Hauptinhalt

Research group Prof. Dr. Shu-Ming Li

Highlights 2019

  • Coupling of hypoxanthin with cyclodipeptides catalyzed by cytochrome P450 enzymes, Org. Lett.  2019, 21, 9104
  • Two cytochrome P450 enzymes catalyze new dimerization patterns of tryptophan–containing cyclodipeptides, Org. Lett. 2019, 21,7094
  • Small but effective: Two similar five gene-clusters of about 4 kbps from two Streptomyces strains are responsible for the biosynthesis of guanitryptmycins, Angew. Chem. Intern. Ed. 2019, 58, 11534, Highlighted in Hot off the Press in Nat. Prod. Rep. 2019, Pressemitteilung der Universität
  • A fungus of deep-sea sediment as a potential host for gene expression, ACS Chem. Biol. 2019, 14, 1227
  • Non-enzymatic 1,4-Michael Additions in the formation of fungal metabolites, J. Am. Chem. Soc. 2019, 141, 4225, Pressemitteilung der Universität
  • Domain recombination of nonribosomal peptide synthetase (NRPS)-like enzymes in Saccharomyces cerevisiae, Org. Lett. 2019, 21, 498

Highlights 2018

  • Increasing structural diversity of geranylated cyclic dipeptides by site-directed mutagenesis of the available dimethylallyl transferases, Org. Lett. 2018, 20, 7201
  • Hydroxylation and double bond migration within a dimethylallyl moiety, ACS Chem. Biol. 2018, 13, 2949
  • A bacterial cytochrome P450 enzyme functions as a guaninyl transferase of cyclodipeptides, Org. Lett. 2018, 20, 4921

Highlights 2017

  • Gem-diprenylation by one fungal prenyltransferase, Org. Lett. 2017, 19, 388
  • One prenyltransferase catalyzes at least three prenylation steps, Org. Lett. 2017, 19, 5928
  • Spontaneous formation of prenylated β-carbolines after tryptophan prenylation in Saccharomyces cerevisiae, ACS Syn. Biol. 2017, 6, 1056
  • Very high promiscuity of an aromatic prenyltransferase, Nature Chem. Biol. 2017, 13, 226

Highlights 2016

  • Moving in the newly renovated institute building at the Robert-Koch-Str.

Highlights 2015

Highlights 2013

  • Stereospecific formation of cis-configured prenylated pyrroloindoline diketopiperazines, Chem. Biol. 2013, 20, 1492

Highlights 2012

Highlights 2011

Highlights 2010

  • The first crystal structure of tryptophan-containing cyclic dipeptide prenyltransferases, J. Am. Chem. Soc. 2010, 132, 17849
  • Fungal prenylated indole derivatives as important natural products, Nat. Prod. Rep. 2010, 27, 57

Highlights 2009