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Originalarbeiten und Reviews 2023

Originalarbeiten 2023:

1. Projection of Healthcare Demand in Germany and Switzerland Urged by Omicron Wave (January-March 2022).
   Gorji H, Stauffer N, Lunati I, Caduff A, Bühler M, Engel D, Chung HR, Loukas O, Feig S, Renz H.
   Epidemics 43:100680, 2023 (Epub 2023)
   doi: 10.1016/j.epidem.2023.100680 PMID: 36963246
2. Autoantibodies are highly prevalent in non-SARS-CoV-2 respiratory infections and critical illness.
   Feng A, Yang EY, Moore AR, Dhingra S, Chang SE, Yin X, Pi R, Mack EK, Völkel S, Geßner R, Gündisch M, Neubauer A, Renz H, Tsiodras S, Fragkou PC, Asuni AA, Levitt JE, Wilson JG, Leong M, Lumb JH, Mao R, Pinedo K, Roque J, Richards CM, Stabile M, Swaminathan G, Salagianni ML, Triantafyllia V, Bertrams W, Blish CA, Carette JE, Frankovich J, Meffre E, Nadeau KC, Singh U, Wang TT, Luning Prak ET, Herold S, Andreakos E, Schmeck B, Skevaki C, Rogers AJ, Utz PJ.
   doi: 10.1172/jci.insight.163150 PMID: 36752204
3. Comorbidity defines risk of asthmatics for COVID-19 hospitalization: a global perspective.
   Skevaki C, Chinthrajah S, Formina D, Rohde G, Cao S, He Z, Serdotetskova S, Seidemann C, Grünewaldt A, Vengadeswaran A, Xie M, Karsonova A, Karaulov A, Nadeau KC, Chung H-R, Renz H.
   J Allergy Clin Immunol. 151(1):110-117, 2023
   doi: 10.1016/j.jaci.2022.09.039 PMID: 36336123
   
