From 21. to 23. July, the 2. Sino-German Forum on Frontiers and Innovations in Natural Product Chemistry has been successfully held in Rauischholzhausen.
A catalytic cascade consisting of a flavin-containing monooxygenase, an epoxide expandase, and a cytochrome P450 enzyme is responsible for the construction of an epoxytetrahydrofuran ring system in the deoxyverrucosidin biosynthesis. Chem. Sci., 16, DOI: 10.1039/D5SC03423J
Highly coordinated consecutive oxidation steps are involved in the formation of isoindolinone derivatives. Org. Lett., 26, DOI: 10.1021/acs.orglett.5c00328
Highlights 2024
Successful doctoral defence in 2024: Sina Stierle, Daniel Janzen, Andreas Martin, Zhengxi Zhang, Jenny Zhou, Marlies Peter, Zhanghai Li, Yu Dai
Crosstalk of multiple pathways in Penicillium crustosum. Org. Lett., 26, DOI: 10.1021/acs.orglett.4c03698
Alkyl and hydride migrations in sesquiterpenoid biosynthesis. Org. Lett., 26, DOI: 10.1021/acs.orglett.4c0235
Structural basis of cytochrome P450 enzymes for intramolecular coupling and nucleobase transfer. ChemCatChem, 16, DOI: 10.1002/cctc.202400105
Summary on cytochrome P450 enzymes as nucleobase transferases. Methods Enzymol., vol 693, 2023, DOI: 10.1016/bs.mie.2023.09.012
Biosynthesis of p-terphenyls in fungi. Org. Lett.2023, DOI: 10.1021/acs.orglett.3c02234
Flavin-catalyzed oxidative indole ring opening of indole diterpenes and oxygen incorporation from solvent water. Org. Lett. 2023, DOI: 10.1021/acs.orglett.3c01320
Highlights 2022
A berberine bridge enzyme-like protein catalyzes an oxidative lactonization between two hydroxyl groups. Org. Lett. 2022, 24, 6072–6077, DOI: 10.1021/acs.orglett.2c02438
Widely distributed bifunctional cytochrome P450 enzymes for both intramolecular C-C bond formation in cYY and its coupling with guanine and hypoxanthine. Angew.Chem.Intern.Ed.2022, 61, e202200377.
A bifunctional nonreducing polyketide synthase from Penicillium crustosum.Org. Lett. 2022, 24, 462–466.
Two different oxidases install exo-double bonds at the diketopiperazine ring. ACS Catal. 2022, 12, 648–654.Pressemitteilung der Universität Marburg, Highlighted in Hot off the Press in Nat. Prod. Rep. 2022
Cytochrome P450-mediated meta hydroxylation at a monoalkylated benzene ring. Org. Lett. 2022, 24, 262–267.
Summary on prenylated chalcones from plants. Nat. Prod. Rep. 2021,
Specific and stereoselective ring expansion in the biosynthesis of oxepinamides. Org. Lett.2021, 23, 2024-2028. Highlighted in Hot off the Press in Nat. Prod. Rep. 2021.
Phenethyl derivative formation in Aspergillus ustus. Org. Lett. 2020, 22, 7837. Highlighted in Hot off the Press in Nat. Prod. Rep. 2020.
Elucidation of the first oxepinamide biosynthetic pathway in fungi. Nature Commun. 2020,11, 4914
Two new cyclodipeptide dimerases from Saccharopolyspora antimicrobica. ChemComm2020, 56, 11042–11045. Highlighted inHot off the Pressin Nat. Prod. Rep. 2020.
Accumulation of an isocoumarin in an Aspergillus nidulans strain carrying a polyketide synthase gene and its modification by host enzymes, Org. Biomol. Chem. 2020, 18, 4946-4948. Highlighted in Hot off the Press in Nat. Prod. Rep. 2020.
Biosynthesis of the prenylated salicylaldehyde flavoglaucin provides an example for a highly programmed machinery in natural product biosynthesis, Org. Lett. 2020, 22, 2256
ortho-Quinone methide as highly reactive coupling reagent with diverse natural products, J. Org. Chem, 2020, 85, 1298
Conversion of a 5ß-carboxylmethyl acyltetronate to a 5a-methyl derivative by consecutive oxidation and reduction, Org. Lett. 2020, 22, 88. Highlighted in Hot off the Press in Nat. Prod. Rep. 2020.
Highlights 2019
Coupling of hypoxanthin with cyclodipeptides catalyzed by cytochrome P450 enzymes, Org. Lett. 2019, 21, 9104
Two cytochrome P450 enzymes catalyze new dimerization patterns of tryptophan–containing cyclodipeptides, Org. Lett. 2019, 21,7094
Small but effective: Two similar five gene-clusters of about 4 kbps from two Streptomyces strains are responsible for the biosynthesis of guanitryptmycins, Angew. Chem. Intern. Ed. 2019, 58, 11534, Highlighted in Hot off the Press in Nat. Prod. Rep. 2019, Pressemitteilungder Universität Marburg
A fungus of deep-sea sediment as a potential host for gene expression, ACS Chem. Biol. 2019, 14, 1227
Non-enzymatic 1,4-Michael Additions in the formation of fungal metabolites, J. Am. Chem. Soc. 2019, 141, 4225, Pressemitteilung der Universität Marburg
Domain recombination of nonribosomal peptide synthetase (NRPS)-like enzymes in Saccharomyces cerevisiae, Org. Lett. 2019, 21, 498
Highlights 2018
Increasing structural diversity of geranylated cyclic dipeptides by site-directed mutagenesis of the available dimethylallyl transferases, Org. Lett.2018, 20, 7201
Hydroxylation and double bond migration within a dimethylallyl moiety, ACS Chem. Biol. 2018, 13, 2949
A bacterial cytochrome P450 enzyme functions as a guaninyl transferase of cyclodipeptides, Org. Lett. 2018, 20, 4921
Highlights 2017
Gem-diprenylation by one fungal prenyltransferase, Org. Lett.2017, 19, 388
One prenyltransferase catalyzes at least three prenylation steps, Org. Lett.2017, 19, 5928
Spontaneous formation of prenylated β-carbolines after tryptophan prenylation in Saccharomyces cerevisiae, ACS Syn. Biol. 2017, 6, 1056
Very high promiscuity of an aromatic prenyltransferase, Nature Chem. Biol. 2017, 13, 226
Highlights 2016
Moving in the newly renovated institute building at the Robert-Koch-Str.