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Originalarbeiten und Reviews 2025

Originalarbeiten 2025:

1. Differential expression of eicosanoid pathways after whole blood stimulation in asthma patients
   Skevaki C, Tafo P, Bahmer T, Abdo M, Watz H, Pedersen F, Herzmann C, Rabe KF, Renz H, Nockher WA; ALLIANCE Study  Group as part of the German Center for Lung Research (DZL)
   World Allergy Organization Journal 2;18(4):101047, 2025
   DOI:   10.1016/j.waojou.2025.101047  PMID:  40235674
2. Relationship between hypercoagulability and mesenteric ischemia early after cardiac surgery
   Taghiyev ZT, Sadowski M, Beier LM, Leweling C, Gunkel S, Keschenau P, Kalder J, Arneth BM, Skevaki C, Sachs U, Müller J, 
   Böning A.
   Journal of Thrombosis and Thrombolysis Open Access, 2025
   DOI:   10.1007/s11239-025-03186-z  PMID:  41071254
3. Early detection of mesenteric ischemia in critically ill patients following cardiac surgery
   Taghiyev ZT, Gunkel S, Beier LM, Leweling C, Sadowski KM, Arneth BM, Skevaki C, Kalder J, Keschenau PR, Böning A.
   Scientific Reports 10;15(1):24854, 2025
   DOI:   10.1038/s41598-025-10534-9  PMID:  40640442
4. The Janus face of Bifidobacterium in the development of atopic eczema: A role for compositional maturation
   Depner M, Ege MJ, Hazard Taft D, Peschel S, Roduit C, Karvonen AM, Barnig C, Divaret-Chauveau A,Riedler J, Pekkanen J, Schmausser-Hechfellner E, Lauener R, Roponen M, Renz H, Pfefferle PI, Schaub B, von Mutius E, Kirjavainen PV and the PASTURE study group
   Pediatr Allergy Immunol. 2025 Feb; 36(2):e70041, 2025
   DOI:   10.1111/pai.70041  PMID:  39932047
5. Stability of Hemolytic, Lipemic and Icteric Indices in blood samples transported by Drone: A focused report
   Stirlin N, Hemmerle A, Renz H, Risch L and Risch M. 
   The Journal of Applied Laboratory Medicine, May 2025,704–709, 2025
6. T follicular helper cell expansion and hyperimmunoglobulinemia with spontaneous IgE production to dietary antigens in IgA-deficient mice
   El Ansari YS, Kanagarathma C, Furiness KN, Brodeur KE, Lee PY, Renz H, Oettgen HC
   Mucosal Immunol. 2025 Apr; 18(2):481-490
   DOI:   10.1016/j.mucimm.2025.01.005  PMID:  39824503
7. Targeted Knockdown of Epithelial Estrogen Receptor α to Mitigate Ferroptosis and Epithelial-Mesenchymal Transition in Eosinophilic Asthma
   Zhang W, Zhang S, Hua L, Bai W, Qin L, Yue J, Wang D, Guo M, Wang X, Renz H, Skevaki C, Wang G, Chen Z, Dong H, Xie M
   ACS Nano 2025, 19, 21105-21117
   DOI:   10.1021/acsnano.5c05314  PMID:  40424612
8. Low type-2 immune effectros modulate atopic diseases’ protective role in pancreatic cancer risk
   He J, Alhamwe BA, Sabroso S, Carrato A, Hidalgo M, Molero X, Iglesias M, Perea J, Farre A, Tardon A, Dominuez-Munoz E, Barbera V, Munoz-Bellvis L, Löhr M, Greenhalf W, O’Rorke M, Gress T, Crnogorac-Jurcevic T, Gaya A, Langtry A, Kleeff J, Lawlor R, Real FX, Renz H, Malats N
   Int. J. Cancer. 2025; 157:468-479
   DOI:   10.1002/ijc.35397  PMID:  40098454
9. Differential impact of manic versus depressive episode recurrence on longitudinal gray matter volume changes in bipolar disorder
