.

  • Schneider F, Duong T, Metz I, Winkelmeier J, Hübner CA, Endesfelder U, Rust MB (2020). CAP1 and cofilin1 cooperate in neuronal actin dynamics, growth cone function and neuron connectivity, bioRxiv 2020.08.12.247932; doi: https://doi.org/10.1101/2020.08.12.247932  

  • Pelucchi S, Vandermeulen L, Pizzamiglio L, Aksan B, Yan J, Konietzny A, Bonomi E, Borroni B, Padovani A, Rust M, Di Marino D, Mikhaylova M, Mauceri D, Antonucci F, Edefonti V, Gardoni F, Di Luca M, Marcello E (2020). Cyclase-associated protein 2 dimerization regulates cofilin in synaptic plasticity and Alzheimer's disease. Brain Commun 2(2):fcaa086. doi: 10.1093/braincomms/fcaa086. eCollection 2020.

  • Kullmann J A, Meyer S, Pipicelli F, Kyrousi C, Schneider F, Bartels N, Cappello S, Rust M B (2020). Profilin1-dependent F-actin assembly controls division of apical radial glia and neocortex development. Cereb Cortex 30, 3467-3482.

  • Rust MB, Khudayberdiev S, Pelucchi S, Marcello E (2020) CAPt'n of Actin Dynamics: Recent Advances in the Molecular, Developmental and Physiological Functions of Cyclase-Associated Protein (CAP). Front Cell Dev Biol 8, 586631. doi: 10.3389/fcell.2020.586631. 

  • Li M, Nishio S Y, Naruse C, Riddell M, Sapski S, Katsuno T, Hikita T, Mizapourshafiyi F, Smith F M, Cooper LT, Lee M G, Asano M, Boettger T, Krueger M, Wietelmann A, Graumann J, Day B W, Boyd A W, Offermanns S, Kitajiri S I, Usami S I, Nakayama M. (2020) Digenic Inheritance of Mutations in EPHA2 and SLC26A4 in Pendred Syndrome. Nat Commun 12; 11(1):1343. doi: 10.1038/s41467-020-15198-9.

  • Selvaggio G, Chizhik A, Nißler R, Kuhlemann L, Meyer D, Vuong L, Preiß H, Herrmann N, Mann FA, Lv Z, Oswald TA, Spreinat A, Erpenbeck L, Großhans J, Karius V, Janshoff A, Pablo Giraldo J, Kruss S. (2020) Exfoliated near infrared fluorescent silicate nanosheets for (bio)photonics. Nat Commun 11, 1495.

  • Lv Z, Rosenbaum J, Mohr S, Zhang X, Kong D, Preiß H, Kruss S, Alim K, Aspelmeier T, Großhans J. (2020) The Emergent Yo-yo Movement of Nuclei Driven by Cytoskeletal Remodeling in Pseudo-synchronous Mitotic Cycles. Curr Biol S0960-9822, 30626-6. Online ahead of print.

 

  • Liu B, Gregor I, Müller HA, Großhans J. (2020) Fluorescence fluctuation analysis reveals PpV dependent Cdc25 protein dynamics in living embryos. PLoS Genet. 16, e1008735.

  • Holz O, Apel D, Hassel M. (2020) Alternative pathways control actomyosin contractility in epitheliomuscle cells during morphogenesis and body contraction. Dev Biol 463(1):88-98. doi: 10.1016/j.ydbio.2020.04.001.

  • Suryawanshi A, Schaefer K, Holz O, Apel D, Lange E, Hayward D C, Miller D J, Hassel M. (2020) What lies beneath: Hydra provides cnidarian perspectives into the evolution of FGFR docking proteins. Dev Genes Evol 230(3):227-238. doi: 10.1007/s00427-020-00659-4.

  • Dierich M, Altoè A, Koppelmann J, Evers S, Renigunta V, Schäfer M K, Naumann R,Verhulst S, Oliver D, Leitner M G (2020). Optimised tuning of auditory inner hair cells to encode complex sound through synergistic activity of six independent K+ current entities (in press).

  • Thallmair V, Schultz L, Evers S, Goecke C, Thallmair S, Leitner MG, Oliver D (2020) Local PI(4,5)P2 pool dynamics detected by the coincidence biosensor tubbyCT maintain the integrity of ER-PM junctions during PLC signaling. bioRxiv 2020.2009.2025.313403.