4. Spurious transcription causing innate immune responses is prevented by 5hmC.
   Wu F, Li X, Looso M, Liu H, Ding D, Günther S, Kuenne C, Liu S, Weissmann N, Böttger T, Atzberger A, Kolahian S, Renz H, Offermanns S, Gärtner U, Potente M, Zhou Yonggang, Yuan X, Braun T.
   Nat Genet. 55(1):100-111, 2023 (Epub 2022)
   doi: 10.1038/s41588-022-01252-3 PMID: 36539616
5. Trajectories of cough without a cold in early childhood and associations with atopic diseases.
   Divaret-Chauveau A, Mauny F, Hose A, Depner M, Dalphin ML, Kaulek V, Barnig C, Schaub B, Schmausser-Hechfellner E, Renz H, Riedler J, Pekkanen J, Karvonen AM, Täubel M, Lauener R, Roduit C, Vuitton DA, von Mutius E, Demoulin-Alexikova S; PASTURE study group.
   Clin Exp Allergy. 53(4):429-442, 2023 (Epub 2022)
   doi: 10.1111/cea.14257 PMID: 36453463
6. Intranasal administration of Acinetobacter lwoffii in a murine model of asthma induces IL-6 mediated protection associated with caecal microbiota changes.
   Alashkar Alhamwe B, Gao Z, Alhamdan F, Harb H, Pichene M, Garnier A, El Andari J, Kaufmann A, Graumann PL, Kesper D, Daviaud C, Garn H, Tost J, Potaczek DP, Blaser MJ, Renz H.
   Allergy 78(5):1245-1257, 2023 (Epub 2022)
   doi: 10.1111/all.15606 PMID: 36458896
7. Acute orchitis deciphered: Coxsackievirus B strains are the main etiology and their presence in semen is associated with acute inflammation and risk of persistent oligozoospermia.
   Pilatz A, Arneth B, Kaiser R, Heger E, Pirkl M, Böttcher S, Fritzenwanker M, Renz H, Mankertz A, Schuppe HC, Wagenlehner F.
   J Med Virol. 95(7):e28970, 2023.
   doi: 10.1002/jmv.28970 PMID: 37477797
8. Intranasal EP4 agonist and arginase-1 therapy in a murine model of asthma.
   Gercke P, Lautenschlager N, Vedder N, van Geffen C, Renz H, Kolahian S.
   Eur J Pharmacol. 957:176040. 2023 (Epub 2023)
   doi: 10.1016/j.ejphar.2023.176040 PMID: 37666288
9. Cross-reactive MHC class I T cell epitopes may dictate heterologous immune responses between respiratory viruses and food allergens.
   Balz K, Kaushik A, Cemic F, Sampath V, Heger V, Renz H, Nadeau K, Skevaki C.
   Sci Rep. 13(1):14874,2023
   doi: 10.1038/s41598-023-41187-1 PMID: 37684288
10. Serum proteomics hint at an early T-cell response and modulation of SARS-CoV-2-related pathogenic pathways in COVID-19-ARDS treated with Ruxolitinib.
    Völkel S, Tarawneh TS, Sacher L, Bhagwat AM, Karim I, Mack HID, Wiesmann T, Beutel B, Hoyer J, Keller C, Renz H, Burchert A, Neubauer A, Graumann J, Skevaki C, Mack EKM.
    Front Med (Lausanne) 10:1176427, 2023
    doi: 10.3389/fmed.2023.1176427 PMID: 37293294
11. Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1.
    Kılıç A, Halu A, De Marzio M, Maiorino E, Duvall MG, Brueggemann T, Rojas JJ, Chase R, Mirzakhani H, Özge Sungur A, Koepke J, Nakano T, Peh HY, Krishnamoorthy N, Abdulnour R-E, Georgopoulos K, Litonjua AA, Demay MB, Renz H, Levy BD, Weiss ST.
    eLife12:RP89270, 2023 (Reviewed Preprint)
12. Sex-specific differences in physiological parameters related to SARS-CoV-2 infections among a national cohort (COVI-GAPP study).
    Grossmann K, Risch M, Markovic A, Aeschbacher S, Weideli OC, Velez L, Kovac M, Pereira F, Wohlwend N, Risch C, Hillmann D, Lung T, Renz H, Twerenbold R, Rothenbühler M, Leibovitz D, Kovacevic V, Klaver P, Brakenhoff TB, Franks B, Mitratza M, Downward GS, Dowling A, Montes S, Veen D, Grobbee DE, Cronin M, Conen D, Goodale BM, Risch L.
    medRxiv 2023.09.17.23295693 (Preprint 2023)
13. Changes in the degree of substitution of HES in vivo and their influence on methods for determining HES concentrations in plasma.
    Lukasewitz P, Rischer P, Schedel N, Stay D, Wulf H, Stief T, Volberg C.
    PLoS One 22;18(8):e0290339, 2023
    doi: 10.1371/journal.pone.0290339 PMID: 37607177
14. Update of ESCMID COVID-19 guidelines: diagnostic testing for SARS-CoV-2.
    Fragkou PC, De Angelis G, Menchinelli G, Can F, Garcia F, Morfin-Sherpa F, Dimopoulou D, Dimopoulou K, Zelli S, de Salazar A, Reiter R, Janocha H, Grossi A, Omony J, Skevaki C.
    Clin Microbiol Infect. 29(7):876-886, 2023
