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Maren Nattermann

In our group, we are focusing on synthetic cofactors for more efficient microbial production. Within M4C, we investigate how non-natural cofactors can aid in the implementation of synthetic CO₂ assimilation pathways into host organisms. One-carbon metabolism requires a delicate energy balance, which is difficult to maintain when shared cofactor pools are drained by both the synthetic pathway and the natural metabolism surrounding it. Here, metabolic orthogonality can be applied, separating metabolic branches on the biochemical level to avoid cross-talk. Using synthetic cofactors in synthetic reactions creates such a level of separation, which the group wants to use to enable the in vivo implementation of challenging to introduce and currently impossible to introduce synthetic CO₂ fixation pathways.

Research Focus:

Microbes providing Solutions

Key Publication(s):

Wichmann P, Cox-Fermandois A, Küffner AM, Linne U, Erb TJ, Nattermann M. Engineering a formic acid reductase. ACS Catalysis 2025 15:20485 - 20495. doi: 10.1021/acscatal.5c04079

Bakker J, Boinot M, Schann K, Kahnt J, Glatter T, Erb TJ, Nattermann M, Wenk S. Evolution-assisted engineering of formate assimilation via the formyl phosphate route in Escherichia coli. Metabolic Engineering 2025 93:208 - 217. doi: 10.1016/j.ymben.2025.10.004

Nattermann M, Wenk S, Pfister P, He H, Lee SH, Szymanski W, Guntermann N, Zhu F, Nickel L, Wallner C, Zarzycki J, Paczia N, Gaißert N, Franciò G, Leitner W, Gonzalez R, Erb TJ. Engineering a new-to-nature cascade for phosphate-dependent formate to formaldehyde conversion in vitro and in vivo. Nature Communications 2023 14:2682. doi: 10.1038/s41467-023-38072-w

For more information, please visit:

https://www.mpi-marburg.mpg.de/1484346/Maren-Nattermann

Main Content

Maren Nattermann

Research Focus:

Key Publication(s):

For more information, please visit:

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