  • Thallmair V, Schultz L, Marrink S, Oliver D, Thallmair S. (2020) A second PI(4,5)P2 binding site determines PI(4,5)P2 sensitivity of the tubby domain. bioRxiv 2020.09.23.309492; doi: https://doi.org/10.1101/2020.09.23.309492

  • Effertz T, Moser T, Oliver D (2020)  Recent advances in cochlear hair cell nanophysiology: subcellular compartmentalization of electrical signaling in compact sensory cells. (In Press) F1000Res

  • Helker CSM, Eberlein J, Wilhelm K, Sugino T, Malchow J, Schuermann A, Baumeister S, Kwon H, Maischein H, Potente M, Herzog W, Stainier DYR (2020). Apelin signaling drives vascular endothelial cells towards a pro-angiogenic state. ELife 9:e55589. doi: 10.7554/eLife.55589. Online ahead of print. PMID: 32955436

  • Bensimon-Brito A, Boezio G L M, Cardeira-da-Silva J, Wietelmann A, Helker C S M, Ramadass R, Piesker J, Nauerth A, Mueller C, Stainier D Y R (2020) Integration of multiple imaging platforms to uncover cardiac defects in adult zebrafish. bioRxiv doi: 2020.05.21.108548.

  • Boezio G L M, Bensimon-Brito A, Piesker J, Guenther S, Helker C S M*, Stainier D Y R * (2020). Endothelial TGF-β signaling instructs smooth muscle development in the cardiac outflow tract. bioRxiv doi: 2020.01.30.925412. *shared last authorship

  • Jiang C, Javed A, Kaiser L, Nava M M, Zhao D, Brandt D T, Fernández-Baldovinos J, Zhou L, Höß C, Sawmynaden K, Oleksy A, Matthews D, Weinstein L S, Gröne H J, Niessen C M, Offermanns S, Wickström S A, Worzfeld T (2020). Mechanochemical control of epidermal stem cell divisions by B-plexins. bioRxiv doi: https://doi.org/10.1101/2020.04.30.070359

  • Lübke S, Braukmann C, Rexer K , Cigoja L, Önel SF (2020) The Abl-interactor Abi suppresses the function of the BRAG2 GEF family member Schizo bioRxiv MS: 317990

  • Hoffmann L, Waclawczyk MS, Hanschmann E, Gellert M, Rust MB, Culmsee C (2020). Cofilin1 oxidation links oxidative distress to mitochondrial demise and neuronal cell death. bioRxiv 2020.09.09.289710; doi: https://doi.org/10.1101/2020.09.09.289710

  • Mirzapourshafiyi F, Kametani Y, Hikita T, Hasegawa Y, Nakayama M (2020). Numerical evaluation reveals the effect of branching morphology on vessel transport properties during angiogenesis. bioRxiv 2020.10.13.337295; doi: https://doi.org/10.1101/2020.10.13.337295

2019

  • Helker C S, Mullapudi S T, Mueller L M, Preussner J, Tunaru S, Skog O, Kwon HB, Kreuder F, Lancman JJ, Bonnavion R, Dong P D S, Looso M, Offermanns S, Korsgren O, Spagnoli F M, Stainier D Y R (2019) Whole organism small molecule screen identifies novel regulators of pancreatic endocrine development. Development dev. 172569.

  • Bensimon-Brito A, Ramkumar S, Boezio G L M, Guenther S, Kuenne C, Helker C S M, Sánchez-Iranzo H, Iloska D, Piesker J, Pullamsetti S, Mercader N, Beis D, Stainier D Y R (2019) TGF-β Signaling Promotes Tissue Formation during Cardiac Valve Regeneration in Adult Zebrafish. Dev Cell 52, 9-20.

 

  • Marín-Juez R, El-Sammak H, Helker C S M, Kamezaki A, Mullapuli S T, Bibli S I, Foglia M J, Fleming I, Poss K D, Stainier D Y R. (2019) Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation. Dev Cell 51, 503-515.

 

  • Mullapudi S T, Boezio G L M, Rossi A, Marass M, Matsuoka R L, Matsuda H, Helker C S M, Yang Y H C, Stainier D Y R. (2019) Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function. Development 146, dev173674.

  • Töpfer U, Bischoff M C, Bartkuhn M, Holz A (2019). Serpent/dGATAb regulates Laminin B1 and Laminin B2 expression during Drosophila embryogenesis. Sci Rep 9, 15910.

  • Gärtner S M K, Hundertmark T, Nolte H, Theofel I, Eren-Ghiani Z, Tetzner C, Duchow  T B, Rathke C, Krüger M, Renkawitz-Pohl R (2019). Stage-specific testes proteomics of /Drosophila melanogaster/ identifies essential proteins for male fertility. Eur J Cell Biol 98, 103-115.

