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Silke Reinartz / Thomas Worzfeld: Influence of tumor-host secretome on ovarian cancer cell invasion and metastasis

Using these biomaterials Silke Reinartz and Thomas Worzfeld will investigate the mutual influence of the cancer, immune cell, and mesothelial cell secretomes on cancer cell adhesion, invasion, and metastasis. One central topic of their project addresses the question of how p53-dependent mutations of the tumor cell secretome affect the hosttumor interplay to promote invasion. A second focus will be on the role NF-κB in mesothelial cell plasticity and NF-κB-mediated secretion for cancer cell metastasis.

Application of the primary cell culture system to study the role of the secretome on invasion and metastasis. DC: dendritic cell.