   Thomas-Odenthal F, Teutenberg L, Stein F, Alexander N, Bonnekoh LM, Brosch K, Flinkenflügel K, Goltermann J, Grotegerd D, Hahn T, Jansen A, Leehr EJ, Meinert S, Pfarr JK, Renz H, Ringwald K, Schürmeyer N, Stief T, Straube B, Thiel K, Usemann P, Krug A, Nenadić I, Dannlowski U, Kircher T
   Neuropsychopharmacology, 2025 Aug 15
   DOI: 10.1038/s41386-025-02197-x  PMCID: PMC12824149
10. Genome-based development and clinical evaluation of a customized LAMP panel to rapidly detect, quantify, and determine antibiotic sensitivity of Escherichia coli in native urine samples from urological patients
    Fritzenwanker M, Grabitz MO, Negwer V, Schwengers O, Arneth B, Chakraborty T, Imirzalioglu C, Wagenlehner F
    Eur J Clin Microbiol Infect Dis. 2025 Mar;44(3):703-715
    DOI: 10.1007/s10096-024-05030-3  PMID: 39775368 
11. Optimized Hesperidin-Loaded Lipid Nanoparticles with Tea Tree Oil for Enhanced Wound Healing: Formulation, Characterization, and Evaluation
    Arneth B, Abdelmonem R, El-Nabarawi MA, Teaima MH, Rashwan KO, Soliman MA, Al-Samadi IEI
    Pharmaceuticals (Basel). 2025 Feb 20;18(3):290 
    DOI: 10.3390/ph18030290  PMID: 40143069
12. Anti-Tumor Potential of Frankincense Essential Oil and Its Nano-Formulation in Breast Cancer: An In Vivo and In Vitro Study
    Mohamed N, Ismail H, Nasr GM, Abdel-Ghany S, Arneth B, Sabit H
    Pharmaceutics. 2025 Mar 27;17(4):426 
    DOI: 10.3390/pharmaceutics17040426  PMID: 40284420
13. Immunopathological Dysregulation in Acute Myeloid Leukemia: The Impact of T-bet, RORγt, and FOXP3 on Disease Dynamics
    Mohy El-Din AMM, AlShaarawy BA, Kandeel EZ, AlDewi DM, Refaat LAA, Arneth B, Sabit H
    Cells. 2025 Apr 1;14(7):528 
    DOI: 10.3390/cells14070528  PMID: 40214482
14. Regulatory Roles of miR-155-5p, miR-21-5p, miR-93-5p, and miR-140-5p in Breast Cancer Progression
    Degheidy MS, Abou-Elalla AA, Kamel MM, Abdel-Ghany S, Arneth B, Sabit H
    Curr Issues Mol Biol. 2025 May 20;47(5):377 
    DOI: 10.3390/cimb47050377  PMID: 40699776
15. Natural Nanoparticles for Drug Delivery: Proteomic Insights and Anticancer Potential of Doxorubicin-Loaded Avocado Exosomes
    Salem D, Abdel-Ghany S, Mohamed E, Alahmady NF, Alqosaibi A, Al-Dhuayan IS, Alnamshan MM, Arneth R, Arneth B, Sabit H
    Pharmaceuticals (Basel). 2025 Jun 4;18(6):844 
    DOI: 10.3390/ph18060844  PMID: 40573239
16. Diagnostic and Prognostic Roles of miR-155 and miR-3173 in Breast and Ovarian Cancer: Implications for Early Detection and Personalized Treatment
    Altrawy A, Talaat RM, Nasr GM, Badr EAE, Arneth R, Arneth B, Sabit H
    Biomedicines. 2025 Jun 30;13(7):1604 
    DOI: 10.3390/biomedicines13071604  PMID: 40722677
17. Correlation Between Coronary Artery Disease Severity Detected by CT Coronary Angiography and Grade of Left Ventricular Diastolic Dysfunction Detected by Echocardiography
    El-Barbary A, Elsayed MA, Yousef Selim YA, Elkaffas SMH, Sabit H, Arneth B, Taghiyev ZT, Tantawy MA
    J Clin Med. 2025 Oct 13;14(20):7218
    DOI: 10.3390/jcm14207218  PMID: 41156088
18. Serum and CSF cytokine profile in patients with facial palsy (Bell's palsy): a pilot study