    doi: 10.1016/j.cmi.2023.04.019 PMID: 37088423
15. Continuous Rather Than Solely Early Farm Exposure Protects From Hay Fever Development.
    Pechlivanis S, Depner M, Kirjavainen PV, Roduit C, Täubel M, Frei R, Skevaki C, Hose A, Barnig C, Schmausser-Hechfellner E, Ege MJ, Schaub B, Divaret-Chauveau A, Lauener R, Karvonen AM, Pekkanen J, Riedler J, Illi S, von Mutius E; PASTURE Study Group*.
    J Allergy Clin Immunol Pract. 11(2):591-601, 2023
    doi: 10.1016/j.jaip.2022.10.035 PMID: 36356926
16. Impaired systemic nuceocapsid antigen clearance in severe COVID-19.
    Bauer C, Mack E, Hefter V, Fischer A, Volland K, Skevaki C, Neubauer A, Gress T, Becker S, Keller C.
    J Med Virol. 95(8):e29032, 2023
    doi: 10.1002/jmv.29032 PMID: 37581876
17. Fungi in Early-Life House Dust Samples and the Development of Asthma: A Birth Cohort Study.
    Täubel M, Jalanka J, Kirjavainen PV, Tuoresmäki P, Hyvärinen A, Skevaki C, Piippo-Savolainen E, Pekkanen J, Karvonen A M.
    Ann Am Thorac Soc. 20(10):1456-1464, 2023
    doi: 10.1513/AnnalsATS.202303-187OC  PMID: 37535826
18. Acute iv CRH administration significantly increases serum active ghrelin in postmenopausal PCOS women compared to postmenopausal controls.
    Markopoulos M, Barber TM, Bargiota A, Skevaki C, Papassotiriou I, Kumar S, Vlahos NF, Mastorakos G, Valsamakis G
    Endocrine 81(3):613-620, 2023
    doi: 10.1007/s12020-023-03406-7 PMID: 37249728
19. Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE Cohort.
    Grychtol R, Riemann L, Gaedcke S, Liu B, DeLuca D, Förster R, Maison N, Thiele D, Jakobs N, Bahmer T, Meyer M, Foth S, Weber S, Rietschel E, Rabe KF, Kopp MV, von Mutius E, Dittrich AM, Hansen G; ALLIANCE Study Group*.
    J Allergy Clin Immunol. 151(6):1525-1535.e4, 2023
    doi: 10.1016/j.jaci.2023.01.027 PMID: 36804993
20. Cold Atmospheric Plasma Triggers Apoptosis via the Unfolded Protein Response in Melanoma Cells.
    Zimmermann T, Staebler S, Taudte RV, Ünüvar S, Grösch S, Arndt S, Karrer S, Fromm MF, Bosserhoff A-K.
    Cancers 15 (4), 1064, 2023
    doi: 10.3390/cancers15041064 PMID: 36831408
21. High-fat-dietassociated intestinal microbiota exacerbates psoriasis-like inflammation by enhancing systemic γδ T cell IL-17 production.
    Sonomoto K, Song R, Eriksson D, Hahn AM, Meng X, Lyu P, Cao S, Liu N, Taudte RV, Wirtz S, Tanaka Y, Winkler TH, Schett G, Soulat D, Bozec A.
    Cell Reports 42 (7), 112713, 2023.
    doi: 10.1016/j.celrep.2023.112713 PMID: 37421628
22. A supervised machine-learning approach for the efficient development of a multi method (LC-MS) for a large number of drugs and subsets thereof: focus on oral antitumor agents.
    Kehl N, Gessner A, Maas R, Fromm MF, Taudte RV.
    Clinical Chemistry and Laboratory Medicine 62(2):293-302, 2023.
    doi: 10.1515/cclm-2023-0468 PMID: 37606251
23. Immunometabolic Profiling of Chronic Subdural Hematoma through Untargeted Mass Spectrometry Analysis: Preliminary Findings of a Novel Approach.
    Kipele M, Buchfelder M, Taudte RV, Stadlbauer A, Kinfe T, Bozhkov Y.
    Diagnostics 13 (21), 3345, 2023.
    doi: 10.3390/diagnostics13213345 PMID: 37958242
24. L-arginine metabolism inhibits arthritis and inflammatory bone los.
    Cao S, Li Y, Song R, Meng X, Fuchs M, Liang C, Kachler K, Meng X, Wen J, Schlötzer-Schrehardt U, Taudte RV, Gessner A, Kunz M, Schleicher U, Zaiss MM, Kastbom A, Chen X, Schett G, Bozec A.
    Annals of Rheumatic Diseases 0, 1-16, 2023
    doi: 10.1136/ard-2022-223626 PMID: 37775153
25. 17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma.
    Jakwerth CA, Weckmann M, Illi S, Charles H, Zissler UM, Oelsner M, Guerth F, Omony J, Nemani SSP, Grychtol R, Dittrich AM, Skevaki C, Foth S, Weber S, Alejandre Alcazar MA, van Koningsbruggen-Rietschel S, Brock R, Blau S, Hansen G, Bahmer T, Rabe KF, Brinkmann F, Kopp MV, Chaker AM, Schaub B, von Mutius E, Schmidt-Weber CB; ALLIANCE Study Group as part of the German Center for Lung
    Research (DZL).
    Am J Respir Crit Care Med. 2023 Dec 8 (Epub ahead of print)
    doi: 10.1164/rccm.202305-0934OC PMID: 38064241