  • Hundertmark T, Kreutz S, Merle N, Nist A, Lamp B, Stiewe S, Brehm A, Renkawitz-Pohl R, Rathke C (2019). Drosophila melanogaster/tPlus3a and tPlus3b ensure full male fertility by regulating transcription of Y-chromosomal, seminal fluid, and heat shock genes. PLOS ONE 14 e0213177.

  • Puzik K, Tonnier V, Opper I, Eckert A, Zhou L, Kratzer M C, Le Noble F, Nienhaus G U, Gradl D (2019) Lef1 regulates caveolin expression and caveolin dependent endocytosis, a process necessary for Wnt5a/Ror2 signaling during Xenopus gastrulation. Sci Rep 9, 15645.

  • Misas Villamil J C, Mueller A N, Demir F, Meyer U, Ökmen B, Schulze Hüynck J, Breuer M, Dauben H, Win J, Huesgen P F, Doehlemann G (2019). A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif. Nat Commun 10, 1576.

  • Kratzer M C, England L, Apel D, Hassel M, Borchers A (2019). Evolution of the Rho guanine nucleotide exchange factor Kalirin and Trio and their gene expression in Xenopus development. Gene Expression Patterns 32, 18-27.

  • Schwenty-Lara J, Nurnberger A, Borchers A (2019). Loss of function of Kmt2d, a gene mutated in Kabuki syndrome, affects heart development in Xenopus laevis. Dev Dyn 248, 465-476.

  • Shmukler B E, Rivera A, Bhargava P, Nishimura K, Hsu A, Kim E H, Trudel M, Rust M B, Hubner C A, Brugnara C, Alper S L (2019). Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease. Blood Cells Mol Dis (in press).

  • Bartsch JW, Rust MB. (2019). Highlight: dynamics of the nervous system in health and disease. Biol Chem. 400, 1087-1088.

  • Bartsch J W, Rust M B (2019). Guest Editorial - Highlight: Dynamics of the Nervous System in Health and Disease. Biol Chem (in press).

  • Hoffmann L, Rust M B , Culmsee C (2019). Actin(g) on mitochondria – A role for cofilin1 in neuronal cell death. Biol Chem 400, 1089-1097.

  • Kepser L J, Damar F, De Cicco T, Chaponnier C, Proszynski T J, Pagenstecher A, Rust M B (2019). CAP2 deficiency delays myofibril actin cytoskeleton differentiation and disturbs skeletal muscle architecture and function. Proc Natl Acad Sci USA 116, 8397-8402.

  • Lackinger M, Sungur A Ö, Daswani R, Soutschek M, Bicker S, Stemmler L, Wüst T, Fiore R, Dieterich C, Schwarting RK, Wöhr M, Schratt G (2019). A placental mammal-specific microRNA cluster acts as a natural brake for sociability in mice. EMBO Rep 20, e46429.

  • Lübke S, Löwer A, Papendieken M, Önel S F (2019). Wie mehrkernige Muskelzellen gebildet werden – News in fusion. Biologie in unserer Zeit 5/2019, 49.

  • Leitner M G, Thallmair V, Wilke B U, Neubert V, Kronimus Y, Halaszovich C R, Oliver D (2019) The N-terminal homology (ENTH) domain of Epsin 1 is a sensitive reporter of physiological PI(4,5)P2 dynamics. Biochim Biophys Acta Mol Cell Biol Lipids. 1864, 433-442.

  • Dierich M, Hartmann S, Dietrich N, Moeser P, Brede F, Johnson Chacko L, Tziridis K, Schilling A, Krauss P, Hessler S, Karch S, Schrott-Fischer A, Blumer M, Birchmeier C, Oliver D, Moser T, Schulze H, Alzheimer C, Leitner MG, Huth T. J ( 2019). β-Secretase BACE1 Is Required for Normal Cochlear Function. Neurosci. 39, 9013-9027.

  • Chang YN, Jaumann EA, Reichel K, Hartmann J, Oliver D, Hummer G, Joseph B, Geertsma ER (2019).Structural basis for functional interactions in dimers of SLC26 transporters. Nat Commun. 102032.

  • Dierich M, Hartmann S, Dietrich N, Moeser P, Brede F, Johnson Chacko L, Tziridis K, Schilling A, Krauss P, Hessler S, Karch S, Schrott-Fischer A, Blumer M, Birchmeier C, Oliver D, Moser T, Schulze H, Alzheimer C, Leitner MG, Huth T (2019) beta-Secretase BACE1 Is Required for Normal Cochlear Function. J Neurosci 39, 9013-9027.