    Ustinov A, Heckmann JG, Singh V, Arneth B, Schwab S
    J Neurol. 2025 Dec 9;273(1):17
    DOI: 10.1007/s00415-025-13561-8  PMID: 41366113
19. Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation
    Meng X, Asadi-Asadabad S, Cao S, Song R, Lin Z,Safhi M, Qin Y, Tcheumi Tactoum E, Taudte RV, Ekici A, Mielenz D, Wirtz S, Schett G, Bozec A
    Cellular & Molecular Immunology, 22, 54-67
    DOI: 10.1038/s41423-024-01233-y  PMID: 39543372
20. Overfeeding and overweight rapidly reprogram inflammatory signaling
    Elkins M, Horrelt M, Woods B, Lawton S, Ohsumi TK, Fleischman A, Taudte RV, Chou J
    Clinical Immunology, 271, 110428, 2025
    DOI: 10.1016/j.clim.2025.110428  PMID: 39788355
21. Targeting PI3K inhibitor resistance in breast cancer with metabolic drugs 
    Gremke N, Besong I, Stroh A, von Wichert L, Witt M, Elmshäuser S, Wanzel M, Fromm MF, Taudte RV, Schmatloch S, Karn T, Reinisch M, Hirmas N, Loibl S, Wündisch T, Litmeyer AS, Jank P, Denkert C, Griewing S,Wagner U, Stiewe T
    Signal Transduction and Targeted Therapy, 10, 92; 2025
    DOI: 10.1038/s41392-025-02180-4  PMID: 40113784
22. Guilty by association: direct interaction with the tetraspanin CD63 suggests a role for organic cation transporter 3 in histamine release from granulocytes
    Pernecker M, Dibos M, Götz S,Al-Monajjed R, Barz V, Albiker C, Schröter R, Neugebauer U, Ludwig-Radtke L,Taudte RV, Vogl T,  Ciarimboli G
    Journal of Biomedical Science, 32,1,68
    DOI: 10.1186/s12929-025-01158-2  PMID: 40652190
23. Gut-specific histamine 3 receptor signaling orchestrates microglia-dependent resolution of peripheral inflammation
    Dürholz K,Ehnes L, Linnerbauer M, Schmid E, Danzer H, Hinzpeter-Schmidt M,Lößlein L, Amend L, Frech M, Azizov V, Schälter F,  Gessner A, Lucas S, Lesker TR,Taudte RV, Hofmann J,Beyer F, Bootz-Maoz H, Reich Y, Romano H, Mauro D, Beckervordersandforth R, Skov Kragsnaes M, Ellingsen T, Xiang W, Haghikia A, Akdis CA, Ciccia F, Bäuerle T, Sarter K, Strowig T, Yissachar N, Schett G, Rothhammer V, Zaiss MM
    Journal of Clinical Investigation, 135,18
    DOI: 10.1172/JCI184697  PMID: 40638239
24. Transmission Electron Microscopy-based characterization of Extracellular Vesicles from plasma and serum from Parkinson´s Disease patients
    Weiss A, Florin Meissner A, Boros FA,  Regensburger M, Taudte RV, Matamoros-Angles A,Arnold P, Zunke F 
    Cell Communication and Signaling, 23, 395
    DOI: 10.1186/s12964-025-02383-w  PMID: 40968382
25. Beyond the Hydrashift assay: the utility of isoelectric focusing for therapeutic antibody and paraprotein detection
    Reiter R, Mann C, Nockher WA
    Clin Chem Lab Med. 2025 May 1;63(9):1766-1772
    DOI: 10.1515/cclm-2025-0352  PMID: 40305408
26. Laboratory diagnostic in multiple myeloma: Quantification of daratumumab blood levels using isoelectric focusing
    Reiter R, Mann C, Nockher WA
    Clin Chim Acta. Epub 2025
    DOI: 10.1016/j.cca.2025.120650  PMID: 41067485
     

Reviews 2025:

1. Long COVID: Pathophysiology, current concepts, and future directions 
   Skevaki C, Moschopoulos CD, Fragkou PC, Grote K, Schieffer E, Schieffer B.