Übersichten

1. Respiratory viral co‐infections in patients with COVID‐19 and associated outcomes: A systematic review and metaanalysis.
   Krumbein H, Kümmel LS, Paraskevi CF, Thölken C, Hünerbein BL, Reiter R, Papathanasiou KA, Renz H, Skevaki C.
   Med Virol. 33(1):e2365, 2023 (Epub 2022)
   doi: 10.1002/rmv.2365 PMID: 35686619
2. From big data to better patient outcomes.
   Hulsen T, Friedecký D, Renz H, Melis E, Vermeersch P, Fernandez-Calle P.
   Clin Chem Lab Med. 61(4):580-586, 2023 (Epub 2022)
   doi: 10.1515/cclm-2022-1096  PMID: 36539928
3. Impact of local human microbiota on the allergic diseases: organ-organ interaction.
   Alashkar Alhamwe B, Zhernov Y, Lopez-Crespo JF, Karaulov A, Kolahian S, Renz H.
   Pediatr Allergy Immunol. 34(6):e13976, 2023
   doi: 10.1111/pai.13976 PMID: 37366206
4. Acute and chronic consequences of Heat Stress on Planetary Health.
   Sampath V, Shalakhti O, Veidis E, Efobi JAI, Shamji MH, Daily G, Agache I, Skevaki C, Renz H, Nadeau KN.
   Allergy 78(8):2109-2120, 2023
   doi: 10.1111/all.15702 PMID: 36883412
5. Type 2 chronic inflammatory diseases: targets, therapies and unmet needs.
   Kolkhir P, Akdis CA, Akdis M, Bachert C, Bieber T, Canonica GW, Guttman-Yassky E, Metz M, Mullol J, Palomares O, Renz H, Ständer S, Zuberbier T, Maurer M.
   Nat Rev Drug Discov. 22(9):743-767, 2023
   doi: 10.1038/s41573-023-00750-1 PMID: 37528191
6. The role of PGE2 and EP receptors on lung’s immune and structural cells; possibilities for future asthma therapy.
   Cebulla D, van Geffen C, Kolahian S.
   Pharmacology & Therapeutics 241:108313, 2023.
   doi: 10.1016/j.pharmthera.2022.108313 PMID: 36427569
7. Clinical Microbiology and Infection Study Group for Respiratory Viruses. Performance of point-of care molecular and antigen-based tests for SARS-CoV-2: a living systematic review and meta-analysis.
   Fragkou PC, Moschopoulos CD, Dimopoulou D, Ong DSY, Dimopoulou K, Nelson PP, Schweitzer VA, Janocha H, Karofylakis E, Papathanasiou KA, Tsiordras S, De Angelis G, Thölken C, Sanguinetti M, Chung HR, Skevaki C; European Society of Clinical Microbiology and Infection Study Group for Respiratory Viruses.
   Clin Microbiol Infect. 29(3):291-301, 2023 (Epub 2022)
   doi: 10.1016/j.cmi.2022.10.028  PMID: 36336237
8. Epidemiology of respiratory viruses among children during the SARS-CoV-2 pandemic: A systematic review and meta-analysis.
   Dallmeyer LK, Schüz ML, Fragkou PC, Omony J, Krumbein H, Dimopoulou D, Dimopoulou K, Skevaki C.
   Int J Infect Dis. 138:10-18, 2024 (Epub 2023)
   doi: 10.1016/j.ijid.2023.10.023 PMID: 37951460
9. Global prevalence of respiratory virus infections in adults and adolescents during the COVID-19 pandemic: A systematic review and meta-analysis.
   Schüz ML, Dallmeyer L, Fragkou PC, Omony J, Krumbein H, Hünerbein BL, Skevaki C.
   Int J Infect Dis. 137:16-24, 2023 (Epub 2023)
   doi: 10.1016/j.ijid.2023.10.001 PMID: 37806653

S2 und S3 Leitlinien

1. Antibody Repertoire and Autoimmunity.
   Skevaki C, Wesemann DR.
   J Allergy Clin Immunol. S0091-6749(23)00222-1. 20 Feb. 2023
   doi: 10.1016/j.jaci.2023.02.008 PMID: 36813185