  • Liu B, Großhans J. (2019) Cell Cycle. The role of dNTP metabolites in control of the embryonic cell cycle. Epub 18, 2817-2827.

  • Leitner MG, Oliver D (2019) A choreography of intracellular Ca^2+ and extracellular ATP to refine auditory nociceptors before hearing. EMBO J 38, e101980.

  • Kawamura A, Kawamura T, Riddell M, Hikita T, Yanagi T, Umemura H, Nakayama M (2019). Regulation of programmed cell death ligand 1 expression by atypical protein kinase C lambda/iota in cutaneous angiosarcoma. Cancer Sci 110, 1780-1789.

  • Simonetti M, Paldy E, Njoo C, Bali KK, Worzfeld T, Pitzer C, Kuner T, Offermanns S, Mauceri D, Kuner R (2019). The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology. Mol Psychiatry doi: 10.1038/s41380-019-0491-4. Online ahead of print.

  • R. Singh, P.S. Holz, K. Roth, A. Hupfer, W. Meissner, R. Müller, M. Buchholz, T.M. Gress, H.P. Elsässer, R. Jacob und M. Lauth (2019): DYRK1B regulates Hedgehog-induced microtubule acetylation. Cellular and Molecular Life Sciences, 76, 193-207 doi: 10.1007/s00018-018-2942-5.

2018

  • Riddell M, Nakayama A, Hikita T, Mirzapourshafiyi F, Kawamura T, Pasha A, Li M, Masuzawa M, Looso M, Steinbacher T, Ebnet K, Potente M, Hirose T, Ohno S, Fleming I, Gattenlöhner S, Aung PP, Phung T, Yamasaki O, Yanagi T, Umemura H, Nakayama M (2018). aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability. Nature Communications 9, 5357.

  • Hikita T, Mirzapourshafiyi F, Barbacena P, Riddell M, Pasha A, Li M, Kawamura T, Brandes R P, Hirose T, Ohno S, Gerhardt H, Matsuda M, Franco CA, Nakayama M (2018). PAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow. EMBO Rep 19, e45253.

  • Ringer K, Riehl J, Müller M, Dewes J, Hoff F, Jacob R (2018). The large GTPase Mx1 binds Kif5B for cargo transport along microtubules. Traffic 19, 947-964.

  • Hönig E, Ringer K, Dewes J, von Mach T, Kamm N, Kreitzer G, Jacob R (2018). Galectin-3 modulates the polarized surface delivery of β1-integrin in epithelial cells. J Cell Sci 131, jcs213199.

  • Johannes L, Jacob R, Leffler H (2018). Galectins at a glance. J Cell Sci 131, jcs208884.

  • Antoniou A, Khudayberdiev S, Idziak A, Bicker S, Jacob R, Schratt G (2018). The dynamic membrane recruitment of miRNA processing complexes in neurons controls dendritogenesis. EMBO Rep 19, e44853.

  • Bänfer S, Schneider D, Dewes J, Strauss M R, Freibert S-A, Maier U G, Elsässer H-P, Jungmann R, Jacob R (2018). Molecular mechanism to recruit galectin-3 into multivesicular bodies for polarized exosomal secretion. PNAS 115, E4396-E4405.

  • Stehling O, Jeoung JH, Freibert SA, Paul VD, Bänfer S, Niggemeyer B, Rösser R, Dobbek H, Lill R. (2018). Function and crystal structure of the dimeric P-loop ATPase CFD1 coordinating an exposed [4Fe-4S] cluster for transfer to apoproteins. Proc Natl Acad Sci U S A. 115, E9085-E9094.

  • Leitner MG, Hobiger K, Mavrantoni A, Feuer A, Oberwinkler J, Oliver D, Halaszovich CR. (2018). A126 in the active site and TI167/168 in the TI loop are essential determinants of the substrate specificity of PTEN. Cell Mol Life Sci. 75, 4235-4250.

  • Hackelberg S, Oliver D. (2018) Metabotropic Acetylcholine and Glutamate Receptors Mediate PI(4,5)P_2 Depletion and Oscillations in Hippocampal CA1 Pyramidal Neurons in situ. Sci Rep. 8, 12987.