   Journal of Allergy and Clinical Immunology 155(4):1059-1070, 2025
   DOI:   10.1016/j.jaci.2024.12.1074  PMID:  39724975
2. Infections in immunocompromised hosts: progress made and challenges ahead
   Sassine J, Skevaki C, Chemaly RF; European Society for Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses (ESGREV)
   Clinical Microbiology and Infection 31(1):22-23
   DOI: 10.1016/j.cmi.2024.10.017  PMID: 39447745
3. Effects of long-term corticosteroid use on susceptibility to respiratory viruses: a narrative review
   Fragkou PC, Dimopoulou D, Moschopoulos CD, Skevaki C; ESCMID Study Group for Respiratory Viruses (ESGREV)
   Clinical Microbiology and Infection 31(1):43-48
   DOI: 10.1016/j.cmi.2024.09.014  PMID: 39332599
4. Can we improve immune health by restoring microbial biodiversity?
   Sinkkonen A, Roslund M, Skevaki C, Mmbaga BT, Nadeau KC, Renz H.
   Nature Reviews Immunology 25(7):477-478
   DOI: 10.1038/s41577-025-01190-1  PMID: 40425820
5. The Care Continuum of Patients With Influenza in the Post–COVID-19 Era: A Position Paper
   Karakonstantis S, Lytras T, Keske S, Tsiodras S, Papst L, Ioannou P, Velikov P, Berg LP, De Angelis G, Prendki V, Adlhoch C, Penttinen P, Rello J, Gavazzi G, Malhotra-Kumar S, Skevaki C, Slafkosky M, Rath B. 
   Journal of Infectious Diseases 232:333-346
   DOI: 10.1093/infdis/jiaf333  PMID: 41102611
6. Roads to remission: evolving treatment concepts in type 2 inflammatory diseases
   Lommatzsch M, Blumchen K, Beck LA, Bousquet J, Brusselle GG, Fokkens WJ, Hamelmann E, Lau S, Ott H, Pfarr O, Sampson HA, Smolen JS, Taube C, Tarner ICH, Wagemann M, Werfel T, Worm M, Renz H
   EClinicalMedicine 8;80:103050
   DOI: 10.1016/j.eclinm.2024.103050  PMID: 39867971
7. Wege zur Remission: Neue Behandlungskonzepte bei entzündlichen Typ-2-Erkrankungen 
   Lommatzsch M, Blumchen K, Beck LA, Bousquet J, Brusselle GG, Fokkens WJ, Hamelmann E, Lau S, Ott H, Pfarr O, Sampson HA, Smolen JS, Taube C, Tarner ICH, Wagemann M, Werfel T, Worm M, Renz H
   Allergologie, Jahrgang 48, Nr. 12/2025, S.678-679
8. Impact of Residential Greeness Exposure on the Development of Allergic Diseases and Asthma and on Asthma Control – A Systematic Review for the EAACI Guidelines of Environmental Science for Allergic Diseases and Asthma
   Agache I, Balbin-Ramon GJ, Fernandez Saenz FK, Sola-Arnau I, Alonso-Coello P, Haahtela T, Traidl-Hoffmann C, O’Mahony L, Damialis A, Lauerma A, Nadeau KC, Pali-Schöll I, Palomares O, Renz H, Schwarze J, Vercelli D, Canelo-Aybar C, Jutel M, Akdis CA
   Allergy, 2025; 0:1-16
   DOI: 10.1111/all.16653  PMID: 40632014

S2 und S3 Leitlinien:

1. S3 - Leitlinie „Diagnostik auf Vorliegen eines primären Immundefekts“ Abklärung von Infektionsanfälligkeit, Immundysregulation und weiteren Symptomen von primären Immundefekten
   Farmand S, Aydin S, Baumann U, von Bernuth H, Bickel M, Boztug K, Dunst F, Faßhauer M, Förster-Wald E, Gröger M, Habermehl P, Hahn G, Hanitsch L, von Hardenberg S, Hartmann P, Hauck F, Klemann C, Klock G, Kurz H, Morbach H, Neubert J, Niehues T, Pachlopnik Schmid J, Pickl WF, Renz H, Sachs U, Schuetz C, Thee S, Warnatz K, Wehr C, Welte T†, Witte T, Wittke K, Ehl S.
   AWMF Online; Reg.-Nr. 189-003, 2025