  • Leitner MG, Hobiger K, Mavrantoni A, Feuer A, Oberwinkler J, Oliver D, Halaszovich CR (2018). A126 in the active site and TI167/168 in the TI loop are essential determinants of the substrate specificity of PTEN. Cell Mol Life Sci. 75, 4235-4250.

  • Siegemund M, Schneider F, Hutt M, Seifert O, Müller I, Kulms D, Pfizenmaier K, Kontermann RE (2018). IgG-single-chain TRAIL fusion proteins for tumour therapy. Sci Rep 8, 7808.

  • Sungur AÖ, Stemmler L, Wöhr M, Rust MB (2018). Impaired Object Recognition but Normal Social Behavior and Ultrasonic Communication in Cofilin1 Mutant Mice. Front Behav Neurosci 12:25.

  • Bouchard C, Sahu P, Meixner M, Nötzold RR, Rust MB, Kremmer E, Feederle R, Hart-Smith G, Finkernagel F, Bartkuhn M, Pullamsetti SS, Nist A, Stiewe T, Philipsen S, Bauer UM (2018). Genomic location of PRMT6-dependent H3R2 methylation is decisive for the transcriptional outcome of associated genes. Cell Rep 24, 3339-3352.

  • Ganjam GK, Terpolilli NA, Diemert S, Eisenbach I, Hoffmann L, Reuther C, Herden C, Roth J, Plesnila N, Culmsee C (2018). Cylindromatosis mediates neuronal cell death in vitro and in vivo. Cell Death Differ. 25, 1394-1407.

2017

  • Berger H, Wodarz A, Borchers A (2017). PTK7 Faces the Wnt in Development and Disease. Front Cell Dev Biol. 5:31.

  • Berger H, Breuer M, Peradziryi H, Podleschny M, Jacob R, Borchers A (2017). PTK7 localization and protein stability is affected by canonical Wnt ligands. J Cell Sci. 130, 1890-1903.

  • Hikita T, Mirzapourshafiyi F, Barbacena P, Riddell M, Pasha A, Li M, Kawamura T, Brandes RP, Hirose T, Ohno S, Gerhardt H, Matsuda M, Franco CA, Nakayama M (2018). PAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow. EMBO Reports 19, e45253.

  • Sun T, Yang L, Kaur H, Pestel J, Looso M, Nolte H, Krasel C, Heil D, Krishnan RK, Santoni M-J, Borg J-P, Bünemann M, Offermanns S, Swiercz JM, Worzfeld T (2017). A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib. J Cell Biol 216, 199–215.

  • Paldy E, Simonetti M, Worzfeld T, Bali KK, Vicuña L, Offermanns S, Kuner R (2017). Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain. Nat Commun 8, 176.

  • Soto Hinojosa L, Holst M, Baarlink C, Grosse R (2017). MRTF transcription and Ezrin-dependent plasma membrane blebbing are required for entotic invasion. J Cell Biol 216, 3087-3095.

  • Rothenbusch-Fender S, Fritzen K, Bischoff MC, Buttgereit D, Oenel SF, Renkawitz-Pohl R (2017). Myotube migration to cover and shape the testis of Drosophila depends on Heartless, Cadherin/Catenin, and myosin II. Biol Open. 6, 1876-1888.

  • Rehklau K, Hoffmann L, Gurniak CB, Ott M, Witke W, Scorrano L, Culmsee C, Rust MB (2017). Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission. Cell Death Dis 8, e3063.

  • Neitemeier S, Jelinek A, Laino V, Hoffmann L, Eisenbach I, Eying R, Ganjam GK, Dolga AM, Oppermann S, Culmsee C (2017). BID links ferroptosis to mitochondrial cell death pathways. Redox Biol 12, 558-570.

  • Özge Sungur A, Stemmler L, Wöhr M, Rust MB (2018). Impaired Object Recognition but Normal Social Behavior and Ultrasonic Communication in Cofilin1 Mutant Mice. Front Behav Neurosci 12:25.

  • Holz O, Apel D, Steinmetz P, Lange E, Hopfenmüller S, Ohler K, Sudhop S, Hassel M (2017). Bud detachment in hydra requires activation of fibroblast growth factor receptor and a Rho-ROCK-myosin II signaling pathway to ensure formation of a basal constriction. Dev Dyn 246, 502-516.

  • Meister M, Bänfer S, Gärtner U, Koskimies J, Amaddii M, Jacob R, Tikkanen R (2017). Regulation of cargo transfer between ESCRT-0 and ESCRT-I complexes by flotillin-1 during endosomal sorting of ubiquitinated cargo. Oncogenesis 6, e344.

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